Shizuo Mukai, M.D.

Harvard Medical School

Associate Professor of Ophthalmology, Department of Ophthalmology

Massachusetts Eye and Ear

Associate Scientist



Research Summary

Center/Research Area Affiliations

Research Summary

Dr. Mukai is a clinician scientist with clinical expertise in the surgical and medical management of vitreoretinal diseases, including complex retinal detachments, pediatric retina, intraocular tumors of the posterior segment (especially retinoblastoma), genetic retinal diseases, and retinal imaging. His research interests include molecular biology of retinal diseases (especially retinoblastoma) and proliferative vitreoretinopathy, new treatment approaches to retinoblastoma, smartphone-based retinal imaging and computerized image analysis, phenotype-genotype correlations in genetic retinal conditions, and retinal stem cells.


1979: AB, Studio Art, Brown University

1979: ScB, Biology, Brown University

1982: Biology, Brown University Graduate School

1982: MD, Brown University School of Medicine

Postgraduate Training

1983: Internship, Medicine, Mount Auburn Hospital

1985: Research Fellowship, Molecular Genetics and Eye Pathology, Massachusetts Eye an Ear

1988: Residency, Ophthalmology, Massachusetts Eye and Ear

1990: Clinical Fellowship, Chief Fellow, Retina, Massachusetts Eye and Ear

Academic Appointments

2012-present: Associate Professor of Ophthalmology, Harvard Medical School

1992-2012: Assistant Professor of Ophthalmology, Harvard Medical School

1990-1992: Instructor in Ophthalmology, Harvard Medical School


Selected Publications

For a full list of publications, please see his CV.

Haddock LJ, Kim DY, Mukai S. Simple, inexpensive technique for high-quality smartphone fundus photography in human and animal eyesJournal of Ophthalmology 2013, Article ID 518479, 5 pages. 

Mouw KW, Sethi RV, Yeap BY, MacDonald SM, Chen Y-LE, Tarbell NJ, Yock TI, Munzenrider JE, Adams J, Grabowski E, Mukai S, Shih HA. Proton radiation therapy for the treatment of retinoblastoma. Int J Radiation Oncol Biol Phys 2014 Nov 15;90(4):863-9. Epub 2014 Sep 13.

Jakobiec FA, Trief D, Rashid A, Rose MF, Minkler D, Vanderveen D, Mukai S. New insights into the development of infantile intraocular medulloepitheioma. Am J Ophthalmol 2014 Dec;158(6):1275-1296.e1. Epub 2014 Aug 28.

Gupta MP, Talcott KE, Kim DY, Agarwal S, Mukai S Retinal findings and a novel TINF2 mutation in Revesz syndrome: clinical and molecular correlations with pediatric retinal vasculopathiesOphthalmic Genetics 2017; 38(1): 51-60.  

Shen BY, Mukai S.  A portable, inexpensive, non-mydriatic fundus camera based on the Raspberry Pi computer.  Journal of Ophthalmology 2017, Article ID 4526243, 5 pages.  

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