Dr. Lucia Sobrin is a full-time clinician scientist with Mass. Eye and Ear's Retina and Uveitis Services. She has unique expertise diagnosing and treating rare and complicated eye disorders that affect the middle (uvea) and back (retina) portions of the eye. She also serves as Director of the Morse Laser Center.
After obtaining her medical degree from the University Miami School of Medicine, Dr. Sobrin completed her ophthalmology residency training at Bascom Palmer Eye Institute. She then completed a medical and surgical retina fellowship at Mass. Eye and Ear followed by a uveitis and ocular immunology fellowship at the Massachusetts Eye Research and Surgery Institute. In 2006, she became one of the Department's first Harvard Vision Clinical Scientist Research Program (K12) recipients and later received her Master of Public Health Degree from the Harvard School of Public Health.
In research, Dr. Sobrin is particularly interested in elucidating the genetics of diabetic retinopathy in African Americans. As a Department of Ophthalmology Scholar, she led a candidate gene association study of diabetic retinopathy within the Candidate gene Association Resource (CARe), which included patients from several large population-based cohorts. Currently, she is the principal investigator on an admixture genetic association study for diabetic retinopathy in African Americans and a multi-ethnic genome-wide association study of diabetic retinopathy. In 2011, she was honored with the ARVO/Alcon Early Career Clinician Scientist Research Award.
Dr. Sobrin shares her in-depth knowledge of rare and complex cases with uveitis and retina fellows as well as ophthalmology residents. She also co-directs Mass. Eye and Ear's Uveitis Fellowship Program.
Retina, uveitis, diabetic retinopathy
Genetics of diabetic retinopathy, uveitis
For a full publication list, please see her CV.
Genetic profile for five common variants associated with age-related macular degeneration in densely affected families: a novel analytic approach. Sobrin L, Maller JB, Neale BM, Reynolds RC, Fagerness JA, Daly MJ, Seddon JM. Eur J Hum Genet. 2010 Apr; 18(4): 496-501.
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Neale BM, Fagerness J, Reynolds R, Sobrin L, Parker M, Raychaudhuri S, Tan PL, Oh EC, Merriam JE, Souied E, Bernstein PS, Li B, Frederick JM, Zhang K, Brantley MA Jr, Lee AY, Zack DJ, Campochiaro B, Campochiaro P, Ripke S, Smith RT, Barile GR, Katsanis N, Allikmets R, Daly MJ, Seddon JM. Proc Natl Acad Sci USA. 2010 Apr 20; 107(16): 7395-400.
ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration. Sobrin L, Reynolds R, Yu Y, Fagerness J, Leveziel N, Bernstein PS, Souied EH, Daly MJ, Seddon JM. Am J Ophthalmol. 2011 Feb; 151(2): 345-52.e3.
Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe). Sobrin L, Green T, Sim X, Jensen RA, Tai ES, Tay WT, Wang JJ, Mitchell P, Sandholm N, Liu Y, Hietala K, Iyengar SK, Family Investigation of Nephropathy and Diabetes-Eye Research Group, Brooks M, Buraczynska M, Van Zuydam N, Smith AV, Gudnason V, Doney AS, Morris AD, Leese GP, Palmer CN, Wellcome Trust Case Control Consortium 2, Swaroop A, Taylor HA Jr, Wilson JG, Penman A, Chen CJ, Groop PH, Saw SM, Aung T, Klein BE, Rotter JI, Siscovick DS, Cotch MF, Klein R, Daly MJ, Wong TY. Invest Ophthalmol Vis Sci. 2011 Sep; 52(10): 7593-602.
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Yu Y, Bhangale TR, Fagerness J, Ripke S, Thorleifsson G, Tan PL, Souied EH, Richardson AJ, Merriam JE, Buitendijk GH, Reynolds R, Raychaudhuri S, Chin KA, Sobrin L, Evangelou E, Lee PH, Lee AY, Leveziel N, Zack DJ, Campochiaro B, Campochiaro P, Smith RT, Barile GR, Guymer RH, Hogg R, Chakravarthy U, Robman LD, Gustafsson O, Sigurdsson H, Ortmann W, Behrens TW, Stefansson K, Uitterlinden AG, van Duijn CM, Vingerling JR, Klaver CC, Allikmets R, Brantley MA Jr, Baird PN, Katsanis N, Thorsteinsdottir U, Ioannidis JP, Daly MJ, Graham RR, Seddon JM. Hum Mol Genet. 2011 Sep 15; 20(18): 3699-709.
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