Deeba Husain,
MD
Massachusetts Eye and Ear
Associate Scientist
Harvard Medical School
Associate Professor of Ophthalmology
Co-Director, AMD Center of Excellence
deeba_husain@meei.harvard.edu
For investigator inquiries only
About My Research
Centers of Excellence/Institutes
- AMD Center of Excellence
- Diabetic Eye Disease Center of Excellence
- Mobility Enhancement and Vision Rehabilitation Center of Excellence
Research Programs/Laboratories
- Harvard Retinal Metabolomics Program
- Ines and Frederick Yeatts Retina Research Laboratory
- Harvard Retinal Imaging Laboratory
- JW Miller AMD Research Group
Biography
Dr. Husain is a clinician scientist who is involved in evaluating the pathogenesis of, and newer treatments for, age related macular degeneration. She has played an important role in innovative research that led to discovery of two new treatments of the ocular neovascularization including Wet age-related macular degeneration. This included pioneering work on the treatment parameters of photodynamic therapy (PDT) on animal model, and she helped established the role of vascular endothelial growth factor in combination with PDT in the primate model of choroidal neovascularization.
She is currently serving as the principal investigator of the Harvard Retina Metabolomics program. She has developed a collaborative group with expertise in retinal disease from Mass Eye and Ear, expertise in metabolomics and biostats from Channing Lab of Brigham and Women’s Hospital, Harvard Medical School, and genetics epidemiology Harvard School of Public Health. The collaboration is improving our understanding of pathogenesis of age-related macular degeneration, by using a novel tool called metabolomics, and correlating it with genomics, retinal structure and function. This work is helping us find novel biomarkers for disease and point to new targets for treatment of age-related macular degeneration. She will continue to head both investigator-initiated and industry-sponsored trials to find better therapeutics for retinal diseases.
Education
1986: MD Jawaharlal Nehru Medical College, Aligarh University, Aligarh, India
1990: Master of Surgery in Ophthalmology. Institute of Ophthalmology Aligarh University, Aligarh, India
Postgraduate Training
1986: Rotating Internship, Jawaharlal Nehru Medical School, Aligarh University, Aligarh, India
7/91-6/92: Research Fellow Department of Ophthalmology, University of Maryland, Baltimore, USA.
4/94-12/95: Research Fellow with Prof. E. S. Gragoudas and Dr. Joan W. Miller. Retina Service, Laser Lab, MEEI Harvard University School of Medicine, Boston, USA
1/96 -6/96: Fellow with Prof. J. D. M. Gass Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, Nashville, USA
9/96-6/97: Clinical Research Fellow Retina Service, Massachusetts Eye & Ear Infirmary, Harvard University School of Medicine, Boston, USA
6/97-6/98: Internship in Preliminary Medicine. Newton Wellesley Hospital, Tufts University, Boston, USA
7/98-6/01 Residency in Ophthalmology Massachusetts Eye & Ear Infirmary, Harvard University School of Medicine, Boston, USA
7/01–6/03 Vitreoretinal Fellowship. Massachusetts Eye & Ear Infirmary, Harvard University School of Medicine, Boston, USA
Academic Appointments
2003 - 11: Assistant Professor of Ophthalmology, Boston University School of Medicine,
2011 - 2014: Associate Professor of Ophthalmology, Boston University School of Medicine
2014 - present: Associate Professor of Ophthalmology, Harvard Medical School Professional Memberships
1990: Life Member, All India Ophthalmic Society
1990: Life Member, Uttar Pradesh State Ophthalmic Society, India
1991: Federation of Ophthalmic Research and Education, India
1997: American Academy of Ophthalmology
2000: Association for Research in Vision and Ophthalmology
2006: New England Ophthalmological Society
2007: Retina Society
2011: Mass Medical Society
Honors
1986: Gold Medal for First Position in Anatomy, Physiology, Biochemistry, Pathology, Social and Preventive Medicine, Ophthalmology, Obstetrics and Gynecology, Internal Medicine
1986: President of India Award for top rank in MBBS
1987: Pfizer award for outstanding medical student
1994: Research to Prevent Blindness award.
2004: Outstanding Teacher award (Dept of Ophthalmology, BUSM)
2010: Academic Excellence award (Dept of Ophthalmology, BUSM)
2011: Behrooz Koleini best clinical teacher award (Department of Ophthalmology, BUSM)
Publications powered by Harvard Catalyst Profiles
- Assessment of Microvascular Changes After Rhegmatogenous Retinal Detachment Repair Using Wide-Field Swept-Source Optical Coherence Tomography Angiography. Ophthalmic Surg Lasers Imaging Retina. 2024 Mar 01; 1-8.
- Changes in wider field swept-source OCT angiography vascular metrics with anti-vascular endothelial growth factor therapy in central retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. 2024 Feb 20.
- Quantitative Contrast Sensitivity Function and the Effect of Aging in Healthy Adult Eyes: A Normative Database. Ophthalmic Surg Lasers Imaging Retina. 2024 Feb 01; 1-9.
- Evaluation of a mobile app for dark adaptation measurement in individuals with age-related macular degeneration. Sci Rep. 2023 12 14; 13(1):22191.
- Characterizing Macular Neovascularization in Myopic Macular Degeneration and Age-Related Macular Degeneration Using Swept Source OCTA. Clin Ophthalmol. 2023; 17:3855-3866.
- Widefield swept-source optical coherence tomography angiography metrics associated with neovascular glaucoma in patients with proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol. 2024 Apr; 262(4):1111-1120.
- Associations of quantitative contrast sensitivity with wide-field swept-source optical coherence tomography angiography in retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. 2024 Mar; 262(3):789-799.
- Comparative study of widefield swept-source optical coherence tomography angiography in eyes with concomitant age-related macular degeneration and diabetic retinopathy. Br J Ophthalmol. 2023 Oct 16.
- Quantitative Wide-Field Swept-Source Optical Coherence Tomography Angiography and Visual Outcomes in RAO. Clin Ophthalmol. 2023; 17:2505-2513.
- Plasma Metabolites Associated with OCT Features of Age-Related Macular Degeneration. Ophthalmol Sci. 2024 Jan-Feb; 4(1):100357.
- Integrating genetics and metabolomics from multi-ethnic and multi-fluid data reveals putative mechanisms for age-related macular degeneration. Cell Rep Med. 2023 07 18; 4(7):101085.
- Structure-function associations between contrast sensitivity and widefield swept-source optical coherence tomography angiography in diabetic macular edema. Graefes Arch Clin Exp Ophthalmol. 2023 Nov; 261(11):3113-3124.
- Prevalence of venous loops and association with retinal ischemia in diabetic retinopathy using widefield swept-source OCT angiography. Graefes Arch Clin Exp Ophthalmol. 2023 Jul; 261(7):1861-1870.
- Controversies and Disparities in the Management of Age-Related Macular Degeneration. Semin Ophthalmol. 2023 Feb; 38(2):134-142.
- Structure-function association between contrast sensitivity and retinal thickness (total, regional, and individual retinal layer) in patients with idiopathic epiretinal membrane. Graefes Arch Clin Exp Ophthalmol. 2023 Mar; 261(3):631-639.
- The Effect of Sample Medication Use on Subsequent Anti-VEGF Agent Selection for Neovascular Age-Related Macular Degeneration. Semin Ophthalmol. 2022 Oct-Nov; 37(7-8):902-908.
- Nonperfusion Area and Other Vascular Metrics by Wider Field Swept-Source OCT Angiography as Biomarkers of Diabetic Retinopathy Severity. Ophthalmol Sci. 2022 Jun; 2(2).
- Dark Adaptation and Its Role in Age-Related Macular Degeneration. J Clin Med. 2022 Mar 01; 11(5).
- Urinary Mass Spectrometry Profiles in Age-Related Macular Degeneration. J Clin Med. 2022 Feb 11; 11(4).
- RP2 X-LINKED RETINITIS PIGMENTOSA CARRIER STATE PRESENTING WITH VASCULAR LEAKAGE AND UNILATERAL MACULAR ATROPHY. Retin Cases Brief Rep. 2023 Sep 01; 17(5):533-537.
- Dyslipidemia in age-related macular degeneration. Eye (Lond). 2022 02; 36(2):312-318.
- Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration. Metabolites. 2022 Jan 01; 12(1).
- BASELINE PREDICTORS ASSOCIATED WITH 3-YEAR CHANGES IN DARK ADAPTATION IN AGE-RELATED MACULAR DEGENERATION. Retina. 2021 Oct 01; 41(10):2098-2105.
- Wide-field swept-source optical coherence tomography angiography in the assessment of retinal microvasculature and choroidal thickness in patients with myopia. Br J Ophthalmol. 2023 01; 107(1):102-108.
- Area under the dark adaptation curve as a reliable alternate measure of dark adaptation response. Br J Ophthalmol. 2022 10; 106(10):1450-1456.
- Delayed dark adaptation in central serous chorioretinopathy. Am J Ophthalmol Case Rep. 2021 Jun; 22:101098.
- Association of Human Plasma Metabolomics with Delayed Dark Adaptation in Age-Related Macular Degeneration. Metabolites. 2021 Mar 21; 11(3).
- Genomic-Metabolomic Associations Support the Role of LIPC and Glycerophospholipids in Age-Related Macular Degeneration. Ophthalmol Sci. 2021 Mar; 1(1).
- Age-Related Macular Degeneration (AMD): A View to the Future. J Clin Med. 2021 Mar 08; 10(5).
- COVID-19 Launches Retinal Telemedicine into the Next Frontier. Semin Ophthalmol. 2021 May 19; 36(4):258-263.
- Widefield Swept-Source OCT Angiography Metrics Associated with the Development of Diabetic Vitreous Hemorrhage: A Prospective Study. Ophthalmology. 2021 09; 128(9):1312-1324.
- Contrast sensitivity function in patients with macular disease and good visual acuity. Br J Ophthalmol. 2022 06; 106(6):839-844.
- Detection of neovascularisation in the vitreoretinal interface slab using widefield swept-source optical coherence tomography angiography in diabetic retinopathy. Br J Ophthalmol. 2022 04; 106(4):534-539.
- A quantitative comparison of four optical coherence tomography angiography devices in healthy eyes. Graefes Arch Clin Exp Ophthalmol. 2021 Jun; 259(6):1493-1501.
- Comparison of widefield swept-source optical coherence tomography angiography with ultra-widefield colour fundus photography and fluorescein angiography for detection of lesions in diabetic retinopathy. Br J Ophthalmol. 2021 04; 105(4):577-581.
- Advances in Telemedicine in Ophthalmology. Semin Ophthalmol. 2020 May 18; 35(4):210-215.
- Subthreshold Exudative Choroidal Neovascularization Associated With Age-Related Macular Degeneration Identified by Optical Coherence Tomography Angiography. J Vitreoretin Dis. 2020 Oct; 4(5):377-385.
- Different Scan Protocols Affect the Detection Rates of Diabetic Retinopathy Lesions by Wide-Field Swept-Source Optical Coherence Tomography Angiography. Am J Ophthalmol. 2020 07; 215:72-80.
- Higher Intake of Polyunsaturated Fatty Acid and Monounsaturated Fatty Acid is Inversely Associated With AMD. Invest Ophthalmol Vis Sci. 2020 02 07; 61(2):20.
- MULTIMODAL IMAGING IN ACUTE RETINAL NECROSIS PRESENTING WITH MACULAR INVOLVEMENT. Retin Cases Brief Rep. 2022 May 01; 16(3):347-350.
- Imaging Artifacts and Segmentation Errors With Wide-Field Swept-Source Optical Coherence Tomography Angiography in Diabetic Retinopathy. Transl Vis Sci Technol. 2019 Nov; 8(6):18.
- Validation of RetmarkerAMD as a semiautomatic grading software for AMD. Eye (Lond). 2020 03; 34(3):600-602.
- Percentage of Foveal vs Total Macular Geographic Atrophy as a Predictor of Visual Acuity in Age-Related Macular Degeneration. J Vitreoretin Dis. 2019 Sep; 3(5):278-282.
- Human Plasma Metabolomics in Age-Related Macular Degeneration: Meta-Analysis of Two Cohorts. Metabolites. 2019 Jul 02; 9(7).
- Urine Nuclear Magnetic Resonance (NMR) Metabolomics in Age-Related Macular Degeneration. J Proteome Res. 2019 03 01; 18(3):1278-1288.
- Microperimetry in age-related macular degeneration: association with macular morphology assessed by optical coherence tomography. Br J Ophthalmol. 2019 12; 103(12):1769-1776.
- Mouse model of ocular hypertension with retinal ganglion cell degeneration. PLoS One. 2019; 14(1):e0208713.
- Metabolomics in the study of retinal health and disease. Prog Retin Eye Res. 2019 03; 69:57-79.
- Reply. Ophthalmology. 2018 07; 125(7):e46-e47.
- Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment. Proc Natl Acad Sci U S A. 2018 07 03; 115(27):E6264-E6273.
- HEALTH CONDITIONS LINKED TO AGE-RELATED MACULAR DEGENERATION ASSOCIATED WITH DARK ADAPTATION. Retina. 2018 Jun; 38(6):1145-1155.
- Imaging the Deep Choroidal Vasculature Using Spectral Domain and Swept Source Optical Coherence Tomography Angiography. J Vitreoretin Dis. 2018 May-Jun; 2(3):146-154.
- Peripheral Changes Associated With Delayed Dark Adaptation in Age-related Macular Degeneration. Am J Ophthalmol. 2018 06; 190:113-124.
- Evaluation of choroidal lesions with swept-source optical coherence tomography. Br J Ophthalmol. 2019 01; 103(1):88-93.
- The Complement System Is Critical in Maintaining Retinal Integrity during Aging. Front Aging Neurosci. 2018; 10:15.
- CHOROIDAL THICKNESS IN DIABETIC RETINOPATHY ASSESSED WITH SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY. Retina. 2018 Jan; 38(1):173-182.
- Panretinal Photocoagulation: A Review of Complications. Semin Ophthalmol. 2018; 33(1):83-88.
- Novel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration. Clin Ophthalmol. 2017; 11:1967-1974.
- Diabetic Choroidopathy: Choroidal Vascular Density and Volume in Diabetic Retinopathy With Swept-Source Optical Coherence Tomography. Am J Ophthalmol. 2017 Dec; 184:75-83.
- Human Plasma Metabolomics Study across All Stages of Age-Related Macular Degeneration Identifies Potential Lipid Biomarkers. Ophthalmology. 2018 02; 125(2):245-254.
- Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization. Proc Natl Acad Sci U S A. 2017 09 05; 114(36):E7545-E7553.
- Choroidal Changes Associated With Subretinal Drusenoid Deposits in Age-related Macular Degeneration Using Swept-source Optical Coherence Tomography. Am J Ophthalmol. 2017 Aug; 180:55-63.
- Human plasma metabolomics in age-related macular degeneration (AMD) using nuclear magnetic resonance spectroscopy. PLoS One. 2017; 12(5):e0177749.
- Structural Changes Associated with Delayed Dark Adaptation in Age-Related Macular Degeneration. Ophthalmology. 2017 09; 124(9):1340-1352.
- Automated Brightness and Contrast Adjustment of Color Fundus Photographs for the Grading of Age-Related Macular Degeneration. Transl Vis Sci Technol. 2017 Mar; 6(2):3.
- Intravenous Drug Use-Associated Endophthalmitis. Ophthalmol Retina. 2017 May - Jun; 1(3):192-199.
- The Efficacy and Safety Profile of Ocriplasmin in Vitreomacular Interface Disorders. Semin Ophthalmol. 2017; 32(1):52-55.
- Association of serum lipid levels with retinal hard exudate area in African Americans with type 2 diabetes. Graefes Arch Clin Exp Ophthalmol. 2017 Mar; 255(3):509-517.
- OPTICAL COHERENCE TOMOGRAPHY CHARACTERISTICS OF MACULAR EDEMA AND HARD EXUDATES AND THEIR ASSOCIATION WITH LIPID SERUM LEVELS IN TYPE 2 DIABETES. Retina. 2016 Sep; 36(9):1622-9.
- Characteristics and Outcomes of Simultaneous Bilateral Rhegmatogenous Retinal Detachments. Ophthalmic Surg Lasers Imaging Retina. 2016 09 01; 47(9):840-5.
- Endogenous Endophthalmitis in the American and Korean Population: An 8-year Retrospective Study. Ocul Immunol Inflamm. 2018; 26(4):496-503.
- Iris abscess a rare presentation of intravenous drug abuse associated Candida endophthalmitis. Am J Ophthalmol Case Rep. 2016 Dec; 4:27-29.
- Risk Factors for Proliferative Diabetic Retinopathy in African Americans with Type 2 Diabetes. Ophthalmic Epidemiol. 2016; 23(2):88-93.
- Second Primary Neoplasms in Patients With Uveal Melanoma: A SEER Database Analysis. Am J Ophthalmol. 2016 05; 165:54-64.
- Intravitreal aflibercept for macular oedema secondary to central retinal vein occlusion in patients with prior treatment with bevacizumab or ranibizumab. Eye (Lond). 2016 Jan; 30(1):79-84.
- Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury. Sci Transl Med. 2015 Jul 22; 7(297):297ra116.
- African Ancestry Analysis and Admixture Genetic Mapping for Proliferative Diabetic Retinopathy in African Americans. Invest Ophthalmol Vis Sci. 2015 Jun; 56(6):3999-4005.
- Vitreous evaluation: a diagnostic challenge. Ophthalmology. 2015 Mar; 122(3):531-7.
- Characterization of a spontaneous retinal neovascular mouse model. PLoS One. 2014; 9(9):e106507.
- Retinal detachment associated with traumatic chorioretinal rupture. Ophthalmic Surg Lasers Imaging Retina. 2014 Sep-Oct; 45(5):451-5.
- Ocriplasmin for treatment of stage 2 macular holes: early clinical results. Ophthalmic Surg Lasers Imaging Retina. 2014 Jul-Aug; 45(4):293-7.
- Angiography with a multifunctional line scanning ophthalmoscope. J Biomed Opt. 2012 Feb; 17(2):026008.
- c-Cbl inhibits angiogenesis and tumor growth by suppressing activation of PLC?1. Oncogene. 2011 May 12; 30(19):2198-206.
- Role of c-Cbl-dependent regulation of phospholipase Cgamma1 activation in experimental choroidal neovascularization. Invest Ophthalmol Vis Sci. 2010 Dec; 51(12):6803-9.
- High-definition spectral domain OCT of a subretinal nematode. Eye (Lond). 2010 Feb; 24(2):393-4.
- Chorioretinal changes heralding metastatic malignancy. Arch Ophthalmol. 2006 Dec; 124(12):1790-2.
- Investigating the effect of ciliary body photodynamic therapy in a glaucoma mouse model. Invest Ophthalmol Vis Sci. 2006 Jun; 47(6):2498-507.
- Effect of intravitreal injection of ranibizumab in combination with verteporfin PDT on normal primate retina and choroid. Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):357-63.
- Safety and efficacy of intravitreal injection of ranibizumab in combination with verteporfin PDT on experimental choroidal neovascularization in the monkey. Arch Ophthalmol. 2005 Apr; 123(4):509-16.
- Surgical approaches to retinal prosthesis implantation. Int Ophthalmol Clin. 2004; 44(1):105-11.
- Mechanisms of age-related macular degeneration. Ophthalmol Clin North Am. 2002 Mar; 15(1):87-91.
- Angiography of fluoresceinated anti-vascular endothelial growth factor antibody and dextrans in experimental choroidal neovascularization. Arch Ophthalmol. 2000 Jan; 118(1):78-84.
- Verteporfin photodynamic therapy retreatment of normal retina and choroid in the cynomolgus monkey. Ophthalmology. 1999 Oct; 106(10):1915-23.
- Effects of photodynamic therapy using verteporfin on experimental choroidal neovascularization and normal retina and choroid up to 7 weeks after treatment. Invest Ophthalmol Vis Sci. 1999 Sep; 40(10):2322-31.
- Systemic hyperoxia decreases vascular endothelial growth factor gene expression in ischemic primate retina. Arch Ophthalmol. 1997 Dec; 115(12):1553-8.
- The role of neuronal and endothelial nitric oxide synthase in retinal excitotoxicity. Invest Ophthalmol Vis Sci. 1997 Sep; 38(10):2038-44.
- Photodynamic therapy and digital angiography of experimental iris neovascularization using liposomal benzoporphyrin derivative. Ophthalmology. 1997 Aug; 104(8):1242-50.
- Intravenous infusion of liposomal benzoporphyrin derivative for photodynamic therapy of experimental choroidal neovascularization. Arch Ophthalmol. 1996 Aug; 114(8):978-85.
- Posterior capsulotomy as a complication of indirect laser photocoagulation. Am J Ophthalmol. 1992 Nov 15; 114(5):600-2.
- Vibrational relaxation of HBr(nu'' = 1) by HCl at 300 K. Nature. 1970 Aug 08; 227(5258):602-3.
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