M. Charles Liberman,
PhD
Massachusetts Eye and Ear
Investigator, Eaton-Peabody Laboratories
Harvard Medical School
Harold F. Schuknecht Professor of Otolaryngology–Head and Neck Surgery
charles_liberman@meei.harvard.edu
For investigator inquiries only
About My Research
Dr. Charlie Liberman's research interests include 1) the coding of acoustic stimuli as neural responses in the auditory periphery, 2) efferent feedback control of the auditory periphery, 3) the mechanisms underlying noise-induced and age-related hearing loss, 4) the signaling pathways mediating nerve survival in the inner ear, and 5) the application of cell- and drug-based therapies to the repair of a damaged inner ear. His work uses a variety of approaches from systems neuroscience to cell and molecular biology.
Dr. Liberman has been on the faculty at Harvard since 1979 and has published more than 180 papers on a variety of topics in auditory neuroscience.
Publications powered by Harvard Catalyst Profiles
- On the Difficulty Predicting Word Recognition Performance After Cochlear Implantation. Otol Neurotol. 2024 Apr 05.
- Noise-induced synaptic loss and its post-exposure recovery in CBA/CaJ vs. C57BL/6J mice. Hear Res. 2024 Apr; 445:108996.
- Predicting Atrophy of the Cochlear Stria Vascularis from the Shape of the Threshold Audiogram. J Neurosci. 2023 12 13; 43(50):8801-8811.
- Evidence of cochlear neural degeneration in normal-hearing subjects with tinnitus. Sci Rep. 2023 11 30; 13(1):19870.
- Neural Degeneration in Normal-Aging Human Cochleas: Machine-Learning Counts and 3D Mapping in Archival Sections. J Assoc Res Otolaryngol. 2023 Oct; 24(5):499-511.
- Ultrastructure of noise-induced cochlear synaptopathy. Sci Rep. 2023 11 09; 13(1):19456.
- Large-scale annotated dataset for cochlear hair cell detection and classification. bioRxiv. 2023 Sep 01.
- Supporting-cell vs. hair-cell survival in the human cochlea: Implications for regenerative therapies. Hear Res. 2023 Aug; 435:108815.
- Supporting-cell vs. hair-cell survival in the human cochlea: Implications for regenerative therapies. bioRxiv. 2023 Apr 24.
- Isolating auditory-nerve contributions to electrocochleography by high-pass filtering: A better biomarker for cochlear nerve degeneration? JASA Express Lett. 2023 02; 3(2):024401.
- Three-dimensional quantification of fibrosis and ossification after cochlear implantation via virtual re-sectioning: Potential implications for residual hearing. Hear Res. 2023 02; 428:108681.
- Cochlear Neurotrophin-3 overexpression at mid-life prevents age-related inner hair cell synaptopathy and slows age-related hearing loss. Aging Cell. 2022 10; 21(10):e13708.
- Predicting neural deficits in sensorineural hearing loss from word recognition scores. Sci Rep. 2022 06 23; 12(1):8929.
- Age-related stereocilia pathology in the human cochlea. Hear Res. 2022 09 01; 422:108551.
- Dopaminergic and cholinergic innervation in the mouse cochlea after noise-induced or age-related synaptopathy. Hear Res. 2022 09 01; 422:108533.
- Noise Masking in Cochlear Synaptopathy: Auditory Brainstem Response vs. Auditory Nerve Response in Mouse. J Neurophysiol. 2022 May 18.
- Human vestibular schwannoma reduces density of auditory nerve fibers in the osseous spiral lamina. Hear Res. 2022 05; 418:108458.
- Age-related reduction in frequency-following responses as a potential marker of cochlear neural degeneration. Hear Res. 2022 02; 414:108411.
- Auditory-nerve responses in mice with noise-induced cochlear synaptopathy. J Neurophysiol. 2021 12 01; 126(6):2027-2038.
- The summating potential in human electrocochleography: Gaussian models and Fourier analysis. J Acoust Soc Am. 2021 10; 150(4):2492.
- Cochlear Synaptic Degeneration and Regeneration After Noise: Effects of Age and Neuronal Subgroup. Front Cell Neurosci. 2021; 15:684706.
- Idiopathic Sudden Sensorineural Hearing Loss: Speech Intelligibility Deficits Following Threshold Recovery. Ear Hear. 2021 July/Aug; 42(4):782-792.
- Primary Neural Degeneration in Noise-Exposed Human Cochleas: Correlations with Outer Hair Cell Loss and Word-Discrimination Scores. J Neurosci. 2021 05 19; 41(20):4439-4447.
- Envelope following responses predict speech-in-noise performance in normal-hearing listeners. J Neurophysiol. 2021 04 01; 125(4):1213-1222.
- Correlations between cochlear pathophysiology and behavioral measures of temporal and spatial processing in noise exposed macaques. Hear Res. 2021 03 01; 401:108156.
- Synaptic migration and reorganization after noise exposure suggests regeneration in a mature mammalian cochlea. Sci Rep. 2020 11 17; 10(1):19945.
- Age-Related Hearing Loss Is Dominated by Damage to Inner Ear Sensory Cells, Not the Cellular Battery That Powers Them. J Neurosci. 2020 08 12; 40(33):6357-6366.
- Electrophysiological markers of cochlear function correlate with hearing-in-noise performance among audiometrically normal subjects. J Neurophysiol. 2020 08 01; 124(2):418-431.
- Chronic Conductive Hearing Loss Is Associated With Speech Intelligibility Deficits in Patients With Normal Bone Conduction Thresholds. Ear Hear. 2020 May/Jun; 41(3):500-507.
- Middle Ear Muscle Reflex and Word Recognition in Normal-Hearing Adults: Evidence for Cochlear Synaptopathy? Ear Hear. 2020 Jan/Feb; 41(1):25-38.
- Noise-induced Cochlear Synaptopathy with and Without Sensory Cell Loss. Neuroscience. 2020 02 10; 427:43-57.
- Protection from noise-induced cochlear synaptopathy by virally mediated overexpression of NT3. Sci Rep. 2019 10 25; 9(1):15362.
- Cochlear Efferent Innervation Is Sparse in Humans and Decreases with Age. J Neurosci. 2019 11 27; 39(48):9560-9569.
- Morphological Immaturity of the Neonatal Organ of Corti and Associated Structures in Humans. J Assoc Res Otolaryngol. 2019 10; 20(5):461-474.
- A simple algorithm for objective threshold determination of auditory brainstem responses. Hear Res. 2019 09 15; 381:107782.
- Assessing fractional hair cell survival in archival human temporal bones. Laryngoscope. 2020 02; 130(2):487-495.
- Translating animal models to human therapeutics in noise-induced and age-related hearing loss. Hear Res. 2019 06; 377:44-52.
- Loss of LDAH associated with prostate cancer and hearing loss. Hum Mol Genet. 2018 12 15; 27(24):4194-4203.
- Inner ear pathologies impair sodium-regulated ion transport in Meniere's disease. Acta Neuropathol. 2019 02; 137(2):343-357.
- Primary Neural Degeneration in the Human Cochlea: Evidence for Hidden Hearing Loss in the Aging Ear. Neuroscience. 2019 05 21; 407:8-20.
- Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity. Cell. 2018 08 23; 174(5):1229-1246.e17.
- Blast-induced cochlear synaptopathy in chinchillas. Sci Rep. 2018 Jul 16; 8(1):10740.
- A Gain-of-Function Mutation in the a9 Nicotinic Acetylcholine Receptor Alters Medial Olivocochlear Efferent Short-Term Synaptic Plasticity. J Neurosci. 2018 04 18; 38(16):3939-3954.
- Effects of cochlear synaptopathy on middle-ear muscle reflexes in unanesthetized mice. Hear Res. 2018 06; 363:109-118.
- Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. Nature. 2018 01 11; 553(7687):217-221.
- Noise-induced cochlear synaptopathy in rhesus monkeys (Macaca mulatta). Hear Res. 2017 09; 353:213-223.
- Noise-induced and age-related hearing loss: Â new perspectives and potential therapies. F1000Res. 2017; 6:927.
- Corrigendum: Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction. Sci Rep. 2017 05 22; 7:46827.
- Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction. Sci Rep. 2017 04 03; 7:45524.
- Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms. Hear Res. 2017 06; 349:138-147.
- Toward a Differential Diagnosis of Hidden Hearing Loss in Humans. PLoS One. 2016; 11(9):e0162726.
- Type II Cochlear Ganglion Neurons Do Not Drive the Olivocochlear Reflex: Re-Examination of the Cochlear Phenotype in Peripherin Knock-Out Mice. eNeuro. 2016 Jul-Aug; 3(4).
- Postnatal maturation of auditory-nerve heterogeneity, as seen in spatial gradients of synapse morphology in the inner hair cell area. Hear Res. 2016 09; 339:12-22.
- Round-window delivery of neurotrophin 3 regenerates cochlear synapses after acoustic overexposure. Sci Rep. 2016 04 25; 6:24907.
- Auditory Brainstem Response Latency in Noise as a Marker of Cochlear Synaptopathy. J Neurosci. 2016 Mar 30; 36(13):3755-64.
- Perinatal thiamine deficiency causes cochlear innervation abnormalities in mice. Hear Res. 2016 05; 335:94-104.
- Oncomodulin, an EF-Hand Ca2+ Buffer, Is Critical for Maintaining Cochlear Function in Mice. J Neurosci. 2016 Feb 03; 36(5):1631-5.
- Central Gain Restores Auditory Processing following Near-Complete Cochlear Denervation. Neuron. 2016 Feb 17; 89(4):867-79.
- Noise-Induced Hearing Loss: Permanent Versus Temporary Threshold Shifts and the Effects of Hair Cell Versus Neuronal Degeneration. Adv Exp Med Biol. 2016; 875:1-7.
- The middle ear muscle reflex in the diagnosis of cochlear neuropathy. Hear Res. 2016 Feb; 332:29-38.
- Chronic Conductive Hearing Loss Leads to Cochlear Degeneration. PLoS One. 2015; 10(11):e0142341.
- Towards a Diagnosis of Cochlear Neuropathy with Envelope Following Responses. J Assoc Res Otolaryngol. 2015 Dec; 16(6):727-45.
- Adenomatous Polyposis Coli Protein Deletion in Efferent Olivocochlear Neurons Perturbs Afferent Synaptic Maturation and Reduces the Dynamic Range of Hearing. J Neurosci. 2015 Jun 17; 35(24):9236-45.
- Cochlear neuropathy in human presbycusis: Confocal analysis of hidden hearing loss in post-mortem tissue. Hear Res. 2015 Sep; 327:78-88.
- Aging after noise exposure: acceleration of cochlear synaptopathy in recovered ears. J Neurosci. 2015 May 13; 35(19):7509-20.
- Immediate and delayed cochlear neuropathy after noise exposure in pubescent mice. PLoS One. 2015; 10(5):e0125160.
- Erratum to: dynamics of cochlear synaptopathy after acoustic overexposure. J Assoc Res Otolaryngol. 2015 Apr; 16(2):221.
- Synaptopathy in the noise-exposed and aging cochlea: Primary neural degeneration in acquired sensorineural hearing loss. Hear Res. 2015 Dec; 330(Pt B):191-9.
- Dynamics of cochlear synaptopathy after acoustic overexposure. J Assoc Res Otolaryngol. 2015 Apr; 16(2):205-19.
- A non-canonical pathway from cochlea to brain signals tissue-damaging noise. Curr Biol. 2015 Mar 02; 25(5):606-12.
- Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma. Elife. 2014 Oct 20; 3.
- Resistance to noise-induced hearing loss in 129S6 and MOLF mice: identification of independent, overlapping, and interacting chromosomal regions. J Assoc Res Otolaryngol. 2014 Oct; 15(5):721-38.
- Olivocochlear innervation maintains the normal modiolar-pillar and habenular-cuticular gradients in cochlear synaptic morphology. J Assoc Res Otolaryngol. 2014 Aug; 15(4):571-83.
- Hot Topics-Hidden hearing loss: Permanent cochlear-nerve degeneration after temporary noise-induced threshold shift. J Acoust Soc Am. 2014 Apr; 135(4):2311.
- Shelter from the Glutamate storm: Loss of olivocochlear efferents increases cochlear nerve degeneration during aging. J Acoust Soc Am. 2014 Apr; 135(4):2384.
- Efferent feedback slows cochlear aging. J Neurosci. 2014 Mar 26; 34(13):4599-607.
- Is noise-induced cochlear neuropathy key to the generation of hyperacusis or tinnitus? J Neurophysiol. 2014 Feb; 111(3):552-64.
- Ouabain-induced cochlear nerve degeneration: synaptic loss and plasticity in a mouse model of auditory neuropathy. J Assoc Res Otolaryngol. 2014 Feb; 15(1):31-43.
- Quantitative analysis of ribbons, vesicles, and cisterns at the cat inner hair cell synapse: correlations with spontaneous rate. J Comp Neurol. 2013 Oct 01; 521(14):3260-71.
- Hair cell overexpression of Islet1 reduces age-related and noise-induced hearing loss. J Neurosci. 2013 Sep 18; 33(38):15086-94.
- Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline. J Neurosci. 2013 Aug 21; 33(34):13686-94.
- Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates. J Neurophysiol. 2013 Aug; 110(3):577-86.
- Efferent feedback minimizes cochlear neuropathy from moderate noise exposure. J Neurosci. 2013 Mar 27; 33(13):5542-52.
- Olivocochlear suppression of outer hair cells in vivo: evidence for combined action of BK and SK2 channels throughout the cochlea. J Neurophysiol. 2013 Mar; 109(6):1525-34.
- Generating synchrony from the asynchronous: compensation for cochlear traveling wave delays by the dendrites of individual brainstem neurons. J Neurosci. 2012 Jul 04; 32(27):9301-11.
- Contralateral-noise effects on cochlear responses in anesthetized mice are dominated by feedback from an unknown pathway. J Neurophysiol. 2012 Jul; 108(2):491-500.
- Inner hair cells are not required for survival of spiral ganglion neurons in the adult cochlea. J Neurosci. 2012 Jan 11; 32(2):405-10.
- Dopaminergic signaling in the cochlea: receptor expression patterns and deletion phenotypes. J Neurosci. 2012 Jan 04; 32(1):344-55.
- Sound-evoked olivocochlear activation in unanesthetized mice. J Assoc Res Otolaryngol. 2012 Apr; 13(2):209-217.
- Age-related primary cochlear neuronal degeneration in human temporal bones. J Assoc Res Otolaryngol. 2011 Dec; 12(6):711-7.
- Primary neural degeneration in the Guinea pig cochlea after reversible noise-induced threshold shift. J Assoc Res Otolaryngol. 2011 Oct; 12(5):605-16.
- Selective inner hair cell loss in prematurity: a temporal bone study of infants from a neonatal intensive care unit. J Assoc Res Otolaryngol. 2011 Oct; 12(5):595-604.
- Olivocochlear efferent control in sound localization and experience-dependent learning. J Neurosci. 2011 Feb 16; 31(7):2493-501.
- Opposing gradients of ribbon size and AMPA receptor expression underlie sensitivity differences among cochlear-nerve/hair-cell synapses. J Neurosci. 2011 Jan 19; 31(3):801-8.
- Hearing and vestibular deficits in the Coch(-/-) null mouse model: comparison to the Coch(G88E/G88E) mouse and to DFNA9 hearing and balance disorder. Hear Res. 2011 Feb; 272(1-2):42-8.
- Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons. J Neurosci. 2010 Jun 02; 30(22):7587-97.
- Mice lacking adrenergic signaling have normal cochlear responses and normal resistance to acoustic injury but enhanced susceptibility to middle-ear infection. J Assoc Res Otolaryngol. 2010 Sep; 11(3):449-61.
- Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss. PLoS Genet. 2010 May 20; 6(5):e1000955.
- Muscarinic signaling in the cochlea: presynaptic and postsynaptic effects on efferent feedback and afferent excitability. J Neurosci. 2010 May 12; 30(19):6751-62.
- Contralateral cochlear effects of ipsilateral damage: no evidence for interaural coupling. Hear Res. 2010 Feb; 260(1-2):70-80.
- Adding insult to injury: cochlear nerve degeneration after temporary noise-induced hearing loss. J Neurosci. 2009 Nov 11; 29(45):14077-85.
- Tailored cricoplasty: an improved modification for reconstruction in subglottic tracheal stenosis. J Thorac Cardiovasc Surg. 2009 Mar; 137(3):573-8; discussion 578-9.
- Slow build-up of cochlear suppression during sustained contralateral noise: central modulation of olivocochlear efferents? Hear Res. 2009 Oct; 256(1-2):1-10.
- A point mutation in the hair cell nicotinic cholinergic receptor prolongs cochlear inhibition and enhances noise protection. PLoS Biol. 2009 Jan 20; 7(1):e18.
- Complete pulmonary venous occlusion after radiofrequency ablation for atrial fibrillation. Ann Thorac Surg. 2009 Jan; 87(1):292-5.
- Loss of GABAB receptors in cochlear neurons: threshold elevation suggests modulation of outer hair cell function by type II afferent fibers. J Assoc Res Otolaryngol. 2009 Mar; 10(1):50-63.
- SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cells. Mol Cell Neurosci. 2009 Jan; 40(1):39-49.
- A targeted Coch missense mutation: a knock-in mouse model for DFNA9 late-onset hearing loss and vestibular dysfunction. Hum Mol Genet. 2008 Nov 01; 17(21):3426-34.
- Reciprocal synapses between outer hair cells and their afferent terminals: evidence for a local neural network in the mammalian cochlea. J Assoc Res Otolaryngol. 2008 Dec; 9(4):477-89.
- Eya4-deficient mice are a model for heritable otitis media. J Clin Invest. 2008 Feb; 118(2):651-8.
- Expression studies of osteoglycin/mimecan (OGN) in the cochlea and auditory phenotype of Ogn-deficient mice. Hear Res. 2008 Mar; 237(1-2):57-65.
- The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20594-9.
- BMP4 induction of sensory neurons from human embryonic stem cells and reinnervation of sensory epithelium. Eur J Neurosci. 2007 Dec; 26(11):3016-23.
- Methylthioadenosine phosphorylase (MTAP) in hearing: gene disruption by chromosomal rearrangement in a hearing impaired individual and model organism analysis. Am J Med Genet A. 2007 Jul 15; 143A(14):1630-9.
- Orphan glutamate receptor delta1 subunit required for high-frequency hearing. Mol Cell Biol. 2007 Jun; 27(12):4500-12.
- A novel effect of cochlear efferents: in vivo response enhancement does not require alpha9 cholinergic receptors. J Neurophysiol. 2007 May; 97(5):3269-78.
- Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4413-8.
- Dynamic patterns of neurotrophin 3 expression in the postnatal mouse inner ear. J Comp Neurol. 2007 Mar 01; 501(1):30-7.
- Overexpression of SK2 channels enhances efferent suppression of cochlear responses without enhancing noise resistance. J Neurophysiol. 2007 Apr; 97(4):2930-6.
- Cochlear efferent feedback balances interaural sensitivity. Nat Neurosci. 2006 Dec; 9(12):1474-6.
- Selective removal of lateral olivocochlear efferents increases vulnerability to acute acoustic injury. J Neurophysiol. 2007 Feb; 97(2):1775-85.
- Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of Corti. J Neurobiol. 2006 Nov; 66(13):1489-500.
- Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta. J Neurosci. 2006 Oct 04; 26(40):10315-26.
- Dopaminergic innervation of the mouse inner ear: evidence for a separate cytochemical group of cochlear efferent fibers. J Comp Neurol. 2006 Sep 20; 498(3):403-14.
- The role of BKCa channels in electrical signal encoding in the mammalian auditory periphery. J Neurosci. 2006 Jun 07; 26(23):6181-9.
- Three-dimensional virtual model of the human temporal bone: a stand-alone, downloadable teaching tool. Otol Neurotol. 2006 Jun; 27(4):452-7.
- Deletion of SLC19A2, the high affinity thiamine transporter, causes selective inner hair cell loss and an auditory neuropathy phenotype. J Assoc Res Otolaryngol. 2006 Sep; 7(3):211-7.
- Acceleration of age-related hearing loss by early noise exposure: evidence of a misspent youth. J Neurosci. 2006 Feb 15; 26(7):2115-23.
- Cochlin immunostaining of inner ear pathologic deposits and proteomic analysis in DFNA9 deafness and vestibular dysfunction. Hum Mol Genet. 2006 Apr 01; 15(7):1071-85.
- The histone deacetylase inhibitor sodium butyrate protects against cisplatin-induced hearing loss in guinea pigs. Laryngoscope. 2006 Feb; 116(2):292-6.
- Medial olivocochlear reflex interneurons are located in the posteroventral cochlear nucleus: a kainic acid lesion study in guinea pigs. J Comp Neurol. 2005 Jul 11; 487(4):345-60.
- Influence of supporting cells on neuronal degeneration after hair cell loss. J Assoc Res Otolaryngol. 2005 Jun; 6(2):136-47.
- Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear. J Neurosci. 2004 Oct 06; 24(40):8651-61.
- Response properties of single auditory nerve fibers in the mouse. J Neurophysiol. 2005 Jan; 93(1):557-69.
- Otoacoustic emissions without somatic motility: can stereocilia mechanics drive the mammalian cochlea? J Acoust Soc Am. 2004 Sep; 116(3):1649-55.
- Modulation of cochlear afferent response by the lateral olivocochlear system: activation via electrical stimulation of the inferior colliculus. J Neurophysiol. 2003 Nov; 90(5):3178-200.
- Lateral wall histopathology and endocochlear potential in the noise-damaged mouse cochlea. J Assoc Res Otolaryngol. 2003 Sep; 4(3):339-52.
- Loss of alpha CGRP reduces sound-evoked activity in the cochlear nerve. J Neurophysiol. 2003 Nov; 90(5):2941-9.
- Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo. J Clin Invest. 2003 Aug; 112(4):588-97.
- Olivocochlear innervation in the mouse: immunocytochemical maps, crossed versus uncrossed contributions, and transmitter colocalization. J Comp Neurol. 2003 Jan 13; 455(3):406-16.
- Efferent protection from acoustic injury is mediated via alpha9 nicotinic acetylcholine receptors on outer hair cells. J Neurosci. 2002 Dec 15; 22(24):10838-46.
- Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier. Nature. 2002 Sep 19; 419(6904):300-4.
- Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior. Nat Genet. 2002 Aug; 31(4):363-9.
- Restraint stress and protection from acoustic injury in mice. Hear Res. 2002 Mar; 165(1-2):96-102.
- Dynamics of noise-induced cellular injury and repair in the mouse cochlea. J Assoc Res Otolaryngol. 2002 Sep; 3(3):248-68.
- Effects of anesthesia on efferent-mediated adaptation of the DPOAE. J Assoc Res Otolaryngol. 2002 Sep; 3(3):362-73.
- Glial fibrillary acidic protein expression and promoter activity in the inner ear of developing and adult mice. J Comp Neurol. 2002 Jan 07; 442(2):156-62.
- Morphometric analysis of age-related changes in the human basilar membrane. Ann Otol Rhinol Laryngol. 2001 Dec; 110(12):1147-53.
- Effects of olivocochlear feedback on distortion product otoacoustic emissions in guinea pig. J Assoc Res Otolaryngol. 2001 Sep; 2(3):268-78.
- Spiral ligament pathology: a major aspect of age-related cochlear degeneration in C57BL/6 mice. J Assoc Res Otolaryngol. 2001 Jun; 2(2):118-29.
- Selective inner hair cell loss in premature infants and cochlea pathological patterns from neonatal intensive care unit autopsies. Arch Otolaryngol Head Neck Surg. 2001 Jun; 127(6):629-36.
- Fast, but not slow, effects of olivocochlear activation are resistant to apamin. J Neurophysiol. 2001 Jan; 85(1):84-8.
- Sound conditioning reduces noise-induced permanent threshold shift in mice. Hear Res. 2000 Oct; 148(1-2):213-9.
- Afferent innervation of outer and inner hair cells is normal in neonatally de-efferented cats. J Comp Neurol. 2000 Jul 17; 423(1):132-9.
- Predicting vulnerability to acoustic injury with a noninvasive assay of olivocochlear reflex strength. J Neurosci. 2000 Jun 15; 20(12):4701-7.
- Acoustic injury in mice: 129/SvEv is exceptionally resistant to noise-induced hearing loss. Hear Res. 2000 03; 141(1-2):97-106.
- Gentamicin blocks both fast and slow effects of olivocochlear activation in anesthetized guinea pigs. J Neurophysiol. 1999 Dec; 82(6):3168-74.
- Heat stress and protection from permanent acoustic injury in mice. J Neurosci. 1999 Nov 15; 19(22):10116-24.
- Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system. J Clin Invest. 1999 Aug; 104(3):291-300.
- Long-term sound conditioning enhances cochlear sensitivity. J Neurophysiol. 1999 Aug; 82(2):863-73.
- Stereociliary anomaly in the guinea pig: effects of hair bundle rotation on cochlear sensitivity. Hear Res. 1999 May; 131(1-2):29-38.
- Role of alpha9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation. Neuron. 1999 May; 23(1):93-103.
- Feedback control of the auditory periphery: anti-masking effects of middle ear muscles vs. olivocochlear efferents. J Commun Disord. 1998 Nov-Dec; 31(6):471-82; quiz 483; 553.
- Dense innervation of Deiters' and Hensen's cells persists after chronic deefferentation of guinea pig cochleas. J Comp Neurol. 1998 Oct 26; 400(3):299-309.
- Single olivocochlear neurons in the guinea pig. II. Response plasticity due to noise conditioning. J Neurophysiol. 1998 Jun; 79(6):3088-97.
- Long-term effects of sectioning the olivocochlear bundle in neonatal cats. J Neurosci. 1998 May 15; 18(10):3859-69.
- Conditioning-related protection from acoustic injury: effects of chronic deefferentation and sham surgery. J Neurophysiol. 1997 Dec; 78(6):3095-106.
- Intracellular labeling of auditory nerve fibers in guinea pig: central and peripheral projections. J Comp Neurol. 1997 May 05; 381(2):188-202.
- Morphological subclasses of lateral olivocochlear terminals? Ultrastructural analysis of inner spiral bundle in cat and guinea pig. J Comp Neurol. 1996 Aug 05; 371(4):621-32.
- Ultrastructural differences among afferent synapses on cochlear hair cells: correlations with spontaneous discharge rate. J Comp Neurol. 1996 Jul 22; 371(2):208-21.
- The ipsilaterally evoked olivocochlear reflex causes rapid adaptation of the 2f1-f2 distortion product otoacoustic emission. J Acoust Soc Am. 1996 Jun; 99(6):3572-84.
- Olivocochlear reflex assays: effects of contralateral sound on compound action potentials versus ear-canal distortion products. J Acoust Soc Am. 1996 Jan; 99(1):500-7.
- Chronic cochlear de-efferentation and susceptibility to permanent acoustic injury. Hear Res. 1995 Oct; 90(1-2):158-68.
- A novel cholinergic slow effect of efferent stimulation on cochlear potentials in the guinea pig. J Neurosci. 1995 May; 15(5 Pt 1):3667-78.
- Efferent-mediated protection from acoustic overexposure: relation to slow effects of olivocochlear stimulation. J Neurophysiol. 1995 Feb; 73(2):506-14.
- Antimasking effects of the olivocochlear reflex. II. Enhancement of auditory-nerve response to masked tones. J Neurophysiol. 1993 Dec; 70(6):2533-49.
- Antimasking effects of the olivocochlear reflex. I. Enhancement of compound action potentials to masked tones. J Neurophysiol. 1993 Dec; 70(6):2519-32.
- Central projections of auditory nerve fibers of differing spontaneous rate, II: Posteroventral and dorsal cochlear nuclei. J Comp Neurol. 1993 Jan 01; 327(1):17-36.
- Spatial organization of the auditory nerve according to spontaneous discharge rate. J Comp Neurol. 1992 May 08; 319(2):312-8.
- Central projections of auditory-nerve fibers of differing spontaneous rate. I. Anteroventral cochlear nucleus. J Comp Neurol. 1991 Nov 08; 313(2):240-58.
- The olivocochlear efferent bundle and susceptibility of the inner ear to acoustic injury. J Neurophysiol. 1991 Jan; 65(1):123-32.
- Afferent and efferent innervation of the cat cochlea: quantitative analysis with light and electron microscopy. J Comp Neurol. 1990 Nov 15; 301(3):443-60.
- Effects of chronic cochlear de-efferentation on auditory-nerve response. Hear Res. 1990 Nov; 49(1-3):209-23.
- Quantitative assessment of inner ear pathology following ototoxic drugs or acoustic trauma. Toxicol Pathol. 1990; 18(1 Pt 2):138-48.
- Rapid assessment of sound-evoked olivocochlear feedback: suppression of compound action potentials by contralateral sound. Hear Res. 1989 Mar; 38(1-2):47-56.
- Effects of contralateral sound on auditory-nerve responses. I. Contributions of cochlear efferents. Hear Res. 1989 Jan; 37(2):89-104.
- Effects of contralateral sound on auditory-nerve responses. II. Dependence on stimulus variables. Hear Res. 1989 Jan; 37(2):105-21.
- Brainstem branches from olivocochlear axons in cats and rodents. J Comp Neurol. 1988 Dec 22; 278(4):591-603.
- Response properties of cochlear efferent neurons: monaural vs. binaural stimulation and the effects of noise. J Neurophysiol. 1988 Nov; 60(5):1779-98.
- Physiology of cochlear efferent and afferent neurons: direct comparisons in the same animal. Hear Res. 1988 Jul 15; 34(2):179-91.
- Afferent innervation of outer hair cells in adult cats: I. Light microscopic analysis of fibers labeled with horseradish peroxidase. J Comp Neurol. 1988 Apr 01; 270(1):132-44.
- Afferent innervation of outer hair cells in adult cats: II. Electron microscopic analysis of fibers labeled with horseradish peroxidase. J Comp Neurol. 1988 Apr 01; 270(1):145-54.
- Acute ultrastructural changes in acoustic trauma: serial-section reconstruction of stereocilia and cuticular plates. Hear Res. 1987; 26(1):45-64.
- Chronic ultrastructural changes in acoustic trauma: serial-section reconstruction of stereocilia and cuticular plates. Hear Res. 1987; 26(1):65-88.
- Single unit clues to cochlear mechanisms. Hear Res. 1986; 22:171-82.
- Physiology and anatomy of single olivocochlear neurons in the cat. Hear Res. 1986; 24(1):17-36.
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