Darlene A. Dartt, Ph.D.

Harvard Medical School

Professor of Ophthalmology, Department of Ophthalmology

Schepens Eye Research Institute of Massachusetts Eye and Ear

Senior Scientist

Vecillo Dry Eye Laboratory

Harold F. Johnson Research Scholar and Director

Research Summary

Center/Research Area Affiliations

Research Summary

Dr. Dartt studies the neural regulation of tear production, focusing on the cellular signaling pathways that nerves and growth factors use to stimulate protein secretion from the lacrimal gland and mucin secretion from conjunctival goblet cells. Her goal is to identify the signaling pathways used to stimulate secretion under normal conditions and to determine the dysfunction of these pathways in dry eye, LASIK, allergic conjunctivitis, and infection. A major area of her research is the role of conjunctival goblet cells in inflammation and the active resolution of inflammation.