Qin Liu, M.D., Ph.D.

Harvard Medical School

Assistant Professor of Ophthalmology, Department of Ophthalmology

Massachusetts Eye and Ear

Assistant Scientist



Research Summary

Center/Research Area Affiliations

Research Summary

Dr. Liu’s research focuses on improving the understanding of the genetic causes and molecular bases of inherited retinal degenerations (IRDs), and developing novel CRISPR/Cas-based gene editing therapeutic approaches to overcome hurdles of conventional AAV-mediated gene augmentation therapy for treating dominant IRDs and recessive IRDs that are caused by mutations in large genes.

For more information, download her CV [PDF].


1988: MD, Xuzhou Medical College, China

1998: PhD, Molecular Ophthalmology, Peking Union Medical College, China

Postgraduate Training

1993: Residency, Ophthalmology, Xuzhou Medical College Hospital, China

1999: Postdoctoral Fellowship, Ocular Pharmacology, Institute of Ocular Pharmacology, Texas A & M University

2002: Postdoctoral Fellowship, Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania

Academic Appointments

2002-2006: Research Associate, Ophthalmology, University of Pennsylvania School of Medicine

2006-2011: Research Assistant Professor of Ophthalmology, University of Pennsylvania School of Medicine

2011-2013: Lecturer in Ophthalmology, Harvard Medcial School

2013-present: Assistant Professor of Ophthalmology, Harvard Medical School

Professional Memberships

1998-present: Association for Research in Vision and Ophthalmology (ARVO)

1998-1999: Association of Ocular Pharmacology and Therapeutics

2001-present: Society for Neuroscience

2017-present: American Society of Human Genetics


1994, 1996: Zhou Zizhuan Foundation Award, Chinese Academy of Medical Sciences

1995, 1997: Excellent Graduate Fellowship Award, Peking Union Medical College

2000: Retina Research Foundation/Lawrence Travel Fellowship Grant, ARVO

2006: Jackson Laboratory Travel Award, Jackson Laboratory

2008, 2018: Young Investigator Award, XIIIth International Symposium on Retinal Degenerations

2008: ISER Young Investigator Fellowship Award, International Society for Eye Research


Selected Publications

Li P, Kleinstiver BP, Leon MY, Prew MS, Navarro-Gomez D, Greenwald SH, Pierce EA, Joung JK, Liu QAllele-specific editing of rhodopsin P23H knock-in mice broadens therapeutic potential of CRISPR/Cas for dominant genetic diseases. The CRISPR Journal 1:55-64, 2018. 

Gupta PR, Pendse N, Greenwald SH, Leon M, Liu Q, Pierce EA, Bujakowska KM. Ift172 conditional knock-out mice exhibit rapid retinal degeneration and protein trafficking defects. Hum Mol Genet. 2018 Jun 1;27(11):2012-2024. 

Bujakowska KM, Liu Q, Pierce EA. Photoreceptor Cilia and Retinal Ciliopathies. Cold Spring Harb Perspect Biol. 2017 Oct 3;9(10). 

Consugar MB, Navarro-Gomez D, Place EM, Bujakowska KM, Sousa ME, Fonseca-Kelly ZD, Taub DG, Janessian M, Wang DY, Au ED, Sims KB, Sweetser DA, Fulton AB, Liu Q, Wiggs JL, Gai X, Pierce EA. Panel-based genetic diagnostic testing for inherited eye diseases is highly accurate and reproducible, and more sensitive for variant detection, than exome sequencing. Genet Med. 2015 Apr;17(4):253-261. 

Liu Q, Collin RW, Cremers FP, den Hollander AI, van den Born LI, Pierce EA. Expression of wild-type Rp1 protein in Rp1 knock-in mice rescues the retinal degeneration phenotype. PLoS One.  2012 7(8): 43251.

View a complete list of publications on pubmed.gov>>