Tavé van Zyl, M.D.

Research Summary

Biography

Dr. van Zyl’s research is driven by two objectives:

  1. Advancing our understanding how the human trabecular meshwork—the eye’s primary drainage structure for aqueous humor—functions
  2. Identifying the molecular underpinnings of trabecular meshwork dysfunction and ocular hypertension, with the ultimate goal of identifying novel therapeutic targets

To pursue these objectives, she is using single-cell RNA sequencing technology and associated methodologies to molecularly profile both normal trabecular meshwork, as well as that obtained from surgical patients in a bedside-to-bench translational approach.

Education

2008: AB, cum laude, Biochemical Sciences, Harvard College
2013: MD, Yale School of Medicine

Postgraduate Training

2014: Transitional Year Internship, Yale New Haven Hospital - St Raphael Campus
2017: Residency, Ophthalmology, Harvard Medical School
2018: Clinical Fellowship, Anterior Segment, Mass. Eye and Ear

Honors

2011: Richard K. Gershon one-year Endowed Student Research Fellowship, Yale School of Medicine
2012: Farr Scholar, Yale School of Medicine
2014: Most Outstanding Transitional Year Resident, Yale New Haven Hospital
2015: Paul A. Chandler Visiting Professor Resident Co-chair, Harvard Medical School
2017: Ophthalmic Photographer’s Society Exhibit Award Winner

Publications

Selected Publications

View her publications on PubMed.

  1. van Zyl T, Turalba A. Adjunctive Imaging for Canal-based Glaucoma Surgery. Int Ophthalmol Clin. 2017 Fall;57(4):73-84.
  2. Lam JD, Oh DJ, Wong LL, Amarnani D, Park-Windhol C, Sanchez AV, Cardona-Velez J, McGuone D, Stemmer-Rachamimov AO, Eliott D, Bielenberg DR, van Zyl T, Shen L, Gai X, D'Amore PA, Kim LA, Arboleda-Velasquez JF. Identification of RUNX1 as a Mediator of Aberrant Retinal Angiogenesis. Diabetes. 2017 Jul;66(7):1950-1956.
  3. Modjtahedi BS, van Zyl T, Pandya HK, Leonard RE 2nd, Eliott D. Endophthalmitis After Intravitreal Injections in Patients With Self-reported Iodine Allergy. Am J Ophthalmol. 2016 Oct;170:68-74.
  4. van Zyl T, Stagner AM, Lee NG. An Atypical Ulcerated Lesion at the Eyelid Margin. JAMA Ophthalmol. 2016 Jun 1;134(6):703-4.
  5. van Zyl, T., Stagner, A. M., Jakobiec, F. A., & Yoon, M. K. Histopathologic features of a resolving orbital Langerhans cell histiocytosis. Graefe's Archive for Clinical and Experimental Ophthalmology. 2015 Dec;253(12):2341-3