Michael S. Gilmore, PhD

Harvard Medical School

Sir William Osler Professor of Ophthalmology (Microbiology and Immunobiology)
Director, Infectious Disease Institute

Massachusetts Eye and Ear

Senior Scientist

Broad Institute of MIT and Harvard

Associate Member

Research Summary

Center/Research Area Affiliations

Research Summary

Dr. Gilmore is the founder and Principal Investigator of the Harvard-wide Program on Antibiotic Resistance, and of the academic/industry consortium Boston-Area Antibiotic Resistance Network (BAARN, www.abresistance.net). His research focuses on the evolution and development of multidrug resistant strains of enterococci, streptococci and staphylococci, and the development of new therapeutic approaches. Currently, he is developing new ways to prevent and treat the most problematic multidrug resistant infections. He serves on numerous advisory boards and committees for public (NIH, FDA, VA, NSF, EU) and private organizations, mainly focused on drug discovery, antibiotic resistance, and bacterial pathogenesis.

Dr. Gilmore's laboratory focuses on developing new ways to treat and prevent antibiotic resistant infection of the eye, ear, skin and other sites caused by enterococci and staphylococci. Enterococci and staphylococci are leading causes of multidrug resistant infection, particularly following surgery and in hospitalized patients. Since 2005, more people in the US have been killed by methicillin-resistant Staphylococcus aureus infection than by HIV/AIDS, and antibiotic resistant infection is adding more than $30 Billion per year to health care costs.

Education

1977: B.A., Health Science, Kalamazoo College

1978: M.S., Grain Science and Industry, Kansas State University

1981: M.S., Biochemistry and Molecular Biology, Colin MacLeod Fellow, University of Oklahoma Health Sciences Center

1982: Ph.D., Biochemistry and Molecular Biology, Colin MacLeod Fellow, University of Oklahoma Health Sciences Center

2004: M.A. (Honorary), Medicine, Harvard University

Postgraduate Training

1981: US National Academy of Sciences Exchange Fellow to the German Democratic Republic (DDR), Molecular Genetics/Pathogenesis, Central Institute für Experimentelle Therapie

1984: Akademischer Rat/Postdoctoral Research Associate, Molecular Genetics/Pathogenesis, Universität Würzburg, Institut fur Genetik und Mikrobiologie

1984: Postdoctoral Research Associate, Molecular Genetics/Pathogenesis, University of Michigan

Academic Appointments

2010-present: Sir William Osler Professor of Ophthalmology (Microbiology and Immunobiology), Harvard Medical School

2005-present: Faculty Member, Microbial Sciences Initiative, Harvard University

2004-2010: Charles L. Schepens Professor of Ophthalmology (Microbiology and Immunobiology), Harvard Medical School

1999-2004: Vice President for Research, University of Oklahoma Health Sciences Center

1999-2004: MG McCool Endowed Chair in Ophthalmology, University of Oklahoma Health Sciences Center

1998-2004: George Lynn Cross Research Professor, College of Medicine, University of Oklahoma Health Sciences Center

1997-2004: Professor of Microbiology and Immunology, University of Oklahoma Health Sciences Center

1997-2004: Professor of Ophthalmology, University of Oklahoma Health Sciences Center

1994-1996: Associate Professor of Ophthalmology (with Tenure), University of Oklahoma Health Sciences Center

1991-1996: Associate Professor of Microbiology and Immunology (with Tenure), University of Oklahoma Health Sciences Center

1984-1990: Assistant Professor of Microbiology and Immunology, University of Oklahoma Health Sciences Center

Professional Memberships

Fellow, American Academy of Microbiology

Association for Research in Vision and Ophthalmology

American Society for Microbiology

Honors

2018 Keynote Speaker, International Symposium Frontiers in Microbiology
Session Chair, Streptococcal Biology GRC
Platform Lecture, GRC Cornea and Ocular Surface Biology
2017 Neil Groman Lecturer, University of Washington
Keynote Address, Microbiotec 2017
Keynote Address, Antimicrobials and Resistance: Opportunities and Challenges
Keynote Address, 20th Lancefield International Symposium on Streptococci and Streptococcal Diseases
Keynote Address, 29th Annual Buffalo Conference on Microbial Pathogenesis
2016 Keynote Address, 8th International Conference on Streptococcal Genetics
Keynote speaker Sequencing, Finishing, and Analysis in the Future, Santa Fe, NM
Keynote speaker Center for Microbial Interface Biology, Columbus, OH
2015 Organizer and chair, Colloquium " Nouveaux antibiotiques actifs sur la paroi", Pasteur Institute, Paris F
2013 Phillips Thygeson Lecture, Ocular Microbiology and Immunology Group, AAO New Orleans, LA
2012 Keynote Address, International Conference on Gram Positive Pathogens, Omaha, NE
2012 Organizer, 1st Industry, Academic, Government Workshop on Audacious Thinking for the Advancement of Antimicrobial Therapeutics: Envisioning the next “Game-Changer”
2012 20th Anniversity of ZINF Lecture: The New Infection Biology, Uinversitaet Wuerzburg, Germany
2011 Keynote address, New England Regional Center of Excellence for Biodefense, Newport, RI
2011 Eleventh Annual John C. Crano Lecture, University of Pittsburgh Medical Center, Pittsburgh PA
2010 Co-Organizer, 3rd International Conference on Enterococci, Portland, OR
2009 Co-Organizer, 5th International Conference on Gram Positive Functional Genomics, San Diego, CA
2009 Keynote Address, 113th Meeting of the Japanese Ophthalmological Society, Tokyo, Japan
2009 Keynote Address, Conférence de lancement: Maladies infectieuses, parasitaires et nosocomiales émergentes, Institut Pasteur, Paris France
2009 Keynote Address, European Association for Vision and Eye Research, Portoroz, Slovenia
2009-2011 Chairman, Gordon Research Conference on Microbial Adhesion and Signal Transduction
2008 – 2009 American Society for Microbiology Division D [Bacteria of Medical Importance] Chair Elect
2008 SUNY Buffalo, Keynote Address, Symposium on the Molecular Pathogenesis of Infectious Disease, Buffalo, NY
2007-2009 Chair-Elect, Gordon Research Conference on Microbial Adhesion and Signal Transduction
2007 Keynote Address, Japanese Society for Cataract and Refractive Surgery, Matsuyama, Japan
2007 Co-Organizer, 4th International Conference on Gram Positive Functional Genomics, Pisa, IT
2006Division B/D Lecturer, American Society for Microbiology
2006 Keynote Address, International External Advisory Committee, European Comission Network of Excellence in Pathogenomics (Euro Patho Genomics), Menaggio, Lake Cuomo, IT
2005 Co-Organizer, 3rd International Conference on Gram Positive Functional Genomics, San Diego, CA
2004 Keynote Address - Biofilms in Infection, Infectious Disease Society of America, Biofilms Section
2004 International Advisory Board, 2nd International ASM Conference on Enterococci, Helsingor, DK
2004 Humboldt Senior International Fellow, Alexander v. Humboldt Foundation
2004 Association for Research in Vision and Ophthalmology, Immunology and Microbiology (ARVO IM) Section Chair
2004-2008 Charles L. Schepens Endowed Chair in Ophthalmology, Harvard Medical School
2003 Co-Organizer, 2nd International Conference on Gram Positive Functional Genomics, Baveno, IT
2002 Keynote Address - Biofilms in Ocular Surface Infection, 11th Meeting International Society for Contact Lens Research
2001 Co-Organizer, 1st International Conference on Gram Positive Functional Genomics, San Diego, CA
2000 Oxyopia Lecture, U. Of California Berkeley
2000 Founding Organizer, 1st International ASM Conference on Enterococci, Banff Can.
1999 Distinguished Lectures in Medicine, U. New Mexico
1999-2004 MG McCool Endowed Chair in Ophthalmology, U. of Oklahoma Health Sciences Center
1998-2004 George Lynn Cross Professor, U. of Oklahoma Health Sciences Center
1998 Kenote Speaker - Molecular pathogenesis of endophthalmitis, 2nd International Conference on Ocular Infections
1997 Lew Wasserman Merit Award, Research to Prevent Blindness
1996-1998 Waxman Foundation Lecturer, American Society for Microbiology
1996 Regents Award for Superior Research and Creative Activity, University of Oklahoma
1994 Co-Organizer, 4th International ASM Conference on Streptococcal Genetics, Santa Fe,NM
1991 Fogarty Senior International Fellow, Cambridge University
1989 VH Honeymon Distinguished Lecturer Award, U. of Oklahoma Health Sciences Center
1982Cora M. Downs Award for Excellence in Research, American Society for Microbiology, Missouri Valley Branch
1981 National Academy of Science/National Science Foundation Exchange Scientist to the German Dem. Rep., National Academy of Science/National Science Foundation
1979-1982Colin Munro MacLeod Research Fellow, Oklahoma Medical Research Foundation

Publications

For a full publication list, please see his CV.

  1. Bispo PJM, Davoudi S, Sahm ML, Ren A, Miller J, Romano J, Sobrin L, Gilmore MS. 2018. Rapid Detection and Identification of Uveitis Pathogens by Qualitative Multiplex Real-Time PCR. Invest Ophthalmol Vis Sci. 59(1):582-589. 
  2. Dabul ANG, Avaca-Crusca JS, Van Tyne D, Gilmore MS, Camargo ILBC. 2018. Resistance in In Vitro Selected Tigecycline-Resistant Methicillin-Resistant Staphylococcus aureus Sequence Type 5 Is Driven by Mutations in mepR and mepA Genes. Microb Drug Resist. 24(5):519-526. 
  3. Keohane CE, Steele AD, Fetzer C, Khowsathit J, Van Tyne D, Moynié L, Gilmore MS, Karanicolas J, Sieber SA, Wuest WM. 2018. Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase. J Am Chem Soc. 140(5):1774-1782.  
  4. Zhang S, Lebreton F, Mansfield MJ, Miyashita SI, Zhang J, Schwartzman JA, Tao L, Masuyer G, Martínez-Carranza M, Stenmark P, Gilmore MS, Doxey AC, Dong M. 2018. Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium. Cell Host Microbe. 23(2):169-176.e6.  
  5. Kim W, Zhu W, Hendricks GL, Van Tyne D, Steele AD, Keohane CE, Fricke N, Conery AL, Shen S, Pan W, Lee K, Rajamuthiah R, Fuchs BB, Vlahovska PM, Wuest WM, Gilmore MS, Gao H, Ausubel FM, Mylonakis E. 2018. A new class of synthetic retinoid antibiotics effective against bacterial persisters. Nature. 2018 Apr 5;556(7699):103-107.