Baojian Fan, M.D., Ph.D.

Research Summary

Center/Research Area Affiliations

Research Summary

Dr. Fan has dedicated his academic career to understanding the genetic basis of glaucoma and other eye disorders. He has fellowship training in Ophthalmology and in Statistical Genetics. He is experienced in analyzing large-scale genomic and genetic data. His research has yielded 119 publications, which have been cited in more than 2,526 publications (h-index: 29).

Dr. Fan is primarily interested in the identification and modeling of genes for glaucoma and other eye diseases. He is also involved in identifying genetic loci for ocular quantitative traits. As a principle investigator, Dr. Fan has completed a project funded by the BrightFocus Foundation to discover genes for pigmentary glaucoma using whole exome sequencing. He is a co-investigator on a NIH R01 grant to identify genes for ocular quantitative traits related to glaucoma using whole genome sequencing. Currently Dr. Fan is a PI on a grant given by the Massachusetts Lions Eye Research Fund to model new genes for pigmentary glaucoma in zebrafish models.

Selected Publications

For a full publication list, please see his CV.

Fan BJ, Liu K, Wang DY, Tham CC, Tam PO, Lam DS, Pang CP. Association of polymorphisms of tumor necrosis factor and tumor protein p53 with primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2010;51:4110-6.

Fan BJ, Wang DY, Pasquale LR, Haines JL, Wiggs JL. Genetic variants associated with optic nerve vertical cup-to-disc ratio are risk factors for primary open angle glaucoma in a US Caucasian population. Invest Ophthalmol Vis Sci. 2011;52:1788-92.

Fan BJ, Pasquale LR, Kang JH, Levkovitch-Verbin H, Haines JL, Wiggs JL. Association of clusterin (CLU) variants and exfoliation syndrome: An analysis in two Caucasian studies and a meta-analysis. Exp Eye Res. 2015;139:115-22.

Chen X, Chen Y, Wiggs JL, Pasquale LR, Sun X, Fan BJ. Association of matrix metalloproteinase-9 (MMP9) variants with primary angle closure and primary angle closure glaucoma. PLoS One. 2016;11: e0157093.

View a complete list of publications on pubmed.gov>>

View a complete list of publications on Google Scholar>>

Biosketch

Education

1993: M.D., Preventative Medicine, Southeast University, Nanjing, China

1997: Master of Medicine, Epidemiology, Southeast University, Nanjing, China

2004: Ph.D., Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, China

Postgraduate Training

1994: Residency, Infectious disease control and prevention, Centre for Disease Control and Prevention, Pukou District, Nanjing, China

2006: Postdoctoral Fellowship, Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, China

2007: Postdoctoral Fellowship, Biochemistry, University of Hong Kong, Hong Kong, China

2011: Senior Research Fellowship, Ophthalmology, Harvard Medical School

Academic Appointments

2012-present: Instructor in Ophthalmology, Harvard Medical School

2000-2001: Lecturer on Epidemiology & Biostatistics, Southeast University, Nanjing, China

1999-2000: Visiting Scholar, Chinese University of Hong Kong, Hong Kong, China

1997-1999: Assistant Lecturer on Epidemiology & Biostatistics, Southeast University, Nanjing, China

Professional Memberships

2000, 2004, 2006-present: Association for Research in Vision and Ophthalmology

2007-present: Oversea Chinese Association for Vision and Eye Research

2010-2013: American Society of Human Genetics

2002: Association of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases

Honors

1997: National Scientific and Technological Achievements, Ministry of Science and Technology, China

1998: First Prize Winner of Scientific and Technological Progress, Beijing Railway Bureau, China

2000: Outstanding Poster Award, Chinese Congress of Clinical Chemistry & Laboratory Medicine, Hong Kong, China

2002: Postgraduate Student Grants for Overseas Academic Activities, The Chinese University of Hong Kong, Hong Kong, China

2003: Postgraduate Student Grants for Overseas Academic Activities, The Chinese University of Hong Kong, Hong Kong, China

2005: AFV Young Researcher of the Year, Action for Vision Eye Foundation, Hong Kong, China

2005: Contract-end Merit Award, The Chinese University of Hong Kong, Hong Kong, China

2009: Winner of the Poster Contest, Ophthalmology Annual Meeting, Harvard Medical School