Gregory W. Randolph, M.D., FACS, FACE

Harvard Medical School

Professor of Otolaryngology
Claire and John Bertucci Endowed Chair in Thyroid Surgical Oncology

Massachusetts Eye and Ear

Director, General and Thyroid/Parathyroid Endocrine Surgical Divisions

Research Summary

Research Summary

Dr. Randolph’s primary research interests include anatomy, preservation, and intraoperative monitoring of recurrent laryngeal nerve, superior laryngeal nerve, and vagus nerve; improving outcomes; and decreasing morbidity of thyroid cancer surgery, with focus on voice and laryngeal exams, recognition of lymph node metastasis, and revision cancer surgery.

Dr. Randolph pioneered a clinical intraoperative neural monitoring program involving our Anesthesia, Audiology, and Otolaryngology Departments, which provides electrophysiologic neural monitoring during thyroid and parathyroid surgery. Dr. Randolph’s work on voice and laryngeal exams has stimulated importance of voice preservation and awareness of role of laryngeal exams before and after thyroid surgery in the surgical community. His work on intraoperative nerve monitoring as well as voice has culminated into international guidelines for recurrent laryngeal nerve and superior laryngeal nerve intraoperative monitoring and improving voice outcomes guidelines. He has lead thyroid surgical missions to thyroid surgical units in St. Petersburg, Russia; Guangzhou, China; and in the Chernobyl region of the Ukraine. He directs the Harvard Thyroid and Parathyroid Surgery Course for surgeons and has directed international surgical courses in Italy, Germany, Switzerland, and Russia. He founded the first otolaryngology-based Thyroid and Parathyroid surgical fellowship in the US.     

He has published an endocrine surgical text: Surgery of the Thyroid and Parathyroid Glands, published by Saunders. This text has been nominated for a publishing industry award as a new and innovative surgical text and is being translated to Russian, Portuguese, Turkish, and Chinese.

Dr. Randolph continues investigations to improve intraoperative nerve monitoring, preservation of voice, and to generate algorithms to improve thyroid cancer management.

Current Projects:

  1. In collaboration with Guillermo Tearney, MGH Wellman Lab, and MIT, Dr. Randolph studies spectrally encoded laser confocal microscopy to provide intraoperative histologic information without tissue resection.
  2. In collaboration with Dr. Halle, Germany, Dr. Randolph is conducting a study on vagal electrode intraoperative real-time monitoring.
  3. Study of patients who are voice professionals undergoing thyroid surgery.
  4. Study of recurrent laryngeal nerve malignant invasion.

Select Publications

Electrophysiologic recurrent laryngeal and nerve monitoring during thyroid and parathyroid surgery:  International standards guidelines statement.  Randolph GW, Dralle H and the International Neural Monitoring Study Group. Laryngoscope 2011; 121:S1-S16.

2014 American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer Haugen B, Alexander E, Bible K, Doherty G, Mandel S, Nikiforov Y, Pacini F, Randolph G, Sawka A, Schlumberger M, Schuff  K, Sherman S, Sosa J, Steward D, Tuttle M, Wartofsky L The American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer submitted Thyroid

External Branch of the Superior Laryngeal Nerve Monitoring during Thyroid and Parathyroid Surgery: International Neural Monitoring Study Group Standards Guideline Statement. Barczynski M, Randolph GW, Cernea C et al Laryngoscope. 2013 Sep;123 Suppl 4:S1-14

Clinical practice guideline: improving voice outcomes after thyroid surgery. Chandrasekhar SS, Randolph GW, Seidman MD, et al, American Academy of Otolaryngology-Head and Neck Surgery. Otolaryngol Head Neck Surg. 2013 Jun;148(6 Suppl):S1-37.

The prognostic significance of nodal metastases from papillary thyroid carcinoma can be stratified based on the size and number of metastatic lymph nodes, as well as the presence of extranodal extension. Randolph GW, Duh QY, Heller KS, et al Thyroid. 2012 Nov;22(11):1144-52. American Thyroid Association Surgical Affairs Committee’s Taskforce on Thyroid Cancer Nodal Surgery.

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B.S. Cornell University, 1982
M.D. Cornell Medical College, 1987

Postgraduate Training

Internship in General Surgery, Cornell Medical Center, 1988
Residency in Otolaryngology, Massachusetts Eye and Ear Infirmary/Harvard Medical School, 1992
Research Fellowship in Thyroid Oncology, Massachusetts General Hospital, 1993

Professional Memberships

2013–present, International Federation of Otolaryngology Societies (AAOHNS representative to the Executive Board)
2007–present, American Thyroid Association (2013 Treasurer-elect, Executive Board of Directors)
2006–present, American Association of Clinical Endocrinologists (2013 Chair, Endocrine Surgery Committee; Member Council on AACE Membership)
2006–present, European Association of Endocrine Surgeons (2013 European Board of Surgery Qualification Examination in Neck Endocrine Surgery, Examination Board of the Division of Endocrine Surgery)
2003–present, American College of Surgeons (2013 AAOHNS representative to the ACS Advisory Council for Otolaryngology; 2013 nominated ACS Board of Regents)
1993-present, American Academy of Otolaryngology-Head and Neck Surgery (2015 President-elect)

Advisory Boards

2013, European Board of Surgery Qualification Examination in Neck Endocrine Surgery, EU Board of Surgery
2013, Executive Board, International Federation of Otolaryngology Societies
2009, Invited International Observer, European Union Medical Specialists

Editorial Roles (select)
2003-present         Editorial Board, Head and Neck Surgery
2006-present         Editorial Board, Vestnik Khhirurch  (Russian Journal of Surgery)
2009-present         Editorial Board, Thyroid (journal for the ATA)
2009-present         Editorial Board, Endocrine Practice (journal for the AACE)
2009-present         Senior Associate Editorial Board, World Journal of Endocrine Surgery
2009-present         International Associate Editor, Otolaryngology Head and Neck Surgery Journal (Journal of AAOHNS)    
2010                      Book Series Editor, Karger Advances in Otorhinolaryngology
2011-present         Founding Associate Editor for Thyroid Laryngoscope and Parathyroid Surgery


1996-2011   Course Director:Surgery of the Thyroid and Parathyroid Glands, Harvard CME Course, Massachusetts Eye and Ear Infirmary and Massachusetts General Hospital.  
2013   ACS Panel Moderator: Avoidance of Complication in Thyroid/Parathyroid Surgery
2013   MGH Surgical Oncology CME Harvard course –Thyroid cancer and the RLN
2013   AAOHNS Annual meeting activities: Egyptian Society satellite  invited speaker and panelist.
2013   Chair Tumor board panel -ATA annual meeting in PR
2006-present   Northeastern University audiology lectures on Nerve monitoring
2011- present   Children’s Hospital Boston endocrine surgical lecture for fellows.
2003   Co-Director: International Conference on Endocrine St. Petersburg, Russia Surgery
2006   Co Director:Geneva Intraoperative Nerve Monitoring International Course on Standards.


2013 Nominated for the Massachusetts General Hospital Brian A. McGovern Award for Clinical Excellence
2012 AAO–HNS Distinguished Honor Award
2007 Nominated for Medical School Mentoring Award for Harvard Medical School faculty
2001 AAO–HNS Honor Award for work on Endocrine Surgery Subcommittee
2000 Daniel D. Federman Outstanding Clinical Educator Award for Harvard Medical School faculty