Anne E. Takesian, Ph.D.

Harvard Medical School

Assistant Professor of Otolaryngology

Massachusetts Eye and Ear

Assistant Scientist

Research Summary

Research Area Affiliations

Research Summary

Dr. Takesian obtained her PhD from the Center for Neural Science at New York University with thesis advisor Dan H. Sanes, PhD, before completing postdoctoral training with Takao K. Hensch, PhD, at Boston Children’s Hospital/Harvard University. Her research is focused on understanding how sound experience shapes and perturbs auditory cortical circuits. She uses electrophysiology, optogenetics, neural imaging, and transcriptional analysis to identify molecular and circuit level mechanisms underlying plasticity in the mouse auditory cortex. Her goal is to develop new treatments to promote cortical plasticity to reverse pathological processes and recover auditory function following hearing loss.

Select Publications

Sensory integration in mouse insular cortex reflects GABA circuit maturation. Gogolla N, Takesian AE, Feng G, Fagiolini M, Hensch TK. Neuron. 2014 Aug 20;83(4):894–905.

Balancing plasticity/stability across brain development. Takesian AE, Hensch TK. Prog Brain Res. 2013;207:3–34.

Hearing loss differentially affects thalamic drive to two cortical interneuron subtypes. Takesian AE, Kotak VC, Sharma N, Sanes DH. J Neurophysiol. 2013 Aug;110(4):999–1008.

Rescue of inhibitory synapse strength following developmental hearing loss. Kotak VC, Takesian AE, MacKenzie PC, Sanes DH. PLoS One. 2013;8(1):e53438.

Age-dependent effect of hearing loss on cortical inhibitory synapse function. Takesian AE, Kotak VC, Sanes DH. J Neurophysiol. 2012 Feb;107(3):937–47.

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2003: BS, Biomedical Engineering and Biopsychology, Tufts University
2010: PhD, Center for Neural Science, New York University

Postgraduate Training

2010–2017: Postdoctoral Fellow, Department of Neurology, Boston Children’s Hospital

Professional Memberships

2005–Present: Society for Neuroscience
2006–2012: Association for Research in Otolaryngology

Editorial Roles

Ad hoc Reviewer: Cell Reports, Cerebral Cortex, Developmental Neuroscience, Journal of Neuroscience, Journal of Physiology, PLOS One, PNAS

Awards and Honors

2005–2006: NIH Institutional Training Grant, Center for Neural Science, New York University
2007–2010: Individual Predoctoral National Research Service Award (NRSA), NIDCD
2010–2011: NIH Institutional Training Grant, Developmental Neurology, Boston Children’s Hospital
2011–2013: Junior Fellowship, Canadian Institute for Advanced Research (CIFAR)
2012: Travel Award, FENS/IBRO
2013–2015: Fellowship, Nancy Lurie Marks Family Foundation