About My Research
Dr. Zebardast’s research focuses on developing precision medicine-based tools for disease detection, aiding clinicians in assessing for disease progression and eventually optimizing patient-related outcomes. She collaborates widely with experts from Mass General and the Ocular Genomics Institute to define image-based and longitudinal endophenotypes for glaucoma using machine learning methods and to understand the genetic underpinning of vision loss in this blinding disease. This work could lay the foundation for precision medicine approaches to screening and diagnosis that combines clinical phenotypes and genetic background to improve assessment of disease risk for any individual.
Dr. Zebardast was selected for the NIH/NEI-funded K12 Harvard-Vision Clinical Scientist Training Program as well as the Gliklich Innovation Scholarship program in 2019. She is currently funded by an NIH K23 career development award, an NIH R21 award as well as the Research to Prevent Blindness Career development award.
Education
2007: BASc, with honors, Engineering Science Biomedical Track, University of Toronto
2008: MSc, Tissue Engineering, University of Toronto
2013: MD, Yale School of Medicine
Postgraduate Training
2014: Transitional Year Internship, Yale New Haven Hospital
2017: Residency, Ophthalmology, Wilmer Eye Institute, Johns Hopkins University
2018: Fellowship, Glaucoma, Wilmer Eye Institute, Johns Hopkins University
Honors
2014 and 2015: Wilmer Research Grant Award
2015 and 2016: Wilmer Mitchell Prize for best research by a Wilmer resident
2016: American Glaucoma Society Bernard Schwartz Memorial Award for best poster or paper presentation
2017: Paul S. Lietman Global Travel Fellowship
2021: Research to Prevent Blindness Career Development Award
- Racial Disparities in Glaucoma Vision Outcomes and Eye Care Utilization: An IRIS® Registry Analysis. Am J Ophthalmol. 2024 Mar 26.
- Association of retinal optical coherence tomography metrics and polygenic risk scores with cognitive function and future cognitive decline. Br J Ophthalmol. 2024 Mar 20; 108(4):599-606.
- Effectiveness of angle based minimally invasive glaucoma surgery after laser trabeculoplasty: an analysis of the IRIS® Registry. Ophthalmol Glaucoma. 2024 Mar 20.
- Harvard Glaucoma Fairness: A Retinal Nerve Disease Dataset for Fairness Learning and Fair Identity Normalization. IEEE Trans Med Imaging. 2024 Mar 18; PP.
- Polygenic Risk Scores for Glaucoma Onset in the Ocular Hypertension Treatment Study. JAMA Ophthalmol. 2024 Mar 14.
- Anti-inflammatory medication use after cataract surgery: online survey of practice patterns. J Cataract Refract Surg. 2024 Mar 01; 50(3):224-229.
- Trends in Anti-Vascular Endothelial Growth Factor Original Medicare Part B Claims in the United States, 2014-2019. Ophthalmic Epidemiol. 2024 Feb 05; 1-10.
- Machine Learning-Derived Baseline Visual Field Patterns Predict Future Glaucoma Onset in the Ocular Hypertension Treatment Study. Invest Ophthalmol Vis Sci. 2024 Feb 01; 65(2):35.
- Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health. Sci Transl Med. 2024 Jan 24; 16(731):eadg4517.
- Wound modulation in glaucoma surgery: The role of anti-scarring agents. Indian J Ophthalmol. 2024 Mar 01; 72(3):320-327.
- TIE1 and TEK signalling, intraocular pressure, and primary open-angle glaucoma: a Mendelian randomization study. J Transl Med. 2023 11 24; 21(1):847.
- Normative Percentiles of Retinal Nerve Fiber Layer Thickness and Glaucomatous Visual Field Loss. Transl Vis Sci Technol. 2023 10 03; 12(10):13.
- Artifact-Tolerant Clustering-Guided Contrastive Embedding Learning for Ophthalmic Images in Glaucoma. IEEE J Biomed Health Inform. 2023 09; 27(9):4329-4340.
- Deep Ocular Phenotyping Across Primary Open-Angle Glaucoma Genetic Burden. JAMA Ophthalmol. 2023 09 01; 141(9):891-899.
- Automated detection of genetic relatedness from fundus photographs using Siamese Neural Networks. medRxiv. 2023 Aug 23.
- Polygenic Risk Score Improves Prediction of Primary Open Angle Glaucoma Onset in the Ocular Hypertension Treatment Study. medRxiv. 2023 Aug 16.
- Insights into human health from phenome- and genome-wide analyses of UK Biobank retinal optical coherence tomography phenotypes. medRxiv. 2023 May 17.
- Is Prophylactic Laser Peripheral Iridotomy Cost Effective? Maybe Not. Ophthalmol Glaucoma. 2023 Jul-Aug; 6(4):323-324.
- PyVisualFields: A Python Package for Visual Field Analysis. Transl Vis Sci Technol. 2023 02 01; 12(2):6.
- Relationship between Claims-Based Frailty Index and Eye Care Utilization among Medicare Beneficiaries with Glaucoma. Ophthalmology. 2023 06; 130(6):646-654.
- Reply. Ophthalmology. 2023 Apr; 130(4):e15-e16.
- The Growing Need for Ophthalmic Data Standardization. Ophthalmol Sci. 2023 Mar; 3(1):100262.
- Effect of visual impairment on depression and anxiety during the COVID-19 pandemic in the United States. Can J Ophthalmol. 2022 Dec 01.
- Effectiveness of Microinvasive Glaucoma Surgery in the United States: Intelligent Research in Sight Registry Analysis 2013-2019. Ophthalmology. 2023 03; 130(3):242-255.
- Improving Ophthalmic Workforce Diversity: A Call to Action. Ophthalmology. 2022 10; 129(10):1081-1082.
- Enhancing Diversity in the Ophthalmology Workforce. Ophthalmology. 2022 10; 129(10):e127-e136.
- Reply. Ophthalmology. 2022 Nov; 129(11):e155-e156.
- Effectiveness of Trabeculectomy and Tube Shunt with versus without Concurrent Phacoemulsification: Intelligent Research in Sight Registry Longitudinal Analysis. Ophthalmol Glaucoma. 2023 Jan-Feb; 6(1):42-53.
- Interaction of background genetic risk, psychotropic medications, and primary angle closure glaucoma in the UK Biobank. PLoS One. 2022; 17(6):e0270530.
- Impact of the Affordable Care Act on Glaucoma Severity at First Presentation. Ophthalmic Epidemiol. 2023 06; 30(3):326-329.
- Race and Ethnicity Differences in Disease Severity and Visual Field Progression Among Glaucoma Patients. Am J Ophthalmol. 2022 10; 242:69-76.
- Sex-Based Differences in Medicare Reimbursements among Ophthalmologists Persist across Time. Ophthalmology. 2022 09; 129(9):1056-1063.
- Factors associated with glaucoma-specific quality of life in a US glaucoma clinic in a pilot implementation of an online computerised adaptive test (GlauCAT). Br J Ophthalmol. 2023 08; 107(8):1079-1085.
- Assessing Surface Shapes of the Optic Nerve Head and Peripapillary Retinal Nerve Fiber Layer in Glaucoma with Artificial Intelligence. Ophthalmol Sci. 2022 Sep; 2(3):100161.
- Background polygenic risk modulates the association between glaucoma and cardiopulmonary diseases and measures: an analysis from the UK Biobank. Br J Ophthalmol. 2023 08; 107(8):1112-1118.
- Photoreceptor Layer Thinning Is an Early Biomarker for Age-Related Macular Degeneration: Epidemiologic and Genetic Evidence from UK Biobank OCT Data. Ophthalmology. 2022 06; 129(6):694-707.
- Implementation of an Online Glaucoma-Specific Quality of Life Computerized Adaptive Test System in a US Glaucoma Hospital. Transl Vis Sci Technol. 2022 Feb 01; 11(2):24.
- Corneal Endothelial Transplantation in Uveitis: Incidence and Risk Factors. Am J Ophthalmol. 2022 04; 236:288-297.
- Deep Learning of the Retina Enables Phenome- and Genome-Wide Analyses of the Microvasculature. Circulation. 2022 01 11; 145(2):134-150.
- Racial and Socioeconomic Differences in Eye Care Utilization among Medicare Beneficiaries with Glaucoma. Ophthalmology. 2022 04; 129(4):397-405.
- Association Between Diabetes, Diabetic Retinopathy, and Glaucoma. Curr Diab Rep. 2021 09 08; 21(10):38.
- Changing trends in ocular trauma during the COVID-19 pandemic in the USA. Br J Ophthalmol. 2023 02; 107(2):295-298.
- Usage Patterns of Minimally Invasive Glaucoma Surgery (MIGS) Differ by Glaucoma Type: IRIS Registry Analysis 2013-2018. Ophthalmic Epidemiol. 2022 08; 29(4):443-451.
- Population-Based Utility of van Herick Grading for Angle-Closure Detection. Ophthalmology. 2021 12; 128(12):1779-1782.
- The Heritability of Primary Angle Closure Anatomic Traits and Predictors of Angle Closure in South Indian Siblings. Am J Ophthalmol. 2021 10; 230:188-199.
- The functional burden of diabetic retinopathy in the United States. Graefes Arch Clin Exp Ophthalmol. 2021 Oct; 259(10):2977-2986.
- Fall-Related Eye Injury Among Older Adults in the United States. Am J Ophthalmol. 2021 09; 229:82-89.
- Glaucoma and Machine Learning: A Call for Increased Diversity in Data. Ophthalmol Glaucoma. 2021 Jul-Aug; 4(4):339-342.
- Trends and Usage Patterns of Minimally Invasive Glaucoma Surgery in the United States: IRIS® Registry Analysis 2013-2018. Ophthalmol Glaucoma. 2021 Nov-Dec; 4(6):558-568.
- Characteristics of p.Gln368Ter Myocilin Variant and Influence of Polygenic Risk on Glaucoma Penetrance in the UK Biobank. Ophthalmology. 2021 09; 128(9):1300-1311.
- Psychometric validation techniques applied to the IND-VFQ-33 visual function questionnaire: the Hyderabad ocular morbidity in the elderly study (HOMES). BMC Med Res Methodol. 2021 02 05; 21(1):26.
- Age-Related Macular Degeneration and Visual and Physical Disability in a Nationally Representative Sample from the United States. Transl Vis Sci Technol. 2020 12; 9(13):42.
- Impact of Vision Loss on Visual Function Among Elderly Residents in the Home for the Aged in India: The Hyderabad Ocular Morbidity in Elderly Study. Transl Vis Sci Technol. 2020 12; 9(13):11.
- Post-operative intracranial gas migration with optic nerve infiltration and atrophy following retinal detachment repair. Am J Ophthalmol Case Rep. 2020 Dec; 20:100920.
- The Effectiveness of Intracameral Moxifloxacin Endophthalmitis Prophylaxis for Trabeculectomy. Ophthalmol Glaucoma. 2021 Jan-Feb; 4(1):11-19.
- Retrospective cross-sectional analysis of the changes in marijuana use in the USA, 2005-2018. BMJ Open. 2020 07 28; 10(7):e037905.
- Comparison of the corrected intraocular pressure by tonopachy with that of Goldmann applanation tonometry in normal and glaucomatous patients. Indian J Ophthalmol. 2020 04; 68(4):620-626.
- Effect of a Schlemm's Canal Microstent on Early Postoperative Intraocular Pressure after Cataract Surgery: An Analysis of the HORIZON Randomized Controlled Trial. Ophthalmology. 2020 10; 127(10):1303-1310.
- Corneal Endothelium Changes 6 Months after Laser Peripheral Iridotomy: Prospective Study. Ophthalmol Glaucoma. 2020 May - Jun; 3(3):220-221.
- Remission of Non-Infectious Anterior Scleritis: Incidence and Predictive Factors. Am J Ophthalmol. 2021 03; 223:377-395.
- Predictors of Short-Term Intraocular Pressure Change after Laser Peripheral Iridotomy: A Prospective Randomized Study. Ophthalmol Glaucoma. 2018 Nov - Dec; 1(3):197-205.
- Resolution of Visual Dysphotopsias after Laser Iridotomy: Six-Month Follow-up. Ophthalmology. 2019 03; 126(3):469-471.e1.
- Dual sensory impairment: The association between glaucomatous vision loss and hearing impairment and function. PLoS One. 2018; 13(7):e0199889.
- Reply. Ophthalmology. 2018 05; 125(5):e36-e37.
- Comparison of New Visual Disturbances after Superior versus Nasal/Temporal Laser Peripheral Iridotomy: A Prospective Randomized Trial. Ophthalmology. 2018 03; 125(3):345-351.
- The Prevalence and Demographic Associations of Presenting Near-Vision Impairment Among Adults Living in the United States. Am J Ophthalmol. 2017 Feb; 174:134-144.
- Changes in Anterior Segment Morphology and Predictors of Angle Widening after Laser Iridotomy in South Indian Eyes. Ophthalmology. 2016 12; 123(12):2519-2526.
- Angle Closure Phenotypes in Siblings of Patients at Different Stages of Angle Closure. Ophthalmology. 2016 07; 123(7):1622-4.
- Comparison of resident and glaucoma faculty practice patterns in the care of open-angle glaucoma. BMC Ophthalmol. 2015 Apr 14; 15:41.
- Comparing the Impact of Refractive and Nonrefractive Vision Loss on Functioning and Disability: The Salisbury Eye Evaluation. Ophthalmology. 2015 Jun; 122(6):1102-10.
- Family history is a strong risk factor for prevalent angle closure in a South Indian population. Ophthalmology. 2014 Nov; 121(11):2091-7.
- Cardiorespiratory fitness and vision loss among young and middle-age U.S. adults. Am J Health Promot. 2015 Mar-Apr; 29(4):226-9.
- Aflibercept in the treatment of neovascular age-related macular degeneration in previously treated patients. J Ocul Pharmacol Ther. 2014 May; 30(4):346-52.
- Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: initial findings. Psychiatry Res. 2013 Oct 30; 214(1):33-41.
- Twenty-four-hour pattern of intraocular pressure in untreated patients with ocular hypertension. Invest Ophthalmol Vis Sci. 2013 Jan 17; 54(1):512-7.
- Pathology quiz case 1. Ceruminous gland adenocarcinoma. Arch Otolaryngol Head Neck Surg. 2012 Sep; 138(9):871-2.
- Intravitreal ranibizumab for treatment of choroidal neovascularization secondary to angioid streaks in pseudoxanthoma elasticum: five-year follow-up. Semin Ophthalmol. 2012 May-Jul; 27(3-4):61-4.
- Response of patients with refractory myasthenia gravis to rituximab: a retrospective study. Ther Adv Neurol Disord. 2011 Sep; 4(5):259-66.
- Human umbilical cord perivascular cells (HUCPVC): A mesenchymal cell source for dermal wound healing. Organogenesis. 2010 Oct-Dec; 6(4):197-203.
- Rituximab in the management of refractory myasthenia gravis. Muscle Nerve. 2010 Mar; 41(3):375-8.
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