Milica Margeta, M.D., Ph.D.

Research Summary

Center/Research Area Affiliations

Research Summary

Dr. Margeta specializes in glaucoma, which is a chronic blinding disease characterized by gradual loss of retinal ganglion cells and cupping of the optic nerve. Elevated intraocular pressure remains the only modifiable risk factor for glaucoma; currently there no treatments conferring retinal ganglion cell neuroprotection or reversing existing visual field loss. As a Harvard-Vision Clinical Scientist Development Program (K12) scholar, Dr. Margeta is investigating the role of retinal neuroinflammation in the pathogenesis of glaucoma, with the goal of developing novel neuroprotective treatments for this progressive blinding disease.

Selected Publications

For a full publications list, please see her CV.

Margeta MA, Lad EM, Proia AD. CD163+ macrophages infiltrate axon bundles of postmortem optic nerves with glaucoma. Graefes Arch Clin Exp Ophthalmol, 2018 Aug 2. [Epub ahead of print]

Margeta MA, Proia AD, Freedman SF. 2017. Staying away from the optic nerve: a formula for modifying glaucoma drainage device surgery in pediatric and other small eyes. J AAPOS. 21:39-43.

Low cerebrospinal fluid protein in prepubertal children with idiopathic intracranial hypertension. Margeta MA, Buckley EG, El-Dairi M. J AAPOS. 2015;19:135-9.

Molecular mechanisms of synaptic specificity. Margeta MA, Shen K. Mol Cell Neurosci. 2010;43:261-7

Clathrin adaptor AP-1 complex excludes multiple postsynaptic receptors from axons in C. elegans. Margeta MA, Wang GJ, Shen K. Proc Natl Acad Sci USA. 2009;106:1632-7

Building a synapse: lessons on synaptic specificity and presynaptic assembly from the nematode C. elegans.  Margeta, MA, Shen, K, Grill B. Curr Opin Neurobiol. 2008;18:69-76

Glia promote local synaptogenesis through UNC-6 (netrin) signaling in C. elegans. Colón-Ramos DA, Margeta MA, Shen K. Science. 2007; 318: 103-6.

View a complete list of publications on pubmed.gov>>

View a complete list on Google Scholar>>

Biosketch

Education

2003: BS, Stanford University, Biological Sciences

2009: PhD, Stanford University, Neuroscience

2011: MD, Stanford University

Postgraduate Training

2015: Residency, Ophthalmology, Duke University

2016: Fellowship, Glaucoma, Duke University

Academic Appointments

2016-present: Instructor in Ophthalmology, Harvard Medical School

Professional Memberships

2015-present: American Glaucoma Society

2015-present: Association for Research in Vision and Ophthalmology

2017-present: New England Ophthalmological Society

Honors

2013: Robert Machemer Resident Research Award, Duke University Eye Center

2015: Ocular Innovation Award, Duke University Eye Center

2016: Best Research Presentation by a Clinical Fellow, Duke University Eye Center