John B. Miller,
MD
Massachusetts Eye and Ear
Assistant Scientist
Harvard Medical School
Assistant Professor of Ophthalmology
About My Research
Centers of Excellence/Institutes
Research Programs/Laboratories
- Ines and Frederick Yeatts Retina Research Laboratory
- Harvard Retinal Imaging Laboratory
- JW Miller AMD Research Group
- Harvard Retinal Metabolomics Program
Research Summary
Dr. Miller maintains an active research program in addition to his strong clinical retina practice. As a clinician scientist, his work focuses both on clinical research and the basic mechanisms of retinal disease through study in the laboratory. In the Ines and Frederick Yeatts Retina Research Laboratory at Mass Eye and Ear, he has explored the mechanisms of retinal toxicity of systemic medications. Ongoing work explores the pathogenesis of age-related macular degeneration, macular telangiectasia, macular hole, and drug retinal toxicities.
His clinical research includes age-related macular degeneration, traumatic macular holes, and macular telangiectasia. He maintains a particular focus on retinal imaging devices, including Swept Source OCT (investigational). With additional advances in retinal imaging, he hopes to provide earlier detection of disease or predisposing factors, better prognostic information, and disease maintenance.
Dr. Miller has received multiple investigator awards, including those from top subspecialty societies: the Retina Society and Macula Society.
He maintains a close association with the latest developments in both diagnostics and therapeutics through regular attendance at subspecialty meetings, including the Retina Society, the American Society of Retina Specialists (ASRS), Association of Research in Vision and Ophthalmology (ARVO), and the Vit Buckle Society (VBS). He serves on the education committee of the Vit Buckle Society, striving to improve the surgical techniques of others through collaboration.
Education
BS, Massachusetts Institute of Technology
MD, University of Michigan Medical School
Postgraduate Training
Ophthalmology Residency, Harvard Medical School
Surgical and Medical Retina Fellowship, Mass Eye and Ear (Served as Chief Retina Fellow)
Honors and Awards
2015: AMD Center of Excellence Grimshaw Grant Co-Investigator
2015: Macula Society Evangelos Gragoudas Award
2014: Retina Society Raymond Margherio Award
2013: Heed Ophthalmic Foundation Fellow
Publications powered by Harvard Catalyst Profiles
- Restoration of Vision in Severe, Cicatricial, Ocular Surface Disease With the Boston Keratoprosthesis Type II. Am J Ophthalmol. 2022 11; 243:42-54.
- Retinal microvasculature and vasoreactivity changes in hypertension using optical coherence tomography-angiography. Graefes Arch Clin Exp Ophthalmol. 2022 Nov; 260(11):3505-3515.
- Short- and Long-Term Visual Outcomes in Patients Receiving Intravitreal Injections: The Impact of the Coronavirus 2019 Disease (COVID-19)-Related Lockdown. J Clin Med. 2022 Apr 08; 11(8).
- Subthreshold Exudative Choroidal Neovascularization (CNV): Presentation of This Uncommon Subtype and Other CNVs in Age-Related Macular Degeneration (AMD). J Clin Med. 2022 Apr 07; 11(8).
- Nonperfusion Area and Other Vascular Metrics by Wider Field Swept-Source OCT Angiography as Biomarkers of Diabetic Retinopathy Severity. Ophthalmol Sci. 2022 Jun; 2(2).
- Complete Resolution of Central Soft Drusen without Geographic Atrophy or Choroidal Neovascularization. J Clin Med. 2022 Mar 16; 11(6).
- Quantitative contrast sensitivity test to assess visual function in central serous chorioretinopathy. Br J Ophthalmol. 2023 08; 107(8):1139-1143.
- Detection of Choroidal Hypoperfusion in Giant Cell Arteritis Using Swept-Source Optical Coherence Tomographic Angiography. J Neuroophthalmol. 2023 Dec 01; 43(4):e117-e119.
- Remote Imaging Capture with Widefield Swept-Source OCT Angiography During the COVID-19 Pandemic. Clin Ophthalmol. 2022; 16:477-486.
- Urinary Mass Spectrometry Profiles in Age-Related Macular Degeneration. J Clin Med. 2022 Feb 11; 11(4).
- Telemedicine for the Diagnosis and Management of Age-Related Macular Degeneration: A Review. J Clin Med. 2022 Feb 05; 11(3).
- Quantifying Retinal Microvascular Morphology in Schizophrenia Using Swept-Source Optical Coherence Tomography Angiography. Schizophr Bull. 2022 01 21; 48(1):80-89.
- Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration. Metabolites. 2022 Jan 01; 12(1).
- BASELINE PREDICTORS ASSOCIATED WITH 3-YEAR CHANGES IN DARK ADAPTATION IN AGE-RELATED MACULAR DEGENERATION. Retina. 2021 Oct 01; 41(10):2098-2105.
- Retrospective Analysis of Retinal Imaging in COVID-19 Positive Patients at a Tertiary Eye Care Center. Clin Ophthalmol. 2021; 15:3727-3731.
- Wide-field swept-source optical coherence tomography angiography in the assessment of retinal microvasculature and choroidal thickness in patients with myopia. Br J Ophthalmol. 2023 01; 107(1):102-108.
- Three-dimensional telesurgery and remote proctoring over a 5G network. Digit J Ophthalmol. 2021; 27(3):38-43.
- Measuring the Contrast Sensitivity Function in Non-Neovascular and Neovascular Age-Related Macular Degeneration: The Quantitative Contrast Sensitivity Function Test. J Clin Med. 2021 Jun 24; 10(13).
- Juxtapapillary Choroidal Neovascular Membrane as a Complication of Optic Disc Drusen: Multimodal Imaging With Swept Source-Optical Coherence Tomography and Optical Coherence Tomography Angiography. J Neuroophthalmol. 2022 03 01; 42(1):e430-e433.
- Absent Foveal Avascular Zone in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay. J Neuroophthalmol. 2021 06 01; 41(2):e166-e168.
- Area under the dark adaptation curve as a reliable alternate measure of dark adaptation response. Br J Ophthalmol. 2022 10; 106(10):1450-1456.
- Quantitative autofluorescence: Review of Current Technical Aspects and Applications in Chorioretinal Disease. Semin Ophthalmol. 2021 May 19; 36(4):346-350.
- Microvasculopathy in Lyme-Associated Papillitis Revealed by Optical Coherence Tomographic Angiography. J Neuroophthalmol. 2022 03 01; 42(1):e338-e340.
- Association of Human Plasma Metabolomics with Delayed Dark Adaptation in Age-Related Macular Degeneration. Metabolites. 2021 Mar 21; 11(3).
- Genomic-Metabolomic Associations Support the Role of LIPC and Glycerophospholipids in Age-Related Macular Degeneration. Ophthalmol Sci. 2021 Mar; 1(1).
- Wide Field Swept Source Optical Coherence Tomography Angiography for the Evaluation of Proliferative Diabetic Retinopathy and Associated Lesions: A Review. Semin Ophthalmol. 2021 May 19; 36(4):162-167.
- Artificial Intelligence (AI) and Retinal Optical Coherence Tomography (OCT). Semin Ophthalmol. 2021 May 19; 36(4):341-345.
- Age-Related Macular Degeneration (AMD): A View to the Future. J Clin Med. 2021 Mar 08; 10(5).
- Widefield Swept-Source OCT Angiography Metrics Associated with the Development of Diabetic Vitreous Hemorrhage: A Prospective Study. Ophthalmology. 2021 09; 128(9):1312-1324.
- Combined pars plana glaucoma drainage device placement and vitrectomy using a vitrectomy sclerotomy site for tube placement: a case series. BMC Ophthalmol. 2021 Feb 25; 21(1):106.
- Ultra-Widefield Imaging for Evaluation of the Myopic Eye. Semin Ophthalmol. 2021 May 19; 36(4):185-190.
- Application of Deep Learning for Diagnosing, Classifying, and Treating Age-Related Macular Degeneration. Semin Ophthalmol. 2021 May 19; 36(4):198-204.
- Contrast sensitivity function in patients with macular disease and good visual acuity. Br J Ophthalmol. 2022 06; 106(6):839-844.
- Retinal applications of swept source optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). Prog Retin Eye Res. 2021 09; 84:100951.
- Anatomical and Functional Recovery Kinetics After Epiretinal Membrane Removal. Clin Ophthalmol. 2021; 15:175-181.
- Retinal Imaging Findings in Carriers With PSEN1-Associated Early-Onset Familial Alzheimer Disease Before Onset of Cognitive Symptoms. JAMA Ophthalmol. 2021 01 01; 139(1):49-56.
- Detection of neovascularisation in the vitreoretinal interface slab using widefield swept-source optical coherence tomography angiography in diabetic retinopathy. Br J Ophthalmol. 2022 04; 106(4):534-539.
- The Impact of the COVID-19 Pandemic on Ophthalmic Care at an Eye-Specific Emergency Department in an Outbreak Hotspot. Clin Ophthalmol. 2020; 14:4155-4163.
- Topical delivery of a small molecule RUNX1 transcription factor inhibitor for the treatment of proliferative vitreoretinopathy. Sci Rep. 2020 11 30; 10(1):20554.
- Open Globe Injury with Intraocular Foreign Body. J Vitreoretin Dis. 2021 Jul 01; 5(4):288-294.
- Disorganisation of retinal inner layers is associated with reduced contrast sensitivity in retinal vein occlusion. Br J Ophthalmol. 2022 02; 106(2):241-245.
- A quantitative comparison of four optical coherence tomography angiography devices in healthy eyes. Graefes Arch Clin Exp Ophthalmol. 2021 Jun; 259(6):1493-1501.
- Outcomes of primary rhegmatogenous retinal detachment repair with extensive scleral-depressed vitreous removal and dynamic examination. PLoS One. 2020; 15(9):e0239138.
- A guarded light pipe for direct visualization during primary scleral buckling on the Ngenuity platform. Int J Retina Vitreous. 2020; 6:42.
- Accelerating ophthalmic artificial intelligence research: the role of an open access data repository. Curr Opin Ophthalmol. 2020 Sep; 31(5):337-350.
- Concerns about the interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication. Eye (Lond). 2020 12; 34(12):2153-2154.
- A Young Man With Peripheral Vision Loss. JAMA Ophthalmol. 2020 07 01; 138(7):791-792.
- Widefield Swept-Source OCTA in Vogt-Koyanagi-Harada Disease. Ophthalmic Surg Lasers Imaging Retina. 2020 07 01; 51(7):407-412.
- Comparison of widefield swept-source optical coherence tomography angiography with ultra-widefield colour fundus photography and fluorescein angiography for detection of lesions in diabetic retinopathy. Br J Ophthalmol. 2021 04; 105(4):577-581.
- Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography. Clin Ophthalmol. 2020; 14:1759-1767.
- Subthreshold Exudative Choroidal Neovascularization Associated With Age-Related Macular Degeneration Identified by Optical Coherence Tomography Angiography. J Vitreoretin Dis. 2020 Oct; 4(5):377-385.
- Optical Coherence Tomography-Angiography of a large retinal microaneurysm. Am J Ophthalmol Case Rep. 2020 Jun; 18:100690.
- Different Scan Protocols Affect the Detection Rates of Diabetic Retinopathy Lesions by Wide-Field Swept-Source Optical Coherence Tomography Angiography. Am J Ophthalmol. 2020 07; 215:72-80.
- Detection of retinal microvascular changes in von Hippel-Lindau disease using optical coherence tomography angiography. PLoS One. 2020; 15(2):e0229213.
- Higher Intake of Polyunsaturated Fatty Acid and Monounsaturated Fatty Acid is Inversely Associated With AMD. Invest Ophthalmol Vis Sci. 2020 02 07; 61(2):20.
- Imaging Artifacts and Segmentation Errors With Wide-Field Swept-Source Optical Coherence Tomography Angiography in Diabetic Retinopathy. Transl Vis Sci Technol. 2019 Nov; 8(6):18.
- Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report. Nat Med. 2019 11; 25(11):1680-1683.
- The Scope Of Three-Dimensional Digital Visualization Systems In Vitreoretinal Surgery. Clin Ophthalmol. 2019; 13:2093-2096.
- Validation of RetmarkerAMD as a semiautomatic grading software for AMD. Eye (Lond). 2020 03; 34(3):600-602.
- Quantitative Comparison Of Microvascular Metrics On Three Optical Coherence Tomography Angiography Devices In Chorioretinal Disease. Clin Ophthalmol. 2019; 13:2063-2069.
- Human Plasma Metabolomics in Age-Related Macular Degeneration: Meta-Analysis of Two Cohorts. Metabolites. 2019 Jul 02; 9(7).
- Intraoperative Optical Coherence Tomography in Vitreoretinal Surgery. Semin Ophthalmol. 2019; 34(4):312-316.
- Optical Coherence Tomography Angiography: Review of Current Technical Aspects and Applications in Chorioretinal Disease. Semin Ophthalmol. 2019; 34(4):211-217.
- Urine Nuclear Magnetic Resonance (NMR) Metabolomics in Age-Related Macular Degeneration. J Proteome Res. 2019 03 01; 18(3):1278-1288.
- Retinal Exudates and Hemorrhages in a Survivor of Breast Cancer. JAMA Ophthalmol. 2019 Feb 01; 137(2):218-219.
- Microperimetry in age-related macular degeneration: association with macular morphology assessed by optical coherence tomography. Br J Ophthalmol. 2019 12; 103(12):1769-1776.
- Choroidal thickness and vascular density in macular telangiectasia type 2 using enface swept-source optical coherence tomography. Br J Ophthalmol. 2019 11; 103(11):1584-1589.
- Comparison of choroidal neovascularization secondary to white dot syndromes and age-related macular degeneration by using optical coherence tomography angiography. Clin Ophthalmol. 2019; 13:95-105.
- Visualization of Choriocapillaris and Choroidal Vasculature in Healthy Eyes With En Face Swept-Source Optical Coherence Tomography Versus Angiography. Transl Vis Sci Technol. 2018 Nov; 7(6):25.
- Reply. Ophthalmology. 2018 07; 125(7):e46-e47.
- Quantitative analysis of optical coherence tomographic angiography (OCT-A) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) corresponds to visual function. PLoS One. 2018; 13(6):e0199793.
- Perfluorocarbon liquid-assisted intraocular foreign body removal. Clin Ophthalmol. 2018; 12:1099-1104.
- HEALTH CONDITIONS LINKED TO AGE-RELATED MACULAR DEGENERATION ASSOCIATED WITH DARK ADAPTATION. Retina. 2018 Jun; 38(6):1145-1155.
- Imaging the Deep Choroidal Vasculature Using Spectral Domain and Swept Source Optical Coherence Tomography Angiography. J Vitreoretin Dis. 2018 May-Jun; 2(3):146-154.
- Peripheral Changes Associated With Delayed Dark Adaptation in Age-related Macular Degeneration. Am J Ophthalmol. 2018 06; 190:113-124.
- Evaluation of choroidal lesions with swept-source optical coherence tomography. Br J Ophthalmol. 2019 01; 103(1):88-93.
- Fundus Densitometry Findings Suggest Optic Disc Hemorrhages in Primary Open-Angle Glaucoma Have an Arterial Origin. Am J Ophthalmol. 2018 03; 187:108-116.
- CHOROIDAL THICKNESS IN DIABETIC RETINOPATHY ASSESSED WITH SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY. Retina. 2018 Jan; 38(1):173-182.
- Focal Capillary Dropout Associated With Optic Disc Drusen Using Optical Coherence Tomographic Angiography. J Neuroophthalmol. 2017 12; 37(4):405-410.
- Complications Assoicated with MIRAgel for Treatment of Retinal Detachment. Semin Ophthalmol. 2018; 33(1):89-94.
- Optical coherence tomographic angiography identifies peripapillary microvascular dilation and focal non-perfusion in giant cell arteritis. Br J Ophthalmol. 2018 08; 102(8):1141-1146.
- Novel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration. Clin Ophthalmol. 2017; 11:1967-1974.
- Diabetic Choroidopathy: Choroidal Vascular Density and Volume in Diabetic Retinopathy With Swept-Source Optical Coherence Tomography. Am J Ophthalmol. 2017 Dec; 184:75-83.
- Retinal Whitening After Uncomplicated Cataract Surgery. JAMA Ophthalmol. 2017 10 01; 135(10):1117-1118.
- Human Plasma Metabolomics Study across All Stages of Age-Related Macular Degeneration Identifies Potential Lipid Biomarkers. Ophthalmology. 2018 02; 125(2):245-254.
- Volumetric Measurement of Optic Nerve Head Drusen Using Swept-Source Optical Coherence Tomography. J Glaucoma. 2017 09; 26(9):798-804.
- Retinal Loop Vessel Captured with Optical Coherence Tomography-Angiography. Ophthalmology. 2017 08; 124(8):1174.
- Distinguishing White Dot Syndromes With Patterns of Choroidal Hypoperfusion on Optical Coherence Tomography Angiography. Ophthalmic Surg Lasers Imaging Retina. 2017 08 01; 48(8):638-646.
- Choroidal Changes Associated With Subretinal Drusenoid Deposits in Age-related Macular Degeneration Using Swept-source Optical Coherence Tomography. Am J Ophthalmol. 2017 Aug; 180:55-63.
- Human plasma metabolomics in age-related macular degeneration (AMD) using nuclear magnetic resonance spectroscopy. PLoS One. 2017; 12(5):e0177749.
- Structural Changes Associated with Delayed Dark Adaptation in Age-Related Macular Degeneration. Ophthalmology. 2017 09; 124(9):1340-1352.
- Early Performance on an Eye Surgery Simulator Predicts Subsequent Resident Surgical Performance. J Surg Educ. 2017 Nov - Dec; 74(6):1105-1115.
- Combined Central Retinal Vein Occlusion and Central Retinal Arterial Obstruction with Cilioretinal Artery Sparing. Ophthalmology. 2017 04; 124(4):576.
- Automated Brightness and Contrast Adjustment of Color Fundus Photographs for the Grading of Age-Related Macular Degeneration. Transl Vis Sci Technol. 2017 Mar; 6(2):3.
- Severe corneal ulcer with progression to endophthalmitis and high-grade bacteremia. Am J Ophthalmol Case Rep. 2017 Jun; 6:30-32.
- Peripapillary Capillary Dilation in Leber Hereditary Optic Neuropathy Revealed by Optical Coherence Tomographic Angiography. JAMA Ophthalmol. 2016 11 01; 134(11):1332-1334.
- The Efficacy and Safety Profile of Ocriplasmin in Vitreomacular Interface Disorders. Semin Ophthalmol. 2017; 32(1):52-55.
- miR-17-3p Exacerbates Oxidative Damage in Human Retinal Pigment Epithelial Cells. PLoS One. 2016; 11(8):e0160887.
- Comparison of swept-source and enhanced depth imaging spectral-domain optical coherence tomography in quantitative characterisation of the optic nerve head. Br J Ophthalmol. 2017 03; 101(3):299-304.
- Long-term Follow-up and Outcomes in Traumatic Macular Holes. Am J Ophthalmol. 2016 06; 166:206-207.
- Unilateral Eye Findings: A Rare Herald of Acute Leukemia. Ocul Oncol Pathol. 2016 Apr; 2(3):166-70.
- SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN CONVALESCENT PHASE OF TREATED SARCOID CHOROIDAL GRANULOMAS. Retin Cases Brief Rep. 2016; 10(1):32-6.
- Long-term Follow-up and Outcomes in Traumatic Macular Holes. Am J Ophthalmol. 2015 Dec; 160(6):1255-1258.e1.
- Mitochondrial DNA has a pro-inflammatory role in AMD. Biochim Biophys Acta. 2015 Nov; 1853(11 Pt A):2897-906.
- Complications of emulsified silicone oil after retinal detachment repair. Semin Ophthalmol. 2014 Sep-Nov; 29(5-6):312-8.
- Conversion to aflibercept for chronic refractory or recurrent neovascular age-related macular degeneration. Am J Ophthalmol. 2013 Jul; 156(1):29-35.e2.
- Traumatic macular hole from intentional basketball overinflation. Ophthalmic Surg Lasers Imaging Retina. 2013 May-Jun; 44(3):303-5.
- Intravitreal daptomycin: a safety and efficacy study. Retina. 2011 Jun; 31(6):1199-206.
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