About My Research
As an auditory physiologist, Dr. Stéphane Maison studies the peripheral auditory system and has published more than 45 peer-reviewed papers in the field. Having spent nearly 20 years honing his skills in the study of sensorineural hearing loss in animal models, Dr. Maison wants to bring the important research questions back to human subjects in a clinical context.
His research interests focus on 1) identifying hidden hearing loss (cochlear synaptopathy) in patients with "normal" audiograms, 2) identifying if tinnitus results from cochlear synaptopathy, and 3) therapies to restore speech intelligibility in adverse environments.
His work has been featured in many media outlets including the Wall Street Journal, Scientific American, and Consumer Report.
Education
BS, Biology, University Claude Bernard Lyon 1
MS, Physiology, University Claude Bernard Lyon 1
PhD, Neurosciences, University Claude Bernard Lyon 1
Postgraduate Training
Research Fellowship, Otology and Laryngology, Harvard Medical School
Professional Societies
Association for Research in Otolaryngology
Society for Neuroscience
Advisory Boards
Otolaryngology–BioMed Research International, Editorial Board
Teaching
Biology of the Inner Ear (SHBT 201), Harvard Program in Speech and Hearing Bioscience and Technology Introductory Audiology (CD467), Emerson College
- Isolating auditory-nerve contributions to electrocochleography by high-pass filtering: A better biomarker for cochlear nerve degeneration? JASA Express Lett. 2023 02; 3(2):024401.
- Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms. JASA Express Lett. 2022 Jun; 2(6):064403.
- Perinatal thiamine deficiency causes cochlear innervation abnormalities in mice. Hear Res. 2016 05; 335:94-104.
- Shelter from the Glutamate storm: Loss of olivocochlear efferents increases cochlear nerve degeneration during aging. J Acoust Soc Am. 2014 Apr; 135(4):2384.
- Efferent feedback minimizes cochlear neuropathy from moderate noise exposure. J Neurosci. 2013 Mar 27; 33(13):5542-52.
- Olivocochlear suppression of outer hair cells in vivo: evidence for combined action of BK and SK2 channels throughout the cochlea. J Neurophysiol. 2013 Mar; 109(6):1525-34.
- Contralateral-noise effects on cochlear responses in anesthetized mice are dominated by feedback from an unknown pathway. J Neurophysiol. 2012 Jul; 108(2):491-500.
- Dopaminergic signaling in the cochlea: receptor expression patterns and deletion phenotypes. J Neurosci. 2012 Jan 04; 32(1):344-55.
- Mice lacking adrenergic signaling have normal cochlear responses and normal resistance to acoustic injury but enhanced susceptibility to middle-ear infection. J Assoc Res Otolaryngol. 2010 Sep; 11(3):449-61.
- Muscarinic signaling in the cochlea: presynaptic and postsynaptic effects on efferent feedback and afferent excitability. J Neurosci. 2010 May 12; 30(19):6751-62.
- Loss of GABAB receptors in cochlear neurons: threshold elevation suggests modulation of outer hair cell function by type II afferent fibers. J Assoc Res Otolaryngol. 2009 Mar; 10(1):50-63.
- A novel effect of cochlear efferents: in vivo response enhancement does not require alpha9 cholinergic receptors. J Neurophysiol. 2007 May; 97(5):3269-78.
- Overexpression of SK2 channels enhances efferent suppression of cochlear responses without enhancing noise resistance. J Neurophysiol. 2007 Apr; 97(4):2930-6.
- Cochlear efferent feedback balances interaural sensitivity. Nat Neurosci. 2006 Dec; 9(12):1474-6.
- Selective removal of lateral olivocochlear efferents increases vulnerability to acute acoustic injury. J Neurophysiol. 2007 Feb; 97(2):1775-85.
- Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta. J Neurosci. 2006 Oct 04; 26(40):10315-26.
- Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse. J Biol Chem. 2004 Jan 16; 279(3):1581-4.
- Loss of alpha CGRP reduces sound-evoked activity in the cochlear nerve. J Neurophysiol. 2003 Nov; 90(5):2941-9.
- Olivocochlear innervation in the mouse: immunocytochemical maps, crossed versus uncrossed contributions, and transmitter colocalization. J Comp Neurol. 2003 Jan 13; 455(3):406-16.
- [Are we sectioning the cochlear efferent system during vestibular neurotomy?]. Rev Laryngol Otol Rhinol (Bord). 2003; 124(1):53-8.
- Efferent protection from acoustic injury is mediated via alpha9 nicotinic acetylcholine receptors on outer hair cells. J Neurosci. 2002 Dec 15; 22(24):10838-46.
- Delay and temporal integration in medial olivocochlear bundle activation in humans. Ear Hear. 2001 Feb; 22(1):65-74.
- Predicting vulnerability to acoustic injury with a noninvasive assay of olivocochlear reflex strength. J Neurosci. 2000 Jun 15; 20(12):4701-7.
- Activation of medial olivocochlear efferent system in humans: influence of stimulus bandwidth. Hear Res. 2000 Feb; 140(1-2):111-25.
- Contralateral suppression of transiently evoked otoacoustic emissions by harmonic complex tones in humans. J Acoust Soc Am. 1999 Jan; 105(1):293-305.
- Contralateral frequency-modulated tones suppress transient-evoked otoacoustic emissions in humans. Hear Res. 1998 Mar; 117(1-2):114-8.
- Medial olivocochlear system stabilizes active cochlear micromechanical properties in humans. Hear Res. 1997 Nov; 113(1-2):89-98.
- Medial olivocochlear efferent system in humans studied with amplitude-modulated tones. J Neurophysiol. 1997 Apr; 77(4):1759-68.
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