Laboratory Publications (Select)

Tillotson Cell Biology Unit 

β-catenin is required for hair cell differentiation in the cochlea. Shi, F., Hu, L., Jacques, B., Mulvaney, J.F., Dabdoub, A., Edge, A.S.B.  J Neurosci, 34:6470-6479, 2014.

Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea. Bramhall, N., Shi, F., Arnold, K., Hochedlinger, K. and Edge, A.S.B. Stem Cell Reports 2:311-322, 2014.

An independent construct for conditional expression of atonal homolog-1. Parker, M., Kinouchi, H., Cheng, Y. and Edge, A.S.B.  Hum Gene Ther Methods 25:1-13, 2014.

Inhibition of repulsive guidance molecule, RGMa, increases afferent synapse formation with auditory hair cells. Brugeaud, A., Tong, M., Luo, L., Edge, A.S.B. Dev Neurobiol 74:457-466, 2014.

Ouabain- induced cochlear nerve degeneration: synaptic loss and plasticity in a mouse model of auditory neuropathy. Yuan, Y., Shi, F., Yin, Y., Tong, M., Lang, H., Polley, D.B., Liberman, M.C. and Edge, A.S.B.  J. Assoc. Res. Otolarygol. J Assoc Res Otolaryngol 15:31-43, 2014.

Hair cell generation by β-catenin overexpression in Lgr5-positive cochlear progenitors. Shi, F., Hu, L. and Edge, A.S.B.  Proc, Natl. Acad. Sci. 110:13851-13856, 2013.

Loss of osteoprotegerin expression in the inner ear causes degeneration of the cochlear nerve and sensorineural hearing loss. Kao, S.Y., Kempfle, J.S., Jensen, J.B., Perez-Fernandez, D., Lysaght, A.C., Edge, A.S.B. and Stankovic, K.M. Neurobiol. Dis. 56:25-33, 2013.

Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma. Mizutari, K., Fujioka, M., Hosoya, M., Bramhall, N., Okano, H.J., Okano, H. and Edge, A.S.B. Neuron 77:58-69, 2013.

Regenerated synapses between postnatal hair cells and auditory neurons. Tong, M., Brugeaud, A. and Edge, A.S.B.  J. Assoc. Res. Otolaryngol. 14:321-329, 2013.

An in vitro model of developmental synaptogenesis using cocultures of human neural progenitors and cochlear explants. Nayagam, B.A., Edge, A.S.B., Needham, K., Hyakumura, T., Leung, J., Nayagam, D.A. and Dottori, M. Stem Cells Dev. 22:901-912, 2013.

Prospects for replacement of auditory neurons by stem cells. Shi, F., Edge, A.S.B. Hearing Res. 297:106-12, 2013.

Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea. Shi, F., Kempfle, J. and Edge, A.S.B. J. Neurosci. 32:9639-9648, 2012.

Generating mouse models of degenerative diseases using Cre/lox mediated in vivo mosaic cell ablation. Fujioka, M., Tokano, H., Fujioka, K.S., Okano, H. and Edge, A.S.B. J. Clin. Invest. 121:2462-2469, 2011.

Notch signaling alters sensory or neuronal cell fate specification of inner ear stem cells. Jeon, S-J., Fujioka, M. Kim, S-C. and Edge, A.S.B. J. Neurosci. 31:8351-8358, 2011.

TAK1 expression in the cochlea: a specific marker for adult supporting cells. Parker, M.A., Jiang, K., Kempfle, J., Mizutari, K., Simmons, C.L., Bieber, R., Adams, J. and Edge, A.S.B. J. Assoc. Res. Otolaryngol. 12:471-483, 2011.

β-catenin upregulates Atoh1 in neural progenitor cells by interaction with an Atoh1 3’ enhancer. Shi, F., Cheng, Y., Wang, X.L. and Edge, A.S.B.  J. Biol. Chem. 285:392-400, 2010.  PMCID19864427

Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cells. Li, H., Liu, H., Corrales, C.E., Risner, J., Forrester, J., Holt, J., Heller, S. and Edge, A.S.B.  BMC Neurosci. 10:122, 2009. PMCID19778451

Hair cell regeneration. Edge, A.S.B. and Chen, Z.Y. Curr. Opin. Neurobiol. 18:377-382, 2008. PMCID18929656

Differentiation of inner ear stem cells to functional sensory neurons.  Martinez-Monedero, R., Yi, E., Glowatzki, E. and Edge, A.S.B. Dev. Neurobiol. 68:669-84, 2008. PMCID18278797

BMP4 induction of sensory neurons from human embryonic stem cells and reinnervation of sensory epithelium. Shi, F., Corrales, C.E., Liberman, M.C. and Edge, A.S.B.  Eur. J. Neurosci. 26:3016-3023, 2007. PMCID18005071

Bone marrow mesenchymal stem cells are progenitors in vitro for inner ear hair cells.  Jeon, S.-J., Oshima, K., Heller, S. and Edge, A.S.B.  Mol. Cell. Neurosci. 34:59-68, 2007. PMCID17113786

Stem cells for the replacement of inner ear neurons and hair cells. Martinez-Monedero, R. and Edge, A.S.B.  Int. J. Dev. Biol. 51:655-661, 2007. PMCID17891724

Differential distribution of stem cells in the auditory and vestibular organs of the inner ear. Oshima, K., Corrales, C.E., Grimm, C., Senn, P., Martinez-Monedero, R., Geleoc, G.S.G., Edge, A., Holt, J.R. and Heller, S. J. Assoc. Res. Otolaryngol. 8:18-31, 2007. PMCID17171473

The potential role of endogenous stem cells in regeneration of the inner ear.  Martinez-Monedero, R., Oshima, K., Heller, S. and Edge, A.S.B. Hearing Res. 227:48-52, 2007. PMCID17321086

Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of Corti. Corrales, C.E., Pan, L., Li, H., Liberman, M.C., Heller, S. and Edge, A.S.B.  J. Neurobiol. 66:1489-1500, 2006. PMCID17013931

Identification and characterization of a human monoclonal antagonistic antibody AL-57 specific for the high affinity form of lymphocyte function-associated antigen-1.  Huang, L., Shimaoka, M., Rondon, I., Roy, I., Chang, Q., Po. M., Dransfield, D.T., Ladner, R.C., Edge, A.S.B., Salas, A., Wood, C.R., Springer, T.A. and Cohen, E.H.  J. Leukocyte Biol. 80:905-914, 2006. PMCID16888085

Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of Corti. Corrales, C.E., Pan, L., Li, H., Liberman, M.C., Heller, S. and Edge, A.S.B.  J. Neurobiol. 66:1489-1500, 2006.

Regeneration of synaptic connections between neurons and hair cells after selective removal of auditory neurons. Martinez-Monedero, R., Corrales, C.E., Cuajungo, M., Heller, S. and Edge, A.S.B.  J. Neurobiol. 66: 319-331, 2006. PMCID16408287

Stem cells as therapy for hearing loss. Li, H., Corrales, E., Edge, A and Heller, S.  Trends Mol. Med. 10:309-315, 2004. PMCID15242678

A novel monoclonal antibody inhibits the immune response of human cells against porcine cells: identification of a porcine antigen homologous to CD58.  Crosby, K.E., Yatko, C., DerSimonian, H., Pan, L. and Edge, A.S.B. Transplantation 77:1288-1294, 2004. PMCID15114100

Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in patients:  histological analysis of cell survival and differentiation. Pagani FD, DerSimonian H, Zawadzka A, Wetzel K, Edge ASB, Jacoby DB, Dinsmore JH, Wright S, Aretz TH, Eisen HJ, Aaronson KD.  J Am Coll Cardiol 41:879-888, 2003.

Treatment of cirrhosis and liver failure in rats by hepatocyte xenotransplantation.  Nagata, H., Ito, M., Cai, J., Edge, A.S.B., Platt, J.L. and Fox, I. Gastroenterology 124:422-431, 2003.

Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance following myocardial infarction. Jain, M., DerSimonian, H., Brenner, D.A., Ngoy, S., Teller, P., Edge, A.S.B., Zawadska, A., Wetzel, K., Sawyer, D.B., Colucci, W.S., Apstein, C.S., and Liao, R.  Circulation 103:1920-1927, 2001. PMCID11294813

Human anti-porcine T cell response: blocking with anti-class I antibody leads to hyporesponsiveness and a switch in cytokine production. DerSimonian, H., Pan, L.-Y., Yatko, C., Rodrigue-Way, A., Johnson, E. and Edge, A.S.B.  J. Immunology 162:6993-7001, 1999. PMCID13058140

Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease. Deacon, T., Schumacher, J., Dinsmore, J., Thomas, C., Palmer, P., Kott, S., Edge, A.S.B., Penney, D., Kassissieh, S., Dempsey, P. and Isacson, O.  Nature Medicine 3:350-353, 1997. PMCID9055867

Species-specific detection of porcine xenografts with an antibody against a novel epitope of the lymphocyte homing receptor CD44. Oettinger, H.F., Sullivan, J.A., Horvath, K.E., Kelley, J.A., Jacoby, D.B., Dinsmore, J., Zawadzka, A. and Edge, A.S.B.  Xenotransplantation 4:252-261, 1997.

Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation. Gunsalus, J.R., Brady, D.A., Coulter, S.M., Gray, B.M. and Edge, A.S.B.  Nature Medicine 3:48-53, 1997. PMCID8986740