About My Research
Dr. Bertrand Delgutte’s research focuses on how the auditory system processes biologically significant sounds, such as speech, with the goal of understanding the neural basis of auditory perception. He is also interested in applying this knowledge to improve hearing aids and cochlear implants.
His research is motivated by the observation that hearing impaired listeners, deaf users of cochlear implants, and automatic speech recognition systems all have trouble understanding speech in noisy and reverberant settings, even if they do well in quiet. Understanding the neural mechanisms underlying the good performance of normal hearing listeners in these everyday challenging conditions may suggest improvements in both assistive devices and artificial systems.
Specific topics of research include the neural coding of musical pitch and neural mechanisms for listening in everyday reverberant environments. Dr. Delgutte is also investigating neural coding and brain plasticity in animal models of cochlear implants.
A key question is whether the degradations in the neural coding of sound observed with cochlear implants are caused by the abnormal patterns of neural activity produced by electric stimulation of the cochlea or by maladaptive plastic changes in brain circuits resulting from deafness and cochlear implantation itself. This question is addressed by recording neural activity produced by electric and acoustic stimulation in animal models with controlled amount and timing of residual hearing. This research will inform and motivate the design of new processing strategies and rehabilitation procedures for cochlear implants that work better in everyday noisy environments, and that are adapted to the history of auditory experience of individual deaf patients.
- Effect of Reverberation on Neural Responses to Natural Speech in Rabbit Auditory Midbrain: No Evidence for a Neural Dereverberation Mechanism. eNeuro. 2023 05; 10(5).
- Neural coding of dichotic pitches in auditory midbrain. J Neurophysiol. 2023 04 01; 129(4):872-893.
- Rabbits use both spectral and temporal cues to discriminate the fundamental frequency of harmonic complexes with missing fundamentals. J Neurophysiol. 2022 01 01; 127(1):290-312.
- Rate and Temporal Coding of Regular and Irregular Pulse Trains in Auditory Midbrain of Normal-Hearing and Cochlear-Implanted Rabbits. J Assoc Res Otolaryngol. 2021 06; 22(3):319-347.
- Chronic Bilateral Cochlear Implant Stimulation Partially Restores Neural Binaural Sensitivity in Neonatally-Deaf Rabbits. J Neurosci. 2021 04 21; 41(16):3651-3664.
- Robust Rate-Place Coding of Resolved Components in Harmonic and Inharmonic Complex Tones in Auditory Midbrain. J Neurosci. 2020 03 04; 40(10):2080-2093.
- Pitch of harmonic complex tones: rate and temporal coding of envelope repetition rate in inferior colliculus of unanesthetized rabbits. J Neurophysiol. 2019 12 01; 122(6):2468-2485.
- Neural coding and perception of auditory motion direction based on interaural time differences. J Neurophysiol. 2019 10 01; 122(4):1821-1842.
- Neural ITD Sensitivity and Temporal Coding with Cochlear Implants in an Animal Model of Early-Onset Deafness. J Assoc Res Otolaryngol. 2019 02; 20(1):37-56.
- Improved Neural Coding of ITD with Bilateral Cochlear Implants by Introducing Short Inter-pulse Intervals. J Assoc Res Otolaryngol. 2018 12; 19(6):681-702.
- Pitch of Harmonic Complex Tones: Rate Coding of Envelope Repetition Rate in the Auditory Midbrain. Acta Acust United Acust. 2018 Sep-Oct; 104(5):860-864.
- Introducing Short Interpulse Intervals in High-Rate Pulse Trains Enhances Binaural Timing Sensitivity in Electric Hearing. J Assoc Res Otolaryngol. 2018 06; 19(3):301-315.
- Temporal Envelope Coding by Inferior Colliculus Neurons with Cochlear Implant Stimulation. J Assoc Res Otolaryngol. 2017 Dec; 18(6):771-788.
- Neural coding of time-varying interaural time differences and time-varying amplitude in the inferior colliculus. J Neurophysiol. 2017 07 01; 118(1):544-563.
- Neural Coding of Interaural Time Differences with Bilateral Cochlear Implants in Unanesthetized Rabbits. J Neurosci. 2016 05 18; 36(20):5520-31.
- Neural population encoding and decoding of sound source location across sound level in the rabbit inferior colliculus. J Neurophysiol. 2016 Jan 01; 115(1):193-207.
- Neural coding of sound envelope in reverberant environments. J Neurosci. 2015 Mar 11; 35(10):4452-68.
- Modeling binaural responses in the auditory brainstem to electric stimulation of the auditory nerve. J Assoc Res Otolaryngol. 2015 Feb; 16(1):135-58.
- Coding of electric pulse trains presented through cochlear implants in the auditory midbrain of awake rabbit: comparison with anesthetized preparations. J Neurosci. 2014 Jan 01; 34(1):218-31.
- Dual sensitivity of inferior colliculus neurons to ITD in the envelopes of high-frequency sounds: experimental and modeling study. J Neurophysiol. 2014 Jan; 111(1):164-81.
- Decoding sound source location and separation using neural population activity patterns. J Neurosci. 2013 Oct 02; 33(40):15837-47.
- Congenital and prolonged adult-onset deafness cause distinct degradations in neural ITD coding with bilateral cochlear implants. J Assoc Res Otolaryngol. 2013 Jun; 14(3):393-411.
- Better temporal neural coding with cochlear implants in awake animals. Adv Exp Med Biol. 2013; 787:353-61.
- Neural correlates of the perception of sound source separation. Adv Exp Med Biol. 2013; 787:255-62.
- Sensitivity of cochlear nucleus neurons to spatio-temporal changes in auditory nerve activity. J Neurophysiol. 2012 Dec; 108(12):3172-95.
- Neural encoding of sound source location in the presence of a concurrent, spatially separated source. J Neurophysiol. 2012 Nov; 108(9):2612-28.
- Neural ITD coding with bilateral cochlear implants: effect of binaurally coherent jitter. J Neurophysiol. 2012 Aug 01; 108(3):714-28.
- Time course of dynamic range adaptation in the auditory nerve. J Neurophysiol. 2012 Jul; 108(1):69-82.
- A point process model for auditory neurons considering both their intrinsic dynamics and the spectrotemporal properties of an extrinsic signal. IEEE Trans Biomed Eng. 2011 Jun; 58(6):1507-10.
- Neural coding of interaural time differences with bilateral cochlear implants: effects of congenital deafness. J Neurosci. 2010 Oct 20; 30(42):14068-79.
- Spatiotemporal representation of the pitch of harmonic complex tones in the auditory nerve. J Neurosci. 2010 Sep 22; 30(38):12712-24.
- Effects of reverberation on the directional sensitivity of auditory neurons across the tonotopic axis: influences of interaural time and level differences. J Neurosci. 2010 Jun 09; 30(23):7826-37.
- Dynamic range adaptation to sound level statistics in the auditory nerve. J Neurosci. 2009 Nov 04; 29(44):13797-808.
- Accurate sound localization in reverberant environments is mediated by robust encoding of spatial cues in the auditory midbrain. Neuron. 2009 Apr 16; 62(1):123-34.
- Pitch representations in the auditory nerve: two concurrent complex tones. J Neurophysiol. 2008 Sep; 100(3):1301-19.
- Sensitivity of inferior colliculus neurons to interaural time differences in the envelope versus the fine structure with bilateral cochlear implants. J Neurophysiol. 2008 May; 99(5):2390-407.
- Response properties of neighboring neurons in the auditory midbrain for pure-tone stimulation: a tetrode study. J Neurophysiol. 2007 Oct; 98(4):2058-73.
- Sensitivity to interaural time differences in the inferior colliculus with bilateral cochlear implants. J Neurosci. 2007 Jun 20; 27(25):6740-50.
- Using evoked potentials to match interaural electrode pairs with bilateral cochlear implants. J Assoc Res Otolaryngol. 2007 Mar; 8(1):134-51.
- Phase locking of auditory-nerve fibers to the envelopes of high-frequency sounds: implications for sound localization. J Neurophysiol. 2006 Nov; 96(5):2327-41.
- Neural correlates and mechanisms of spatial release from masking: single-unit and population responses in the inferior colliculus. J Neurophysiol. 2005 Aug; 94(2):1180-98.
- Pitch of complex tones: rate-place and interspike interval representations in the auditory nerve. J Neurophysiol. 2005 Jul; 94(1):347-62.
- A physiologically based model of interaural time difference discrimination. J Neurosci. 2004 Aug 11; 24(32):7110-7.
- Improved neural representation of vowels in electric stimulation using desynchronizing pulse trains. J Acoust Soc Am. 2003 Oct; 114(4 Pt 1):2099-111.
- Desynchronization of electrically evoked auditory-nerve activity by high-frequency pulse trains of long duration. J Acoust Soc Am. 2003 Oct; 114(4 Pt 1):2066-78.
- Improved temporal coding of sinusoids in electric stimulation of the auditory nerve using desynchronizing pulse trains. J Acoust Soc Am. 2003 Oct; 114(4 Pt 1):2079-98.
- Hands-on learning in biomedical signal processing. IEEE Eng Med Biol Mag. 2003 Jul-Aug; 22(4):71-9.
- Mathematical models of cochlear nucleus onset neurons: II. model with dynamic spike-blocking state. J Comput Neurosci. 2003 Jan-Feb; 14(1):91-110.
- Mathematical models of cochlear nucleus onset neurons: I. Point neuron with many weak synaptic inputs. J Comput Neurosci. 2003 Jan-Feb; 14(1):71-90.
- Chimaeric sounds reveal dichotomies in auditory perception. Nature. 2002 Mar 07; 416(6876):87-90.
- Neural correlates of the precedence effect in the inferior colliculus: effect of localization cues. J Neurophysiol. 2002 Feb; 87(2):976-94.
- Auditory nerve fiber responses to electric stimulation: modulated and unmodulated pulse trains. J Acoust Soc Am. 2001 Jul; 110(1):368-79.
- Neurobiological foundations for the theory of harmony in western tonal music. Ann N Y Acad Sci. 2001 Jun; 930:92-116.
- A possible neurophysiological basis of the octave enlargement effect. J Acoust Soc Am. 1999 Nov; 106(5):2679-92.
- Receptive fields and binaural interactions for virtual-space stimuli in the cat inferior colliculus. J Neurophysiol. 1999 Jun; 81(6):2833-51.
- Neural correlates of the pitch of complex tones. I. Pitch and pitch salience. J Neurophysiol. 1996 Sep; 76(3):1698-716.
- Neural correlates of the pitch of complex tones. II. Pitch shift, pitch ambiguity, phase invariance, pitch circularity, rate pitch, and the dominance region for pitch. J Neurophysiol. 1996 Sep; 76(3):1717-34.
- Fractal noise strength in auditory-nerve fiber recordings. J Acoust Soc Am. 1996 Apr; 99(4 Pt 1):2210-20.
- Antimasking effects of the olivocochlear reflex. II. Enhancement of auditory-nerve response to masked tones. J Neurophysiol. 1993 Dec; 70(6):2533-49.
- Phase-locking of auditory-nerve discharges to sinusoidal electric stimulation of the cochlea. Hear Res. 1992 Feb; 58(1):79-90.
- Two-tone rate suppression in auditory-nerve fibers: dependence on suppressor frequency and level. Hear Res. 1990 Nov; 49(1-3):225-46.
- Physiological mechanisms of psychophysical masking: observations from auditory-nerve fibers. J Acoust Soc Am. 1990 Feb; 87(2):791-809.
- Speech coding in the auditory nerve: II. Processing schemes for vowel-like sounds. J Acoust Soc Am. 1984 Mar; 75(3):879-86.
- Speech coding in the auditory nerve: IV. Sounds with consonant-like dynamic characteristics. J Acoust Soc Am. 1984 Mar; 75(3):897-907.
- Speech coding in the auditory nerve: I. Vowel-like sounds. J Acoust Soc Am. 1984 Mar; 75(3):866-78.
- Speech coding in the auditory nerve: V. Vowels in background noise. J Acoust Soc Am. 1984 Mar; 75(3):908-18.
- Speech coding in the auditory nerve: III. Voiceless fricative consonants. J Acoust Soc Am. 1984 Mar; 75(3):887-96.
- Representation of speech-like sounds in the discharge patterns of auditory-nerve fibers. J Acoust Soc Am. 1980 Sep; 68(3):843-57.
- Fundamental considerations in designing auditory implants. Acta Otolaryngol. 1979 Mar-Apr; 87(3-4):204-18.
- [Response of the auditory nerve to pure sounds having abrupt onset]. Electrodiagn Ther. 1979; 16(3):139.
- Technique for the perceptual investigation of F0 contours with application to French. J Acoust Soc Am. 1978 Nov; 64(5):1319-32.
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