Teresa C. Chen,
MD
Massachusetts Eye and Ear
Senior Scientist
Harvard Medical School
Associate Professor of Ophthalmology
teresa_chen@meei.harvard.edu
For investigator inquiries only
About My Research
Center/Research Area Affiliations
Biography
Dr. Chen focuses her research on three-dimensional (3D) imaging of the eye using spectral domain optical coherence tomography (SDOCT) and swept source imaging. Along with collaborators at Massachusetts General Hospital, her research group was the first to image the human eye in vivo with video rate SDOCT, a widely used imaging modality for the care of glaucoma patients. With SDOCT, ultra-highresolution 3D video imaging of the optic nerve and the retina is now possible. Her group was the first to prove that the commercially available scanning laser polarimeter (GDx machine) produces incorrect nerve fiber layer measurements and is based on a false principle. Dr. Chen has been both first and last author on major papers published in the top three ophthalmology journals, Archives of Ophthalmology (now JAMA Ophthalmology), American Journal of Ophthalmology, and Ophthalmology. Dr. Chen also has clinical and research interests in pediatric glaucoma.
Education
1991: BS, Biology, Rensselaer Polytechnic Institute
1993: MD, Albany Medical College
Academic Appointments
Internship, Internal Medicine, Brigham and Women's Hospital
Residency, Ophthalmology, University of Illinois
Fellowship, Glaucoma, Massachusetts Eye and Ear
Professional Memberships
1994-present: Member, American Academy of Ophthalmology
1998-present: Member, Association for Research in Vision and Ophthalmology
2004-2008: Vice-President, Chandler Grant Glaucoma Society
2006: Practicing Ophthalmologists Curriculum Panel, American Academy of Ophthalmology
2006-2013: Advisory Board, The Glaucoma Foundation New England chapter
2006-2011: Adult Vision Advisory Committee, Prevent Blindness America
2009-present: Member, American Ophthalmological Society
2011-2015: President, Chandler Grant Glaucoma Society
2011-present: Member, Multimedia Committee, American Academy of Ophthalmology
2012-2014: Glaucoma Subspecialty Day Committee member, American Academy of Ophthalmology
2013-present: Chair, Ophthalmology Technology Assessment Committee, Glaucoma Section, American Academy of Ophthalmology
Honors
1986: NSTA and NASA Award
1986: International Science and Engineering Fair Finalist
1987: Westinghouse Honors Group
1987: All-USA High School Scholar (top 20 high school students in the country)
1987: National Merit Scholarship
1989: The National Dean's List Multiple Year Award for Outstanding Achievement
1989: Alpha Epsilon Delta, The Premedical Honor Society
1991: Rensselaer Polytechnic Institute (College) Rank 1 of 1063
1991: Dean's Award for Outstanding Research
1991: NIH Research Fellowship Award
1991: AOA Student Research Fellowship Award
1991: Junior Alpha Omega Alpha (AOA)
1992: Dean's Award for Outstanding Research
1993: Dean's Senior Research Award
1993: The Robert D. Reinecke Prize for Research in Ophthalmology
1993: Albany Medical College (Medical School) Rank 1 of 125
1997: Heed Fellowship
2002: America's Top Ophthalmologists Consumer Research Council of America
2006: Top Ten Presentations of the American Glaucoma Society (International Glaucoma Rev.)
2007: Best Doctors in America
2008: Nomination for Harvard Medical School's Excellence in Mentoring Award
2009: American Academy of Ophthalmology Achievement Award
2012: Nomination for Partners Outstanding Clinical Teacher Award
2014: Nomination for Harvard Medical School's Excellence in Mentoring Award
2017: Harvard Medical School’s Clifford Barger Excellence in Mentoring Award
2018: American Academy of Ophthalmology Senior Achievement Award
Publications powered by Harvard Catalyst Profiles
- Facilitating glaucoma diagnosis with intereye neuroretinal rim asymmetry analysis using spectral-domain optical coherence tomography. Digit J Ophthalmol. 2022; 28(4):100-109.
- Evidence for Complementary and Alternative Therapies to Treat Glaucoma. Semin Ophthalmol. 2022 Dec 05; 1-7.
- Reproducibility of Neuroretinal Rim Measurements Obtained from High-Density Spectral Domain Optical Coherence Tomography Volume Scans. Clin Ophthalmol. 2022; 16:2595-2608.
- Restoration of Vision in Severe, Cicatricial, Ocular Surface Disease With the Boston Keratoprosthesis Type II. Am J Ophthalmol. 2022 11; 243:42-54.
- Two pediatric cases of reticular corneal epithelial edema associated with netarsudil. Am J Ophthalmol Case Rep. 2022 Sep; 27:101638.
- Large Subconjunctival Mass in a Patient With a History of Multiple Previous Ocular Surgeries. JAMA Ophthalmol. 2022 05 01; 140(5):534-535.
- New views on three-dimensional imaging technologies for glaucoma: an overview. Curr Opin Ophthalmol. 2022 Mar 01; 33(2):103-111.
- Netarsudil-associated reticular corneal epithelial edema. Am J Ophthalmol Case Rep. 2022 Mar; 25:101287.
- Endoscopic Cyclophotocoagulation in Boston Keratoprosthesis Type II. Ophthalmol Glaucoma. 2022 Jan-Feb; 5(1):120-123.
- Disc Hemorrhages Are Associated With Localized Three-Dimensional Neuroretinal Rim Thickness Progression in Open-Angle Glaucoma. Am J Ophthalmol. 2022 02; 234:188-198.
- Structure-Function Mapping Using a Three-Dimensional Neuroretinal Rim Parameter Derived From Spectral Domain Optical Coherence Tomography Volume Scans. Transl Vis Sci Technol. 2021 05 03; 10(6):28.
- Earlier Detection of Glaucoma Progression Using High-Density 3-Dimensional Spectral-Domain OCT Optic Nerve Volume Scans. Ophthalmol Glaucoma. 2021 Nov-Dec; 4(6):604-616.
- Three-dimensional Neuroretinal Rim Thickness and Visual Fields in Glaucoma: A Broken-stick Model. J Glaucoma. 2020 10; 29(10):952-963.
- A Patient With Glaucoma With Corneal Edema. JAMA Ophthalmol. 2020 08 01; 138(8):917-918.
- Repair of Tube Erosion by Modifying the Tube Extender. J Glaucoma. 2020 07; 29(7):604-606.
- Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Retinal Nerve Fiber Layer Volume. Transl Vis Sci Technol. 2020 02 12; 9(3):12.
- In Reply: Protocol For Titrated Endocycloplasty When Combined With Phacoemulsification in an Exclusive Cohort of Angle Closure Glaucoma. J Glaucoma. 2019 12; 28(12):e178-e179.
- Three-Dimensional Optical Coherence Tomography Imaging For Glaucoma Associated With Boston Keratoprosthesis Type I and II. J Glaucoma. 2019 08; 28(8):718-726.
- Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software. J Glaucoma. 2019 08; 28(8):708-717.
- Pediatric intraocular pressure measurements: Tonometers, central corneal thickness, and anesthesia. Surv Ophthalmol. 2019 Nov - Dec; 64(6):810-825.
- Differential Efficacy of Combined Phacoemulsification and Endocyclophotocoagulation in Open-angle Glaucoma Versus Angle-closure Glaucoma. J Glaucoma. 2019 05; 28(5):473-480.
- Effects of Age, Race, and Ethnicity on the Optic Nerve and Peripapillary Region Using Spectral-Domain OCT 3D Volume Scans. Transl Vis Sci Technol. 2018 Nov; 7(6):12.
- A Comprehensive Surgical Curriculum Reduced Intra-operative Complication Rates of Resident-performed Cataract Surgeries. J Surg Educ. 2019 Jan - Feb; 76(1):150-157.
- Spectral-Domain OCT: Helping the Clinician Diagnose Glaucoma: A Report by the American Academy of Ophthalmology. Ophthalmology. 2018 11; 125(11):1817-1827.
- The ISNT Rule: How Often Does It Apply to Disc Photographs and Retinal Nerve Fiber Layer Measurements in the Normal Population? Am J Ophthalmol. 2017 Dec; 184:19-27.
- Volumetric Measurement of Optic Nerve Head Drusen Using Swept-Source Optical Coherence Tomography. J Glaucoma. 2017 09; 26(9):798-804.
- Diagnostic Capability of Peripapillary Three-dimensional Retinal Nerve Fiber Layer Volume for Glaucoma Using Optical Coherence Tomography Volume Scans. Am J Ophthalmol. 2017 Oct; 182:180-193.
- Diagnostic Capability of Peripapillary Retinal Volume Measurements in Glaucoma. J Glaucoma. 2017 Jun; 26(6):592-601.
- Structural Changes Associated with Delayed Dark Adaptation in Age-Related Macular Degeneration. Ophthalmology. 2017 09; 124(9):1340-1352.
- Enhanced Diagnostic Capability for Glaucoma of 3-Dimensional Versus 2-Dimensional Neuroretinal Rim Parameters Using Spectral Domain Optical Coherence Tomography. J Glaucoma. 2017 05; 26(5):450-458.
- Endoscopic Cyclophotocoagulation for the Treatment of Glaucoma in Boston Keratoprosthesis Type II Patient. J Glaucoma. 2017 Apr; 26(4):e146-e149.
- Automated Brightness and Contrast Adjustment of Color Fundus Photographs for the Grading of Age-Related Macular Degeneration. Transl Vis Sci Technol. 2017 Mar; 6(2):3.
- Case 34-2016. A 17-Year-Old Boy with Myopia and Craniofacial and Skeletal Abnormalities. N Engl J Med. 2016 11 10; 375(19):1879-1890.
- Comprehensive Three-Dimensional Analysis of the Neuroretinal Rim in Glaucoma Using High-Density Spectral-Domain Optical Coherence Tomography Volume Scans. Invest Ophthalmol Vis Sci. 2016 Oct 01; 57(13):5498-5508.
- Patterns of Retinal Nerve Fiber Layer Loss in Different Subtypes of Open Angle Glaucoma Using Spectral Domain Optical Coherence Tomography. J Glaucoma. 2016 10; 25(10):865-872.
- Long-term Visual Outcomes and Complications of Boston Keratoprosthesis Type II Implantation. Ophthalmology. 2017 01; 124(1):27-35.
- New Ultrasound Biomicroscopy Iris Findings in Juvenile Xanthogranuloma. J Glaucoma. 2016 08; 25(8):e759-60.
- Diagnostic Performance of a Novel Three-Dimensional Neuroretinal Rim Parameter for Glaucoma Using High-Density Volume Scans. Am J Ophthalmol. 2016 09; 169:168-178.
- Assessing Resident Cataract Surgery Outcomes Using Medicare Physician Quality Reporting System Measures. J Surg Educ. 2016 Sep-Oct; 73(5):774-9.
- Facilitating Glaucoma Diagnosis With Intereye Retinal Nerve Fiber Layer Asymmetry Using Spectral-Domain Optical Coherence Tomography. J Glaucoma. 2016 Feb; 25(2):167-76.
- Unilateral Eye Findings: A Rare Herald of Acute Leukemia. Ocul Oncol Pathol. 2016 Apr; 2(3):166-70.
- Sentinel Events, Serious Reportable Events, and Root Cause Analysis. JAMA Ophthalmol. 2015 Jun; 133(6):631-2.
- Patterns of functional vision loss in glaucoma determined with archetypal analysis. J R Soc Interface. 2015 Feb 06; 12(103).
- Patient characteristics associated with artifacts in Spectralis optical coherence tomography imaging of the retinal nerve fiber layer in glaucoma. Am J Ophthalmol. 2015 Mar; 159(3):565-76.e2.
- Diagnostic capability of peripapillary retinal thickness in glaucoma using 3D volume scans. Am J Ophthalmol. 2015 Mar; 159(3):545-56.e2.
- Cataract surgery in pseudoexfoliation syndrome. Semin Ophthalmol. 2014 Sep-Nov; 29(5-6):403-8.
- Pediatric glaucoma surgery: a report by the American Academy Of Ophthalmology. Ophthalmology. 2014 Nov; 121(11):2107-15.
- A survey of preoperative blood tests in primary open-angle glaucoma patients versus cataract surgery patients. Digit J Ophthalmol. 2014; 20(2):20-8.
- Effect of brimonidine on retinal vascular autoregulation and short-term visual function in normal tension glaucoma. Am J Ophthalmol. 2014 Jul; 158(1):105-112.e1.
- Correlation of retinal nerve fiber layer thickness and visual fields in glaucoma: a broken stick model. Am J Ophthalmol. 2014 May; 157(5):953-59.
- Achieving target refraction after cataract surgery. Ophthalmology. 2014 Feb; 121(2):440-4.
- Analysis of normal retinal nerve fiber layer thickness by age, sex, and race using spectral domain optical coherence tomography. J Glaucoma. 2013 Sep; 22(7):532-41.
- Inadvertent filtering bleb due to corneal stromal wick syndrome. J Glaucoma. 2013 Sep; 22(7):e14-5.
- Intravitreal injections at the Massachusetts Eye and Ear Infirmary: analysis of treatment indications and postinjection endophthalmitis rates. Br J Ophthalmol. 2013 Apr; 97(4):460-5.
- CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States. Am J Ophthalmol. 2013 Feb; 155(2):342-353.e5.
- Macular imaging for glaucoma using spectral-domain optical coherence tomography: a review. Semin Ophthalmol. 2012 Sep-Nov; 27(5-6):160-6.
- Diagnostic capability of spectral-domain optical coherence tomography for glaucoma. Am J Ophthalmol. 2012 May; 153(5):815-826.e2.
- Bilateral uveal effusion and angle-closure glaucoma associated with bupropion use. Arch Ophthalmol. 2012 Jan; 130(1):120-2.
- Reproducibility of retinal nerve fiber layer thickness measurements using spectral domain optical coherence tomography. J Glaucoma. 2011 Oct; 20(8):470-6.
- Peripapillary retinal thickness maps in the evaluation of glaucoma patients: a novel concept. ISRN Ophthalmol. 2011; 2011:146813.
- The use of prostaglandin analogs in the uveitic patient. Semin Ophthalmol. 2011 Jul-Sep; 26(4-5):285-9.
- Delayed sterile endophthalmitis after glaucoma drainage implantation. Semin Ophthalmol. 2011 Jul-Sep; 26(4-5):290-4.
- Prenatal diagnosis of rhabdomyomas and cerebral tuberous sclerosis by magnetic resonance imaging in one fetus of a dizygotic twin pregnancy associated with a frameshift mutation in the TSC2 gene. Taiwan J Obstet Gynecol. 2010 Sep; 49(3):387-9.
- Prenatal diagnosis of persistent cloaca with hydrometrocolpos and ascites by magnetic resonance imaging in one fetus of a dizygotic twin pregnancy. Taiwan J Obstet Gynecol. 2010 Sep; 49(3):385-6.
- Lack of association of polymorphisms in elastin with pseudoexfoliation syndrome and glaucoma. J Glaucoma. 2010 Sep; 19(7):432-6.
- Shunts to divert aqueous humor to distant epithelialized cavities after keratoprosthesis surgery. J Glaucoma. 2010 Feb; 19(2):111-5.
- Combined cataract and glaucoma surgeries: traditional and new combinations. Int Ophthalmol Clin. 2010; 50(1):95-106.
- Spectral domain optical coherence tomography in glaucoma: qualitative and quantitative analysis of the optic nerve head and retinal nerve fiber layer (an AOS thesis). Trans Am Ophthalmol Soc. 2009 Dec; 107:254-81.
- Terminal 2q deletion and distal 15q duplication: prenatal diagnosis by array comparative genomic hybridization using uncultured amniocytes. Taiwan J Obstet Gynecol. 2009 Dec; 48(4):441-5.
- Imaging of optic nerve head drusen: improvements with spectral domain optical coherence tomography. J Glaucoma. 2009 Jun-Jul; 18(5):373-8.
- The effects of intravitreal ophthalmic medications on intraocular pressure. Semin Ophthalmol. 2009 Mar-Apr; 24(2):100-5.
- Correlation of filtration bleb morphology with histology. Int Ophthalmol Clin. 2009; 49(1):71-82.
- In vivo three-dimensional imaging of neovascular age-related macular degeneration using optical frequency domain imaging at 1050 nm. Invest Ophthalmol Vis Sci. 2008 Oct; 49(10):4545-52.
- Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):3005-10.
- Aniridia. Int Ophthalmol Clin. 2008; 48(2):79-85.
- Spectral domain optical coherence tomography and glaucoma. Int Ophthalmol Clin. 2008; 48(4):29-45.
- Aphakic glaucoma after congenital cataract surgery. Int Ophthalmol Clin. 2008; 48(2):87-94.
- Clinical and genetic characteristics of primary juvenile-onset open-angle glaucoma (JOAG). Semin Ophthalmol. 2008 Jan-Feb; 23(1):19-25.
- Corneal blood staining after traumatic hyphema. J Pediatr Ophthalmol Strabismus. 2007 Jul-Aug; 44(4):256.
- Autocalibration of spectral-domain optical coherence tomography spectrometers for in vivo quantitative retinal nerve fiber layer birefringence determination. J Biomed Opt. 2007 Jul-Aug; 12(4):041205.
- Endophthalmitis after glaucoma drainage implant surgery. Int Ophthalmol Clin. 2007; 47(2):109-15.
- Risk factors for the development of aphakic glaucoma after congenital cataract surgery. J Pediatr Ophthalmol Strabismus. 2006 Sep-Oct; 43(5):274-80; quiz 306-7.
- The course of glaucoma during pregnancy: a retrospective case series. Arch Ophthalmol. 2006 Aug; 124(8):1089-94.
- Histologic correlation of in vivo optical coherence tomography images of the human retina. Am J Ophthalmol. 2006 Jun; 141(6):1165-8.
- Ultra-high speed and ultra-high resolution spectral-domain optical coherence tomography and optical Doppler tomography in ophthalmology. Bull Soc Belge Ophtalmol. 2006; (302):123-32.
- In vivo thickness and birefringence determination of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography. Bull Soc Belge Ophtalmol. 2006; (302):109-21.
- Risk factors for the development of aphakic glaucoma after congenital cataract surgery. Trans Am Ophthalmol Soc. 2006; 104:241-51.
- Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging. Arch Ophthalmol. 2005 Dec; 123(12):1715-20.
- Brimonidine 0.15% versus apraclonidine 0.5% for prevention of intraocular pressure elevation after anterior segment laser surgery. J Cataract Refract Surg. 2005 Sep; 31(9):1707-12.
- Ahmed valve surgery for refractory pediatric glaucoma: a report of 52 eyes. J Pediatr Ophthalmol Strabismus. 2005 Sep-Oct; 42(5):274-83; quiz 304-5.
- Complications of pediatric lensectomy in 193 eyes. Ophthalmic Surg Lasers Imaging. 2005 Jan-Feb; 36(1):6-13.
- Aphakic glaucoma after congenital cataract surgery. Arch Ophthalmol. 2004 Dec; 122(12):1819-25.
- Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography. Invest Ophthalmol Vis Sci. 2004 Aug; 45(8):2606-12.
- In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography. Opt Lett. 2004 Mar 01; 29(5):480-2.
- Management and prevention of thin, cystic blebs. Int Ophthalmol Clin. 2004; 44(1):29-42.
- Prevention of aniridic glaucoma with goniosurgery. Int Ophthalmol Clin. 2004; 44(1):67-71.
- In vivo birefringence and thickness measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography. J Biomed Opt. 2004 Jan-Feb; 9(1):121-5.
- New Ahmed valve designs. Int Ophthalmol Clin. 2004; 44(1):123-38.
- Topiramate induced myopic shift and angle closure glaucoma. Br J Ophthalmol. 2003 May; 87(5):648-9.
- Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4712-7.
- Retrobulbar chlorpromazine injections for the management of blind and seeing painful eyes. J Glaucoma. 2002 Jun; 11(3):209-13.
- Traumatic hyphema. Int Ophthalmol Clin. 2002; 42(3):57-68.
- Brimonidine 0.2% versus apraclonidine 0.5% for prevention of intraocular pressure elevations after anterior segment laser surgery. Ophthalmology. 2001 Jun; 108(6):1033-8.
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