Laboratory Publications (Select)

2011

Generating mouse models of degenerative diseases using Cre/lox mediated in vivo mosaic cell ablation. Fujioka M, Tokano H, Fujioka KS, Okano H, Edge ASB. J Clin Invest. 2011;121:2462–2469.


2012

Wnt responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea. Shi F, Kempfle J, Edge ASB. J Neurosci. 2012;32:9639–9648.


2013

Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma. Mizutari K, Fujioka M, Hosoya M, Bramhall N, Okano HJ, Okano H, Edge ASB. Neuron. 2013;77:58–69. 

Hair cell generation by β-catenin overexpression in Lgr5-positive cochlear progenitors. Shi F, Hu L, Edge ASB. Proc Natl Acad Sci. 2013;110:13851–13856.


2014

Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea. Bramhall N, Shi F, Arnold K, Hochedlinger K, Edge ASB. Stem Cell Reports. 2014;2:311–322.


2016

Destabilization of Atoh1 by E3 ubiquitin ligase Huwe1 and casein kinase 1 is essential for normal hair cell development. Cheng YF, Tong M, Edge ASB. J Biol Chem. 2016;291:21096–21109. 

Distinct capacity for differentiation to inner ear cell types by progenitor cells of the cochlea and vestibular organs. McLean WJ, McLean DT, Eatock RA, Edge ASB. Development. 2016;143:4381–93. 

Diphtheris toxin-induced cell death triggers Wnt-dependent hair cell regeneration in neonatal mice. Hu L, Lu J, Chiang H, Wu H, Edge ASB, Shi F. J Neurosci. 2016;36:9479–86.


2017

Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery. Rees HA, Komor AC, Yeh WH, Caetano-Lopes J, Warman M, Edge ASB, Liu DR. Nat Commun. 2017;8:15790. 

Clonal expansion of Lgr5-positive cells from mammalian cochlea and high-purity generation of sensory hair cells. McLean WJ, Yin X, Lu L, Lenz DR, McLean DT, Langer R, Karp JM, Edge ASB. Cell Reports. 2017;18:1979–1929.


2018

In vivo base editing of post-mitotic sensory cells. Yeh WH, Chiang H, Rees HA, Edge ASB, Liu DR. Nat Commun. ePub ahead of print, 2018.