Evangelos S. Gragoudas,
MD
Massachusetts Eye and Ear
Co-Director, Laser Laboratory
Co-Director, Retina Research Institute
Harvard Medical School
Charles Edward Whitten Distinguished Professor of Ophthalmology
evangelos_gragoudas@meei.harvard.edu
For investigator inquiries only
About My Research
Center/Research Area Affiliations
- Ines and Frederick Yeatts Retina Research Laboratory
- AMD Center of Excellence
- Ocular Oncology Center of Excellence
Biography
Dr. Gragoudas is a Senior Scientist and Co-Director of the Laser Laboratory, Ines and Frederick Yeatts Retina Research Laboratory, and Retina Research Institute at Mass Eye and Ear. He played a pivotal role in the development of proton bean therapy (PBT) for uveal melanoma, and performed both preclinical studies and the first clinical studies in patients. He continues to refine PBT and has taken a multidisciplinary approach to developing new strategies for managing uveal melanoma.Studies initiated in the early 1990s with Dr. Joan Miller produced a breakthrough for patients with wetAMD: photodynamictherapy (PDT) with verteporlin (VISudyne®). He and his colleagues identified the important role of vascular endothelial growth factor (VEGF) in ocular neovascularization, which formed the scientific basis for the present antiangiogenic treatments for neovascular AMD and other intraocular vascular diseases.
Education
1965: MD, Athens National and Kapodistrian University, Athens, Greece
Postgraduate Training
1970: Research Fellowship, E.P. Joslin Research, Laboratory Division of Microangiopathy, Harvard Medical School
1972: Residency, Ophthalmology, Boston University Affiliated Hospitals
1973: Chief Resident, Ophthalmology, Boston University Affiliated Hospitals
1974: Clinical Fellowship, Diabetic Retinopathy, Massachusetts Eye and Ear
1975: Fellowship, Retina, Massachusetts Eye and Ear
1976: Research Associate, Eye Research Institute of Retina Foundation, Boston, MA
Academic Appointments
2021-Present: Charles Edward Whitten Distinguished Professor of Ophthalmology, Harvard Medical School
2011-2021: Charles Edward Whitten Professor of Ophthalmology, Harvard Medical School
2002-2003: Acting Chairman, Department of Ophthalmology, Harvard Medical School
1994-2011: Professor of Ophthalmology, Harvard Medical School
1981-1994: Associate Professor of Ophthalmology, Harvard Medical School
1978-1981: Assistant Professor of Ophthalmology, Harvard Medical School
1975-1978: Instructor in Ophthalmology, Harvard Medical School
Publications powered by Harvard Catalyst Profiles
- Impact of gene expression profiling on diagnosis and survival after metastasis in patients with uveal melanoma. Melanoma Res. 2024 Apr 05.
- Detection of Copy-Number Variation in Circulating Cell-Free DNA in Patients With Uveal Melanoma. JCO Precis Oncol. 2024 Jan; 8:e2300368.
- Outcomes after Proton Beam Irradiation in Patients with Choroidal Melanoma Eligible for Investigational AU-011 Treatment. Ocul Oncol Pathol. 2023 Dec; 9(5-6):152-157.
- Survival of patients with recurrent uveal melanoma after treatment with radiation therapy. Br J Ophthalmol. 2023 Jul 03.
- Growth rate of indeterminate choroidal lesions prior to melanoma diagnosis. Graefes Arch Clin Exp Ophthalmol. 2023 Dec; 261(12):3635-3641.
- In Reply to Elmali and Yazici. Int J Radiat Oncol Biol Phys. 2023 Mar 01; 115(3):810-811.
- The NLRP3 inflammasome - interleukin 1ß axis in uveal melanoma. FEBS Open Bio. 2023 03; 13(3):545-555.
- Low-dose proton radiotherapy for pediatric choroidal hemangioma: A case series. Pediatr Blood Cancer. 2022 12; 69(12):e29925.
- The Effect of Sample Medication Use on Subsequent Anti-VEGF Agent Selection for Neovascular Age-Related Macular Degeneration. Semin Ophthalmol. 2022 Oct-Nov; 37(7-8):902-908.
- A Systematic Comparison of Dose Distributions Delivered in 125I Plaque Brachytherapy and Proton Radiation Therapy for Ocular Melanoma. Int J Radiat Oncol Biol Phys. 2023 02 01; 115(2):501-510.
- A Comparison of Treatment Outcomes after Standard Dose (70 Gy) versus Reduced Dose (50 Gy) Proton Radiation in Patients with Uveal Melanoma. Ophthalmol Retina. 2022 11; 6(11):1089-1097.
- Retinal Detachment in a 40-Year-Old Man With Sturge-Weber Syndrome. JAMA Ophthalmol. 2021 05 01; 139(5):581-582.
- Targeting the YAP/TAZ Pathway in Uveal and Conjunctival Melanoma With Verteporfin. Invest Ophthalmol Vis Sci. 2021 04 01; 62(4):3.
- Reply. Ophthalmol Retina. 2021 03; 5(3):e4.
- Proton beam irradiation of uveal melanoma involving the iris, ciliary body and anterior choroid without surgical localisation (light field). Br J Ophthalmol. 2022 04; 106(4):518-521.
- Checkpoint inhibitor-induced sarcoid choroidal granulomas. Am J Ophthalmol Case Rep. 2020 Jun; 18:100652.
- LONG-TERM OBSERVATION OF MULTIFOCAL METASTATIC INTRAOCULAR CARCINOID WITH ACQUIRED IRIS HETEROCHROMIA. Retin Cases Brief Rep. 2020; 14(3):265-267.
- Nonresponders to Ranibizumab Anti-VEGF Treatment Are Actually Short-term Responders: A Prospective Spectral-Domain OCT Study. Ophthalmol Retina. 2020 12; 4(12):1138-1145.
- Conservative management of suspicious melanocytic lesions of the iris. Graefes Arch Clin Exp Ophthalmol. 2019 Jun; 257(6):1319-1324.
- Survival Rates in Patients After Treatment for Metastasis From Uveal Melanoma. JAMA Ophthalmol. 2018 09 01; 136(9):981-986.
- Evaluation of choroidal lesions with swept-source optical coherence tomography. Br J Ophthalmol. 2019 01; 103(1):88-93.
- Genetic Risk Factors for Radiation Vasculopathy. Invest Ophthalmol Vis Sci. 2018 03 01; 59(3):1547-1553.
- Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration. Sci Rep. 2018 01 11; 8(1):461.
- Rare Variant, Gene-Based Association Study of Hereditary Melanoma Using Whole-Exome Sequencing. J Natl Cancer Inst. 2017 12 01; 109(12).
- Long-term Outcomes After Proton Beam Irradiation in Patients With Large Choroidal Melanomas. JAMA Ophthalmol. 2017 11 01; 135(11):1191-1196.
- Verteporfin inhibits growth of human glioma in vitro without light activation. Sci Rep. 2017 08 08; 7(1):7602.
- Systematic genomic and translational efficiency studies of uveal melanoma. PLoS One. 2017; 12(6):e0178189.
- Verteporfin-induced formation of protein cross-linked oligomers and high molecular weight complexes is mediated by light and leads to cell toxicity. Sci Rep. 2017 04 21; 7:46581.
- CHRONICALLY PROGRESSIVE SARCOID GRANULOMA IN AN ASYMPTOMATIC PATIENT. Retin Cases Brief Rep. 2017 Spring; 11(2):183-185.
- Introducing Joan W. Miller, the 2015 Recipient of the Weisenfeld Award. Invest Ophthalmol Vis Sci. 2016 12 01; 57(15):6910.
- Ranibizumab for the Prevention of Radiation Complications in Patients Treated With Proton Beam Irradiation for Choroidal Melanoma. Trans Am Ophthalmol Soc. 2016 Aug; 114:T2.
- Multiple simultaneous choroidal melanomas arising in the same eye: globe salvage by radiotherapy. Acta Ophthalmol. 2016 Dec; 94(8):e799-e802.
- Regression of Some High-risk Features of Age-related Macular Degeneration (AMD) in Patients Receiving Intensive Statin Treatment. EBioMedicine. 2016 Mar; 5:198-203.
- Long-term Risk of Melanoma-Related Mortality After Uveal Melanoma--Reply. JAMA Ophthalmol. 2016 Feb; 134(2):239-40.
- Visual Outcomes after Proton Beam Irradiation for Choroidal Melanomas Involving the Fovea. Ophthalmology. 2016 Feb; 123(2):369-377.
- Severe vision loss with optic disc neovascularization after hemiretinal vascular obstruction associated with optic disc melanocytoma. JAMA Ophthalmol. 2015 Oct; 133(10):e151502.
- Clinical Characteristics of Uveal Melanoma in Patients With Germline BAP1 Mutations. JAMA Ophthalmol. 2015 Aug; 133(8):881-7.
- Long-term Risk of Melanoma-Related Mortality for Patients With Uveal Melanoma Treated With Proton Beam Therapy. JAMA Ophthalmol. 2015 Jul; 133(7):792-6.
- Immunohistochemical investigations of adult intraocular medulloepitheliomas. Clin Exp Ophthalmol. 2015 May-Jun; 43(4):379-85.
- Outcomes of proton therapy for the treatment of uveal metastases. Int J Radiat Oncol Biol Phys. 2014 Dec 01; 90(5):1044-50.
- Effects of metformin on retinoblastoma growth in vitro and in vivo. Int J Oncol. 2014 Dec; 45(6):2311-24.
- The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation. Exp Eye Res. 2014 Jul; 124:67-73.
- Proton beam irradiation for non-AMD CNV: 2-year results of a randomised clinical trial. Br J Ophthalmol. 2014 Sep; 98(9):1212-7.
- Aggressive skull base metastasis from uveal melanoma: a clinicopathologic study. Eur J Ophthalmol. 2014 Sep-Oct; 24(5):811-3.
- Uveal melanoma cell growth is inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase. Invest Ophthalmol Vis Sci. 2014 Apr 29; 55(7):4175-85.
- Choroidal Metastases From EML4-ALK-Positive Non-Small-Cell Lung Adenocarcinoma. J Clin Oncol. 2015 Oct 20; 33(30):e112-4.
- Biopsy of an anterior episcleral nodule as an aid in managing a ciliary body melanocytic tumor. Cornea. 2013 Aug; 32(8):1174-7.
- Aminoimidazole carboxamide ribonucleotide (AICAR) inhibits the growth of retinoblastoma in vivo by decreasing angiogenesis and inducing apoptosis. PLoS One. 2013; 8(1):e52852.
- High throughput mass spectrometry-based mutation profiling of primary uveal melanoma. Invest Ophthalmol Vis Sci. 2012 Oct 09; 53(11):6991-6.
- Enhanced depth imaging spectral-domain optical coherence tomography findings in sclerochoroidal calcification. Retina. 2012 Jun; 32(6):1226-7.
- Germline BAP1 inactivation is preferentially associated with metastatic ocular melanoma and cutaneous-ocular melanoma families. PLoS One. 2012; 7(4):e35295.
- Evaluation of tissue interactions with mechanical elements of a transscleral drug delivery device. Pharmaceutics. 2012 Mar 12; 4(1):212-29.
- Proton irradiation for peripapillary and parapapillary melanomas. Arch Ophthalmol. 2011 Sep; 129(9):1127-30.
- Cancer-associated retinopathy: update on pathogenesis and therapy. Semin Ophthalmol. 2011 Jul-Sep; 26(4-5):321-8.
- In vivo evaluation of laser-induced choroidal neovascularization using spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3880-7.
- Utilizing targeted gene therapy with nanoparticles binding alpha v beta 3 for imaging and treating choroidal neovascularization. PLoS One. 2011 Apr 29; 6(4):e18864.
- Posterior uveal melanoma in young patients treated with proton beam therapy. Retina. 2010 Sep; 30(8):1267-71.
- Mortality after diagnosis of small melanocytic lesions of the choroid. Arch Ophthalmol. 2010 Aug; 128(8):996-1000.
- Survival in patients with presymptomatic diagnosis of metastatic uveal melanoma. Arch Ophthalmol. 2010 Jul; 128(7):871-5.
- Uveal melanoma recurrence after fractionated proton beam therapy: comparison of survival in patients treated with reirradiation or with enucleation. Int J Radiat Oncol Biol Phys. 2011 Mar 01; 79(3):842-6.
- Retinoblastoma cells are inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase. FASEB J. 2010 Aug; 24(8):2620-30.
- Natural history of radiation papillopathy after proton beam irradiation of parapapillary melanoma. Ophthalmology. 2010 Aug; 117(8):1617-22.
- Response of choroidal leiomyoma to treatment with proton beam radiation. Retin Cases Brief Rep. 2010; 4(2):168-73.
- Proton beam irradiation using a light-field technique for the treatment of choroidal hemangiomas. Ophthalmologica. 2010; 224(4):209-16.
- A novel nonradioactive method to evaluate vascular barrier breakdown and leakage. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1677-82.
- Adjuvant interferon therapy for patients with uveal melanoma at high risk of metastasis. Ophthalmology. 2009 Nov; 116(11):2206-12.
- Role of alpha 4 integrin (CD49d) in the pathogenesis of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2009 Oct; 50(10):4898-904.
- Radiation therapy for neovascular age-related macular degeneration revisited. Br J Ophthalmol. 2009 Mar; 93(3):279-80.
- Ocular melanocytoma. Int Ophthalmol Clin. 2009; 49(1):165-75.
- Vascular adhesion protein-1 blockade suppresses choroidal neovascularization. FASEB J. 2008 Aug; 22(8):2928-35.
- Photoreceptor protection after photodynamic therapy using dexamethasone in a rat model of choroidal neovascularization. Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):5008-14.
- Increased choroidal neovascularization following laser induction in mice lacking lysyl oxidase-like 1. Invest Ophthalmol Vis Sci. 2008 Jun; 49(6):2599-605.
- Characterization of azurocidin as a permeability factor in the retina: involvement in VEGF-induced and early diabetic blood-retinal barrier breakdown. Invest Ophthalmol Vis Sci. 2008 Feb; 49(2):726-31.
- In vivo imaging of endothelial injury in choriocapillaris during endotoxin-induced uveitis. FASEB J. 2008 Jun; 22(6):1973-80.
- Inhibition of vascular adhesion protein-1 suppresses endotoxin-induced uveitis. FASEB J. 2008 Apr; 22(4):1094-103.
- Photodynamic therapy induces caspase-dependent apoptosis in rat CNV model. Invest Ophthalmol Vis Sci. 2007 Oct; 48(10):4741-7.
- Endogenous endostatin inhibits choroidal neovascularization. FASEB J. 2007 Dec; 21(14):3809-18.
- Reduced photoreceptor damage after photodynamic therapy through blockade of nitric oxide synthase in a model of choroidal neovascularization. Invest Ophthalmol Vis Sci. 2007 May; 48(5):2268-77.
- Inhibition of Hsp90 attenuates inflammation in endotoxin-induced uveitis. FASEB J. 2007 Jul; 21(9):2113-23.
- VLA-4 blockade suppresses endotoxin-induced uveitis: in vivo evidence for functional integrin up-regulation. FASEB J. 2007 Feb; 21(2):464-74.
- Proton beam irradiation of uveal melanomas: the first 30 years. The Weisenfeld Lecture. Invest Ophthalmol Vis Sci. 2006 Nov; 47(11):4666-73.
- Proton beam irradiation for neovascular age-related macular degeneration. Ophthalmology. 2006 Nov; 113(11):2012-9.
- Dose-dependent effect of pitavastatin on VEGF and angiogenesis in a mouse model of choroidal neovascularization. Invest Ophthalmol Vis Sci. 2006 Jun; 47(6):2623-31.
- Investigating the effect of ciliary body photodynamic therapy in a glaucoma mouse model. Invest Ophthalmol Vis Sci. 2006 Jun; 47(6):2498-507.
- Histologic correlation of in vivo optical coherence tomography images of the human retina. Am J Ophthalmol. 2006 Jun; 141(6):1165-8.
- Melanocytoma of the optic nerve associated with sound-induced phosphenes. Arch Ophthalmol. 2006 Feb; 124(2):273-7.
- Conservation treatment of the eye: Conformal proton reirradiation for recurrent uveal melanoma. Int J Radiat Oncol Biol Phys. 2006 Mar 15; 64(4):1018-22.
- Effect of intravitreal injection of ranibizumab in combination with verteporfin PDT on normal primate retina and choroid. Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):357-63.
- Identification of Chlamydia pneumoniae within human choroidal neovascular membranes secondary to age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2005 Nov; 243(11):1080-90.
- Safety and efficacy of intravitreal injection of ranibizumab in combination with verteporfin PDT on experimental choroidal neovascularization in the monkey. Arch Ophthalmol. 2005 Apr; 123(4):509-16.
- Uveal melanoma: proton beam irradiation. Ophthalmol Clin North Am. 2005 Mar; 18(1):111-8, ix.
- An antisense oligodeoxynucleotide against vascular endothelial growth factor in a nonhuman primate model of iris neovascularization. Arch Ophthalmol. 2005 Feb; 123(2):214-9.
- Treatment of metastatic tumors of the choroid with proton beam irradiation. Ophthalmology. 2005 Feb; 112(2):337-43.
- Pegaptanib for neovascular age-related macular degeneration. N Engl J Med. 2004 Dec 30; 351(27):2805-16.
- Selective photodynamic therapy by targeted verteporfin delivery to experimental choroidal neovascularization mediated by a homing peptide to vascular endothelial growth factor receptor-2. Arch Ophthalmol. 2004 Jul; 122(7):1002-11.
- MRI of blood volume with superparamagnetic iron in choroidal melanoma treated with thermotherapy. Magn Reson Imaging. 2004 Jul; 22(6):779-87.
- Expression of leukocyte adhesion molecules in human subfoveal choroidal neovascular membranes treated with and without photodynamic therapy. Invest Ophthalmol Vis Sci. 2004 Jul; 45(7):2368-73.
- Pupil sparing excision of an atypical iris melanocytoma induces remission of secondary glaucoma. Br J Ophthalmol. 2004 Jun; 88(6):842-3.
- Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: meta-analysis of 2-year safety results in three randomized clinical trials: Treatment Of Age-Related Macular Degeneration With Photodynamic Therapy and Verteporfin In Photodynamic Therapy Study Report no. 4. Retina. 2004 Feb; 24(1):1-12.
- Photosensitizers in photodynamic therapy of choroidal neovascularization. Int Ophthalmol Clin. 2004; 44(3):63-80.
- Preface. Int Ophthalmol Clin. 2004; 44(3):xiii.
- MRI of blood volume with MS 325 in experimental choroidal melanoma. Magn Reson Imaging. 2003 Sep; 21(7):725-32.
- VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization. J Exp Med. 2003 Aug 04; 198(3):483-9.
- Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci. 2003 Jun; 44(6):2743-9.
- Treatment of experimental choroidal melanoma with an Nd:yttrium-lanthanum-fluoride laser at 1047 nm. Arch Ophthalmol. 2003 Mar; 121(3):357-63.
- Tumor basal area and metastatic death after proton beam irradiation for choroidal melanoma. Arch Ophthalmol. 2003 Jan; 121(1):68-72.
- Controlled delivery of the anti-VEGF aptamer EYE001 with poly(lactic-co-glycolic)acid microspheres. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):290-9.
- Evidence-based estimates of outcome in patients irradiated for intraocular melanoma. Arch Ophthalmol. 2002 Dec; 120(12):1665-71.
- Verteporfin therapy of subfoveal choroidal neovascularization in patients with age-related macular degeneration: additional information regarding baseline lesion composition's impact on vision outcomes-TAP report No. 3. Arch Ophthalmol. 2002 Nov; 120(11):1443-54.
- High-grade uveal B-cell lymphoma as the initial feature in Richter syndrome. Arch Ophthalmol. 2002 Oct; 120(10):1383-5.
- Complications of cataract extraction. Semin Ophthalmol. 2002 Sep-Dec; 17(3-4):101.
- [Photodynamic therapy of pigmented choroidal melanomas in rabbits]. Zhonghua Yan Ke Za Zhi. 2002 Aug; 38(8):491-4.
- Verteporfin photodynamic therapy in the rat model of choroidal neovascularization: angiographic and histologic characterization. Invest Ophthalmol Vis Sci. 2002 Jul; 43(7):2384-91.
- MRI of blood volume and cellular uptake of superparamagnetic iron in an animal model of choroidal melanoma. Ophthalmic Res. 2002 Jul-Aug; 34(4):241-50.
- Expression of pigment epithelium-derived factor in experimental choroidal neovascularization. Invest Ophthalmol Vis Sci. 2002 May; 43(5):1574-80.
- Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch Ophthalmol. 2002 Mar; 120(3):338-46.
- Localization of rose bengal, aluminum phthalocyanine tetrasulfonate, and chlorin e6 in the rabbit eye. Retina. 2002 Feb; 22(1):65-74.
- Long-term risk of local failure after proton therapy for choroidal/ciliary body melanoma. Trans Am Ophthalmol Soc. 2002; 100:43-8; discussion 48-9.
- The expanded clinical spectrum of deferoxamine retinopathy. Ophthalmology. 2002 Jan; 109(1):164-71.
- Melanoma-associated retinopathy and recurrent exudative retinal detachments in a patient with choroidal melanoma. Am J Ophthalmol. 2001 Oct; 132(4):578-81.
- Color Doppler imaging of untreated and irradiated choroidal melanomas. Eur J Ophthalmol. 2001 Apr-Jun; 11(2):150-5.
- Neuroretinitis. Int Ophthalmol Clin. 2001; 41(1):83-102.
- Photodynamic therapy using Lu-Tex induces apoptosis in vitro, and its effect is potentiated by angiostatin in retinal capillary endothelial cells. Invest Ophthalmol Vis Sci. 2000 Nov; 41(12):3963-71.
- Metastatic melanoma death rates by anatomic site after proton beam irradiation for uveal melanoma. Arch Ophthalmol. 2000 Aug; 118(8):1066-70.
- Uveal melanoma: a rare malignancy. Ophthalmology. 2000 Aug; 107(8):1441-2.
- Patterns of tumor initiation in choroidal melanoma. Cancer Res. 2000 Jul 15; 60(14):3757-60.
- Discussion by evangelos S. Gragoudas, MD Ophthalmology. 2000 Jul; 107(7):1387-8.
- A randomized controlled trial of varying radiation doses in the treatment of choroidal melanoma. Arch Ophthalmol. 2000 Jun; 118(6):773-8.
- Diffusion of high molecular weight compounds through sclera. Invest Ophthalmol Vis Sci. 2000 Apr; 41(5):1181-5.
- Transscleral delivery of bioactive protein to the choroid and retina. Invest Ophthalmol Vis Sci. 2000 Apr; 41(5):1186-91.
- A preliminary study of photodynamic therapy using verteporfin for choroidal neovascularization in pathologic myopia, ocular histoplasmosis syndrome, angioid streaks, and idiopathic causes. Arch Ophthalmol. 2000 Mar; 118(3):327-36.
- Endothelial cell loss in irradiated optic nerves. Ophthalmology. 2000 Feb; 107(2):370-4.
- Angiography of fluoresceinated anti-vascular endothelial growth factor antibody and dextrans in experimental choroidal neovascularization. Arch Ophthalmol. 2000 Jan; 118(1):78-84.
- Verteporfin photodynamic therapy retreatment of normal retina and choroid in the cynomolgus monkey. Ophthalmology. 1999 Oct; 106(10):1915-23.
- Choroidal metastases. Case 2: lung cancer. J Clin Oncol. 1999 Oct; 17(10):3358-9.
- Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration: results of a single treatment in a phase 1 and 2 study. Arch Ophthalmol. 1999 Sep; 117(9):1161-73.
- Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration: results of retreatments in a phase 1 and 2 study. Arch Ophthalmol. 1999 Sep; 117(9):1177-87.
- Effects of photodynamic therapy using verteporfin on experimental choroidal neovascularization and normal retina and choroid up to 7 weeks after treatment. Invest Ophthalmol Vis Sci. 1999 Sep; 40(10):2322-31.
- Risk factors for radiation maculopathy and papillopathy after intraocular irradiation. Ophthalmology. 1999 Aug; 106(8):1571-7; discussion 1577-8.
- Germline brca2 sequence variants in patients with ocular melanoma. Int J Cancer. 1999 Jul 30; 82(3):325-8.
- Childbearing history associated with improved survival in choroidal melanoma. Arch Ophthalmol. 1999 Jul; 117(7):939-42.
- Blindness as a consequence of a paraneoplastic syndrome in a woman with clear cell carcinoma of the ovary. Gynecol Oncol. 1999 Jun; 73(3):424-9.
- Iris color as a prognostic factor in ocular melanoma. Arch Ophthalmol. 1999 Jun; 117(6):811-4.
- Clinical course of macular holes: the Eye Disease Case-Control Study. Arch Ophthalmol. 1999 Feb; 117(2):242-6.
- Proton beam therapy for age-related macular degeneration: development of a standard plan. Med Dosim. 1999; 24(4):233-8.
- Choroidal metastasis from olfactory neuroblastoma (esthesioneuroblastoma). Retina. 1999; 19(5):459-62.
- Risk factors for hemiretinal vein occlusion: comparison with risk factors for central and branch retinal vein occlusion: the eye disease case-control study. Ophthalmology. 1998 May; 105(5):765-71.
- Photodynamic therapy of subfoveal choroidal neovascularization: clinical and angiographic examples. Graefes Arch Clin Exp Ophthalmol. 1998 May; 236(5):365-74.
- Eye-sparing treatment of massive extrascleral extension of choroidal melanoma. Arch Ophthalmol. 1998 Apr; 116(4):531-3.
- Survival implications of enucleation after definitive radiotherapy for choroidal melanoma: an example of regression on time-dependent covariates. Arch Ophthalmol. 1998 Mar; 116(3):366-70.
- A randomized, controlled trial of varying radiation doses in the treatment of choroidal melanoma. Trans Am Ophthalmol Soc. 1998; 96:691-720.
- Establishment of a rabbit model of extrascleral extension of ocular melanoma. Retina. 1998; 18(4):368-72.
- Systemic hyperoxia decreases vascular endothelial growth factor gene expression in ischemic primate retina. Arch Ophthalmol. 1997 Dec; 115(12):1553-8.
- Central serous chorioretinopathy associated with inhaled or intranasal corticosteroids. Ophthalmology. 1997 Oct; 104(10):1653-60.
- Flow cytometry analysis of peripheral blood lymphocytes in patients with choroidal melanoma. Am J Ophthalmol. 1997 Sep; 124(3):357-61.
- Photodynamic therapy and digital angiography of experimental iris neovascularization using liposomal benzoporphyrin derivative. Ophthalmology. 1997 Aug; 104(8):1242-50.
- Choroidal metastases from renal cell carcinoma. Ophthalmology. 1997 Jul; 104(7):1152-8.
- Digital angiography of experimental choroidal melanomas using benzoporphyrin derivative. Am J Ophthalmol. 1997 Jun; 123(6):810-6.
- An evaluation of tumour vascularity as a prognostic indicator in uveal melanoma. Melanoma Res. 1997 Jun; 7(3):237-42.
- Uveal lymphoid neoplasia: a clinical-pathologic correlation and review of the early form. Surv Ophthalmol. 1997 May-Jun; 41(6):467-76.
- 1996 Jules Gonin Lecture of the Retina Research Foundation. Long-term results after proton irradiation of uveal melanomas. Graefes Arch Clin Exp Ophthalmol. 1997 May; 235(5):265-7.
- Localization of lipoprotein-delivered benzoporphyrin derivative in the rabbit eye. Curr Eye Res. 1997 Feb; 16(2):83-90.
- Advances in treatment of retinal angiomas. Int Ophthalmol Clin. 1997; 37(4):159-70.
- Photodynamic therapy of choroidal melanoma. Int Ophthalmol Clin. 1997; 37(4):117-26.
- Uveal metastases. Int Ophthalmol Clin. 1997; 37(4):183-99.
- Unusual hemorrhagic lesions masquerading as choroidal melanoma. Int Ophthalmol Clin. 1997; 37(4):135-47.
- Photodynamic therapy of pigmented choroidal melanomas of greater than 3-mm thickness. Ophthalmology. 1996 Dec; 103(12):2029-36.
- Constitutional alterations in p16 in patients with uveal melanoma. Melanoma Res. 1996 Dec; 6(6):405-10.
- Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate. Ophthalmology. 1996 Nov; 103(11):1820-8.
- Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate. Arch Ophthalmol. 1996 Aug; 114(8):964-70.
- Intravenous infusion of liposomal benzoporphyrin derivative for photodynamic therapy of experimental choroidal neovascularization. Arch Ophthalmol. 1996 Aug; 114(8):978-85.
- Liposomal benzoporphyrin derivative verteporfin photodynamic therapy. Selective treatment of choroidal neovascularization in monkeys. Ophthalmology. 1996 Mar; 103(3):427-38.
- Photodynamic therapy of pigmented choroidal melanomas using a liposomal preparation of benzoporphyrin derivative. Arch Ophthalmol. 1996 Feb; 114(2):186-92.
- Serpiginous choroiditis. Int Ophthalmol Clin. 1996; 36(1):135-43.
- Benzoporphyrin-lipoprotein-mediated photodestruction of intraocular tumors. Exp Eye Res. 1996 Jan; 62(1):1-10.
- Visual-field deficits associated with proton beam irradiation for parapapillary choroidal melanoma. Ophthalmology. 1996 Jan; 103(1):110-6.
- Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate. Arch Ophthalmol. 1996 Jan; 114(1):66-71.
- The subretinal fibrosis and uveitis syndrome. Int Ophthalmol Clin. 1996; 36(1):145-52.
- Rhegmatogenous retinal detachment in eyes with uveal melanoma. Retina. 1996; 16(6):488-96.
- Serum zinc and serum lipid profiles in 778 adults. Ann Epidemiol. 1995 Nov; 5(6):490-6.
- Photoimmunotherapy of human uveal melanoma cells. Exp Eye Res. 1995 Oct; 61(4):385-91.
- Photodynamic therapy of experimental choroidal neovascularization using lipoprotein-delivered benzoporphyrin. Arch Ophthalmol. 1995 Jun; 113(6):810-8.
- Photodynamic therapy of pigmented choroidal melanomas. Invest Ophthalmol Vis Sci. 1995 Apr; 36(5):871-8.
- Ocular blood flow velocity in age-related macular degeneration. Ophthalmology. 1995 Apr; 102(4):640-6.
- Lens changes after proton beam irradiation for uveal melanoma. Am J Ophthalmol. 1995 Feb; 119(2):157-64.
- Intrascleral foreign body simulating extrascleral extension of uveal melanoma. Arch Ophthalmol. 1994 Dec; 112(12):1620-1.
- Vascular targeting in photodynamic occlusion of subretinal vessels. Ophthalmology. 1994 Dec; 101(12):1953-61.
- [Selective occlusion of subretinal neovascularization with photodynamic therapy]. Ophthalmologe. 1994 Dec; 91(6):789-95.
- Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA. 1994 Nov 09; 272(18):1413-20.
- Experimental transient exudative retinal detachment in the rat. Arch Ophthalmol. 1994 Sep; 112(9):1236-42.
- [Photodynamic therapy of experimental, intraocular tumors with benzoporphyrin-lipoprotein]. Ophthalmologe. 1994 Jun; 91(3):348-56.
- Familial uveal melanoma. Am J Ophthalmol. 1994 Apr 15; 117(4):516-20.
- Adverse reactions due to indocyanine green. Ophthalmology. 1994 Mar; 101(3):529-33.
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