Derrick T. Lin,
MD, FACS
Massachusetts Eye and Ear
Investigator, Mike Toth Head and Neck Cancer Research Center
Harvard Medical School
Daniel Miller Professor of Otolaryngology–Head and Neck Surgery
About My Research
Dr. Derrick Lin’s research interests include head and neck cancer (including oral cavity, oropharynx, sinus, larynx), cranial base surgery, microvascular reconstruction, skull base tumors, head and neck reconstruction, salivary gland tumors, and robotic surgery.
Publications powered by Harvard Catalyst Profiles
- Early Weight-Bearing After Fibula Free Flap Surgery. JAMA Otolaryngol Head Neck Surg. 2024 Feb 01; 150(2):127-132.
- International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors. Int Forum Allergy Rhinol. 2024 Feb; 14(2):149-608.
- Predictors of multiple dilations and functional outcomes after total laryngectomy and laryngopharyngectomy. Head Neck. 2024 Jan; 46(1):138-144.
- Neck scar perception after neck dissection in HPV-associated oropharyngeal squamous cell carcinoma. Am J Otolaryngol. 2024 Jan-Feb; 45(1):104074.
- Depth of resection predicts loss of tongue tip sensation after partial glossectomy in oral tongue cancer: A pilot study. Oral Oncol. 2023 Dec; 147:106595.
- CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers. Science. 2023 08 04; 381(6657):515-524.
- Atypical metastases highlight the true potential of ctDNA liquid biopsies for cancer monitoring. Oral Oncol. 2023 09; 144:106464.
- Protocol for tumor dissociation and fluorescence-activated cell sorting of human head and neck cancers. STAR Protoc. 2023 May 06; 4(2):102294.
- Comparison of patient-reported upper extremity disability following free flaps in head and neck reconstruction: A systematic review and meta-analysis. Head Neck. 2023 07; 45(7):1832-1840.
- Inferring early genetic progression in cancers with unobtainable premalignant disease. Nat Cancer. 2023 04; 4(4):550-563.
- Surgical factors affecting regionally metastatic cutaneous squamous cell carcinoma to the parotid gland. Head Neck. 2023 05; 45(5):1080-1087.
- Comparison of Preoperative DOI Estimation in Oral Tongue Cancer With cN0 Disease. Otolaryngol Head Neck Surg. 2023 10; 169(4):948-953.
- Molecular Evidence for Olfactory Neuroblastoma as a Tumor of Malignant Globose Basal Cells. Mod Pathol. 2023 05; 36(5):100122.
- Cross-legged modification for medial sural artery perforator flap harvest. Head Neck. 2023 03; 45(3):752-756.
- Single-cell RNA sequencing identifies a paracrine interaction that may drive oncogenic notch signaling in human adenoid cystic carcinoma. Cell Rep. 2022 Nov 29; 41(9):111743.
- Rate of atypical nodal metastases in surgically treated HPV-associated oropharyngeal squamous cell carcinoma. Head Neck. 2023 02; 45(2):409-416.
- Chemoradiation therapy alters the PD-L1 score in locoregional recurrent squamous cell carcinomas of the head and neck. Oral Oncol. 2022 12; 135:106183.
- YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4. Cell Rep. 2022 06 14; 39(11):110970.
- Cell-Free HPV DNA Provides an Accurate and Rapid Diagnosis of HPV-Associated Head and Neck Cancer. Clin Cancer Res. 2022 02 15; 28(4):719-727.
- Cell-free human papillomavirus DNA kinetics after surgery for human papillomavirus-associated oropharyngeal cancer. Cancer. 2022 06 01; 128(11):2193-2204.
- Immediate postoperative non-invasive positive pressure ventilation following midface microvascular free flap reconstruction. Cancer Rep (Hoboken). 2022 07; 5(7):e1518.
- Pneumonia, urinary tract infection, bacteremia, and Clostridioides difficile infection following major head and neck free and pedicled flap surgeries. Oral Oncol. 2021 11; 122:105541.
- Assessment of Preoperative Functional Status Prior to Major Head and Neck Surgery: A Pilot Study. Otolaryngol Head Neck Surg. 2022 04; 166(4):688-695.
- Feeding Tube Placement Following Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma. Otolaryngol Head Neck Surg. 2022 04; 166(4):696-703.
- Prediction of Speech, Swallowing, and Quality of Life in Oral Cavity Cancer Patients: A Pilot Study. Laryngoscope. 2021 11; 131(11):2497-2504.
- Nasal and paranasal sinus mucosal melanoma: Long-term survival outcomes and prognostic factors. Am J Otolaryngol. 2021 Nov-Dec; 42(6):103070.
- Impact of surgical margins on local control in patients undergoing single-modality transoral robotic surgery for HPV-related oropharyngeal squamous cell carcinoma. Head Neck. 2021 08; 43(8):2434-2444.
- Prospective assessment of multiple HPV-positive oropharyngeal squamous cell carcinomas. Oral Oncol. 2021 06; 117:105212.
- Adenoid Cystic Carcinoma of the Nasopharynx with Skull Base Involvement: Retrospective National Cohort Analysis of Treatment Paradigms, Outcomes, and Provider Density. J Neurol Surg B Skull Base. 2022 Feb; 83(1):99-104.
- Opioid Usage and Prescribing Predictors Following Transoral Robotic Surgery for Oropharyngeal Cancer. Laryngoscope. 2021 06; 131(6):E1888-E1894.
- AHNS endocrine surgery section consensus statement on nasopharyngolaryngoscopy and clinic reopening during COVID-19: How to get back to optimal safe care. Head Neck. 2021 02; 43(2):733-738.
- Malignant cell-specific CXCL14 promotes tumor lymphocyte infiltration in oral cavity squamous cell carcinoma. J Immunother Cancer. 2020 09; 8(2).
- Risk Factors for Laryngectomy for Dysfunctional Larynx After Organ Preservation Protocols: A Case-Control Analysis. Otolaryngol Head Neck Surg. 2021 03; 164(3):608-615.
- Programmed cell death ligand-1 and cytotoxic T cell infiltrates in metastatic cutaneous squamous cell carcinoma of the head and neck. Head Neck. 2020 11; 42(11):3226-3234.
- RUVBL1 is an amplified epigenetic factor promoting proliferation and inhibiting differentiation program in head and neck squamous cancers. Oral Oncol. 2020 12; 111:104930.
- Controversies in the Workup and Surgical Management of Parotid Neoplasms. Otolaryngol Head Neck Surg. 2021 01; 164(1):27-36.
- Predicting length of stay in head and neck patients who undergo free flap reconstruction. Laryngoscope Investig Otolaryngol. 2020 Jun; 5(3):461-467.
- Prognostic Impact of Adverse Pathologic Features in Sinonasal Squamous Cell Carcinoma. J Neurol Surg B Skull Base. 2021 Jul; 82(Suppl 3):e114-e119.
- Predictive factors for prolonged operative time in head and neck patients undergoing free flap reconstruction. Am J Otolaryngol. 2020 Mar - Apr; 41(2):102392.
- Withdrawal: Peroxisome proliferator-activated receptor ? ligands suppress the transcriptional activation of cyclooxygenase-2: Evidence for involvement of activator protein-1 and CREB-binding protein/p300. J Biol Chem. 2020 01 03; 295(1):291.
- SUPREME-HN: a retrospective biomarker study assessing the prognostic value of PD-L1 expression in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck. J Transl Med. 2019 12 26; 17(1):429.
- Human Papillomavirus Related Multiphenotypic Sinonasal Carcinoma: Report of a Case with Early and Progressive Metastatic Disease. J Neurol Surg Rep. 2019 Oct; 80(4):e41-e43.
- Outcomes and prognostic factors in parotid gland malignancies: A 10-year single center experience. Laryngoscope Investig Otolaryngol. 2019 Dec; 4(6):632-639.
- Immunohistochemical quantification of partial-EMT in oral cavity squamous cell carcinoma primary tumors is associated with nodal metastasis. Oral Oncol. 2019 12; 99:104458.
- Composite Nasoseptal Flap for Palate Reconstruction. J Craniofac Surg. 2019 Oct; 30(7):1990-1993.
- Adenoid Cystic Carcinoma of the Skull Base: Response to Radiation Therapy and Outcomes in a Retrospective Case Series. J Neurol Surg B Skull Base. 2020 Oct; 81(5):505-510.
- Association of Estrogen Receptor Alpha Expression With Survival in Oropharyngeal Cancer Following Chemoradiation Therapy. J Natl Cancer Inst. 2019 09 01; 111(9):933-942.
- Intratumoral delivery of an HPV vaccine elicits a broad anti-tumor immune response that translates into a potent anti-tumor effect in a preclinical murine HPV model. Cancer Immunol Immunother. 2019 Aug; 68(8):1273-1286.
- Mucoepidermoid Carcinoma of the Parotid: Very Close Margins and Adjuvant Radiotherapy. ORL J Otorhinolaryngol Relat Spec. 2019; 81(1):55-62.
- Clinically Integrated Molecular Diagnostics in Adenoid Cystic Carcinoma. Oncologist. 2019 10; 24(10):1356-1367.
- Postoperative care in an intermediate-level medical unit after head and neck microvascular free flap reconstruction. Laryngoscope Investig Otolaryngol. 2019 Feb; 4(1):39-42.
- Exosome swarms eliminate airway pathogens and provide passive epithelial immunoprotection through nitric oxide. J Allergy Clin Immunol. 2019 04; 143(4):1525-1535.e1.
- Close Margins and Adjuvant Radiotherapy in Acinic Cell Carcinoma of the Parotid Gland. JAMA Otolaryngol Head Neck Surg. 2018 11 01; 144(11):1011-1016.
- Transfusion in Head and Neck Cancer Patients Undergoing Pedicled Flap Reconstruction. Laryngoscope. 2018 12; 128(12):E409-E415.
- Tip-on-Tip Scapular (TOTS) Flap for Reconstruction of Combined Palatectomy and Rhinectomy Defects. Facial Plast Surg. 2018 Aug; 34(4):389-393.
- Oncologic and functional outcomes of pretreatment tracheotomy in advanced laryngeal squamous cell carcinoma: A multi-institutional analysis. Oral Oncol. 2018 03; 78:171-176.
- Factors affecting survival and locoregional control in head and neck cSCCA with nodal metastasis. Laryngoscope. 2018 08; 128(8):1881-1886.
- Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer. Cell. 2017 Dec 14; 171(7):1611-1624.e24.
- Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma. Am J Surg Pathol. 2017 Nov; 41(11):1473-1482.
- PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs. Cancer Res. 2017 11 15; 77(22):6365-6374.
- Robotic epiglottopexy for severe epiglottic prolapse limiting decannulation. Int J Pediatr Otorhinolaryngol. 2017 Nov; 102:157-159.
- Risk factors for thirty-day readmission following flap reconstruction of oncologic defects of the head and neck. Laryngoscope. 2018 02; 128(2):343-349.
- Locoregional Flaps for Oral Cavity Reconstruction: A Review of Modern Options. Otolaryngol Head Neck Surg. 2017 08; 157(2):201-209.
- Mucosal Thickening Occurs in Contralateral Paranasal Sinuses following Sinonasal Malignancy Treatment. J Neurol Surg B Skull Base. 2017 Aug; 78(4):331-336.
- The Role of Chemotherapy in the Management of Sinonasal and Ventral Skull Base Malignancies. Otolaryngol Clin North Am. 2017 Apr; 50(2):433-441.
- Locoregional control of tongue base adenoid cystic carcinoma with primary resection and radial forearm free flap reconstruction. Ear Nose Throat J. 2017 Jan; 96(1):37-40.
- Surgical Site Infections in Major Head and Neck Surgeries Involving Pedicled Flap Reconstruction. Ann Otol Rhinol Laryngol. 2017 Jan; 126(1):20-28.
- Perioperative Deep Vein Thrombosis Risk Stratification. Otolaryngol Head Neck Surg. 2017 01; 156(1):118-121.
- Update on Surgical Outcomes of Lateral Temporal Bone Resection for Ear and Temporal Bone Malignancies. J Neurol Surg B Skull Base. 2017 Feb; 78(1):37-42.
- Risk factors for surgical site infection after supraclavicular flap reconstruction in patients undergoing major head and neck surgery. Head Neck. 2016 11; 38(11):1615-1620.
- Head and neck cancer in South Asia: Macroeconomic consequences and the role of the head and neck surgeon. Head Neck. 2016 08; 38(8):1242-7.
- An Algorithm for Surgical Approach to the Anterior Skull Base. J Neurol Surg B Skull Base. 2016 Aug; 77(4):364-70.
- Long-Term Outcomes After Proton Beam Therapy for Sinonasal Squamous Cell Carcinoma. Int J Radiat Oncol Biol Phys. 2016 May 01; 95(1):368-376.
- Skull base erosion and associated complications in sphenoid sinus fungal balls. Allergy Rhinol (Providence). 2016 Jan 01; 7(4):227-232.
- Identification of insertions in PTEN and TP53 in anaplastic thyroid carcinoma with angiogenic brain metastasis. Endocr Relat Cancer. 2015 Dec; 22(6):L23-8.
- Skull Base Surgery Training and Practice Patterns among Recent Otolaryngology Fellowship Graduates. J Neurol Surg B Skull Base. 2016 Aug; 77(4):297-303.
- Comparison of Perioperative Outcomes between the Supraclavicular Artery Island Flap and Fasciocutaneous Free Flap. Otolaryngol Head Neck Surg. 2016 Jan; 154(1):66-72.
- Long-term Functional Outcomes of Total Glossectomy With or Without Total Laryngectomy. JAMA Otolaryngol Head Neck Surg. 2015 Sep; 141(9):797-803.
- Reconstruction of the Lateral Mandibular Defect: A Review and Treatment Algorithm. JAMA Facial Plast Surg. 2015 Sep-Oct; 17(5):367-73.
- Endoscopic sinus surgery for chronic rhinosinusitis in patients previously treated for sinonasal malignancy. Laryngoscope. 2016 Feb; 126(2):304-15.
- Head and neck free flap surgical site infections in the era of the Surgical Care Improvement Project. Head Neck. 2016 04; 38 Suppl 1:E392-8.
- Immediate and Delayed Complications Following Endoscopic Skull Base Surgery. J Neurol Surg B Skull Base. 2015 Sep; 76(5):390-6.
- Reconstruction of Lateral Skull Base Defects with Radial Forearm Free Flaps: The Double-Layer Technique. J Neurol Surg B Skull Base. 2015 Aug; 76(4):257-61.
- Transfusion in head and neck free flap patients: practice patterns and a comparative analysis by flap type. Otolaryngol Head Neck Surg. 2015 Mar; 152(3):449-57.
- The time course and microbiology of surgical site infections after head and neck free flap surgery. Laryngoscope. 2015 May; 125(5):1084-9.
- The value of a collaborative course for advanced head and neck surgery in East Africa. Laryngoscope. 2015 Apr; 125(4):883-7.
- Delayed Endovascular Coil Extrusion following Internal Carotid Artery Embolization. J Neurol Surg Rep. 2014 Dec; 75(2):e255-8.
- Case records of the Massachusetts General Hospital. Case 32-2014. A 78-year-old woman with chronic sore throat and a tonsillar mass. N Engl J Med. 2014 Oct 16; 371(16):1535-43.
- Incidence and survival patterns of sinonasal undifferentiated carcinoma in the United States. J Neurol Surg B Skull Base. 2015 Mar; 76(2):94-100.
- Supraclavicular artery island flap for reconstruction of complex parotidectomy, lateral skull base, and total auriculectomy defects. JAMA Otolaryngol Head Neck Surg. 2014 Sep; 140(9):861-6.
- Locoregional and free flap reconstruction of the lateral skull base. Head Neck. 2015 Sep; 37(9):1387-91.
- Treatment outcomes and prognostic factors, including human papillomavirus, for sinonasal undifferentiated carcinoma: a retrospective review. Head Neck. 2015 Mar; 37(3):366-74.
- Delayed complications after anterior craniofacial resection of malignant skull base tumors. J Neurol Surg B Skull Base. 2014 Apr; 75(2):110-6.
- Incidence and survival patterns of cranial chordoma in the United States. Laryngoscope. 2014 May; 124(5):1097-102.
- Surgical treatment of traumatic injuries of the cranial base. Otolaryngol Clin North Am. 2013 Oct; 46(5):749-57.
- Esthesioneuroblastoma: an update on the massachusetts eye and ear infirmary and massachusetts general hospital experience with craniofacial resection, proton beam radiation, and chemotherapy. J Neurol Surg B Skull Base. 2014 Feb; 75(1):58-64.
- Metastatic renal cell carcinoma to the sinonasal cavity: a case series. J Neurol Surg Rep. 2013 Dec; 74(2):67-72.
- Orbital preservation in patients with esthesioneuroblastoma. J Neurol Surg B Skull Base. 2013 Jun; 74(3):142-5.
- Microvascular free flaps in skull base reconstruction. Adv Otorhinolaryngol. 2013; 74:81-91.
- Rehabilitation of a parotidectomy patient--a systematic approach. Head Neck. 2013 Sep; 35(9):1349-61.
- Free flap reconstruction in 1999 and 2009: changing case characteristics and outcomes. Laryngoscope. 2012 Oct; 122(10):2160-3.
- Pathology quiz case 1. Liposarcoma of the hypopharynx. Arch Otolaryngol Head Neck Surg. 2012 Mar; 138(3):313-5.
- Syndrome of inappropriate antidiuretic hormone secretion in patients with olfactory neuroblastoma. Otolaryngol Head Neck Surg. 2012 Jul; 147(1):147-51.
- Intercalated duct lesion of the parotid. Head Neck Pathol. 2012 Sep; 6(3):373-6.
- Immunohistochemical characterization of human olfactory tissue. Laryngoscope. 2011 Aug; 121(8):1687-701.
- Simplified technique of tracheoesophageal prosthesis placement at the time of secondary tracheoesophageal puncture (TEP). Laryngoscope. 2011 Sep; 121(9):1855-9.
- Vacuum-assisted closure in revision free flap reconstruction. Arch Otolaryngol Head Neck Surg. 2011 Jun; 137(6):622-4.
- Surgical salvage of the oropharynx after failure of organ-sparing therapy. Head Neck. 2011 Apr; 33(4):516-24.
- Closure of laryngectomy defects in the age of chemoradiation therapy. Head Neck. 2012 Apr; 34(4):580-8.
- Risk of incisional recurrence after midface and anterior skull base surgery in sinonasal malignancies. Skull Base. 2011 Mar; 21(2):87-92.
- Pathology quiz case 1. Angiosarcoma. Arch Otolaryngol Head Neck Surg. 2011 Feb; 137(2):198, 200-1.
- Primary TEP placement in patients with laryngopharyngeal free tissue reconstruction and salivary bypass tube placement. Otolaryngol Head Neck Surg. 2011 Mar; 144(3):474-6.
- Efficacy of Proton Beam Therapy in the Treatment of Ewing's Sarcoma of the Paranasal Sinuses and Anterior Skull Base. Skull Base. 2009 Nov; 19(6):409-16.
- Proton radiation therapy for primary sphenoid sinus malignancies: treatment outcome and prognostic factors. Head Neck. 2009 Oct; 31(10):1297-308.
- Malignant transformation of a highly aggressive human papillomavirus type 11-associated recurrent respiratory papillomatosis. Am J Otolaryngol. 2010 Jul-Aug; 31(4):291-6.
- Evaluation of voice prosthesis placement at the time of primary tracheoesophageal puncture with total laryngectomy. Laryngoscope. 2009 Jul; 119(7):1353-7.
- Imaging of optic nerve head drusen: improvements with spectral domain optical coherence tomography. J Glaucoma. 2009 Jun-Jul; 18(5):373-8.
- The use of nasopharyngeal airways for airway diversion in anterior craniofacial resection. Am J Rhinol. 2008 Sep-Oct; 22(5):529-32.
- Esthesioneuroblastoma: the massachusetts eye and ear infirmary and massachusetts general hospital experience with craniofacial resection, proton beam radiation, and chemotherapy. Skull Base. 2008 Sep; 18(5):327-37.
- The occipital flap for reconstruction after lateral temporal bone resection. Arch Otolaryngol Head Neck Surg. 2008 Jun; 134(6):587-91.
- Extent of surgery in the management of locally advanced sinonasal malignancies. Head Neck. 2008 Feb; 30(2):222-9.
- Management outcomes following lateral temporal bone resection for ear and temporal bone malignancies. Otolaryngol Head Neck Surg. 2007 Dec; 137(6):893-8.
- Case records of the Massachusetts General Hospital. Case 20-2007. An 11-year-old boy with a calcified mass in the nose. N Engl J Med. 2007 Jun 28; 356(26):2721-30.
- Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch Otolaryngol Head Neck Surg. 2006 Nov; 132(11):1242-9.
- Immunohistochemical distinction of intestinal-type sinonasal adenocarcinoma from metastatic adenocarcinoma of intestinal origin. Ann Otol Rhinol Laryngol. 2006 Jan; 115(1):59-64.
- Squamous cell carcinoma of the oropharynx and hypopharynx. Otolaryngol Clin North Am. 2005 Feb; 38(1):59-74, viii.
- Success of multiple, sequential, free tissue transfers to the head and neck. Laryngoscope. 2005 Jan; 115(1):101-4.
- Tumors of the accessory lobe of the parotid gland: a 10-year experience. Laryngoscope. 2004 Sep; 114(9):1652-5.
- Current concepts in lip reconstruction. Curr Opin Otolaryngol Head Neck Surg. 2004 Aug; 12(4):281-7.
- Use of the anterolateral thigh flap for reconstruction of the head and neck. Curr Opin Otolaryngol Head Neck Surg. 2004 Aug; 12(4):300-4.
- Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer. Head Neck. 2002 Aug; 24(8):792-9.
- Incidence of inadvertent parathyroid removal during thyroidectomy. Laryngoscope. 2002 Apr; 112(4):608-11.
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