Demetrios Vavvas,
MD, PhD
Harvard Medical School
Solman and Libe Friedman Professor of Ophthalmology
Co-Director, Ocular Regenerative Medical Institute
demetrios_vavvas@meei.harvard.edu
For investigator inquiries only
About My Research
Centers of Excellence/Institutes
- AMD Center of Excellence
- Diabetic Eye Disease Center of Excellence
- Glaucoma Center of Excellence
- Ocular Oncology Center of Excellence
- Ocular Regenerative Medicine Institute
Research Programs/Laboratories
- Ines and Frederick Yeatts Retina Research Laboratory
- Harvard Retinal Imaging Laboratory
- JW Miller AMD Research Group
- Harvard Retinal Metabolomics Program
Research Summary
Dr. Vavvas is actively committed to research, serving as Principal Investigator in the Ines and Frederick Yeatts Retina Research Laboratory. He is especially involved in research of cell death mechanisms and neuroprotection strategies and his lab identified receptor interacting protein kinases (RIPK) mediated programmed necrosis as significant mode of photoreceptor cell loss and showed that simultaneous inhibition of both RIP kinase and caspase pathways is necessary for effective neuroprotection. He is investigating the regulation of the energy sensor of the cell AMP dependent kinase and the potential of its small molecule activator, AICAR, to suppress intraocular inflammation and retinoblastoma tumor growth. He has performed a Phase I/II clinical trial of high dose statins as a potential to reverse high risk features in age related macular degeneration.
Education
1992: BSc, First Class Honors, Biology/Neurosciences, McGill University, Montreal, Canada
1999: MD, PhD., cum laude, Medicine/Physiology, Boston University School of Medicine
Postgraduate Training
2000: Internship, Medicine, Boston Medical Center
2003: Residency, Ophthalmology, Harvard Medical School
2004: Chief Resident, Ophthalmology, Harvard Medical School
2006: Fellowship, Medical Retina and Vitreoretinal Surgery, Mass Eye and Ear
2007: Chief Fellow, Medical Retina and Vitreoretinal Surgery, Mass Eye and Ear
Academic Appointments
2021-Present: Solman and Libe Friedman Professor of Ophthalmology, Harvard Medical School
2016-2021: Monte J. Wallace Ophthalmology Chair in Retina
2013-2021: Associate Professor of Ophthalmology, Harvard Medical School
2010-2013: Assistant Professor of Ophthalmology, Harvard Medical School
2007-2010: Instructor in Ophthalmology, Harvard Medical School
Publications powered by Harvard Catalyst Profiles
- Widefield, Swept-Source Optical Coherence Tomography Angiography Metrics as Predictors of Anti-VEGF Treatment in Retinal Vein Occlusions. Ophthalmic Surg Lasers Imaging Retina. 2024 Mar 01; 1-9.
- Early recurrence of macular schisis in X-linked retinoschisis treated with vitrectomy for rhegmatogenous retinal detachment under silicone oil: case report and brief literature review. Ther Adv Ophthalmol. 2024 Jan-Dec; 16:25158414241232261.
- Quantitative Contrast Sensitivity Function and the Effect of Aging in Healthy Adult Eyes: A Normative Database. Ophthalmic Surg Lasers Imaging Retina. 2024 Feb 01; 1-9.
- Differences in effects of some newer-generation anti-diabetics on diabetic retinopathy versus nephropathy. Graefes Arch Clin Exp Ophthalmol. 2024 Apr; 262(4):1371-1372.
- Reply. Retina. 2024 Jan 01; 44(1):e9-e10.
- Peripheral monocytes and neutrophils promote photoreceptor cell death in an experimental retinal detachment model. Cell Death Dis. 2023 12 16; 14(12):834.
- Characterizing Macular Neovascularization in Myopic Macular Degeneration and Age-Related Macular Degeneration Using Swept Source OCTA. Clin Ophthalmol. 2023; 17:3855-3866.
- Associations of quantitative contrast sensitivity with wide-field swept-source optical coherence tomography angiography in retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. 2024 Mar; 262(3):789-799.
- Towards the validation of quantitative contrast sensitivity as a clinical endpoint: correlations with vision-related quality of life in bilateral AMD. Br J Ophthalmol. 2023 Oct 19.
- Comparative study of widefield swept-source optical coherence tomography angiography in eyes with concomitant age-related macular degeneration and diabetic retinopathy. Br J Ophthalmol. 2023 Oct 16.
- The prophylactic value of TNF-a inhibitors against retinal cell apoptosis and optic nerve axon loss after corneal surgery or trauma. Acta Ophthalmol. 2024 May; 102(3):e381-e394.
- Effects of newer-generation anti-diabetics on diabetic retinopathy: a critical review. Graefes Arch Clin Exp Ophthalmol. 2024 Mar; 262(3):717-752.
- CSF1R inhibition is not specific to innate immune cells but also affects T-helper cell differentiation independently of microglia depletion. Res Sq. 2023 Sep 06.
- SPONTANEOUS CLOSURE AND RECURRENT OPENING TIMES TWO OF A MACULAR HOLE IN A SURGICALLY NAIVE EYE. Retin Cases Brief Rep. 2023 Sep 01; 17(5):581-583.
- Quantitative Wide-Field Swept-Source Optical Coherence Tomography Angiography and Visual Outcomes in RAO. Clin Ophthalmol. 2023; 17:2505-2513.
- Opposing Roles of Blood-Borne Monocytes and Tissue-Resident Macrophages in Limbal Stem Cell Damage after Ocular Injury. Cells. 2023 08 18; 12(16).
- Epilepsy: Mitochondrial connections to the 'Sacred' disease. Mitochondrion. 2023 09; 72:84-101.
- Evolution of macular atrophy in eyes with neovascular age-related macular degeneration compared to fellow non-neovascular eyes. Graefes Arch Clin Exp Ophthalmol. 2023 Dec; 261(12):3425-3436.
- Sustained Inhibition of VEGF and TNF-a Achieves Multi-Ocular Protection and Prevents Formation of Blood Vessels after Severe Ocular Trauma. Pharmaceutics. 2023 Jul 31; 15(8).
- Structure-based network analysis predicts mutations associated with inherited retinal disease. medRxiv. 2023 Jul 06.
- COMPLEMENT INHIBITION FOR GEOGRAPHIC ATROPHY: Review of Salient Functional Outcomes and Perspective. Retina. 2023 07 01; 43(7):1064-1069.
- Plasma Metabolites Associated with OCT Features of Age-Related Macular Degeneration. Ophthalmol Sci. 2024 Jan-Feb; 4(1):100357.
- Integrating genetics and metabolomics from multi-ethnic and multi-fluid data reveals putative mechanisms for age-related macular degeneration. Cell Rep Med. 2023 07 18; 4(7):101085.
- Impact of phacoemulsification on posterior vitreous detachment formation in eyes with vitreomacular traction. Digit J Ophthalmol. 2023; 29(2):26-30.
- Systemic Dyslipidemia in Age-related Macular Degeneration: An Updated Systematic Review and Meta-analysis. Ophthalmol Sci. 2024 Jan-Feb; 4(1):100341.
- RIPK necrotic cell death pathway in both donor photoreceptor and host immune cells synergize to affect photoreceptor graft survival. FASEB J. 2023 04; 37(4):e22847.
- The NLRP3 inflammasome - interleukin 1ß axis in uveal melanoma. FEBS Open Bio. 2023 03; 13(3):545-555.
- UVA induces retinal photoreceptor cell death via receptor interacting protein 3 kinase mediated necroptosis. Cell Death Discov. 2022 Dec 12; 8(1):489.
- Structure-function association between contrast sensitivity and retinal thickness (total, regional, and individual retinal layer) in patients with idiopathic epiretinal membrane. Graefes Arch Clin Exp Ophthalmol. 2023 Mar; 261(3):631-639.
- The Effect of Sample Medication Use on Subsequent Anti-VEGF Agent Selection for Neovascular Age-Related Macular Degeneration. Semin Ophthalmol. 2022 Oct-Nov; 37(7-8):902-908.
- Restoration of Vision in Severe, Cicatricial, Ocular Surface Disease With the Boston Keratoprosthesis Type II. Am J Ophthalmol. 2022 11; 243:42-54.
- Treatment and prevention of pathological mitochondrial dysfunction in retinal degeneration and in photoreceptor injury. Biochem Pharmacol. 2022 09; 203:115168.
- Neuroprotection for Age-Related Macular Degeneration. Ophthalmol Sci. 2022 Dec; 2(4):100192.
- TWO-YEAR RESULTS OF INTRAVITREAL INJECTIONS OF AFLIBERCEPT IN COATS DISEASE: A CASE REPORT. Retin Cases Brief Rep. 2022 Jul 01; 16(4):473-478.
- Reevaluating the Risk of Serious Adverse Events of Carbonic Anhydrase Inhibitors. JAMA Ophthalmol. 2022 07 01; 140(7):745-746.
- Necroptosis and Neuroinflammation in Retinal Degeneration. Front Neurosci. 2022; 16:911430.
- Novel Epigenetic Clock Biomarkers of Age-Related Macular Degeneration. Front Med (Lausanne). 2022; 9:856853.
- Acute Syphilitic Posterior Placoid Chorioretinitis With Subfoveal Choroidal Neovascularization Managed With Anti-VEGF Therapy. J Vitreoretin Dis. 2022 May; 6(3):246-250.
- Systemic Complement Activation Profiles in Nonexudative Age-Related Macular Degeneration: A Meta-Analysis. J Clin Med. 2022 Apr 23; 11(9).
- Short- and Long-Term Visual Outcomes in Patients Receiving Intravitreal Injections: The Impact of the Coronavirus 2019 Disease (COVID-19)-Related Lockdown. J Clin Med. 2022 Apr 08; 11(8).
- Ocular Toxoplasmosis: A Review of Current Literature. Int Ophthalmol Clin. 2022 Apr 01; 62(2):231-250.
- Nonperfusion Area and Other Vascular Metrics by Wider Field Swept-Source OCT Angiography as Biomarkers of Diabetic Retinopathy Severity. Ophthalmol Sci. 2022 Jun; 2(2).
- Circulating inflammatory monocytes oppose microglia and contribute to cone cell death in retinitis pigmentosa. PNAS Nexus. 2022 Mar; 1(1).
- Urinary Mass Spectrometry Profiles in Age-Related Macular Degeneration. J Clin Med. 2022 Feb 11; 11(4).
- Systemic Complement Activation Profiles in Nonexudative Age-Related Macular Degeneration: A Systematic Review. Ophthalmol Sci. 2022 Jun; 2(2).
- Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins. J Cell Sci. 2022 01 15; 135(2).
- Dyslipidemia in age-related macular degeneration. Eye (Lond). 2022 02; 36(2):312-318.
- Referable Macular Hemorrhage-A Clinically Meaningful Screening Target in Newborn Infants. Position Statement of the Association of Pediatric Retina Surgeons. Ophthalmic Surg Lasers Imaging Retina. 2022 01; 53(1):3-6.
- Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration. Metabolites. 2022 Jan 01; 12(1).
- Aflibercept for Retinopathy of Prematurity: A Systematic Review and Meta-Analysis. Ophthalmic Surg Lasers Imaging Retina. 2021 12; 52(12):673-681.
- Receptor interacting protein 3 kinase, not 1 kinase, through MLKL-mediated necroptosis is involved in UVA-induced corneal endothelium cell death. Cell Death Discov. 2021 Nov 23; 7(1):366.
- Pathogenic mitochondrial dysfunction and metabolic abnormalities. Biochem Pharmacol. 2021 11; 193:114809.
- BASELINE PREDICTORS ASSOCIATED WITH 3-YEAR CHANGES IN DARK ADAPTATION IN AGE-RELATED MACULAR DEGENERATION. Retina. 2021 Oct 01; 41(10):2098-2105.
- Local photoreceptor cell death differences in the murine model of retinal detachment. Sci Rep. 2021 09 22; 11(1):18798.
- Retrospective Analysis of Retinal Imaging in COVID-19 Positive Patients at a Tertiary Eye Care Center. Clin Ophthalmol. 2021; 15:3727-3731.
- ALTITUDE-ASSOCIATED INTRAOCULAR PRESSURE CHANGES IN A GAS-FILLED EYE. Retin Cases Brief Rep. 2021 Sep 01; 15(5):564-567.
- Wide-field swept-source optical coherence tomography angiography in the assessment of retinal microvasculature and choroidal thickness in patients with myopia. Br J Ophthalmol. 2023 01; 107(1):102-108.
- Endoscopic Cyclophotocoagulation in Boston Keratoprosthesis Type II. Ophthalmol Glaucoma. 2022 Jan-Feb; 5(1):120-123.
- Complement Inhibition for Geographic Atrophy: A Tempting Target with Mixed Results. J Clin Med. 2021 Jun 29; 10(13).
- Measuring the Contrast Sensitivity Function in Non-Neovascular and Neovascular Age-Related Macular Degeneration: The Quantitative Contrast Sensitivity Function Test. J Clin Med. 2021 Jun 24; 10(13).
- A Review of Completed and Ongoing Complement Inhibitor Trials for Geographic Atrophy Secondary to Age-Related Macular Degeneration. J Clin Med. 2021 Jun 11; 10(12).
- Area under the dark adaptation curve as a reliable alternate measure of dark adaptation response. Br J Ophthalmol. 2022 10; 106(10):1450-1456.
- Targeting the YAP/TAZ Pathway in Uveal and Conjunctival Melanoma With Verteporfin. Invest Ophthalmol Vis Sci. 2021 04 01; 62(4):3.
- Association of Human Plasma Metabolomics with Delayed Dark Adaptation in Age-Related Macular Degeneration. Metabolites. 2021 Mar 21; 11(3).
- Genomic-Metabolomic Associations Support the Role of LIPC and Glycerophospholipids in Age-Related Macular Degeneration. Ophthalmol Sci. 2021 Mar; 1(1).
- Age-Related Macular Degeneration (AMD): A View to the Future. J Clin Med. 2021 Mar 08; 10(5).
- Reply. Ophthalmol Retina. 2021 03; 5(3):e4.
- Widefield Swept-Source OCT Angiography Metrics Associated with the Development of Diabetic Vitreous Hemorrhage: A Prospective Study. Ophthalmology. 2021 09; 128(9):1312-1324.
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382.
- Contrast sensitivity function in patients with macular disease and good visual acuity. Br J Ophthalmol. 2022 06; 106(6):839-844.
- Retinal applications of swept source optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). Prog Retin Eye Res. 2021 09; 84:100951.
- Reply to Green and Hume: Nonmicroglia peripheral immune effects of short-term CSF1R inhibition with PLX5622. Proc Natl Acad Sci U S A. 2021 01 26; 118(4).
- Anatomical and Functional Recovery Kinetics After Epiretinal Membrane Removal. Clin Ophthalmol. 2021; 15:175-181.
- Diagnostic and Therapeutic Challenges. Retina. 2021 Jan 01; 41(1):224-227.
- Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment. Aging (Albany NY). 2020 12 29; 12(24):24504-24521.
- Acadesine suppresses TNF-a induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells. PLoS One. 2020; 15(12):e0244307.
- Detection of neovascularisation in the vitreoretinal interface slab using widefield swept-source optical coherence tomography angiography in diabetic retinopathy. Br J Ophthalmol. 2022 04; 106(4):534-539.
- Macular Hole Closure with Medical Treatment. Ophthalmol Retina. 2021 07; 5(7):711-713.
- Open Globe Injury with Intraocular Foreign Body. J Vitreoretin Dis. 2021 Jul 01; 5(4):288-294.
- Incidence of Endophthalmitis after Intravitreal Anti-Vascular Endothelial Growth Factor Injections in an Operating Room in China. J Ophthalmol. 2020; 2020:5163484.
- ThicknessTool: automated ImageJ retinal layer thickness and profile in digital images. Sci Rep. 2020 10 28; 10(1):18459.
- Bilateral Hemorrhages in a Premature Infant With Subarachnoid Hemorrhage: An Underrecognized Etiology. Ophthalmic Surg Lasers Imaging Retina. 2020 Oct 01; 51(10):596-600.
- A quantitative comparison of four optical coherence tomography angiography devices in healthy eyes. Graefes Arch Clin Exp Ophthalmol. 2021 Jun; 259(6):1493-1501.
- CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23336-23338.
- Infrared attenuated total reflection spectroscopic surface analysis of bovine-tail intervertebral discs after UV-light-activated riboflavin-induced collagen cross-linking. J Biophotonics. 2020 10; 13(10):e202000110.
- Concerns about the interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication. Eye (Lond). 2020 12; 34(12):2153-2154.
- Microporous Drug Delivery System for Sustained Anti-VEGF Delivery to the Eye. Transl Vis Sci Technol. 2020 07; 9(8):5.
- Ultra-widefield autofluorescence imaging findings in retinoschisis, rhegmatogenous retinal detachment and combined retinoschisis retinal detachment. Acta Ophthalmol. 2021 Mar; 99(2):195-200.
- Comparison of widefield swept-source optical coherence tomography angiography with ultra-widefield colour fundus photography and fluorescein angiography for detection of lesions in diabetic retinopathy. Br J Ophthalmol. 2021 04; 105(4):577-581.
- Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography. Clin Ophthalmol. 2020; 14:1759-1767.
- Paediatric ocular adnexal lymphoma: a population-based analysis. BMJ Open Ophthalmol. 2020; 5(1):e000483.
- Biallelic RP1-associated retinal dystrophies: Expanding the mutational and clinical spectrum. Mol Vis. 2020; 26:423-433.
- Subthreshold Exudative Choroidal Neovascularization Associated With Age-Related Macular Degeneration Identified by Optical Coherence Tomography Angiography. J Vitreoretin Dis. 2020 Oct; 4(5):377-385.
- Klotho Pathways, Myelination Disorders, Neurodegenerative Diseases, and Epigenetic Drugs. Biores Open Access. 2020; 9(1):94-105.
- Different Scan Protocols Affect the Detection Rates of Diabetic Retinopathy Lesions by Wide-Field Swept-Source Optical Coherence Tomography Angiography. Am J Ophthalmol. 2020 07; 215:72-80.
- Higher Intake of Polyunsaturated Fatty Acid and Monounsaturated Fatty Acid is Inversely Associated With AMD. Invest Ophthalmol Vis Sci. 2020 02 07; 61(2):20.
- Hyperspectral Imaging of the Retina: A Review. Int Ophthalmol Clin. 2020; 60(1):85-96.
- Imaging Artifacts and Segmentation Errors With Wide-Field Swept-Source Optical Coherence Tomography Angiography in Diabetic Retinopathy. Transl Vis Sci Technol. 2019 Nov; 8(6):18.
- Nonresponders to Ranibizumab Anti-VEGF Treatment Are Actually Short-term Responders: A Prospective Spectral-Domain OCT Study. Ophthalmol Retina. 2020 12; 4(12):1138-1145.
- Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina. Proc Natl Acad Sci U S A. 2019 11 19; 116(47):23724-23734.
- RIP1 kinase mediates angiogenesis by modulating macrophages in experimental neovascularization. Proc Natl Acad Sci U S A. 2019 11 19; 116(47):23705-23713.
- Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells. Biochem Biophys Res Commun. 2020 01 08; 521(2):414-419.
- Validation of RetmarkerAMD as a semiautomatic grading software for AMD. Eye (Lond). 2020 03; 34(3):600-602.
- Quantitative Comparison Of Microvascular Metrics On Three Optical Coherence Tomography Angiography Devices In Chorioretinal Disease. Clin Ophthalmol. 2019; 13:2063-2069.
- Progressive Maculopathy After Discontinuation of Pentosan Polysulfate Sodium. Ophthalmic Surg Lasers Imaging Retina. 2019 10 01; 50(10):656-659.
- Percentage of Foveal vs Total Macular Geographic Atrophy as a Predictor of Visual Acuity in Age-Related Macular Degeneration. J Vitreoretin Dis. 2019 Sep; 3(5):278-282.
- Human Plasma Metabolomics in Age-Related Macular Degeneration: Meta-Analysis of Two Cohorts. Metabolites. 2019 Jul 02; 9(7).
- Topical sustained drug delivery to the retina with a drug-eluting contact lens. Biomaterials. 2019 10; 217:119285.
- Fundus Autofluorescence Change as an Early Indicator of Treatment Effect of Brachytherapy for Choroidal Melanomas. Ocul Oncol Pathol. 2019 Oct; 5(6):445-453.
- Characterization of Epiretinal Proliferation in Full-Thickness Macular Holes and Effects on Surgical Outcomes. Ophthalmol Retina. 2019 08; 3(8):694-702.
- Central Scotoma a Year After Motor Vehicle Crash. JAMA Ophthalmol. 2019 03 01; 137(3):316-317.
- Urine Nuclear Magnetic Resonance (NMR) Metabolomics in Age-Related Macular Degeneration. J Proteome Res. 2019 03 01; 18(3):1278-1288.
- Microperimetry in age-related macular degeneration: association with macular morphology assessed by optical coherence tomography. Br J Ophthalmol. 2019 12; 103(12):1769-1776.
- NLRP3 inflammasome in NMDA-induced retinal excitotoxicity. Exp Eye Res. 2019 04; 181:136-144.
- Receptor interacting protein kinase 3 (RIP3) regulates iPSCs generation through modulating cell cycle progression genes. Stem Cell Res. 2019 03; 35:101387.
- Visualization of Choriocapillaris and Choroidal Vasculature in Healthy Eyes With En Face Swept-Source Optical Coherence Tomography Versus Angiography. Transl Vis Sci Technol. 2018 Nov; 7(6):25.
- Microglia Regulate Neuroglia Remodeling in Various Ocular and Retinal Injuries. J Immunol. 2019 01 15; 202(2):539-549.
- Permanent neuroglial remodeling of the retina following infiltration of CSF1R inhibition-resistant peripheral monocytes. Proc Natl Acad Sci U S A. 2018 11 27; 115(48):E11359-E11368.
- Oxidative stress induces ferroptotic cell death in retinal pigment epithelial cells. Exp Eye Res. 2019 04; 181:316-324.
- Effects of BNN27, a novel C17-spiroepoxy steroid derivative, on experimental retinal detachment-induced photoreceptor cell death. Sci Rep. 2018 Jul 13; 8(1):10661.
- Reply. Ophthalmology. 2018 07; 125(7):e46-e47.
- A New Approach to Treating Neurodegenerative Otologic Disorders. Biores Open Access. 2018; 7(1):107-115.
- Reply to Vickers: Pharmacogenetics and progression to neovascular age-related macular degeneration-Evidence supporting practice change. Proc Natl Acad Sci U S A. 2018 06 19; 115(25):E5640-E5641.
- HEALTH CONDITIONS LINKED TO AGE-RELATED MACULAR DEGENERATION ASSOCIATED WITH DARK ADAPTATION. Retina. 2018 Jun; 38(6):1145-1155.
- Imaging the Deep Choroidal Vasculature Using Spectral Domain and Swept Source Optical Coherence Tomography Angiography. J Vitreoretin Dis. 2018 May-Jun; 2(3):146-154.
- The Role of Microglia and Peripheral Monocytes in Retinal Damage after Corneal Chemical Injury. Am J Pathol. 2018 07; 188(7):1580-1596.
- Lens regeneration in children. Nature. 2018 04 04; 556(7699):E2-E3.
- Peripheral Changes Associated With Delayed Dark Adaptation in Age-related Macular Degeneration. Am J Ophthalmol. 2018 06; 190:113-124.
- Chemical Burns of the Eye: The Role of Retinal Injury and New Therapeutic Possibilities. Cornea. 2018 Feb; 37(2):248-251.
- Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration. Sci Rep. 2018 01 11; 8(1):461.
- CFH and ARMS2 genetic risk determines progression to neovascular age-related macular degeneration after antioxidant and zinc supplementation. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E696-E704.
- Retina Folds and Subretinal Fluid After Bell Palsy. JAMA Ophthalmol. 2018 01 01; 136(1):88-89.
- Double Optic Disc Pit With Glial Plugs Imaged by Wide-Field Optical Coherence Tomography. Ophthalmic Surg Lasers Imaging Retina. 2018 01 01; 49(1):52-54.
- The Effect of Ranibizumab on Normal Neurosensory Retina in the Eyes of Patients with Exudative Age Related Macular Degeneration. Open Ophthalmol J. 2017; 11:368-376.
- AICAR suppresses TNF-a-induced complement factor B in RPE cells. Sci Rep. 2017 12 15; 7(1):17651.
- An Infrared Dye-Conjugated Virus-like Particle for the Treatment of Primary Uveal Melanoma. Mol Cancer Ther. 2018 02; 17(2):565-574.
- Epigenetic Treatment of Neurodegenerative Ophthalmic Disorders: An Eye Toward the Future. Biores Open Access. 2017; 6(1):169-181.
- Postoperative Complications of Scleral Buckling. Semin Ophthalmol. 2018; 33(1):70-74.
- Novel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration. Clin Ophthalmol. 2017; 11:1967-1974.
- Diabetic Choroidopathy: Choroidal Vascular Density and Volume in Diabetic Retinopathy With Swept-Source Optical Coherence Tomography. Am J Ophthalmol. 2017 Dec; 184:75-83.
- Human Plasma Metabolomics Study across All Stages of Age-Related Macular Degeneration Identifies Potential Lipid Biomarkers. Ophthalmology. 2018 02; 125(2):245-254.
- Modified Controlled Encircling Scleral Buckle for Retinal Detachment. J Vitreoretin Dis. 2017 Sep-Oct; 1(5):314-316.
- Subretinal Proliferative Vitreoretinopathy Band With Apparent Splitting of the Photoreceptor Segments. JAMA Ophthalmol. 2017 08 10; 135(8):e171436.
- Verteporfin inhibits growth of human glioma in vitro without light activation. Sci Rep. 2017 08 08; 7(1):7602.
- Choroidal Changes Associated With Subretinal Drusenoid Deposits in Age-related Macular Degeneration Using Swept-source Optical Coherence Tomography. Am J Ophthalmol. 2017 Aug; 180:55-63.
- Atorvastatin Promotes Phagocytosis and Attenuates Pro-Inflammatory Response in Human Retinal Pigment Epithelial Cells. Sci Rep. 2017 05 24; 7(1):2329.
- Human plasma metabolomics in age-related macular degeneration (AMD) using nuclear magnetic resonance spectroscopy. PLoS One. 2017; 12(5):e0177749.
- Metformin inhibits ALK1-mediated angiogenesis via activation of AMPK. Oncotarget. 2017 May 16; 8(20):32794-32806.
- Structural Changes Associated with Delayed Dark Adaptation in Age-Related Macular Degeneration. Ophthalmology. 2017 09; 124(9):1340-1352.
- Verteporfin-induced formation of protein cross-linked oligomers and high molecular weight complexes is mediated by light and leads to cell toxicity. Sci Rep. 2017 04 21; 7:46581.
- Mechanisms of Retinal Damage after Ocular Alkali Burns. Am J Pathol. 2017 Jun; 187(6):1327-1342.
- Endoscopic Cyclophotocoagulation for the Treatment of Glaucoma in Boston Keratoprosthesis Type II Patient. J Glaucoma. 2017 Apr; 26(4):e146-e149.
- Bilateral Retinal Hemorrhages in a Young Man. JAMA Ophthalmol. 2017 04 01; 135(4):395-396.
- Automated Brightness and Contrast Adjustment of Color Fundus Photographs for the Grading of Age-Related Macular Degeneration. Transl Vis Sci Technol. 2017 Mar; 6(2):3.
- Optical coherence tomography findings and successful repair of retina detachment in Knobloch syndrome. Digit J Ophthalmol. 2017; 23(1):29-32.
- Perioperative Risks of Antiplatelet and Anticoagulant Drugs in Vitreoretinal Procedures. Ophthalmic Surg Lasers Imaging Retina. 2017 01 01; 48(1):4-8.
- Advances in Age-related Macular Degeneration Understanding and Therapy. US Ophthalmic Rev. 2017; 10(2):119-130.
- Optic Disk Pit with Sudden Central Visual Field Scotoma. Case Rep Ophthalmol Med. 2016; 2016:1423481.
- Dilated fundus exam and associated findings in spontaneous subconjunctival haemorrhage. Acta Ophthalmol. 2017 08; 95(5):e432-e433.
- Characteristics and Outcomes of Simultaneous Bilateral Rhegmatogenous Retinal Detachments. Ophthalmic Surg Lasers Imaging Retina. 2016 09 01; 47(9):840-5.
- miR-17-3p Exacerbates Oxidative Damage in Human Retinal Pigment Epithelial Cells. PLoS One. 2016; 11(8):e0160887.
- Immediate Sequential Bilateral Pediatric Vitreoretinal Surgery: An International Multicenter Study. Ophthalmology. 2016 08; 123(8):1802-1808.
- An Experimental Animal Model of Photodynamic Optic Nerve Head Injury (PONHI). Curr Eye Res. 2016 11; 41(11):1498-1506.
- Long-term Follow-up and Outcomes in Traumatic Macular Holes. Am J Ophthalmol. 2016 06; 166:206-207.
- A Drug Delivery System for Administration of Anti-TNF-a Antibody. Transl Vis Sci Technol. 2016 Mar; 5(2):11.
- Proliferative Hypertensive Retinopathy. JAMA Ophthalmol. 2016 Mar; 134(3):345-6.
- Reply to 'Comment on: Intravitreal aflibercept for macular oedema secondary to central retinal vein occlusion in patients with prior treatment with bevacizumab or ranibizmab'. Eye (Lond). 2016 05; 30(5):766-7.
- Regression of Some High-risk Features of Age-related Macular Degeneration (AMD) in Patients Receiving Intensive Statin Treatment. EBioMedicine. 2016 Mar; 5:198-203.
- AMPK-Activated Protein Kinase Suppresses Ccr2 Expression by Inhibiting the NF-?B Pathway in RAW264.7 Macrophages. PLoS One. 2016; 11(1):e0147279.
- Lipids and Diabetic Retinopathy. Semin Ophthalmol. 2016; 31(1-2):10-8.
- Drug Delivery Nanoparticles: Toxicity Comparison in Retinal Pigment Epithelium and Retinal Vascular Endothelial Cells. Semin Ophthalmol. 2016; 31(1-2):1-9.
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222.
- Necrotic cone photoreceptor cell death in retinitis pigmentosa. Cell Death Dis. 2015 Dec 31; 6:e2038.
- Unusual focal remnant of the tunica vasculosa lentis. Clin Exp Ophthalmol. 2016 Apr; 44(3):203-5.
- Necrotic enlargement of cone photoreceptor cells and the release of high-mobility group box-1 in retinitis pigmentosa. Cell Death Discov. 2015; 1:15058.
- Myopic foveoschisis: an ectatic retinopathy, not a schisis. Eye (Lond). 2016 Feb; 30(2):328-9.
- Membrane-bound and soluble Fas ligands have opposite functions in photoreceptor cell death following separation from the retinal pigment epithelium. Cell Death Dis. 2015 Nov 19; 6:e1986.
- Intravitreal aflibercept for macular oedema secondary to central retinal vein occlusion in patients with prior treatment with bevacizumab or ranibizumab. Eye (Lond). 2016 Jan; 30(1):79-84.
- Under the guise of retinitis. JAMA Ophthalmol. 2015 Oct; 133(10):1205-6.
- A Novel ImageJ Macro for Automated Cell Death Quantitation in the Retina. Invest Ophthalmol Vis Sci. 2015 Oct; 56(11):6701-8.
- Bilateral tractional retinal detachment in a patient with hemolytic-uremic syndrome. J AAPOS. 2015 Oct; 19(5):484-6.
- Long-term Follow-up and Outcomes in Traumatic Macular Holes. Am J Ophthalmol. 2015 Dec; 160(6):1255-1258.e1.
- Real-world treatment of diabetic macular oedema: a comparison of combined ranibizumab plus macular LASER with macular LASER monotherapy. Hell J Nucl Med. 2015 Sep-Dec; 18 Suppl 1:33-41.
- Mitochondrial DNA has a pro-inflammatory role in AMD. Biochim Biophys Acta. 2015 Nov; 1853(11 Pt A):2897-906.
- Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury. Sci Transl Med. 2015 Jul 22; 7(297):297ra116.
- Prognostic factor analysis of vitrectomy for myopic foveoschisis. Br J Ophthalmol. 2015 Dec; 99(12):1639-43.
- Case records of the Massachusetts General Hospital. Case 15-2015. A 27-year-old man with a nail in the eye. N Engl J Med. 2015 May 14; 372(20):1945-52.
- Macrophage- and RIP3-dependent inflammasome activation exacerbates retinal detachment-induced photoreceptor cell death. Cell Death Dis. 2015 Apr 23; 6:e1731.
- Posterior nodular scleritis. JAMA Ophthalmol. 2015 Jan; 133(1):e141801.
- Removal of Silicone Oil From Intraocular Lens Using Novel Surgical Materials. Transl Vis Sci Technol. 2014 Sep; 3(5):4.
- Effects of metformin on retinoblastoma growth in vitro and in vivo. Int J Oncol. 2014 Dec; 45(6):2311-24.
- Characterization of a spontaneous retinal neovascular mouse model. PLoS One. 2014; 9(9):e106507.
- Choroidal changes associated with bruch membrane pathology in pseudoxanthoma elasticum. Am J Ophthalmol. 2014 Sep; 158(3):644.
- Complications of emulsified silicone oil after retinal detachment repair. Semin Ophthalmol. 2014 Sep-Nov; 29(5-6):312-8.
- LKB1 and AMPK regulate synaptic remodeling in old age. Nat Neurosci. 2014 Sep; 17(9):1190-7.
- Quantitative assessment of central retinal thickness in recurrent neovascular age-related macular degeneration. Br J Ophthalmol. 2014 Sep; 98(9):1308.
- Tamoxifen toxicity in cultured retinal pigment epithelial cells is mediated by concurrent regulated cell death mechanisms. Invest Ophthalmol Vis Sci. 2014 Jul 03; 55(8):4747-58.
- Ocriplasmin for treatment of stage 2 macular holes: early clinical results. Ophthalmic Surg Lasers Imaging Retina. 2014 Jul-Aug; 45(4):293-7.
- Cholesterol crystals induce inflammatory cytokines expression in a human retinal pigment epithelium cell line by activating the NF-?B pathway. Discov Med. 2014 Jul-Aug; 18(97):7-14.
- Evaluating choroidal thickness in diabetic retinopathy. Clin Ophthalmol. 2014; 8:1185-6.
- Cytochrome P450-generated metabolites derived from ?-3 fatty acids attenuate neovascularization. Proc Natl Acad Sci U S A. 2014 Jul 01; 111(26):9603-8.
- Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment. Cell Death Dis. 2014 May 29; 5:e1269.
- Strain difference in photoreceptor cell death after retinal detachment in mice. Invest Ophthalmol Vis Sci. 2014 May 22; 55(7):4165-74.
- The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation. Exp Eye Res. 2014 Jul; 124:67-73.
- Evaluation of choroidal thickness among patients with oculocutaneous albinism. Br J Ophthalmol. 2014 Aug; 98(8):1135.
- Uveal melanoma cell growth is inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase. Invest Ophthalmol Vis Sci. 2014 Apr 29; 55(7):4175-85.
- Alkali burn to the eye: protection using TNF-a inhibition. Cornea. 2014 Apr; 33(4):382-9.
- EGF-like-domain-7 is required for VEGF-induced Akt/ERK activation and vascular tube formation in an ex vivo angiogenesis assay. PLoS One. 2014; 9(3):e91849.
- Idiopathic dacryoadenitis mimicking a primary intraocular tumour in a young girl. Clin Exp Ophthalmol. 2014 Nov; 42(8):785-8.
- Protein kinases and associated pathways in pluripotent state and lineage differentiation. Curr Stem Cell Res Ther. 2014; 9(5):366-87.
- Spontaneous resolution of a postvitrectomy macular hole retinal detachment. Retin Cases Brief Rep. 2014; 8(3):161-3.
- Retinal detachment model in rodents by subretinal injection of sodium hyaluronate. J Vis Exp. 2013 Sep 11; (79).
- Genetic advances in ophthalmology: the role of melanopsin-expressing, intrinsically photosensitive retinal ganglion cells in the circadian organization of the visual system. Semin Ophthalmol. 2013 Sep-Nov; 28(5-6):406-21.
- An albumin leader sequence coupled with a cleavage site modification enhances the yield of recombinant C-terminal Mullerian Inhibiting Substance. Technology. 2013 Sep; 1(1):63-71.
- Photoreceptor cell death and rescue in retinal detachment and degenerations. Prog Retin Eye Res. 2013 Nov; 37:114-40.
- Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration. Cell Death Differ. 2014 Feb; 21(2):270-7.
- Fundus autofluorescence in ampiginous choroiditis. Ophthalmic Surg Lasers Imaging Retina. 2013 Jul-Aug; 44(4):393-7.
- AMP-dependent kinase inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis by suppressing the dissociation between c-Abl and Prdx1 proteins in endothelial cells. J Biol Chem. 2013 Jul 12; 288(28):20581-91.
- Conversion to aflibercept for chronic refractory or recurrent neovascular age-related macular degeneration. Am J Ophthalmol. 2013 Jul; 156(1):29-35.e2.
- Anti-VEGF in retinopathy of prematurity, need to titrate. Invest Ophthalmol Vis Sci. 2013 Mar 21; 54(3).
- Genetic correlates of proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2013 Mar 05; 54(3).
- Aminoimidazole carboxamide ribonucleotide (AICAR) inhibits the growth of retinoblastoma in vivo by decreasing angiogenesis and inducing apoptosis. PLoS One. 2013; 8(1):e52852.
- Retinal detachment after open-globe injury. Int Ophthalmol Clin. 2013; 53(4):79-92.
- A review of traumatic macular hole: diagnosis and treatment. Int Ophthalmol Clin. 2013; 53(4):59-67.
- Neuroprotection for retinal detachment. Int Ophthalmol Clin. 2013; 53(4):105-17.
- Traumatic chorioretinal rupture (sclopetaria). Int Ophthalmol Clin. 2013; 53(4):119-25.
- Mechanisms of inflammation in proliferative vitreoretinopathy: from bench to bedside. Mediators Inflamm. 2012; 2012:815937.
- Therapeutic interventions against inflammatory and angiogenic mediators in proliferative diabetic retinopathy. Mediators Inflamm. 2012; 2012:629452.
- Near infrared autofluorescence imaging of retinal diseases. Semin Ophthalmol. 2012 Sep-Nov; 27(5-6):202-8.
- Enhanced depth imaging optical coherence tomography in age-related macular degeneration. Semin Ophthalmol. 2012 Sep-Nov; 27(5-6):209-12.
- Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14598-603.
- Etanercept, a widely used inhibitor of tumor necrosis factor-a (TNF-a), prevents retinal ganglion cell loss in a rat model of glaucoma. PLoS One. 2012; 7(7):e40065.
- Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2012 Jun 28; 53(7):4158-69.
- The regulatory roles of apoptosis-inducing factor in the formation and regression processes of ocular neovascularization. Am J Pathol. 2012 Jul; 181(1):53-61.
- Choroidal neovascular membrane formation and retinochoroidopathy in a patient with systemic langerhans cell histiocytosis: a case report and review of the literature. Case Rep Ophthalmol. 2012 Jan; 3(1):128-35.
- Evidence for baseline retinal pigment epithelium pathology in the Trp1-Cre mouse. Am J Pathol. 2012 May; 180(5):1917-27.
- Anti-vascular endothelial growth factor monotherapy versus combination treatment with photodynamic therapy for subfoveal choroidal neovascularization secondary to causes other than age-related macular degeneration. Retina. 2011 Nov; 31(10):2078-83.
- Tauroursodeoxycholic acid (TUDCA) protects photoreceptors from cell death after experimental retinal detachment. PLoS One. 2011; 6(9):e24245.
- Inhibitory effect of aminoimidazole carboxamide ribonucleotide (AICAR) on endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci. 2011 Aug 22; 52(9):6565-71.
- Edaravone, an ROS scavenger, ameliorates photoreceptor cell death after experimental retinal detachment. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3825-31.
- RIP kinase-mediated necrosis as an alternative mechanisms of photoreceptor death. Oncotarget. 2011 Jun; 2(6):497-509.
- In vivo evaluation of laser-induced choroidal neovascularization using spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3880-7.
- Utilizing targeted gene therapy with nanoparticles binding alpha v beta 3 for imaging and treating choroidal neovascularization. PLoS One. 2011 Apr 29; 6(4):e18864.
- Tumor necrosis factor-alpha mediates photoreceptor death in a rodent model of retinal detachment. Invest Ophthalmol Vis Sci. 2011 Mar; 52(3):1384-91.
- AMP-activated protein kinase suppresses matrix metalloproteinase-9 expression in mouse embryonic fibroblasts. J Biol Chem. 2011 May 06; 286(18):16030-8.
- Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase. Am J Pathol. 2011 Mar; 178(3):1080-91.
- Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21695-700.
- Posterior uveal melanoma in young patients treated with proton beam therapy. Retina. 2010 Sep; 30(8):1267-71.
- In vivo high-resolution retinal imaging using adaptive optics. Semin Ophthalmol. 2010 Sep-Nov; 25(5-6):186-91.
- Pharmacologic vitreolysis. Semin Ophthalmol. 2010 Sep-Nov; 25(5-6):295-302.
- Intraoperative switch to a temporal surgical approach in 23- and 25-gauge microcannula-based sutureless transconjunctival vitrectomy. Open Ophthalmol J. 2010 May 31; 4:12-4.
- Retinoblastoma cells are inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase. FASEB J. 2010 Aug; 24(8):2620-30.
- A novel nonradioactive method to evaluate vascular barrier breakdown and leakage. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1677-82.
- Development of an efficiently cleaved, bioactive, highly pure FLAG-tagged recombinant human Mullerian Inhibiting Substance. Protein Expr Purif. 2010 Mar; 70(1):32-8.
- Images in clinical medicine. Traumatic bleb. N Engl J Med. 2009 Jul 09; 361(2):e2.
- Optical coherence tomography appearance of a retinal artery macroaneurysm. Ophthalmic Surg Lasers Imaging. 2009 Jul-Aug; 40(4):403-4.
- Intravitreal ranibizumab, intravitreal ranibizumab with PDT, and intravitreal triamcinolone with PDT for the treatment of retinal angiomatous proliferation: a prospective study. Retina. 2009 Apr; 29(4):536-44.
- Review of the ocular angiogenesis animal models. Semin Ophthalmol. 2009 Mar-Apr; 24(2):52-61.
- Low rate of endophthalmitis in a large series of open globe injuries. Am J Ophthalmol. 2009 Apr; 147(4):601-608.e2.
- Progressive hydroxychloroquine toxicity mimicking low-tension glaucoma after discontinuation of the drug. Acta Ophthalmol. 2010 Feb; 88(1):156-7.
- 25-gauge transconjunctival sutureless pars plana vitrectomy for the removal of retained lens fragments and intraocular foreign bodies. Retina. 2008 Oct; 28(9):1346-51.
- Pegaptanib (Macugen): treating neovascular age-related macular degeneration and current role in clinical practice. Ophthalmol Clin North Am. 2006 Sep; 19(3):353-60.
- Immunomodulatory medications in uveitis. Int Ophthalmol Clin. 2004; 44(3):187-203.
- Two cases of orbital lymphangioma associated with vascular abnormalities of the retina and iris. Ophthalmology. 2004 Jan; 111(1):189-92.
- Preface. Int Ophthalmol Clin. 2004; 44(3):xiii.
- Mechanisms of disease: cataracts. Ophthalmol Clin North Am. 2002 Mar; 15(1):49-60.
- Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. Recent Prog Horm Res. 2001; 56:127-55.
- Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. Diabetes. 2000 Aug; 49(8):1295-300.
- Cytosolic citrate and malonyl-CoA regulation in rat muscle in vivo. Am J Physiol. 1999 06; 276(6):E1030-7.
- Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol. 1999 01; 276(1):E1-E18.
- Identification of Nore1 as a potential Ras effector. J Biol Chem. 1998 Mar 06; 273(10):5439-42.
- Malonyl CoA as a metabolic switch and a regulator of insulin sensitivity. Adv Exp Med Biol. 1998; 441:263-70.
- Lipid abnormalities in muscle of insulin-resistant rodents. The malonyl CoA hypothesis. Ann N Y Acad Sci. 1997 Sep 20; 827:221-30.
- Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscle. J Biol Chem. 1997 May 16; 272(20):13255-61.
- Malonyl-CoA regulation in skeletal muscle: its link to cell citrate and the glucose-fatty acid cycle. Am J Physiol. 1997 Apr; 272(4 Pt 1):E641-8.
- Oligomerization activates c-Raf-1 through a Ras-dependent mechanism. Nature. 1996 Sep 12; 383(6596):181-5.
Show More
Show Less
