Michael S. Gilmore,
PhD
Massachusetts Eye and Ear
Chief Scientific Officer
Harvard Medical School
Sir William Osler Professor of Ophthalmology (Microbiology and Immunobiology)
Director, Infectious Disease Institute
michael_gilmore@meei.harvard.edu
For investigator inquiries only
About My Research
Center/Research Area Affiliations
Research Summary
Dr. Gilmore is the founder and Principal Investigator of the Harvard-wide Program on Antibiotic Resistance, and of the academic/industry consortium Boston-Area Antibiotic Resistance Network (BAARN). His research focuses on the evolution and development of multidrug resistant strains of enterococci, streptococci and staphylococci, and the development of new therapeutic approaches. Currently, he is developing new ways to prevent and treat the most problematic multidrug resistant infections. He serves on numerous advisory boards and committees for public (NIH, FDA, VA, NSF, EU) and private organizations, mainly focused on drug discovery, antibiotic resistance, and bacterial pathogenesis.
Dr. Gilmore's laboratory focuses on developing new ways to treat and prevent antibiotic resistant infection of the eye, ear, skin and other sites caused by enterococci and staphylococci. Enterococci and staphylococci are leading causes of multidrug resistant infection, particularly following surgery and in hospitalized patients. Since 2005, more people in the US have been killed by methicillin-resistant Staphylococcus aureus infection than by HIV/AIDS, and antibiotic resistant infection is adding more than $30 billion per year to healthcare costs.
Education
1977: BA, Health Science, Kalamazoo College
1978: MS, Grain Science and Industry, Kansas State University
1981: MS, Biochemistry and Molecular Biology, Colin MacLeod Fellow, University of Oklahoma Health Sciences Center
1982: PhD, Biochemistry and Molecular Biology, Colin MacLeod Fellow, University of Oklahoma Health Sciences Center
2004: MA (Honorary), Medicine, Harvard University
Postgraduate Training
1981: US National Academy of Sciences Exchange Fellow to the German Democratic Republic (DDR), Molecular Genetics/Pathogenesis, Central Institute für Experimentelle Therapie
1984: Akademischer Rat/Postdoctoral Research Associate, Molecular Genetics/Pathogenesis, Universität Würzburg, Institut fur Genetik und Mikrobiologie
1984: Postdoctoral Research Associate, Molecular Genetics/Pathogenesis, University of Michigan
Academic Appointments
2010-present: Sir William Osler Professor of Ophthalmology (Microbiology and Immunobiology), Harvard Medical School
2005-present: Faculty Member, Microbial Sciences Initiative, Harvard University
2004-2010: Charles L. Schepens Professor of Ophthalmology (Microbiology and Immunobiology), Harvard Medical School
1999-2004: Vice President for Research, University of Oklahoma Health Sciences Center
1999-2004: MG McCool Endowed Chair in Ophthalmology, University of Oklahoma Health Sciences Center
1998-2004: George Lynn Cross Research Professor, College of Medicine, University of Oklahoma Health Sciences Center
1997-2004: Professor of Microbiology and Immunology, University of Oklahoma Health Sciences Center
1997-2004: Professor of Ophthalmology, University of Oklahoma Health Sciences Center
1994-1996: Associate Professor of Ophthalmology (with Tenure), University of Oklahoma Health Sciences Center
1991-1996: Associate Professor of Microbiology and Immunology (with Tenure), University of Oklahoma Health Sciences Center
1984-1990: Assistant Professor of Microbiology and Immunology, University of Oklahoma Health Sciences Center
Professional Memberships
Fellow, American Academy of Microbiology
Association for Research in Vision and Ophthalmology
American Society for Microbiology
Honors
2018: Keynote Speaker, International Symposium Frontiers in Microbiology
Session Chair, Streptococcal Biology GRC
Platform Lecture, GRC Cornea and Ocular Surface Biology
2017: Neil Groman Lecturer, University of Washington
Keynote Address, Microbiotec 2017
Keynote Address, Antimicrobials and Resistance: Opportunities and Challenges
Keynote Address, 20th Lancefield International Symposium on Streptococci and Streptococcal Diseases
Keynote Address, 29th Annual Buffalo Conference on Microbial Pathogenesis
2016: Keynote Address, 8th International Conference on Streptococcal Genetics
Keynote speaker Sequencing, Finishing, and Analysis in the Future, Santa Fe, NM
Keynote speaker Center for Microbial Interface Biology, Columbus, OH
2015: Organizer and chair, Colloquium " Nouveaux antibiotiques actifs sur la paroi," Pasteur Institute, Paris F
2013: Phillips Thygeson Lecture, Ocular Microbiology and Immunology Group, AAO New Orleans, LA
2012: Keynote Address, International Conference on Gram Positive Pathogens, Omaha, NE
2012: Organizer, 1st Industry, Academic, Government Workshop on Audacious Thinking for the Advancement of Antimicrobial Therapeutics: Envisioning the next “Game-Changer”
2012: 20th Anniversity of ZINF Lecture: The New Infection Biology, Uinversitaet Wuerzburg, Germany
2011: Keynote address, New England Regional Center of Excellence for Biodefense, Newport, RI
2011: Eleventh Annual John C. Crano Lecture, University of Pittsburgh Medical Center, Pittsburgh PA
2010: Co-Organizer, 3rd International Conference on Enterococci, Portland, OR
2009: Co-Organizer, 5th International Conference on Gram Positive Functional Genomics, San Diego, CA
2009: Keynote Address, 113th Meeting of the Japanese Ophthalmological Society, Tokyo, Japan
2009: Keynote Address, Conférence de lancement: Maladies infectieuses, parasitaires et nosocomiales émergentes, Institut Pasteur, Paris France
2009: Keynote Address, European Association for Vision and Eye Research, Portoroz, Slovenia
2009-2011: Chairman, Gordon Research Conference on Microbial Adhesion and Signal Transduction
2008 – 2009: American Society for Microbiology Division D [Bacteria of Medical Importance] Chair Elect
2008: SUNY Buffalo, Keynote Address, Symposium on the Molecular Pathogenesis of Infectious Disease, Buffalo, NY
2007-2009: Chair-Elect, Gordon Research Conference on Microbial Adhesion and Signal Transduction
2007: Keynote Address, Japanese Society for Cataract and Refractive Surgery, Matsuyama, Japan
2007: Co-Organizer, 4th International Conference on Gram Positive Functional Genomics, Pisa, IT
2006:Division B/D Lecturer, American Society for Microbiology
2006: Keynote Address, International External Advisory Committee, European Comission Network of Excellence in Pathogenomics (Euro Patho Genomics), Menaggio, Lake Cuomo, IT
2005: Co-Organizer, 3rd International Conference on Gram Positive Functional Genomics, San Diego, CA
2004: Keynote Address - Biofilms in Infection, Infectious Disease Society of America, Biofilms Section
2004: International Advisory Board, 2nd International ASM Conference on Enterococci, Helsingor, DK
2004: Humboldt Senior International Fellow, Alexander v. Humboldt Foundation
2004: Association for Research in Vision and Ophthalmology, Immunology and Microbiology (ARVO IM) Section Chair
2004-2008: Charles L. Schepens Endowed Chair in Ophthalmology, Harvard Medical School
2003: Co-Organizer, 2nd International Conference on Gram Positive Functional Genomics, Baveno, IT
2002: Keynote Address - Biofilms in Ocular Surface Infection, 11th Meeting International Society for Contact Lens Research
2001: Co-Organizer, 1st International Conference on Gram Positive Functional Genomics, San Diego, CA
2000: Oxyopia Lecture, U. Of California Berkeley
2000: Founding Organizer, 1st International ASM Conference on Enterococci, Banff Can.
1999: Distinguished Lectures in Medicine, U. New Mexico
1999-2004: MG McCool Endowed Chair in Ophthalmology, U. of Oklahoma Health Sciences Center
1998-2004: George Lynn Cross Professor, U. of Oklahoma Health Sciences Center
1998: Kenote Speaker - Molecular pathogenesis of endophthalmitis, 2nd International Conference on Ocular Infections
1997: Lew Wasserman Merit Award, Research to Prevent Blindness
1996-1998: Waxman Foundation Lecturer, American Society for Microbiology
1996: Regents Award for Superior Research and Creative Activity, University of Oklahoma
1994: Co-Organizer, 4th International ASM Conference on Streptococcal Genetics, Santa Fe,NM
1991: Fogarty Senior International Fellow, Cambridge University
1989: VH Honeymon Distinguished Lecturer Award, U. of Oklahoma Health Sciences Center
1982: Cora M. Downs Award for Excellence in Research, American Society for Microbiology, Missouri Valley Branch
1981: National Academy of Science/National Science Foundation Exchange Scientist to the German Dem. Rep., National Academy of Science/National Science Foundation
1979-1982: Colin Munro MacLeod Research Fellow, Oklahoma Medical Research Foundation
Publications powered by Harvard Catalyst Profiles
- Global diversity of enterococci and description of 18 previously unknown species. Proc Natl Acad Sci U S A. 2024 Mar 05; 121(10):e2310852121.
- Characterization of the resistome and predominant genetic lineages of Gram-positive bacteria causing keratitis. Antimicrob Agents Chemother. 2024 Mar 06; 68(3):e0124723.
- Staphylococcus aureus activates NRLP3-dependent IL-1ß secretion from human conjunctival goblet cells using a toxin and toll-like receptors 2 and 1. Front Cell Infect Microbiol. 2023; 13:1265471.
- zol & fai: large-scale targeted detection and evolutionary investigation of gene clusters. bioRxiv. 2023 Jul 18.
- Global diversity of enterococci and description of 18 novel species. bioRxiv. 2023 Jul 12.
- Gut microbial fatty acid isomerization modulates intraepithelial T cells. Nature. 2023 Jul; 619(7971):837-843.
- Microbiology of Eye Infections at the Massachusetts Eye and Ear: An 8-Year Retrospective Review Combined With Genomic Epidemiology. Am J Ophthalmol. 2023 Nov; 255:43-56.
- An All-in-One Highly Multiplexed Diagnostic Assay for Rapid, Sensitive, and Comprehensive Detection of Intraocular Pathogens. Am J Ophthalmol. 2023 06; 250:82-94.
- Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors. Cell. 2022 03 31; 185(7):1157-1171.e22.
- Population structure of ocular Streptococcus pneumoniae is highly diverse and formed by lineages that escape current vaccines. Microb Genom. 2022 03; 8(3).
- shsA: A novel orthologous of sasX/sesI virulence genes is detected in Staphylococcus haemolyticus Brazilian strains. Infect Genet Evol. 2022 01; 97:105189.
- Novel Molecular Barcoding for Rapid Pathogen Detection in Infectious Keratitis. Ophthalmol Sci. 2021 Dec; 1(4):100066.
- Chronic liver disease enables gut Enterococcus faecalis colonization to promote liver carcinogenesis. Nat Cancer. 2021 10; 2(10):1039-1054.
- Genome Mining for Antimicrobial Compounds in Wild Marine Animals-Associated Enterococci. Mar Drugs. 2021 Jun 06; 19(6).
- Influence of the Alternative Sigma Factor RpoN on Global Gene Expression and Carbon Catabolism in Enterococcus faecalis V583. mBio. 2021 05 18; 12(3).
- A Cluster of Corneal Donor Rim Cultures Positive for Achromobacter Species Associated With Contaminated Eye Solution. Cornea. 2021 Feb 01; 40(2):223-227.
- Genomic and Functional Characterization of Enterococcus faecalis Isolates Recovered From the International Space Station and Their Potential for Pathogenicity. Front Microbiol. 2020; 11:515319.
- The Search for Antifungal Prophylaxis After Artificial Corneal Surgery-An In Vitro Study. Cornea. 2020 Dec; 39(12):1547-1555.
- Genes Contributing to the Unique Biology and Intrinsic Antibiotic Resistance of Enterococcus faecalis. mBio. 2020 11 24; 11(6).
- Coexistence of the Oxazolidinone Resistance-Associated Genes cfr and optrA in Enterococcus faecalis From a Healthy Piglet in Brazil. Front Public Health. 2020; 8:518.
- Enterococci from Wild Magellanic Penguins (Spheniscus magellanicus) as an Indicator of Marine Ecosystem Health and Human Impact. Appl Environ Microbiol. 2020 09 17; 86(19).
- Hospital-Associated Multidrug-Resistant MRSA Lineages Are Trophic to the Ocular Surface and Cause Severe Microbial Keratitis. Front Public Health. 2020; 8:204.
- Transferable Resistance Gene optrA in Enterococcus faecalis from Swine in Brazil. Antimicrob Agents Chemother. 2020 05 21; 64(6).
- Evolution of vancomycin-resistant Enterococcus faecium during colonization and infection in immunocompromised pediatric patients. Proc Natl Acad Sci U S A. 2020 05 26; 117(21):11703-11714.
- A mutation in the glycosyltransferase gene lafB causes daptomycin hypersusceptibility in Enterococcus faecium. J Antimicrob Chemother. 2020 01 01; 75(1):36-45.
- Validation of a Comprehensive Clinical Algorithm for the Assessment and Treatment of Microbial Keratitis. Am J Ophthalmol. 2020 06; 214:97-109.
- The Best of All Worlds: Streptococcus pneumoniae Conjunctivitis through the Lens of Community Ecology and Microbial Biogeography. Microorganisms. 2019 Dec 25; 8(1).
- Infectious corneal ulceration: a proposal for neglected tropical disease status. Bull World Health Organ. 2019 Dec 01; 97(12):854-856.
- Chicken Meat-Associated Enterococci: Influence of Agricultural Antibiotic Use and Connection to the Clinic. Appl Environ Microbiol. 2019 11 15; 85(22).
- Clinical metagenomics for infectious corneal ulcers: Rags to riches? Ocul Surf. 2020 01; 18(1):1-12.
- The CRISPR-Antibiotic Resistance Connection. CRISPR J. 2019 08; 2:199-200.
- Mechanisms and consequences of gut commensal translocation in chronic diseases. Gut Microbes. 2020; 11(2):217-230.
- Authors' response: Povidone-Iodine for the Treatment of Microbial Keratitis. Surv Ophthalmol. 2019 Nov - Dec; 64(6):892-893.
- Pathogenicity of Enterococci. Microbiol Spectr. 2019 07; 7(4).
- Impact of antibiotic treatment and host innate immune pressure on enterococcal adaptation in the human bloodstream. Sci Transl Med. 2019 04 10; 11(487).
- PolyGlcNAc-containing exopolymers enable surface penetration by non-motile Enterococcus faecalis. PLoS Pathog. 2019 02; 15(2):e1007571.
- The persistent dilemma of microbial keratitis: Global burden, diagnosis, and antimicrobial resistance. Surv Ophthalmol. 2019 May - Jun; 64(3):255-271.
- Daptomycin Resistance and Tolerance Due to Loss of Function in Staphylococcus aureus dsp1 and asp23. Antimicrob Agents Chemother. 2019 01; 63(1).
- Staphylococcus aureus from ocular and otolaryngology infections are frequently resistant to clinically important antibiotics and are associated with lineages of community and hospital origins. PLoS One. 2018; 13(12):e0208518.
- A bacterium's enemy isn't your friend. Nature. 2018 11; 563(7733):637-638.
- Molecular basis for the emergence of a new hospital endemic tigecycline-resistant Enterococcus faecalis ST103 lineage. Infect Genet Evol. 2019 01; 67:23-32.
- Resolution of fluoroquinolone-resistant Escherichia coli keratitis with a PROSE device for enhanced targeted antibiotic delivery. Am J Ophthalmol Case Rep. 2018 Dec; 12:73-75.
- Long-Term Colonization Dynamics of Enterococcus faecalis in Implanted Devices in Research Macaques. Appl Environ Microbiol. 2018 09 15; 84(18).
- Transferable vancomycin resistance in clade B commensal-type Enterococcus faecium. J Antimicrob Chemother. 2018 06 01; 73(6):1479-1486.
- Propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC): a new bacteriostatic agent against methicillin-resistant Staphylococcus aureus. Sci Rep. 2018 05 04; 8(1):7062.
- A new class of synthetic retinoid antibiotics effective against bacterial persisters. Nature. 2018 04 05; 556(7699):103-107.
- Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium. Cell Host Microbe. 2018 Feb 14; 23(2):169-176.e6.
- Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase. J Am Chem Soc. 2018 02 07; 140(5):1774-1782.
- Rapid Detection and Identification of Uveitis Pathogens by Qualitative Multiplex Real-Time PCR. Invest Ophthalmol Vis Sci. 2018 01 01; 59(1):582-589.
- Identification of a Functionally Unique Family of Penicillin-Binding Proteins. J Am Chem Soc. 2017 12 13; 139(49):17727-17730.
- Methicillin-resistant Staphylococcus aureus in acute otitis externa. World J Otorhinolaryngol Head Neck Surg. 2018 Dec; 4(4):246-252.
- Neither non-toxigenic Staphylococcus aureus nor commensal S. epidermidi activates NLRP3 inflammasomes in human conjunctival goblet cells. BMJ Open Ophthalmol. 2017; 2(1):e000101.
- Resistance in In Vitro Selected Tigecycline-Resistant Methicillin-Resistant Staphylococcus aureus Sequence Type 5 Is Driven by Mutations in mepR and mepA Genes. Microb Drug Resist. 2018 Jun; 24(5):519-526.
- Genome-wide screen for genes involved in eDNA release during biofilm formation by Staphylococcus aureus. Proc Natl Acad Sci U S A. 2017 07 18; 114(29):E5969-E5978.
- Co-infecting microorganisms dramatically alter pathogen gene essentiality during polymicrobial infection. Nat Microbiol. 2017 May 30; 2:17079.
- Tracing the Enterococci from Paleozoic Origins to the Hospital. Cell. 2017 May 18; 169(5):849-861.e13.
- Mapping Transposon Insertions in Bacterial Genomes by Arbitrarily Primed PCR. Curr Protoc Mol Biol. 2017 04 03; 118:15.15.1-15.15.15.
- Raising the Alarmone: Within-Host Evolution of Antibiotic-Tolerant Enterococcus faecium. mBio. 2017 02 21; 8(1).
- Characterization of Multi-Drug Resistant Enterococcus faecalis Isolated from Cephalic Recording Chambers in Research Macaques (Macaca spp.). PLoS One. 2017; 12(1):e0169293.
- Novel Phagocytosis-Resistant Extended-Spectrum ß-Lactamase-Producing Escherichia coli From Keratitis. JAMA Ophthalmol. 2016 Nov 01; 134(11):1306-1309.
- ArI/ArII laser induced fluorescence system for measurement of neutral and ion dynamics in a large scale helicon plasma. Rev Sci Instrum. 2016 Nov; 87(11):11E560.
- Homologous Recombination within Large Chromosomal Regions Facilitates Acquisition of ß-Lactam and Vancomycin Resistance in Enterococcus faecium. Antimicrob Agents Chemother. 2016 10; 60(10):5777-86.
- High-Quality Draft Genome Sequence of the Multidrug-Resistant Clinical Isolate Enterococcus faecium VRE16. Genome Announc. 2016 Sep 22; 4(5).
- Oxygen as a Virulence Determinant in Polymicrobial Infections. mBio. 2016 08 16; 7(4).
- Multidrug Intrinsic Resistance Factors in Staphylococcus aureus Identified by Profiling Fitness within High-Diversity Transposon Libraries. mBio. 2016 08 16; 7(4).
- A lysin to kill. Elife. 2016 04 27; 5.
- Killing of VRE Enterococcus faecalis by commensal strains: Evidence for evolution and accumulation of mobile elements in the absence of competition. Gut Microbes. 2016; 7(1):90-6.
- Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection. PLoS Pathog. 2015 Dec; 11(12):e1005341.
- Staphylococcus aureus and its Bearing on Ophthalmic Disease. Ocul Immunol Inflamm. 2017 Feb; 25(1):111-121.
- Impact of Antibiotic Use on the Evolution of Enterococcus faecium. J Infect Dis. 2016 06 15; 213(12):1862-5.
- Fungal Infections After Boston Type 1 Keratoprosthesis Implantation: Literature Review and In Vitro Antifungal Activity of Hypochlorous Acid. Cornea. 2015 Dec; 34(12):1599-605.
- Pheromone killing of multidrug-resistant Enterococcus faecalis V583 by native commensal strains. Proc Natl Acad Sci U S A. 2015 Jun 09; 112(23):7273-8.
- Complete Genome Sequence of Linezolid-Susceptible Staphylococcus haemolyticus Sh29/312/L2, a Clonal Derivative of a Linezolid-Resistant Clinical Strain. Genome Announc. 2015 May 21; 3(3).
- A CRISPR View of Cleavage. Cell. 2015 May 21; 161(5):964-966.
- Novel model of innate immunity in corneal infection. In Vitro Cell Dev Biol Anim. 2015 Sep; 51(8):827-34.
- A new platform for ultra-high density Staphylococcus aureus transposon libraries. BMC Genomics. 2015 Mar 29; 16:252.
- Biofilms in infections of the eye. Pathogens. 2015 Mar 23; 4(1):111-36.
- Mutations in pneumococcal cpsE generated via in vitro serial passaging reveal a potential mechanism of reduced encapsulation utilized by a conjunctival isolate. J Bacteriol. 2015 May; 197(10):1781-91.
- A genomic virulence reference map of Enterococcus faecalis reveals an important contribution of phage03-like elements in nosocomial genetic lineages to pathogenicity in a Caenorhabditis elegans infection model. Infect Immun. 2015 May; 83(5):2156-67.
- Unencapsulated Streptococcus pneumoniae from conjunctivitis encode variant traits and belong to a distinct phylogenetic cluster. Nat Commun. 2014 Nov 12; 5:5411.
- In vitro and in vivo models of Staphylococcus aureus endophthalmitis implicate specific nutrients in ocular infection. PLoS One. 2014; 9(10):e110872.
- A delicate balance: maintaining mutualism to prevent disease. Cell Host Microbe. 2014 Oct 08; 16(4):425-7.
- Virulence Plasmids of Nonsporulating Gram-Positive Pathogens. Microbiol Spectr. 2014 Oct; 2(5).
- An ABC transporter is required for secretion of peptide sex pheromones in Enterococcus faecalis. mBio. 2014 Sep 23; 5(5):e01726-14.
- Transcriptomic response of Enterococcus faecalis V583 to low hydrogen peroxide levels. Curr Microbiol. 2015 Feb; 70(2):156-68.
- Genes contributing to Staphylococcus aureus fitness in abscess- and infection-related ecologies. mBio. 2014 Sep 02; 5(5):e01729-14.
- Compound-gene interaction mapping reveals distinct roles for Staphylococcus aureus teichoic acids. Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34):12510-5.
- Cost-effectiveness of follow-up of pulmonary nodules incidentally detected on cardiac computed tomographic angiography in patients with suspected coronary artery disease. Circulation. 2014 Aug 19; 130(8):668-75.
- Friend turned foe: evolution of enterococcal virulence and antibiotic resistance. Annu Rev Microbiol. 2014; 68:337-56.
- Transcriptional response of Enterococcus faecalis to sunlight. J Photochem Photobiol B. 2014 Jan 05; 130:349-56.
- High-Quality Draft Genome Sequence of Vagococcus lutrae Strain LBD1, Isolated from the Largemouth Bass Micropterus salmoides. Genome Announc. 2013 Dec 26; 1(6).
- Dual defensin strategy for targeting Enterococcus faecalis. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):19980-1.
- Draft Genome Sequence of Methicillin-Resistant Staphylococcus aureus Strain SA16, Representative of an Endemic Clone from a Brazilian Hospital. Genome Announc. 2013 Sep 19; 1(5).
- Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells. PLoS One. 2013; 8(9):e74010.
- Emergence of epidemic multidrug-resistant Enterococcus faecium from animal and commensal strains. mBio. 2013 Aug 20; 4(4).
- Drosophila host model reveals new enterococcus faecalis quorum-sensing associated virulence factors. PLoS One. 2013; 8(5):e64740.
- Structure, function, and biology of the Enterococcus faecalis cytolysin. Toxins (Basel). 2013 Apr 29; 5(5):895-911.
- Photodynamic and antibiotic therapy impair the pathogenesis of Enterococcus faecium in a whole animal insect model. PLoS One. 2013; 8(2):e55926.
- Genomic transition of enterococci from gut commensals to leading causes of multidrug-resistant hospital infection in the antibiotic era. Curr Opin Microbiol. 2013 Feb; 16(1):10-6.
- Viral diversity threshold for adaptive immunity in prokaryotes. mBio. 2012 Dec 04; 3(6):e00456-12.
- CRISPR-Cas: to take up DNA or not-that is the question. Cell Host Microbe. 2012 Aug 16; 12(2):125-6.
- Comparative genomics of vancomycin-resistant Staphylococcus aureus strains and their positions within the clade most commonly associated with Methicillin-resistant S. aureus hospital-acquired infection in the United States. mBio. 2012; 3(3).
- Wall teichoic acid protects Staphylococcus aureus from inhibition by Congo red and other dyes. J Antimicrob Chemother. 2012 Sep; 67(9):2143-51.
- Persisting viral sequences shape microbial CRISPR-based immunity. PLoS Comput Biol. 2012; 8(4):e1002475.
- Bacterial endophthalmitis in the age of outpatient intravitreal therapies and cataract surgeries: host-microbe interactions in intraocular infection. Prog Retin Eye Res. 2012 Jul; 31(4):316-31.
- A metalloproteinase secreted by Streptococcus pneumoniae removes membrane mucin MUC16 from the epithelial glycocalyx barrier. PLoS One. 2012; 7(3):e32418.
- Comparative genomics of enterococci: variation in Enterococcus faecalis, clade structure in E. faecium, and defining characteristics of E. gallinarum and E. casseliflavus. mBio. 2012; 3(1):e00318-11.
- An antibiotic that inhibits a late step in wall teichoic acid biosynthesis induces the cell wall stress stimulon in Staphylococcus aureus. Antimicrob Agents Chemother. 2012 Apr; 56(4):1810-20.
- Large-scale screening of a targeted Enterococcus faecalis mutant library identifies envelope fitness factors. PLoS One. 2011; 6(12):e29023.
- Biocompatibility and biofilm inhibition of N,N-hexyl,methyl-polyethylenimine bonded to Boston Keratoprosthesis materials. Biomaterials. 2011 Dec; 32(34):8783-96.
- Role of wall teichoic acids in Staphylococcus aureus endophthalmitis. Invest Ophthalmol Vis Sci. 2011 May 16; 52(6):3187-92.
- SlyA is a transcriptional regulator involved in the virulence of Enterococcus faecalis. Infect Immun. 2011 Jul; 79(7):2638-45.
- Genetic basis for daptomycin resistance in enterococci. Antimicrob Agents Chemother. 2011 Jul; 55(7):3345-56.
- Identification of a new gene, vanV, in vanB operons of Enterococcus faecalis. Int J Antimicrob Agents. 2011 Jun; 37(6):554-7.
- Spontaneous bacterial keratitis in CD36 knockout mice. Invest Ophthalmol Vis Sci. 2011 Jan; 52(1):256-63.
- Prophylaxis against postoperative endophthalmitis in cataract surgery. Int Ophthalmol Clin. 2011; 51(4):67-83.
- In vitro antimicrobial activity of wall teichoic acid biosynthesis inhibitors against Staphylococcus aureus isolates. Antimicrob Agents Chemother. 2011 Feb; 55(2):767-74.
- Multidrug-resistant enterococci lack CRISPR-cas. mBio. 2010 Oct 12; 1(4).
- Horizontal gene transfer and the genomics of enterococcal antibiotic resistance. Curr Opin Microbiol. 2010 Oct; 13(5):632-9.
- Response of corneal epithelial cells to Staphylococcus aureus. Virulence. 2010 Jul-Aug; 1(4):223-35.
- Host-pathogen interactions in the cornea. Jpn J Ophthalmol. 2010 May; 54(3):191-3.
- Mechanism of chromosomal transfer of Enterococcus faecalis pathogenicity island, capsule, antimicrobial resistance, and other traits. Proc Natl Acad Sci U S A. 2010 Jul 06; 107(27):12269-74.
- High-quality draft genome sequences of 28 Enterococcus sp. isolates. J Bacteriol. 2010 May; 192(9):2469-70.
- Discovery of a small molecule that blocks wall teichoic acid biosynthesis in Staphylococcus aureus. ACS Chem Biol. 2009 Oct 16; 4(10):875-83.
- Microbial telesensing: probing the environment for friends, foes, and food. Cell Host Microbe. 2009 Aug 20; 6(2):115-24.
- The (p)ppGpp synthetase RelA contributes to stress adaptation and virulence in Enterococcus faecalis V583. Microbiology (Reading). 2009 Oct; 155(Pt 10):3226-3237.
- Genetic variation and evolution of the pathogenicity island of Enterococcus faecalis. J Bacteriol. 2009 May; 191(10):3392-402.
- Microbial biofilms in ophthalmology and infectious disease. Arch Ophthalmol. 2008 Nov; 126(11):1572-81.
- Contribution of secreted proteases to the pathogenesis of postoperative Enterococcus faecalis endophthalmitis. J Cataract Refract Surg. 2008 Oct; 34(10):1776-84.
- Cell surface O-glycans limit Staphylococcus aureus adherence to corneal epithelial cells. Infect Immun. 2008 Nov; 76(11):5215-20.
- Virulence factors in vancomycin-resistant and vancomycin- susceptible Enterococcus faecalis from Brazil. Braz J Microbiol. 2008 Apr; 39(2):273-8.
- alphaB-crystallin protects retinal tissue during Staphylococcus aureus-induced endophthalmitis. Infect Immun. 2008 Apr; 76(4):1781-90.
- Staphylococcus aureus--probing for host weakness? J Bacteriol. 2008 Apr; 190(7):2253-6.
- Pathogenomics: an updated European Research Agenda. Infect Genet Evol. 2008 May; 8(3):386-93.
- The commensal microbiology of the gastrointestinal tract. Adv Exp Med Biol. 2008; 635:15-28.
- Parasitic and Rickettsial Ocular Infections. In Albert & Jakobiec's Principles & Practice of Ophthalmology,
. 2008. - Microbiology Section Editor. Albert & Jakobiec's. Principles & Practice of Ophthalmology. 2008.
- Functions of MUC16 in corneal epithelial cells. Invest Ophthalmol Vis Sci. 2007 Oct; 48(10):4509-18.
- Introducing Ilene K. Gipson, the 2007 recipient of the Friedenwald award. Invest Ophthalmol Vis Sci. 2007 Oct; 48(10):4390.
- Genetic diversity among Enterococcus faecalis. PLoS One. 2007 Jul 04; 2(7):e582.
- Bacterial endophthalmitis: therapeutic challenges and host-pathogen interactions. Prog Retin Eye Res. 2007 Mar; 26(2):189-203.
- Native microbial colonization of Drosophila melanogaster and its use as a model of Enterococcus faecalis pathogenesis. Infect Immun. 2007 Apr; 75(4):1565-76.
- Role of bacterial and host factors in infectious endophthalmitis. Chem Immunol Allergy. 2007; 92:266-275.
- Commensal microbiology of the gastrointestinal tract. In: GI Microbiota and regulation of the immune system. 2007.
- Multilocus sequence typing and analysis of putative virulence factors in vancomycin-resistant and vancomycin-sensitive Enterococcus faecium isolates from Brazil. Clin Microbiol Infect. 2006 Nov; 12(11):1123-30.
- Pathogenicity island integrase cross-talk: a potential new tool for virulence modulation. Mol Microbiol. 2006 Aug; 61(3):555-9.
- Sequence analysis of Enterococcus faecium strain 10/96A (VanD4), the original vancomycin-resistant E. faecium strain in Brazil. J Clin Microbiol. 2006 Jul; 44(7):2635-7.
- Quorum sensing and DNA release in bacterial biofilms. Curr Opin Microbiol. 2006 Apr; 9(2):133-7.
- Pathogenomics of Enterococcus faecalis. In: Pathogenomics: Genome Analysis of Pathogenic Microbes
. 2006; 125-148. - The Comprehensive Sourcebook of Bacterial Protein Toxins. 3rd edition. Joseph Alouf and Michel Popoff (Eds.). Academic Press/Elsevier. 2006; 717-721.
- Role of Bacterial and Host Factors in Infectious Endophthalmitis. In: Niederkorn JY, Kaplan HJ (eds): Immune Response and the Eye. Chem. Immunol. Allergy. 2006; 92(10):1-10.
- Bacillus endophthalmitis: roles of bacterial toxins and motility during infection. Invest Ophthalmol Vis Sci. 2005 Sep; 46(9):3233-8.
- Biofilm formation by Enterococcus faecalis on intraocular lens material. Curr Eye Res. 2005 Sep; 30(9):741-5.
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