Laboratory Publications (Select)


Generating mouse models of degenerative diseases using Cre/lox mediated in vivo mosaic cell ablation. Fujioka M, Tokano H, Fujioka KS, Okano H, Edge ASB. J Clin Invest. 2011;121:2462–2469.


Wnt responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea. Shi F, Kempfle J, Edge ASB. J Neurosci. 2012;32:9639–9648.


Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma. Mizutari K, Fujioka M, Hosoya M, Bramhall N, Okano HJ, Okano H, Edge ASB. Neuron. 2013;77:58–69. 

Hair cell generation by β-catenin overexpression in Lgr5-positive cochlear progenitors. Shi F, Hu L, Edge ASB. Proc Natl Acad Sci. 2013;110:13851–13856.


Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea. Bramhall N, Shi F, Arnold K, Hochedlinger K, Edge ASB. Stem Cell Reports. 2014;2:311–322.


Destabilization of Atoh1 by E3 ubiquitin ligase Huwe1 and casein kinase 1 is essential for normal hair cell development. Cheng YF, Tong M, Edge ASB. J Biol Chem. 2016;291:21096–21109. 

Distinct capacity for differentiation to inner ear cell types by progenitor cells of the cochlea and vestibular organs. McLean WJ, McLean DT, Eatock RA, Edge ASB. Development. 2016;143:4381–93. 

Diphtheris toxin-induced cell death triggers Wnt-dependent hair cell regeneration in neonatal mice. Hu L, Lu J, Chiang H, Wu H, Edge ASB, Shi F. J Neurosci. 2016;36:9479–86.


Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery. Rees HA, Komor AC, Yeh WH, Caetano-Lopes J, Warman M, Edge ASB, Liu DR. Nat Commun. 2017;8:15790. 

Clonal expansion of Lgr5-positive cells from mammalian cochlea and high-purity generation of sensory hair cells. McLean WJ, Yin X, Lu L, Lenz DR, McLean DT, Langer R, Karp JM, Edge ASB. Cell Reports. 2017;18:1979–1929.


In vivo base editing of post-mitotic sensory cells. Yeh WH, Chiang H, Rees HA, Edge ASB, Liu DR. Nat Commun. ePub ahead of print, 2018.