Jaya Rajaiya, Ph.D.

Harvard Medical School

Assistant Professor of Ophthalmology, Department of Ophthalmology

Massachusetts Eye and Ear

Assistant Scientist


Research Summary

Center/Research Area Affiliation

Research Summary

Dr. Rajaiya works to understand the intracellular trafficking of viruses into cells. She applies her expertise in molecular biology and her background in infectious disease pathogenesis to questions in adenoviral pathogenesis, and expands her expertise to cell signaling upon adenoviral infection. Her present work addresses very basic phenomena in viral entry and intracellular trafficking during infection. Dr. Rajaiya also is involved in complete genome analysis of adenoviruses. This project seeks to elucidate transcriptomes and proteomes of human adenoviruses most closely associated with corneal infections.

Education

1998: Ph.D., Molecular Biology of Mycobacteria, National Institute of Immunology, Jamia Hamdard, New Delhi

Postgraduate Training

2001: Research Associate, Transcription Factors, Oklahoma Medical Research Foundation

2005: Associate Research Scientist, B cell development, Oklahoma Medical Research Foundation

2006: Postdoctoral Research Associate, Virology, Dean McGee Eye Institute, Dept. of Ophthalmology, University of Oklahoma Health Sciences Center

Academic Appointments

2014-present: Assistant Professor of Ophthalmology, Harvard Medical School

2008-2014: Instructor in Ophthalmology, Harvard Medical School

2006-2008: Instructor in Ophthalmology, Dean McGee Eye Institute, Dept. of Ophthalmology, University of Oklahoma Health Sciences Center

Professional Memberships

Association for Research in Vision and Ophthalmology

American Society of Virology

Honors

1996: WHO Exchange Student Award, World Health Organization, Medical Research Council Tuberculosis Center, Hammersmith, London, UK                              

2015: Excellence in Teaching, Harvard Medical School, Molecular and Cellular Basis of Medicine (IN751.0)

Publications

Selected Publications

For a full publicaiton list, please see her CV.

  1. Yousuf  M A, Zhou X, Mukherjee S, Chintakuntlawar A V, Lee J Y, Ramke M, Chodosh J, Rajaiya J. Caveolin-1 associated adenovirus entry into human corneal cells. PLoS ONE. 2013 Oct 11;8(10):e77462. 
  2. Yousuf MA, Lee JS, Zhou X, Ramke M, Lee JY, Chodosh J, Rajaiya J. Protein kinase C signaling in adenoviral infection. Biochemistry. 2016 Oct 4. [Epub ahead of print] 
  3. Ramke M, Lee JY, Dyer DW, Seto D, Rajaiya J, Chodosh J. The 5'UTR in human adenoviruses: leader diversity in late gene expression. Sci Rep. 2017 Apr 4;7(1):618. (Co-corresponding author)
  4. Lee JY, Lee JS, Materne EC, Rajala R, Ismail AM, Seto D, Dyer DW, Rajaiya J, Chodosh J. Bacterial RecA Protein promotes adenoviral recombination during in vitro infection. mSphere. 2018 Jun 20;3(3). pii: e00105-18. (Co-corresponding author)
  5. Ismail AM, Lee JS, Lee JY, Singh G, Dyer DW, Seto D, Chodosh J, Rajaiya J. Adenoviromics: mining the human adenovirus species D genome. Front Microbiol. 2018 Sep 11;9:2178. eCollection 2018.

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