Dr. Lucia Sobrin is a full-time clinician scientist with Mass. Eye and Ear's Retina and Uveitis Services. She has unique expertise diagnosing and treating rare and complicated eye disorders that affect the middle (uvea) and back (retina) portions of the eye. She has a specific clinical interest in the diagnosis and treatment of autoimmune retinopathy and cancer-associated retinopathy. She also serves as Director of the Morse Laser Center.
After obtaining her medical degree from the University Miami School of Medicine, Dr. Sobrin completed her ophthalmology residency training at Bascom Palmer Eye Institute. She then completed a medical and surgical retina fellowship at Mass. Eye and Ear followed by a uveitis and ocular immunology fellowship at the Massachusetts Eye Research and Surgery Institute. In 2006, she became one of the Department's first Harvard Vision Clinical Scientist Research Program (K12) recipients and later received her Master of Public Health Degree from the Harvard School of Public Health.
In research, Dr. Sobrin is particularly interested in elucidating the genetics of diabetic retinopathy. As a Department of Ophthalmology Scholar, she led a candidate gene association study of diabetic retinopathy within the Candidate gene Association Resource (CARe), which included patients from several large population-based cohorts and an admixture genetic association study for diabetic retinopathy in African Americans. She currently leads a multi-ethnic genome-wide association study of diabetic retinopathy. In 2011, she was honored with the ARVO/Alcon Early Career Clinician Scientist Research Award. In 2015 she was honored with the Alcon Research Institute Young Investigator Award.
Dr. Sobrin shares her in-depth knowledge of rare and complex cases with uveitis and retina fellows as well as ophthalmology residents. She also co-directs Mass. Eye and Ear's Uveitis Fellowship Program.
Retina, uveitis, diabetic retinopathy, autoimmune retinopathy, cancer-associated retinopathy
Genetics of diabetic retinopathy, uveitis, autoimmune retinopathy, cancer-associated retinopathy
For a full publication list, please see her CV.
Meng W, Shah KP, Pollack S, Toppila I, Hebert HL, Wellcome Trust Case Control Consortium 2 (WTCCC2), Surrogate markers for Micro- and Macro-vascular hard endpoints for Innovative diabetes Tools (SUMMIT) study group, McCarthy MI, Groop L, Ahlqvist E, Lyssenko V, Agardh E, Daniell M, Kaidonis G, Craig JE, Mitchell P, Liew G, Kifley A, Wang JJ, Christiansen MW, Jensen RA, Penman A, Hancock HA, Chen CJ, Correa A, Kuo JZ, Li X, Chen YI, Rotter JI, Klein R, Klein B, Wong TY, Morris AD, Doney ASF, Colhoun HM, Price AL, Burdon KP, Groop P-H, Sandholm N, Grassi MA, Sobrin L, Palmer CAN. A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes. Acta Ophthalmol 2018.
Sobrin L, Chong YH, Fan Q, Gan A, Stanwyck LK, Kaidonis G, Craig JE, Kim J, Liao L, Huang Y-C, Lee W-J, Hung Y-J, Guo X, Hai Y, Ipp E, Pollack S, Hancock H, Price A, Penman A, Mitchell P, Liew G, Smith AV, Gudnadson V, Tan G, Klein BEK, Kuo J, Li X, Christiansen MW, Psaty BM, Sandow K, Asian Genetic Epidemiology Network Consortium, Jensen RA, Klein R, Cotch MF, Wang JJ, Jia Y, Chen CJ, Chen Y-DI, Rotter JI, Tsai F-J, Hanis CL, Burdon KP, Wong TY, Cheng C-Y. Genetically determined plasma lipid levels and risk of diabetic retinopathy: a Mendelian randomization study. Diabetes 2017; 66:3130-41.
Tandon A, Chen CJ, Penman A, Hancock H, James M, Husain D, Andreoli C, Li X, Kou JZ, Idowu O, Riche DM, Papavasileiou E, Brauner S, Smith SO, Hoadley S, Richardson C, Kieser T, Vazquez V, Chi C, Fernandez M, Harden M, Cotch MF, Siscovick D, Taylor HA, Wilson JG, Reich D, Wong TY, Klein R, Klein BEK, Rotter JI, Patterson N, Sobrin L. African ancestry analysis and admixture genetic mapping for proliferative diabetic retinopathy in African Americans. Invest Ophthalmol Vis Sci 2015; 56:3999-4005.z
Penman A, Hancock H, Papavasileiou E, James M, Idowu O, Riche DM, Fernandez M, Brauner S, Smith SO, Hoadley S, Richardson C, Vazquez V, Chi C, Andreoli C, Husain D, Chen CJ, Sobrin L. Risk factors for proliferative diabetic retinopathy in African Americans with type 2 diabetes. Ophthalmic Epidemiol 2016; 23:88-93.
Davoudi S, Papavasileiou E, Roohipoor R, Cho H, Kudrimoti S, Hancock H, Hoadley S, Husain D, Andreoli C, James M, Penman A, Chen CJ, Sobrin L. Optical coherence tomography characteristics of macular edema and hard exudates and their association with lipid serum levels in type 2 diabetes. RETINA 2016; In Press.
Penman A, Hoadley S, Wilson JG, Taylor HA, Chen CJ, Sobrin L. P-selectin plasma levels and genetic variant associated with diabetic retinopathy in African Americans. Am J Ophthalmol 2015; 159: 1152-60.
Tecilazich F, Feke GT, Mazzantini S, Sobrin L, Lorenzi M. Defective myogenic response of retinal vessels is associated with accelerated onset of retinopathy in type 1 diabetic individuals. Invest Ophthalmol Vis Sci 2016; 57: 1523-9.
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To learn more about Dr. Sobrin, read her "Meet a Specialist" profile here.