Lucy Qing Shen,
MD
Massachusetts Eye and Ear
Associate Scientist
Harvard Medical School
Associate Professor of Ophthalmology
lucy_shen@meei.harvard.edu
For investigator inquiries only
About My Research
Center/Research Area Affiliation
Biography
Dr. Shen's clinical and research interests focus on glaucoma. In the past, she has helped identify structural-functional relationships in patients with visual field defects from glaucoma by conducting optic nerve disc and macular imaging. Most recently, she is collaborating with Dr. Tobias Elze to develop computer algorithms to improve functional and structural tests for patients with glaucoma. She also is using a new imaging device called swept source OCT to image the glaucomatous optic nerve and its blood vessels and is investigating glaucoma associated with keratoprosthesis.
Education
2000: BS, Biology, Chemical Engineering, Massachusetts Institute of Technology
2004: MD, cum laude, Harvard Medical School HST Program
Postgraduate Training
2005: Internship, Internal Medicine, Brigham and Women’s Hospital
2008: Residency, Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles
2009: Fellowship, Glaucoma, Jules Stein Eye Institute, University of California, Los Angeles
2016: Fellowship, Biostatistics, Harvard Medical School, Catalyst Program
Academic Appointments
2021-Present: Associate Professor of Ophthalmology, Harvard Medical School
2014-2021: Assistant Professor of Ophthalmology, Harvard Medical School
2009-2014: Instructor in Ophthalmology, Harvard Medical School
Professional Memberships
2005-Present: American Academy of Ophthalmology, Member
2005-Present: Association for Researh in Vision and Ophthalmology
2008-Present: American Glaucoma Society, Member
2008-Present: Women in Ophthalmology, Member
2012-Present: New England Ophthalmological Society, Member
Honors
2000: Alumnae Senior Academic Award, Massachusetts Institute of Technology
2000: Phi Beta Kappa Honor Society
2000: Volunteer Scholarship, Beth Israel Deaconess Medical Center
2001: Betty Lea Stone Research Fellowship, American Cancer Society
2001: Sumer Research Fellowship, the Angiogenesis Foundation
2004: cum laude, Harvard Medical School
2006: Travel Grant/Retina Research Foundation, Association for Research in Vision and Ophthalmology
2007: Dr. Henry and Lilian Nesburn Award for best research paper by a resident physician
2007: Research Award of the Department of Ophthalmology Association, UCLA
2009: Mentoring for Advancement of Physician Scientist (MAPS) Award, American Glaucoma Society
2012: Best surgery video award, American Glaucoma Society
2012: Young Physician Scientist Grant Award, American Glaucoma Society
2013: Finalist in surgical video competiion, American Glaucoma Society
2015: Eleanor and Miles Shore Felowship, Harvard Medical School
Publications powered by Harvard Catalyst Profiles
- Harvard Glaucoma Fairness: A Retinal Nerve Disease Dataset for Fairness Learning and Fair Identity Normalization. IEEE Trans Med Imaging. 2024 Mar 18; PP.
- Comparison of Structural and Functional Features in Primary Angle Closure and Open Angle Glaucomas. J Glaucoma. 2024 Apr 01; 33(4):254-261.
- Reply. Ophthalmol Glaucoma. 2024 Mar-Apr; 7(2):216-217.
- Artifact Correction in Retinal Nerve Fiber Layer Thickness Maps Using Deep Learning and Its Clinical Utility in Glaucoma. Transl Vis Sci Technol. 2023 11 01; 12(11):12.
- Artifacts in OCT Retinal Nerve Fiber Layer Imaging in Patients with Boston Keratoprosthesis Type 1. Ophthalmol Glaucoma. 2024 Mar-Apr; 7(2):206-215.
- Steroid Response Following Dropless Cataract Surgery Using Subconjunctival Triamcinolone. Clin Ophthalmol. 2023; 17:2803-2814.
- Artifact-Tolerant Clustering-Guided Contrastive Embedding Learning for Ophthalmic Images in Glaucoma. IEEE J Biomed Health Inform. 2023 09; 27(9):4329-4340.
- Association between HSP-Specific T-Cell Counts and Retinal Nerve Fiber Layer Thickness in Patients with Primary Open-Angle Glaucoma. Ophthalmol Sci. 2023 Sep; 3(3):100310.
- Transscleral vs endoscopic cyclophotocoagulation: safety and efficacy when combined with phacoemulsification. BMC Ophthalmol. 2023 Mar 30; 23(1):129.
- Racial Disparities Affecting Black Patients in Glaucoma Diagnosis and Management. Semin Ophthalmol. 2023 Jan 20; 1-11.
- Racial Disparities Affecting Black Patients In Glaucoma Diagnosis And Management. Semin Ophthalmol. 2022 Dec 01; 1-11.
- Glaucoma management in patients with penetrating keratoplasty or keratoprosthesis. Curr Opin Ophthalmol. 2023 Mar 01; 34(2):95-102.
- Detecting disease progression in mild, moderate and severe glaucoma. Curr Opin Ophthalmol. 2023 Mar 01; 34(2):168-175.
- Incidence and risk factors for glaucoma development and progression after corneal transplantation. Eye (Lond). 2023 07; 37(10):2117-2125.
- Combined Model of OCT Angiography and Structural OCT Parameters to Predict Paracentral Visual Field Loss in Primary Open-Angle Glaucoma. Ophthalmol Glaucoma. 2023 May-Jun; 6(3):255-265.
- Glaucoma in Patients With Endothelial Keratoplasty. Cornea. 2022 Dec 01; 41(12):1584-1599.
- Restoration of Vision in Severe, Cicatricial, Ocular Surface Disease With the Boston Keratoprosthesis Type II. Am J Ophthalmol. 2022 11; 243:42-54.
- Assessing Surface Shapes of the Optic Nerve Head and Peripapillary Retinal Nerve Fiber Layer in Glaucoma with Artificial Intelligence. Ophthalmol Sci. 2022 Sep; 2(3):100161.
- The Prevalence of Autoimmune Diseases in Patients with Primary Open-Angle Glaucoma Undergoing Ophthalmic Surgeries. Ophthalmol Glaucoma. 2022 Mar-Apr; 5(2):128-136.
- Endoscopic Cyclophotocoagulation in Boston Keratoprosthesis Type II. Ophthalmol Glaucoma. 2022 Jan-Feb; 5(1):120-123.
- The Effect of Ametropia on Glaucomatous Visual Field Loss. J Clin Med. 2021 Jun 25; 10(13).
- Paired Optic Nerve Microvasculature and Nailfold Capillary Measurements in Primary Open-Angle Glaucoma. Transl Vis Sci Technol. 2021 06 01; 10(7):13.
- Development and Comparison of Machine Learning Algorithms to Determine Visual Field Progression. Transl Vis Sci Technol. 2021 06 01; 10(7):27.
- Variability and Power to Detect Progression of Different Visual Field Patterns. Ophthalmol Glaucoma. 2021 Nov-Dec; 4(6):617-623.
- Predicting Global Test-Retest Variability of Visual Fields in Glaucoma. Ophthalmol Glaucoma. 2021 Jul-Aug; 4(4):390-399.
- Inter-Eye Association of Visual Field Defects in Glaucoma and Its Clinical Utility. Transl Vis Sci Technol. 2020 11; 9(12):22.
- Characterization of Prelaminar Wedge-Shaped Defects in Primary Open-Angle Glaucoma. Curr Eye Res. 2021 06; 46(6):895-902.
- Quantification of the Peripapillary Microvasculature in Eyes with Glaucomatous Paracentral Visual Field Loss. Ophthalmol Glaucoma. 2021 May-Jun; 4(3):286-294.
- An Artificial Intelligence Approach to Assess Spatial Patterns of Retinal Nerve Fiber Layer Thickness Maps in Glaucoma. Transl Vis Sci Technol. 2020 08; 9(9):41.
- Angle Anatomy and Glaucoma in Patients With Boston Keratoprosthesis. Cornea. 2020 Jun; 39(6):713-719.
- Densitometric Profiles of Optic Disc Hemorrhages in the Ocular Hypertension Treatment Study. Am J Ophthalmol. 2020 09; 217:10-19.
- Monitoring Glaucomatous Functional Loss Using an Artificial Intelligence-Enabled Dashboard. Ophthalmology. 2020 09; 127(9):1170-1178.
- Characterization of Central Visual Field Loss in End-stage Glaucoma by Unsupervised Artificial Intelligence. JAMA Ophthalmol. 2020 02 01; 138(2):190-198.
- Baseline Age and Mean Deviation Affect the Rate of Glaucomatous Vision Loss. J Glaucoma. 2020 01; 29(1):31-38.
- Artificial Intelligence Classification of Central Visual Field Patterns in Glaucoma. Ophthalmology. 2020 06; 127(6):731-738.
- Glaucoma After Corneal Trauma or Surgery-A Rapid, Inflammatory, IOP-Independent Pathway. Cornea. 2019 Dec; 38(12):1589-1594.
- In Reply: Protocol For Titrated Endocycloplasty When Combined With Phacoemulsification in an Exclusive Cohort of Angle Closure Glaucoma. J Glaucoma. 2019 12; 28(12):e178-e179.
- Reply. Ophthalmology. 2019 10; 126(10):e78-e79.
- Glaucoma Management in Patients With Aniridia and Boston Type 1 Keratoprosthesis. Am J Ophthalmol. 2019 11; 207:258-267.
- A Review of OCT Angiography in Glaucoma. Semin Ophthalmol. 2019; 34(4):279-286.
- Differential Efficacy of Combined Phacoemulsification and Endocyclophotocoagulation in Open-angle Glaucoma Versus Angle-closure Glaucoma. J Glaucoma. 2019 05; 28(5):473-480.
- Microvasculature of the Optic Nerve Head and Peripapillary Region in Patients With Primary Open-Angle Glaucoma. J Glaucoma. 2019 04; 28(4):281-288.
- Blood Levels of Tumor Necrosis Factor Alpha and Its Type 2 Receptor Are Elevated in Patients with Boston Type I Keratoprosthesis. Curr Eye Res. 2019 06; 44(6):599-606.
- Agreement and Predictors of Discordance of 6 Visual Field Progression Algorithms. Ophthalmology. 2019 06; 126(6):822-828.
- An Artificial Intelligence Approach to Detect Visual Field Progression in Glaucoma Based on Spatial Pattern Analysis. Invest Ophthalmol Vis Sci. 2019 01 02; 60(1):365-375.
- Reply. Ophthalmology. 2018 09; 125(9):e66-e67.
- Resting nailfold capillary blood flow in primary open-angle glaucoma. Br J Ophthalmol. 2019 02; 103(2):203-207.
- Chemical Burns of the Eye: The Role of Retinal Injury and New Therapeutic Possibilities. Cornea. 2018 Feb; 37(2):248-251.
- Fundus Densitometry Findings Suggest Optic Disc Hemorrhages in Primary Open-Angle Glaucoma Have an Arterial Origin. Am J Ophthalmol. 2018 03; 187:108-116.
- Thin minimal rim width at Bruch's membrane opening is associated with glaucomatous paracentral visual field loss. Clin Ophthalmol. 2017; 11:2157-2167.
- Reversal of Glaucoma Hemifield Test Results and Visual Field Features in Glaucoma. Ophthalmology. 2018 03; 125(3):352-360.
- Optic Nerve Head Characteristics in Chronic Angle Closure Glaucoma Detected by Swept-Source OCT. Curr Eye Res. 2017 11; 42(11):1450-1457.
- A retrospective study on the outcomes of Ahmed valve versus Ahmed valve combined with fluocinolone implant in uveitic glaucoma. Digit J Ophthalmol. 2017; 23(3):63-70.
- The Role of the Back Plate in Angle Anatomy with the Boston Type I Keratoprosthesis. Cornea. 2017 Sep; 36(9):1096-1101.
- Impact of Natural Blind Spot Location on Perimetry. Sci Rep. 2017 07 21; 7(1):6143.
- Nailfold capillary morphology in exfoliation syndrome. Eye (Lond). 2017 May; 31(5):698-707.
- Relationship Between Central Retinal Vessel Trunk Location and Visual Field Loss in Glaucoma. Am J Ophthalmol. 2017 Apr; 176:53-60.
- Clinical Correlates of Computationally Derived Visual Field Defect Archetypes in Patients from a Glaucoma Clinic. Curr Eye Res. 2017 04; 42(4):568-574.
- Comparison of swept-source and enhanced depth imaging spectral-domain optical coherence tomography in quantitative characterisation of the optic nerve head. Br J Ophthalmol. 2017 03; 101(3):299-304.
- Infliximab after Boston Keratoprosthesis in Stevens-Johnson Syndrome: An Update. Ocul Immunol Inflamm. 2017 Jun; 25(3):413-417.
- Assessing the Effect of a Glaucoma Surgical Curriculum in Resident Physicians. JAMA Ophthalmol. 2015 Sep; 133(9):1077-80.
- Patterns of functional vision loss in glaucoma determined with archetypal analysis. J R Soc Interface. 2015 Feb 06; 12(103).
- Optic nerve pit and associated macular detachment. JAMA Ophthalmol. 2015 Jan; 133(1):e141775.
- Treatment of Blebitis and Bleb-related Endophthalmitis. Int Ophthalmol Clin. 2015; 55(4):37-49.
- Solar exposure and residential geographic history in relation to exfoliation syndrome in the United States and Israel. JAMA Ophthalmol. 2014 Dec; 132(12):1439-45.
- A survey of preoperative blood tests in primary open-angle glaucoma patients versus cataract surgery patients. Digit J Ophthalmol. 2014; 20(2):20-8.
- Glaucoma progression and role of glaucoma surgery in patients with Boston keratoprosthesis. Cornea. 2014 Apr; 33(4):349-54.
- Macular imaging for glaucoma using spectral-domain optical coherence tomography: a review. Semin Ophthalmol. 2012 Sep-Nov; 27(5-6):160-6.
- Long-term complications associated with glaucoma drainage devices and Boston keratoprosthesis. Am J Ophthalmol. 2012 Jul; 154(1):207-8; author reply 208-9.
- Effects of caffeinated coffee consumption on intraocular pressure, ocular perfusion pressure, and ocular pulse amplitude: a randomized controlled trial. Eye (Lond). 2012 Aug; 26(8):1122-30.
- Coupled parametric model for estimation of visual field tests based on OCT macular thickness maps, and vice versa, in glaucoma care. Med Image Anal. 2012 Jan; 16(1):101-13.
- Rosiglitazone and delayed onset of proliferative diabetic retinopathy. Arch Ophthalmol. 2008 Jun; 126(6):793-9.
- A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects. J Immunol. 2004 Mar 01; 172(5):2994-3002.
- Therapeutic potential of thiazolidinediones as anticancer agents. Expert Opin Investig Drugs. 2003 Dec; 12(12):1925-37.
- A model for predicting likely sites of CYP3A4-mediated metabolism on drug-like molecules. J Med Chem. 2003 Apr 10; 46(8):1330-6.
- PPARgamma ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis. J Clin Invest. 2002 Oct; 110(7):923-32.
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