Frederick A. Jakobiec, M.D., D.Sc.

Harvard Medical School

Henry Willard Williams Professor of Ophthalmology, Emeritus Department of Ophthalmology

Massachusetts Eye and Ear

Director, David G. Cogan Ophthalmic Pathology Laboratory
Director, Eye Pathology Service
Director, Ophthalmic Pathology Fellowship
Senior Scientist


Research Summary

Center/Research Area Affiliations

Research Summary

Dr. Jakobiec's clinical and research interests have centered on inflammation and tumors of the eye and surrounding tissues. As a clinician, he advanced cryotherapy for conjunctival melanomas and squamous carcinomas as well as concentrated on orbital tumors, particularly lymphomas, and was responsible for a 450 page chapter on orbital diseases in Spencer's four volume definitive textbook on Ophthalmic Pathology. Throughout his career, Dr. Jakobiec has focused much of his efforts on ophthalmic education. He has served a myriad of visiting lectureships and professorships at over 50 institutions and societies, and has received numerous awards and medals.

Selected Publications

Please see Dr. Jackobiec's CV

Naming the Precursors of Conjunctival Melanoma. Jakobiec FA. Am J Ophthalmol. 2016 Feb 4.

Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas. Sahm F, Jakobiec FA, Meyer J, Schrimpf D, Eberhart CG, Hovestadt V, Capper D, Lambo S, Ryzhova M, Schüller U, Zheludkova O, Kumirova E, Lichter P, von Deimling A, Jones DT, Pfister SM, Kool M, Korshunov A. Genes Chromosomes Cancer. 2016 Feb 4.

Nonlimbal Squamous Cell Carcinoma of the Conjunctiva. Choi CJ, Stagner AM, Jakobiec FA, Lee NG. Ophthalmology. 2016 Feb;123(2):254.

Limbal Mantle Cell Lymphoma of the Conjunctiva. Choi CJ, Stagner AM, Jakobiec FA, Lee NG. Ophthalmology. 2016 Feb;123(2):377.

Evaluation for High-risk HPV in Squamous Cell Carcinomas and Precursor Lesions Arising in the Conjunctiva and Lacrimal Sac. Afrogheh AH, Jakobiec FA, Hammon R, Grossniklaus HE, Rocco J, Lindeman NI, Sadow PM, Faquin WC. Am J Surg Pathol. 2016 Jan 5.

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