Xiaohong Zhou,
OD, PhD
Massachusetts Eye and Ear
Investigator
Harvard Medical School
Instructor in Ophthalmology
xiaohong_zhou@meei.harvard.edu
For investigator inquiries only
About My Research
Center/Research Area Affiliation
Biography
Dr. Zhou is a scientist who specializes in the immunopathogensis of adenovirus keratitis. Her research addresses questions that range from the precise contributions of bone marrow-derived cells in the cornea to specific aspects of inflammation in adenovirus. Her work plays a central role in defining viral entry pathways in the mouse cornea infected with human adenovirus. In addition to obtaining independent funding from Alcon Research Institute, Dr. Zhou's work has been published in several prominent peer-reviewed journals and has been presented at multiple national and international conferences.
Education
1994: MD, Clinical Medicine, West China University of Medical Sciences, Chengdu, P.R. China
2002: PhD, Ophthalmology, West China University of Medical Sciences, Chengdu, P.R. China
Postgraduate Training
2004-2009: Postdoctoral Fellow, Glaucoma and Retinal Revascularization, Oklahoma Health Science Center
Honors
2001: Academic Scholarship Award, West China University of Medical Sciences
2006: Gene Anderson Award for Best Postdoctoral Paper, OU Vision Workshop
2007: Travel Award, ARVO Conference, National Eye Institute
Publications powered by Harvard Catalyst Profiles
- Simultaneous perfusion, diffusion, T2 *, and T1 mapping with MR fingerprinting. Magn Reson Med. 2024 Feb; 91(2):558-569.
- Quantitative tumor burden imaging parameters of the spleen at MRI for predicting treatment response in patients with acute leukemia. Heliyon. 2023 Oct; 9(10):e20348.
- Three-dimensional echo-shifted EPI with simultaneous blip-up and blip-down acquisitions for correcting geometric distortion. Magn Reson Med. 2023 Dec; 90(6):2375-2387.
- Ethical Considerations for MRI Research in Human Subjects in the Era of Precision Medicine. J Magn Reson Imaging. 2024 May; 59(5):1864-1866.
- Accelerating High b-Value Diffusion-Weighted MRI Using a Convolutional Recurrent Neural Network (CRNN-DWI). Bioengineering (Basel). 2023 Jul 21; 10(7).
- Editorial for Brain-Tumor Interface-Based MRI Radiomics Models to Determine EGFR Mutation, Response to EGFR-TKI and T790M Resistance Mutation in Non-Small Cell Lung Carcinoma Brain Metastasis. J Magn Reson Imaging. 2023 12; 58(6):1848-1849.
- The Relationship Between Sleep and Brain Function in Older Adults With Chronic Kidney Disease and Self-Identified Cognitive Impairment. J Gerontol Nurs. 2023 Jul; 49(7):31-39.
- Predicting chronic postsurgical pain: current evidence and a novel program to develop predictive biomarker signatures. Pain. 2023 09 01; 164(9):1912-1926.
- Optimal selection of b-values for differential diagnosis of mediastinal lymph nodes using diffusion-weighted imaging. Heliyon. 2023 Jun; 9(6):e16702.
- Editorial for Computed Diffusion-Weighted Images of Rectal Cancer: Image Quality, Restaging, and Treatment Response after Neoadjuvant Therapy. J Magn Reson Imaging. 2024 01; 59(1):309-310.
- Time-dependent diffusion MRI using multiple stimulated echoes. Magn Reson Med. 2023 09; 90(3):910-921.
- Characterization of breast lesions using multi-parametric diffusion MRI and machine learning. Phys Med Biol. 2023 04 03; 68(8).
- Multi-readout DWI with a reduced FOV for studying the coupling between diffusion and T2* relaxation in the prostate. Magn Reson Med. 2023 07; 90(1):250-258.
- Comparison of uniform-density, variable-density, and dual-density spiral samplings for multi-shot DWI. Magn Reson Med. 2023 07; 90(1):133-149.
- Simultaneous multi-segment (SMSeg) EPI over multiple focal regions. Phys Med Biol. 2023 02 03; 68(4).
- Incorporating multiple magnetic resonance diffusion models to differentiate low- and high-grade adult gliomas: a machine learning approach. Quant Imaging Med Surg. 2022 Nov; 12(11):5171-5183.
- Gradient-echo-train-based sub-millisecond periodic event encoded dynamic imaging with random (k, t)-space undersampling: k-t get-SPEEDI. Magn Reson Med. 2022 10; 88(4):1690-1701.
- Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol. Front Med (Lausanne). 2022; 9:849214.
- Fluid-attenuated inversion recovery diffusion-weighted imaging (DWI) for evaluating chemotherapy response in patients with acute leukemia: Comparison with conventional DWI. Indian J Cancer. 2022 Apr-Jun; 59(2):230-235.
- Deep Learning Analyses of Brain MRI to Identify Sustained Attention Deficit in Treated Obstructive Sleep Apnea: A Pilot Study. Sleep Vigil. 2022 Jun; 6(1):179-184.
- Exercise Training and Cognitive Function in Kidney Disease: Protocol for a Pilot Randomized Controlled Trial. Nurs Res. 2022 Jan-Feb 01; 71(1):75-82.
- Three-dimensional reduced field-of-view imaging (3D-rFOVI). Magn Reson Med. 2022 05; 87(5):2372-2379.
- Predicting the aggressiveness of peripheral zone prostate cancer using a fractional order calculus diffusion model. Eur J Radiol. 2021 Oct; 143:109913.
- In-plane simultaneous multisegment imaging using a 2D RF pulse. Magn Reson Med. 2022 01; 87(1):263-271.
- Evaluation of a fractional-order calculus diffusion model and bi-parametric VI-RADS for staging and grading bladder urothelial carcinoma. Eur Radiol. 2022 Feb; 32(2):890-900.
- MRI with sub-millisecond temporal resolution over a reduced field of view. Magn Reson Med. 2021 12; 86(6):3166-3174.
- Diffusion in Sephadex Gel Structures: Time Dependency Revealed by Multi-Sequence Acquisition over a Broad Diffusion Time Range. Mathematics (Basel). 2021 Jul 02; 9(14).
- New imaging features of tuberous sclerosis complex: A 7 T MRI study. NMR Biomed. 2021 09; 34(9):e4565.
- Condensation Artifact. J Magn Reson Imaging. 2021 09; 54(3):1024-1027.
- Visualization of Human Aortic Valve Dynamics Using Magnetic Resonance Imaging with Sub-Millisecond Temporal Resolution. J Magn Reson Imaging. 2021 10; 54(4):1246-1254.
- In vivo assessment of Lauren classification for gastric adenocarcinoma using diffusion MRI with a fractional order calculus model. Eur Radiol. 2021 Aug; 31(8):5659-5668.
- Quartile histogram assessment of glioma malignancy using high b-value diffusion MRI with a continuous-time random-walk model. NMR Biomed. 2021 04; 34(4):e4485.
- Magnetic resonance imaging with submillisecond temporal resolution. Magn Reson Med. 2021 05; 85(5):2434-2444.
- Intravoxel Incoherent Motion Diffusion-weighted MRI of Infiltrated Marrow for Predicting Overall Survival in Newly Diagnosed Acute Myeloid Leukemia. Radiology. 2020 04; 295(1):155-161.
- Phantom validation of quantitative susceptibility and dynamic contrast-enhanced permeability MR sequences across instruments and sites. J Magn Reson Imaging. 2020 04; 51(4):1192-1199.
- High-Spatial-Resolution Diffusion MRI in Parkinson Disease: Lateral Asymmetry of the Substantia Nigra. Radiology. 2019 04; 291(1):149-157.
- Brain microstructural alterations in type 2 diabetes: diffusion kurtosis imaging provides added value to diffusion tensor imaging. Eur Radiol. 2019 Apr; 29(4):1997-2008.
- Diffusion MRI of cancer: From low to high b-values. J Magn Reson Imaging. 2019 01; 49(1):23-40.
- Capturing complexity of the diffusion-weighted MR signal decay. Magn Reson Imaging. 2019 02; 56:110-118.
- Conventional MRI to detect the differences between mass-like tuberculosis and lung cancer. J Thorac Dis. 2018 Oct; 10(10):5673-5684.
- White matter structural differences in OSA patients experiencing residual daytime sleepiness with high CPAP use: a non-Gaussian diffusion MRI study. Sleep Med. 2019 01; 53:51-59.
- Protein Kinase C Signaling in Adenoviral Infection. Biochemistry. 2016 Oct 25; 55(42):5938-5946.
- Role of MyD88 in adenovirus keratitis. Immunol Cell Biol. 2017 01; 95(1):108-116.
- Resident corneal c-fms(+) macrophages and dendritic cells mediate early cellular infiltration in adenovirus keratitis. Exp Eye Res. 2016 06; 147:144-147.
- Epidemic Keratoconjunctivitis-Causing Adenoviruses Induce MUC16 Ectodomain Release To Infect Ocular Surface Epithelial Cells. mSphere. 2016 Jan-Feb; 1(1).
- Recombination of the epsilon determinant and corneal tropism: Human adenovirus species D types 15, 29, 56, and 69. Virology. 2015 Nov; 485:452-9.
- Novel model of innate immunity in corneal infection. In Vitro Cell Dev Biol Anim. 2015 Sep; 51(8):827-34.
- Ultrastructure of adenovirus keratitis. Invest Ophthalmol Vis Sci. 2015 Jan 06; 56(1):472-7.
- Caveolin-1 associated adenovirus entry into human corneal cells. PLoS One. 2013; 8(10):e77462.
- Predicting the next eye pathogen: analysis of a novel adenovirus. mBio. 2013 Apr 09; 4(2):e00595-12.
- Analysis of human adenovirus type 19 associated with epidemic keratoconjunctivitis and its reclassification as adenovirus type 64. Invest Ophthalmol Vis Sci. 2012 May 14; 53(6):2804-11.
- The E3 CR1-gamma gene in human adenoviruses associated with epidemic keratoconjunctivitis. Virus Res. 2011 Sep; 160(1-2):120-7.
- Nanoceria extend photoreceptor cell lifespan in tubby mice by modulation of apoptosis/survival signaling pathways. Neurobiol Dis. 2011 Jun; 42(3):514-23.
- Nanoceria inhibit the development and promote the regression of pathologic retinal neovascularization in the Vldlr knockout mouse. PLoS One. 2011 Feb 22; 6(2):e16733.
- Viral capsid is a pathogen-associated molecular pattern in adenovirus keratitis. PLoS Pathog. 2010 Apr 15; 6(4):e1000841.
- Neuroprotective effect of overexpression of thioredoxin on photoreceptor degeneration in Tubby mice. Neurobiol Dis. 2010 Jun; 38(3):446-55.
- Anti-inflammatory effect of pigment epithelium-derived factor in DBA/2J mice. Mol Vis. 2009; 15:438-50.
- Molecular mechanisms underlying cochlear degeneration in the tubby mouse and the therapeutic effect of sulforaphane. Neurochem Int. 2009 Mar-Apr; 54(3-4):172-9.
- Biochemical alterations in the retinas of very low-density lipoprotein receptor knockout mice: an animal model of retinal angiomatous proliferation. Arch Ophthalmol. 2007 Jun; 125(6):795-803.
- Retinal ganglion cell protection by 17-beta-estradiol in a mouse model of inherited glaucoma. Dev Neurobiol. 2007 Apr; 67(5):603-16.
- Delay of photoreceptor degeneration in tubby mouse by sulforaphane. J Neurochem. 2007 May; 101(4):1041-52.
- 17beta-estradiol (betaE2) protects human retinal Müller cell against oxidative stress in vitro: evaluation of its effects on gene expression by cDNA microarray. Glia. 2006 Mar; 53(4):392-400.
- Bright cyclic light accelerates photoreceptor cell degeneration in tubby mice. Neurobiol Dis. 2006 Mar; 21(3):468-77.
- Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma. J Biol Chem. 2005 Sep 02; 280(35):31240-8.
- Involvement of insulin/phosphoinositide 3-kinase/Akt signal pathway in 17 beta-estradiol-mediated neuroprotection. J Biol Chem. 2004 Mar 26; 279(13):13086-94.
Show More
Show Less
