anne_takesian@meei.harvard.edu
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About My Research
Dr. Anne Takesian obtained her PhD from the Center for Neural Science at New York University with thesis advisor Dan H. Sanes, PhD, before completing postdoctoral training with Takao K. Hensch, PhD, at Boston Children’s Hospital/Harvard University. Her research is focused on understanding how sound experience shapes and perturbs auditory cortical circuits. She uses electrophysiology, optogenetics, neural imaging and transcriptional analysis to identify molecular and circuit level mechanisms underlying plasticity in the mouse auditory cortex. Her goal is to develop new treatments to promote cortical plasticity to reverse pathological processes and recover auditory function following hearing loss.
Education
BS, Biomedical Engineering and Biopsychology, Tufts University
PhD, Center for Neural Science, New York University
Postgraduate Training
Postdoctoral Fellow, Department of Neurology, Boston Children’s Hospital
Professional Societies
Society for Neuroscience
Association for Research in Otolaryngology
Editorial Roles
Ad hoc Reviewer: Cell Reports, Cerebral Cortex, Developmental Neuroscience, Journal of Neuroscience, Journal of Physiology, PLOS One, PNAS
Honors
NIH Institutional Training Grant, Center for Neural Science, New York University
Individual Predoctoral National Research Service Award (NRSA), NIDCD
NIH Institutional Training Grant, Developmental Neurology, Boston Children’s Hospital
Junior Fellowship, Canadian Institute for Advanced Research (CIFAR)
Travel Award, FENS/IBRO
Fellowship, Nancy Lurie Marks Family Foundation
- Neural signatures of auditory hypersensitivity following acoustic trauma. Elife. 2022 09 16; 11.
- Sensitive period-regulating genetic pathways and exposure to adversity shape risk for depression. Neuropsychopharmacology. 2022 01; 47(2):497-506.
- Regulation of auditory plasticity during critical periods and following hearing loss. Hear Res. 2020 11; 397:107976.
- All-Optical Electrophysiology Reveals the Role of Lateral Inhibition in Sensory Processing in Cortical Layer 1. Cell. 2020 02 06; 180(3):521-535.e18.
- NMDA 2A receptors in parvalbumin cells mediate sex-specific rapid ketamine response on cortical activity. Mol Psychiatry. 2019 06; 24(6):828-838.
- Publisher Correction: Inhibitory circuit gating of auditory critical-period plasticity. Nat Neurosci. 2018 Oct; 21(10):1495.
- Early Seizures Prematurely Unsilence Auditory Synapses to Disrupt Thalamocortical Critical Period Plasticity. Cell Rep. 2018 05 29; 23(9):2533-2540.
- Inhibitory circuit gating of auditory critical-period plasticity. Nat Neurosci. 2018 02; 21(2):218-227.
- Sensory integration in mouse insular cortex reflects GABA circuit maturation. Neuron. 2014 Aug 20; 83(4):894-905.
- Hearing loss differentially affects thalamic drive to two cortical interneuron subtypes. J Neurophysiol. 2013 Aug; 110(4):999-1008.
- Rescue of inhibitory synapse strength following developmental hearing loss. PLoS One. 2013; 8(1):e53438.
- Balancing plasticity/stability across brain development. Prog Brain Res. 2013; 207:3-34.
- Age-dependent effect of hearing loss on cortical inhibitory synapse function. J Neurophysiol. 2012 Feb; 107(3):937-47.
- Presynaptic GABA(B) receptors regulate experience-dependent development of inhibitory short-term plasticity. J Neurosci. 2010 Feb 17; 30(7):2716-27.
- Developmental hearing loss disrupts synaptic inhibition: implications for auditory processing. Future Neurol. 2009 May 01; 4(3):331-349.
- Hearing loss prevents the maturation of GABAergic transmission in the auditory cortex. Cereb Cortex. 2008 Sep; 18(9):2098-108.
- The biomechanical and neural control of hydrostatic limb movements in Manduca sexta. J Exp Biol. 2004 Aug; 207(Pt 17):3043-53.
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