About My Research
Dr. Dagi has contributed substantially to the development and refinement of two new surgical techniques for managing strabismus from sixth nerve palsy, Duane syndrome, and third nerve palsy. She has employed high resolution orbital magnetic resonance imaging to demonstrate the anatomical relationships resulting from these procedures.
She is the Principal Investigator for a series of studies designed to compare the ophthalmic impact on patients with unicoronal synostosis treated by endoscopic strip craniectomy and helmeting (ESCH) rather than by fronto-orbital advancement (FOA). She demonstrated that those treated with ESCH had reduced astigmatism, amblyopia and strabismus, and a more favorable craniofacial outcome.
She also studies complex strabismus in patients with syndromic craniosynostosis or other craniofacial disorders. Through the use of high resolution orbital imaging and 3D modeling, she has demonstrated that exaggerated V-pattern strabismus has it’s origins at the orbital apex. She has studied surveillance of impending optic neuropathy in this population with OCT and prVEP.
As Director of Quality Assurance, she supervised the development of a goal-determined paradigm to evaluate outcomes of surgery for esotropia and exotropia.This methodology requires surgeons to prospective rank four possible goals of surgery on the day of each procedure.
Education
1978: BS, magna cum laude, Biochemistry, Harvard College
1983: MD, Harvard Medical School
Postgraduate Training
1984: Internship, Internal Medicine, Georgetown University Hospital
1985: Fellowship, Neuro-ophthalmology, National Eye Institute
1988: Residency, Ophthalmology, Georgetown University Hospital
1988: Chief Resident, Ophthalmology, Georgetown University Hospital
1989: Fellowship, Pediatric Ophthalmology, Boston Children's Hospital
Academic Appointments
1990-1996: Clinical Instructor in Ophthalmology, Emory University School of Medicine
1996-2002: Clinical Assistant Professor of Ophthalmology, Emory University School of Medicine
2004-2008: Instructor in Ophthalmology, Harvard Medical School
2009-2014: Assistant Professor of Ophthalmology, Harvard Medical School
2014-present: Associate Professor of Ophthalmology, Harvard Medical School
Professional Memberships
1983-2006: Member, American Medical Women's Association
1983-present: Member, American Medical Association
1989-present: Member, American Academy of Ophthalmology
1991-1994: Member, American Association for Research in Vision and Ophthalmology
1991-present: Member, American Association of Pediatric Ophthalmology and Strabismus
1994-2001: Member, Georgia Society of Ophthalmology
2004-present: Member, New England Ophthalmological Society
2014-present: Member, International Strabismological Association
2014-present: Member, World Society of Pediatric Ophthalmology and Strabismus
2017-present: Member, Association for Research in Strabismus
Honors
1988-1989: Von L. Meyer Traveling Award, Boston Children's Hospital
2004, 2006, 2008, 2011, 2013: Robert A. Petersen MD Resident Teaching Award, Boston Children's Hospital Department of Ophthalmology
2011: Children's Hospital Ophthalmology Foundation Chair, Boston Children's Hospital Department of Ophthalmology
2013: Honor Award, American Association of Pediatric Ophthalmology and Strabismus
- A comparison of chemodnervation to incisional surgery for acute, acquired, comitant esotropia: An international study. Am J Ophthalmol. 2024 Mar 04.
- Adult Strabismus Preferred Practice Pattern®. Ophthalmology. 2024 Feb 12.
- The Incidence of Strabismus After Upper and Lower Blepharoplasty in the United States. Ophthalmic Plast Reconstr Surg. 2024 Feb 09.
- Correlation of Strabismus Surgical Outcomes Graded by Goal-Determined Metric With Patient Satisfaction Survey. Am J Ophthalmol. 2023 Dec 15; 260:140-146.
- Sensitivity, Specificity, and Cutoff Identifying Optic Atrophy by Macular Ganglion Cell Layer Volume in Syndromic Craniosynostosis. Ophthalmology. 2024 Mar; 131(3):341-348.
- Ophthalmic Manifestations of Unilateral Coronal Synostosis. Curr Eye Res. 2023 10; 48(10):879-886.
- Orbital and Eyelid Characteristics, Strabismus, and Intracranial Pressure Control in Apert Children Treated by Endoscopic Strip Craniectomy versus Fronto-Orbital Advancement. Plast Reconstr Surg Glob Open. 2023 May; 11(5):e4937.
- Aberrant regeneration in an international registry of patients with 3rd-nerve palsy. Eur J Ophthalmol. 2023 Nov; 33(6):2154-2161.
- Two siblings with GAPO syndrome: Ophthalmic presentation and histopathologic findings. Ophthalmic Genet. 2023 Dec; 44(6):598-601.
- Strategies for managing strabismus from oculomotor nerve palsy. J AAPOS. 2023 02; 27(1):3-9.
- Extraocular muscle ductions following nasal transposition of the split lateral rectus muscle. Can J Ophthalmol. 2023 12; 58(6):565-569.
- Relationships among Clinical Factors and Patient-reported Outcome Measures in Adults with Convergence Insufficiency. Optom Vis Sci. 2022 09 01; 99(9):692-701.
- Nasal Transposition of the Split Lateral Rectus Muscle for Strabismus Associated With Bilateral 3rd-Nerve Palsy. Am J Ophthalmol. 2022 10; 242:165-172.
- Worldwide outcomes of nasal transposition of the split lateral rectus muscle for strabismus associated with 3rd-nerve palsy. Br J Ophthalmol. 2023 05; 107(5):725-731.
- Impact of Adding Augmented Superior Rectus Transpositions to Medial Rectus Muscle Recessions When Treating Esotropic Moebius Syndrome. Am J Ophthalmol. 2022 05; 237:83-90.
- Complication and Management of Optic Nerve Edema Resulting From Nasal Transposition of the Split Lateral Rectus Muscle. J Pediatr Ophthalmol Strabismus. 2021 May-Jun; 58(3):e12-e15.
- Long-term ophthalmic outcomes in 120 children with unilateral coronal synostosis: a 20-year retrospective analysis. J AAPOS. 2021 04; 25(2):76.e1-76.e5.
- Definition of successful outcomes after surgery for each type of strabismus: a Delphi study. J AAPOS. 2021 02; 25(1):3.e1-3.e5.
- Incidence of symptomatic vertical and torsional diplopia after superior rectus transposition for esotropic Duane syndrome and abducens nerve palsy. J AAPOS. 2020 10; 24(5):270.e1-270.e5.
- Adjustable graded augmentation of superior rectus transposition for treatment of abducens nerve palsy and Duane syndrome. J AAPOS. 2020 10; 24(5):268.e1-268.e7.
- Self-grading effect of inferior oblique myectomy and recession. J AAPOS. 2020 08; 24(4):218.e1-218.e6.
- Age at Craniosynostosis Surgery and Its Impact on Ophthalmologic Diagnoses: A Single-Center Retrospective Review. Plast Reconstr Surg. 2020 09; 146(3):375e-376e.
- Acute, severe dystonia after strabismus surgery in a patient on propofol, ondansetron, and bupropion. J AAPOS. 2020 10; 24(5):312-314.
- Evaluation and Management of V pattern Strabismus in Craniosynostosis. J Binocul Vis Ocul Motil. 2020 Jan-Mar; 70(1):40-45.
- Use of the Delphi process for defining successful outcomes for strabismus surgery. J AAPOS. 2019 12; 23(6):309-312.
- Adult Strabismus Preferred Practice Pattern®. Ophthalmology. 2020 01; 127(1):P182-P298.
- Unicoronal Synostosis. J Pediatr. 2019 10; 213:243-243.e1.
- Impact of Obstructive Sleep Apnea on Optic Nerve Function in Patients With Craniosynostosis and Recurrent Intracranial Hypertension. Am J Ophthalmol. 2019 11; 207:356-362.
- Nonsyndromic Unilateral Coronal Synostosis: A Comparison of Fronto-Orbital Advancement and Endoscopic Suturectomy. Plast Reconstr Surg. 2019 03; 143(3):838-848.
- Plugged In. Orbit. 2020 Feb; 39(1):73-74.
- Commentary: Ernest Codman and the Impact of Quality Improvement in Neurosurgery: A Century Since the Idea of the End Result. Neurosurgery. 2019 02 01; 84(2):E120-E121.
- Acquired reversible Brown syndrome caused by focal abscess of the superior oblique muscle. J AAPOS. 2019 06; 23(3):172-174.
- Consecutive superior oblique palsy after adjustable suture spacer surgery for Brown syndrome: incidence and predicting risk. J AAPOS. 2018 10; 22(5):335-339.e2.
- Management of graves myopathy: Understanding and managing vertical strabismus from thyroid eye disease. J AAPOS. 2018 08; 22(4):252-255.
- A case of Graves' ophthalmopathy associated with pembrolizumab (Keytruda) therapy. J AAPOS. 2018 08; 22(4):310-312.
- A Retrospective Review of Orbital Decompression for Thyroid Orbitopathy with Endoscopic Preservation of the Inferomedial Orbital Bone Strut. Ophthalmic Plast Reconstr Surg. 2017 Sep/Oct; 33(5):334-339.
- Cerebral Vein Malformations Result from Loss of Twist1 Expression and BMP Signaling from Skull Progenitor Cells and Dura. Dev Cell. 2017 09 11; 42(5):445-461.e5.
- Central serous chorioretinopathy following medial transposition of split lateral rectus muscle for complete oculomotor nerve palsy. J AAPOS. 2017 12; 21(6):517-518.
- ACCIDENTAL DUPLICATION: Pericardial patch Graft Repair of Severe Localized Scleral Thinning Encountered during Strabismus Surgery. J AAPOS. 2017 Jun 01.
- Patient Characteristics and Surgical Approach Impacting Simultaneous to Alternate Prism Cover Test Disparity After Exotropia Surgery: A Quantitative Look at the Difference in Motor Outcomes. J Pediatr Ophthalmol Strabismus. 2017 Jul 01; 54(4):222-230.
- Management of Small Vertical Deviations. J Pediatr Ophthalmol Strabismus. 2017 May 01; 54(3):134-136.
- Pericardial patch graft repair of severe localized scleral thinning encountered during strabismus surgery. J AAPOS. 2017 Apr; 21(2):156-156.e1.
- Rectus muscle excyclorotation and V-pattern strabismus: a quantitative appraisal of clinical relevance in syndromic craniosynostosis. Br J Ophthalmol. 2017 11; 101(11):1560-1565.
- Visual Field Loss in a Case of Recurrent Cystic Craniopharyngioma During Concomitant Treatment With Pegylated Interferon a-2b. J Pediatr Hematol Oncol. 2016 Jan; 38(1):e26-8.
- Goal-determined metrics to assess outcomes of exotropia surgery. J AAPOS. 2015 Aug; 19(4):304-10.
- Using spectral-domain optical coherence tomography to detect optic neuropathy in patients with craniosynostosis. J AAPOS. 2014 Dec; 18(6):543-9.
- Iatrogenic inferior oblique palsy: intentional disinsertion during transcaruncular approach to orbital fracture repair. J AAPOS. 2014 Oct; 18(5):511-4.
- Adjustable nasal transposition of split lateral rectus muscle for third nerve palsy. JAMA Ophthalmol. 2014 Aug; 132(8):963-9.
- Goal-determined metrics to assess outcomes of esotropia surgery. J AAPOS. 2014 Jun; 18(3):211-6.
- Superior rectus transposition vs medial rectus recession for treatment of esotropic Duane syndrome. JAMA Ophthalmol. 2014 Jun; 132(6):669-75.
- A 50-year-old man with a long-standing, large-angle exotropia and limitation of adduction in the left eye. Digit J Ophthalmol. 2013; 19(4):64-7.
- Screw implantation in the globe: the risk of delayed hardware migration from craniofacial repair. J Craniofac Surg. 2013 Sep; 24(5):1650-2.
- Improving ophthalmic outcomes in children with unilateral coronal synostosis by treatment with endoscopic strip craniectomy and helmet therapy rather than fronto-orbital advancement. J AAPOS. 2013 Jun; 17(3):259-65.
- Morning glory disc anomaly in association with ipsilateral optic nerve glioma. Arch Ophthalmol. 2012 Aug; 130(8):1082-3.
- Associated signs, demographic characteristics, and management of dacryocystocele in 64 infants. J AAPOS. 2012 Jun; 16(3):255-60.
- Superior rectus transposition and medial rectus recession for Duane syndrome and sixth nerve palsy. Arch Ophthalmol. 2012 Feb; 130(2):195-201.
- Papilledema in the setting of x-linked hypophosphatemic rickets with craniosynostosis. Case Rep Ophthalmol. 2011 Sep; 2(3):376-81.
- Amniotic membrane implantation to reduce extraocular muscle adhesions to a titanium implant. J AAPOS. 2011 Aug; 15(4):404-6.
- Effect of age on response to amblyopia treatment in children. Arch Ophthalmol. 2011 Nov; 129(11):1451-7.
- Thyroid eye disease: honing your skills to improve outcomes. J AAPOS. 2010 Oct; 14(5):425-31.
- Amblyopia. PIER American College of Physicians
. 2010. - Thyroid eye disease: Honing your skills to improve outcomes. JAAPOS. 2010; In press.
- Treatment of unilateral coronal synostosis by endoscopic strip craniectomy or fronto-orbital advancement: Ophthalmologic findings. J AAPOS. 2009 Apr; 13(2):155-60.
- Outcomes of treatment of nasolacrimal duct obstruction in children with down syndrome. JAAPOS. 2009; 13(1):e21-22.
- Managing Graves Orbitopathy: Honing Your Skills to Improve Outcomes. JAAPOS. 2009; 13(1):e33.
- Interobserver reliability of the prism and alternate cover test in children with esotropia. Arch Ophthalmol. 2009; 127(1):59-65.
- Ocular misalignment in Graves disease may mimic that of superior oblique palsy. J Neuroophthalmol. 2008 Dec; 28(4):302-4.
- Instability of ocular alignment in childhood esotropia. Ophthalmology. 2008 Dec; 115(12):2266-2274.e4.
- Pediatric graves' orbitopathy: The pre- and post-pubertal experience. JAAPOS. 2008; 12(4):357-60.
- Visual Outcomes in Pediatric Pseudotumor Cerebri. American Association of Pediatric Ophthalmology and Strabismus April 2008. 2008.
- Endoscopic Strip Craniectomy for Unilateral Coronal Synostosis: Impact on the Evolution of Strabismus. American Association of Pediatric Ophthalmology and Strabismus April 2008. 2008.
- Pediatric Graves' ophthalmopathy: the pre- and postpubertal experience. J AAPOS. 2008 Aug; 12(4):357-60.
- Transient monocular vision loss from acute rheumatic fever. Pediatr Cardiol. 2008 Sep; 29(5):966-8.
- The etiology of V pattern strabismus in patients with craniosynostosis. Int Ophthalmol Clin. 2008; 48(2):215-23.
- Complex Strabismus (Chapter 318). Principals and Practice of Ophthalmology, eds Albert and Miller. 2008; 4(3rd edition):4345-4356.
- Astigmatism in unilateral coronal synostosis: incidence and laterality. J AAPOS. 2007 Aug; 11(4):367-72.
- Stability of visual acuity improvement following discontinuation of amblyopia treatment in children 7 to 12 years old. Arch Ophthalmol. 2007; 125:655-659.
- Visual Outcomes in Pediatric Pseudotumor Cerebri.
. American Academy of Ophthalmology November 2006
. 2006. - Anterior axial lens subluxation, progressive myopia, and angle-closure glaucoma: recognition and treatment of atypical presentation of ectopia lentis. J AAPOS. 2006 Aug; 10(4):345-50.
- Preferred Practice Guidelines; Idiopathic Intracranial Hypertension/ Pseudotumor Cerebri. 2006.
- Incidence and Laterality of Astigmatism in Unilateral Coronal Synostosis
. American Association of Pediatric Ophthalmology and Strabismus March 2005. 2005. - Randomized trial of treatment of amblyopia in children ages 7 to 17 years.
. Arch Ophthalmol. 2005; 123:437-47. - Axial Ectopia Lentis with Synechial Angle Closure in a New Connective Tissue Disorder. American Association of Pediatric Ophthalmology and Strabismus March 2002. 2002.
- Ophthalmic Manifestations of Bear-Stevenson Syndrome. American Association of Pediatric Ophthalmology and Strabismus April 1993. 1993.
- Perinatal and Early Infantile Presentation of Familial Exudative Vitreo-Retinopathy. American Association of Pediatric Ophthalmology and Strabismus February 1992. 1992.
- The evaluation and treatment of secondary optic atrophy associated with craniofacial abnormalities. Act, Second International Congress of the Society of Cranio-Maxillo-Facial Surgery. 1991; 449-453.
- The Evaluation and Treatment of Secondary Optic Atrophy Associated with Craniofacial Abnormalities. Acta, Second International Congress of the Society of Cranio-Maxillo-Facial Surgery. 1991; 449-453.
- Arrangement of ocular dominance columns in human visual cortex. Arch Ophthalmol. 1990 Jul; 108(7):1025-31.
- Hyperopia in complicated Leber's congenital amaurosis. Arch Ophthalmol. 1990 May; 108(5):709-12.
- Hyperopia as a Feature of Complicated and Uncomplicated Leber's Congenital Amaurosis. American Association of Pediatric Ophthalmology and Strabismus April 1989. 1989.
- Observations on the Tradition of Autoexperimentation in Medicine. The Use of Human Beings in Research with Special Reference to Clinical Trials; eds Spicker,S, Alon, A, DeVries, HT, Englehardt,JR. 1988; 249-260.
- Ocular Dominance Columns in Human Visual Cortex. NANOS February 1988. 1988.
- Spasm of the near reflex associated with organic disease. Am J Ophthalmol. 1987 Apr 15; 103(4):582-5.
- Spasm of the Near Reflex Associated with Organic Disease. Association for Research in Vision and Ophthalmology June 1987. 1987.
- Branch retinal artery occlusion in the Churg-Strauss syndrome. J Clin Neuroophthalmol. 1985 Dec; 5(4):229-37.
- Over The Counter Pills that Don't Work. 1983.
- An Applicant's Guide to the New York City Certificate of Need Process. 1981.
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