David H. Jung,
MD, PhD, FACS
Massachusetts Eye and Ear
Medical Director, Joseph B. Nadol, Jr. Surgical Training Laboratory
Harvard Medical School
Assistant Professor of Otolaryngology–Head and Neck Surgery
About My Research
Dr. David Jung’s current research focuses on the development of novel methods for cochlear drug delivery and understanding mechanisms of noise- and age-related hearing loss.
Education
BS, MS, Biological Sciences, Stanford University
MD, Harvard Medical School
PhD, Genetics, Harvard Medical School
Postgraduate Training
Internship: General Surgery, Massachusetts General Hospital
Residency: Otolaryngology–Head and Neck Surgery, Harvard Medical School
Fellowship: Otology and Neurotology, Massachusetts Eye and Ear
Professional Societies
American Academy of Otolaryngology–Head and Neck Surgery
Triological Society
American College of Surgeons
American Neurotology Society
Harold F. Schuknecht Society
Honors (select)
Pre-doctoral Intramural Training Award, National Institutes of Health
Firestone Medal for Excellence in Undergraduate Research, Stanford University
Medical Scientist Training Program Grant, MD/PhD Program, Harvard Medical School
Certificate of Distinction in Teaching, Harvard University
Albert Ryan Fellowship, Harvard University, Division of Medical Sciences
Richard J. Bellucci, MD Resident Research Award, Triological Society Eastern Section
Clinical Fellow Teaching Award, Massachusetts Eye and Ear
Editorial Roles (select)
Otology & Neurotology, Associate Editor
Otolaryngology–Head and Neck Surgery, Reviewer
Journal of Neurological Surgery Reports, Reviewer
Publications powered by Harvard Catalyst Profiles
- Evidence of cochlear neural degeneration in normal-hearing subjects with tinnitus. Sci Rep. 2023 11 30; 13(1):19870.
- Experimental drugs for the prevention or treatment of sensorineural hearing loss. Expert Opin Investig Drugs. 2023 Jul-Dec; 32(7):643-654.
- Voluntary Field Recall of Advanced Bionics HiRes Cochlear Implants: A Single-Institution Experience. Otol Neurotol. 2022 12 01; 43(10):e1094-e1099.
- Training Surgeon Scholars: Grant Writing Workshops During Residency. OTO Open. 2022 Apr-Jun; 6(2):2473974X221104663.
- Gene replacement therapy in a schwannoma mouse model of neurofibromatosis type 2. Mol Ther Methods Clin Dev. 2022 Sep 08; 26:169-180.
- A Subset of Intracanalicular Vestibular Schwannomas Demonstrates Minimal Growth Over a 10-Year Period. Otol Neurotol. 2022 03 01; 43(3):376-384.
- Intracochlear New Fibro-Ossification and Neuronal Degeneration Following Cochlear Implant Electrode Translocation: Long-Term Histopathological Findings in Humans. Otol Neurotol. 2022 02 01; 43(2):e153-e164.
- A Novel Small Molecule Neurotrophin-3 Analogue Promotes Inner Ear Neurite Outgrowth and Synaptogenesis In vitro. Front Cell Neurosci. 2021; 15:666706.
- IMPROVING BARRIER DRAPES FOR THE MITIGATION OF AEROSOL AND PARTICULATE SPREAD DURING MASTOIDECTOMY. Otol Neurotol. 2021 02 01; 42(2):347-349.
- Radiologically-proven New Development of Superior Semicircular Canal Dehiscence Associated With Development of Superior Semicircular Canal Dehiscence Syndrome. Otol Neurotol. 2021 02 01; 42(2):285-289.
- Impact of COVID-19 on Presentation of Sudden Sensorineural Hearing Loss at a Single Institution. Otolaryngol Head Neck Surg. 2021 07; 165(1):163-165.
- Demonstration and Mitigation of Aerosol and Particle Dispersion During Mastoidectomy Relevant to the COVID-19 Era. Otol Neurotol. 2020 10; 41(9):1230-1239.
- Aerosol Dispersion During Mastoidectomy and Custom Mitigation Strategies for Otologic Surgery in the COVID-19 Era. Otolaryngol Head Neck Surg. 2021 01; 164(1):67-73.
- Auditory Quality-of-Life Measures in Patients With Traumatic Brain Injury and Normal Pure Tone Audiometry. Otolaryngol Head Neck Surg. 2020 12; 163(6):1250-1254.
- Topical fibroblast growth factor-2 for treatment of chronic tympanic membrane perforations. Laryngoscope Investig Otolaryngol. 2020 Aug; 5(4):657-664.
- Demonstration and mitigation of aerosol and particle dispersion during mastoidectomy relevant to the COVID-19 era. Otol Neurotol. 2020 May 08.
- Labyrinthine concussion: Historic otopathologic antecedents of a challenging diagnosis. Laryngoscope Investig Otolaryngol. 2020 Apr; 5(2):267-277.
- Protective Efficacy of Monoclonal Antibodies Neutralizing Alpha-Hemolysin and Bicomponent Leukocidins in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia. Antimicrob Agents Chemother. 2020 02 21; 64(3).
- Location of Small Intracanalicular Vestibular Schwannomas Based on Magnetic Resonance Imaging. Otolaryngol Head Neck Surg. 2020 Feb; 162(2):211-214.
- Peripheral Vestibular Organ Degeneration After Temporal Bone Fracture: A Human Otopathology Study. Laryngoscope. 2020 03; 130(3):752-760.
- Patient-reported auditory handicap measures following mild traumatic brain injury. Laryngoscope. 2020 03; 130(3):761-767.
- Otopathology of Unilateral Cochlear Implantation in Patients With Bilateral Temporal Bone Fracture. Otol Neurotol. 2019 01; 40(1):e14-e19.
- Vestibular Traumatic Neuroma Following Temporal Bone Fracture. Otol Neurotol. 2019 01; 40(1):e62-e65.
- High Resolution Computed Tomography Atlas of the Porcine Temporal Bone and Skull Base: Anatomical Correlates for Traumatic Brain Injury Research. J Neurotrauma. 2019 04 01; 36(7):1029-1039.
- Peripheral Vestibular System Histopathologic Changes following Head Injury without Temporal Bone Fracture. Otolaryngol Head Neck Surg. 2019 01; 160(1):122-130.
- Audiometric and cVEMP Thresholds Show Little Correlation With Symptoms in Superior Semicircular Canal Dehiscence Syndrome. Otol Neurotol. 2018 10; 39(9):1153-1162.
- Sequential Imaging in Patient With Suspected Menière's Disease Identifies Endolymphatic Sac Tumor. Otol Neurotol. 2018 10; 39(9):e856-e859.
- Otopathologic Changes in the Cochlea following Head Injury without Temporal Bone Fracture. Otolaryngol Head Neck Surg. 2018 09; 159(3):526-534.
- Otogenic brain abscesses: A systematic review. Laryngoscope Investig Otolaryngol. 2018 Jun; 3(3):198-208.
- Clinical trials for inner ear drugs: Design and execution challenges. Hear Res. 2018 10; 368:123-126.
- Bisphosphonate-Linked TrkB Agonist: Cochlea-Targeted Delivery of a Neurotrophic Agent as a Strategy for the Treatment of Hearing Loss. Bioconjug Chem. 2018 04 18; 29(4):1240-1250.
- Toward Optimizing Cervical Vestibular Evoked Myogenic Potentials (cVEMP): Combining Air-Bone Gap and cVEMP Thresholds to Improve Diagnosis of Superior Canal Dehiscence. Otol Neurotol. 2018 02; 39(2):212-220.
- Systematic review of hearing loss after traumatic brain injury without associated temporal bone fracture. Am J Otolaryngol. 2018 May - Jun; 39(3):338-344.
- Is Serial Electroneuronography Indicated Following Temporal Bone Trauma? Otol Neurotol. 2017 04; 38(4):572-576.
- Improvement in word recognition following treatment failure for sudden sensorineural hearing loss. World J Otorhinolaryngol Head Neck Surg. 2016 Sep; 2(3):168-174.
- Recent advances in therapeutics and drug delivery for the treatment of inner ear diseases: a patent review (2011-2015). Expert Opin Ther Pat. 2017 Feb; 27(2):191-202.
- Response to Drug Diffusion to the Apex of the Human Cochlea?. Otol Neurotol. 2016 10; 37(9):1463-4.
- Measurement of Ototoxicity Following Intracochlear Bisphosphonate Delivery. Otol Neurotol. 2016 07; 37(6):621-6.
- Intracochlear Drug Delivery Through the Oval Window in Fresh Cadaveric Human Temporal Bones. Otol Neurotol. 2016 Mar; 37(3):218-22.
- Health Utility Improves After Surgery for Superior Canal Dehiscence Syndrome. Otol Neurotol. 2015 Dec; 36(10):1695-701.
- Amblyaudia: Review of Pathophysiology, Clinical Presentation, and Treatment of a New Diagnosis. Otolaryngol Head Neck Surg. 2016 Feb; 154(2):247-55.
- Histopathology of the Inner Ear in a Case With Recent Onset of Cogan's Syndrome: Evidence for Vasculitis. Ann Otol Rhinol Laryngol. 2016 Jan; 125(1):20-4.
- Non-Ototoxic Local Delivery of Bisphosphonate to the Mammalian Cochlea. Otol Neurotol. 2015 Jul; 36(6):953-60.
- Auditory brainstem implantation in a 16-month-old boy with cochlear hypoplasia. Otol Neurotol. 2015 Apr; 36(4):618-24.
- Dizziness is more prevalent than autophony among patients who have undergone repair of superior canal dehiscence. Otol Neurotol. 2015 Jan; 36(1):126-32.
- Association of hearing loss with decreased employment and income among adults in the United States. Ann Otol Rhinol Laryngol. 2012 Dec; 121(12):771-5.
- Differential utilization of T cell receptor TCR alpha/TCR delta locus variable region gene segments is mediated by accessibility. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17487-92.
- Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol. 2006; 24:541-70.
- A single DH gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune function. J Immunol. 2005 Nov 15; 175(10):6624-32.
- Unraveling V(D)J recombination; insights into gene regulation. Cell. 2004 Jan 23; 116(2):299-311.
- Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells. Immunity. 2003 Jan; 18(1):65-74.
- Dramatically increased rearrangement and peripheral representation of Vbeta14 driven by the 3'Dbeta1 recombination signal sequence. Immunity. 2003 Jan; 18(1):75-85.
- Overexpression of ptc1 inhibits induction of Shh target genes and prevents normal patterning in the neural tube. Dev Biol. 1999 Jul 15; 211(2):323-34.
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