Daniel L. Faden,
MD, FACS
Massachusetts Eye and Ear
Investigator, Mike Toth Head and Neck Cancer Research Center
Harvard Medical School
Assistant Professor of Otolaryngology–Head and Neck Surgery
daniel_faden@meei.harvard.edu
For investigator inquiries only
About My Research
The Faden Lab studies blood-based cancer diagnostics to non-invasively screen, diagnose and monitor head and neck cancers. He and his team have developed, validated and extensively utilized one of the first liquid biopsies for HPV-associated cancers. They subsequently developed an more sensitive and comprehensive HPV whole genome next generation sequencing assay, termed HPV-DeepSeek, designed for addressing low tumor burden settings such as asymptomatic cancer screening and minimal residual disease detection after surgery. HPV-DeepSeek is currently undergoing implementation in MGH pathology as a clinical test and will become available for clinical use in Mass General Brigham in 2024. The lab utilizes these custom tests, and additional blood and tissue-based mutli-omic profiling approaches, to study how to improve head and neck cancer care. He and his team work closely with collaborating labs in Boston and across the world. Read more about the labs work, here.
Publications powered by Harvard Catalyst Profiles
- ASO Visual Abstract: Circulating Tumor DNA in the Immediate Postoperative Setting. Ann Surg Oncol. 2024 Apr; 31(4):2336.
- Immunotherapy time of infusion impacts survival in head and neck cancer: A propensity score matched analysis. Oral Oncol. 2024 Apr; 151:106761.
- ctDNA predicts recurrence and survival in stage I and II HPV-associated head and neck cancer patients treated with surgery. medRxiv. 2024 Feb 17.
- Assessing the feasibility of a multimodal liquid biopsy for the diagnosis of HPV-associated oropharyngeal squamous cell carcinoma. Am J Clin Pathol. 2024 Feb 13.
- Blood-based screening for HPV-associated cancers. medRxiv. 2024 Feb 02.
- Circulating Tumor DNA in the Immediate Postoperative Setting. Ann Surg Oncol. 2024 Apr; 31(4):2319-2325.
- Comparing the Diagnostic Performance of Quantitative PCR, Digital Droplet PCR, and Next-Generation Sequencing Liquid Biopsies for Human Papillomavirus-Associated Cancers. J Mol Diagn. 2024 Mar; 26(3):179-190.
- Personal Social Networks and Care-Seeking for Head and Neck Cancer: A Qualitative Study. Otolaryngol Head Neck Surg. 2024 Feb; 170(2):457-467.
- Determinants of the level of circulating-tumor HPV16 DNA in patients with HPV-associated oropharyngeal cancer at the time of diagnosis. Sci Rep. 2023 12 01; 13(1):21226.
- circulating tumor DNA in the immediate post-operative setting. medRxiv. 2023 Oct 02.
- Deciphering Knowledge and Opinions of Human Papillomavirus and Human Papillomavirus Vaccination for Facilitation of Point-of-Care Vaccination in Adults. JAMA Otolaryngol Head Neck Surg. 2023 Oct 01; 149(10):870-877.
- Atypical metastases highlight the true potential of ctDNA liquid biopsies for cancer monitoring. Oral Oncol. 2023 09; 144:106464.
- Relationship of HPV16 E6 seropositivity with circulating tumor tissue modified HPV16 DNA before head and neck cancer diagnosis. Oral Oncol. 2023 06; 141:106417.
- Comparison of patient-reported upper extremity disability following free flaps in head and neck reconstruction: A systematic review and meta-analysis. Head Neck. 2023 07; 45(7):1832-1840.
- Double trouble: Synchronous and metachronous primaries confound ctHPVDNA monitoring. Head Neck. 2023 06; 45(6):E25-E30.
- Detection and Monitoring of Circulating Tumor HPV DNA in HPV-Associated Sinonasal and Nasopharyngeal Cancers. JAMA Otolaryngol Head Neck Surg. 2023 02 01; 149(2):179-181.
- Rate of atypical nodal metastases in surgically treated HPV-associated oropharyngeal squamous cell carcinoma. Head Neck. 2023 02; 45(2):409-416.
- Single-cell transcriptomic profiling for inferring tumor origin and mechanisms of therapeutic resistance. NPJ Precis Oncol. 2022 Oct 10; 6(1):71.
- Genetic variation within the human papillomavirus type 16 genome is associated with oropharyngeal cancer prognosis. Ann Oncol. 2022 06; 33(6):638-648.
- Detection of circulating tumor human papillomavirus DNA before diagnosis of HPV-positive head and neck cancer. Int J Cancer. 2022 10 01; 151(7):1081-1085.
- A Contemporary Review of Molecular Therapeutic Targets for Adenoid Cystic Carcinoma. Cancers (Basel). 2022 Feb 16; 14(4).
- Cell-Free HPV DNA Provides an Accurate and Rapid Diagnosis of HPV-Associated Head and Neck Cancer. Clin Cancer Res. 2022 02 15; 28(4):719-727.
- Cell-free human papillomavirus DNA kinetics after surgery for human papillomavirus-associated oropharyngeal cancer. Cancer. 2022 06 01; 128(11):2193-2204.
- Is it Time for a Molecular-based Classification System for Sinonasal Squamous Cell Carcinoma? Am J Surg Pathol. 2022 07 01; 46(7):873-877.
- Long-Term Opioid Use in Post-Surgical Management of Patients With Head and Neck Cancer. Ann Otol Rhinol Laryngol. 2022 Aug; 131(8):844-850.
- APOBEC Mutagenesis Is Concordant between Tumor and Viral Genomes in HPV-Positive Head and Neck Squamous Cell Carcinoma. Viruses. 2021 08 23; 13(8).
- Recurrent Human Papillomavirus-Related Head and Neck Cancer Undergoes Metabolic Reprogramming and Is Driven by Oxidative Phosphorylation. Clin Cancer Res. 2021 11 15; 27(22):6250-6264.
- Liquid biopsy for the diagnosis of HPV-associated head and neck cancer. Cancer Cytopathol. 2022 01; 130(1):12-15.
- Feeding Tube Placement Following Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma. Otolaryngol Head Neck Surg. 2022 04; 166(4):696-703.
- Impact of surgical margins on local control in patients undergoing single-modality transoral robotic surgery for HPV-related oropharyngeal squamous cell carcinoma. Head Neck. 2021 08; 43(8):2434-2444.
- Oropharyngeal Squamous Cell Carcinoma Morphology and Subtypes by Human Papillomavirus Type and by 16 Lineages and Sublineages. Head Neck Pathol. 2021 Dec; 15(4):1089-1098.
- Prolapsed Nasal Polyp Causing Acute Airway Obstruction: An Exceptional Presentation. ORL J Otorhinolaryngol Relat Spec. 2021; 83(3):203-205.
- Prospective assessment of multiple HPV-positive oropharyngeal squamous cell carcinomas. Oral Oncol. 2021 06; 117:105212.
- HPV+ oropharyngeal squamous cell carcinomas from patients with two tumors display synchrony of viral genomes yet discordant mutational profiles and signatures. Carcinogenesis. 2021 02 11; 42(1):14-20.
- A national cancer database analysis on stereotactic body radiation therapy of head and neck cancers. Am J Otolaryngol. 2021 May-Jun; 42(3):102913.
- Human Papillomavirus in Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. Cancers (Basel). 2020 Dec 25; 13(1).
- Opioid Usage and Prescribing Predictors Following Transoral Robotic Surgery for Oropharyngeal Cancer. Laryngoscope. 2021 06; 131(6):E1888-E1894.
- The mutational landscape of early- and typical-onset oral tongue squamous cell carcinoma. Cancer. 2021 02 15; 127(4):544-553.
- Treatment sequence of cetuximab and immune checkpoint inhibitor in head and neck squamous cell carcinoma differentially affects outcomes. Oral Oncol. 2020 12; 111:105024.
- Systematic Review of Second Primary Oropharyngeal Cancers in Patients With p16+ Oropharyngeal Cancer. Otolaryngol Head Neck Surg. 2021 04; 164(4):733-740.
- Otolaryngology in the time of COVID: An overview of common open-source telemedicine platforms. Laryngoscope Investig Otolaryngol. 2020 Oct; 5(5):839-845.
- Endopharyngeal Ultrasound: description of a novel technique to overcome a common diagnostic dilemma in a patient with a deep neck space mass. Clin Otolaryngol. 2020 Nov; 45(6):923-925.
- Sinonasal Squamous Cell Carcinoma: Etiology, Pathogenesis, and the Role of Human Papilloma Virus. Curr Otorhinolaryngol Rep. 2020 Jun; 8(2):111-119.
- Hypofractionated radiotherapy and surgery compared to standard radiotherapy in early glottic cancer. Am J Otolaryngol. 2020 Sep - Oct; 41(5):102544.
- Immune checkpoint inhibitors in sinonasal squamous cell carcinoma. Oral Oncol. 2020 10; 109:104776.
- The age of telemedicine is upon us. Laryngoscope Investig Otolaryngol. 2020 Jun; 5(3):584-585.
- Two for the price of one: Prevalence, demographics and treatment implications of multiple HPV mediated Head and Neck Cancers. Oral Oncol. 2020 01; 100:104475.
- APOBEC mutagenesis is tightly linked to the immune landscape and immunotherapy biomarkers in head and neck squamous cell carcinoma. Oral Oncol. 2019 09; 96:140-147.
- Genomic Correlates of Exceptional Response to ErbB3 Inhibition in Head and Neck Squamous Cell Carcinoma. JCO Precis Oncol. 2019; 3.
- Validation of training levels in endoscopic endonasal surgery of the skull base. Laryngoscope. 2019 10; 129(10):2253-2257.
- Immunogenomic correlates of response to cetuximab monotherapy in head and neck squamous cell carcinoma. Head Neck. 2019 08; 41(8):2591-2601.
- Complications of Nasoseptal Flap Reconstruction: A Systematic Review. J Neurol Surg B Skull Base. 2018 Oct; 79(Suppl 4):S291-S299.
- Diagnosis and endoscopic endonasal management of nontraumatic pseudoaneurysms of the cranial base. Int Forum Allergy Rhinol. 2018 05; 8(5):641-647.
- Multi-modality analysis supports APOBEC as a major source of mutations in head and neck squamous cell carcinoma. Oral Oncol. 2017 11; 74:8-14.
- Spontaneous Iliopsoas Hematoma following Microvascular Free Tissue Transfer. Case Rep Otolaryngol. 2017; 2017:7631673.
- Whole Exome Sequencing of Growing and Non-Growing Cutaneous Neurofibromas from a Single Patient with Neurofibromatosis Type 1. PLoS One. 2017; 12(1):e0170348.
- Durable treatment of ameloblastoma with single agent BRAFi Re: Clinical and radiographic response with combined BRAF-targeted therapy in stage 4 ameloblastoma. J Natl Cancer Inst. 2017 01; 109(1).
- Targeted next-generation sequencing of TP53 in oral tongue carcinoma from non-smokers. J Otolaryngol Head Neck Surg. 2016 Sep 17; 45(1):47.
- Otolaryngologic Manifestations of Levamisole-Induced Vasculitis. JAMA Otolaryngol Head Neck Surg. 2016 Mar; 142(3):299-300.
- Stimulation threshold greatly affects the predictive value of intraoperative nerve monitoring. Laryngoscope. 2015 May; 125(5):1265-70.
- Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke. Head Neck. 2015 Nov; 37(11):1642-9.
Show More
Show Less
