Petr Baranov,
MD, PhD
Massachusetts Eye and Ear
Assistant Scientist
Harvard Medical School
Assistant Professor of Ophthalmology
Associate Director, Ocular Regenerative Medicine Institute
petr_baranov@meei.harvard.edu
For investigator inquiries only
About My Research
Center/Research Area Affiliations
- Age-related Macular Degeneration Center of Excellence
- Glaucoma Centerof Excellence
- Ocular Regenerative Medicine Institute
Biography
An internationally trained scientist, Dr. Baranov is committed to the development of stem-cell based and molecular therapies for blinding diseases. At Schepens Eye Research Institute of Mass Eye and Ear, his lab is spearheading the transplantation of stem-cell derived retinal ganglion cells in animal models of Glaucoma. They have demonstrated that it is possible to produce functional RGCs from stem cells and successfully engraft them into the diseased retina. Now they combine the advancements in stem cell biology with tissue engineering and imaging tools to address major hurdles in RGC replacement. He also works on collaborative projects, that explore neuroprotection and disease modeling.
Education
2007: MSc, MD, Medicine, Medical cybernetics, Russian State Medical University (RSMU)
2011: PhD, Cell Biology, Ophthalmology, RSMU, Research Institute for Eye Diseases, Russian Academy of Medical Sciences
Postgraduate Training
2014: Postdoctoral fellowship, Retinal regeneration/tissue engineering, Schepens Eye Research Institute of Mass Eye and Ear
Academic Appointments
2017-present: Assistant Professor in Ophthalmology, Harvard Medical School
Professional Memberships
2010-present: International Society for Stem Cell Research
2011-present: Association for Research in Vision and Ophthalmology
2015-present: International Society for Eye Research
Honors
2011: Brazilian Council of Ophthalmology Award (with Caio Regatieri and Michael Young), Brazilian Council of Ophthalmology
2017: ARVO/Genentech AMD Fellowship
Publications powered by Harvard Catalyst Profiles
- SOCS3 regulates pathological retinal angiogenesis through modulating SPP1 expression in microglia and macrophages. Mol Ther. 2024 Mar 19.
- Photoreceptors inhibit pathological retinal angiogenesis through transcriptional regulation of Adam17 via c-Fos. Angiogenesis. 2024 Mar 14.
- Sustained neurotrophic factor cotreatment enhances donor and host retinal ganglion cell survival in mice. bioRxiv. 2024 Mar 12.
- Suppressing DNMT3a Alleviates the Intrinsic Epigenetic Barrier for Optic Nerve Regeneration and Restores Vision in Adult Mice. bioRxiv. 2023 Nov 23.
- Controlling donor and newborn neuron migration and maturation in the eye through microenvironment engineering. Proc Natl Acad Sci U S A. 2023 Nov 14; 120(46):e2302089120.
- Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium. Mol Neurodegener. 2023 09 21; 18(1):64.
- The Retinal Ganglion Cell Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration Consortium. Ophthalmol Sci. 2023 Dec; 3(4):100390.
- IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinflammation in glaucoma and brain tauopathy. Cell Rep. 2023 08 29; 42(8):112889.
- The importance of unambiguous cell origin determination in neuronal repopulation studies. iScience. 2023 Apr 21; 26(4):106361.
- In vivo study to assess dosage of allogeneic pig retinal progenitor cells: Long-term survival, engraftment, differentiation and safety. J Cell Mol Med. 2022 06; 26(11):3254-3268.
- Transplantation of miPSC/mESC-derived retinal ganglion cells into healthy and glaucomatous retinas. Mol Ther Methods Clin Dev. 2021 Jun 11; 21:180-198.
- Semi-Automated Approach for Retinal Tissue Differentiation. Transl Vis Sci Technol. 2020 09; 9(10):24.
- Convolutional Neural Networks Can Predict Retinal Differentiation in Retinal Organoids. Front Cell Neurosci. 2020; 14:171.
- C6 Cell Injection into the Optic Nerve of Long-Evans Rats: A Short-Term Model of Optic Pathway Gliomas. Cell Transplant. 2020 Jan-Dec; 29:963689720964383.
- Optimizing the Conditions and Use of Synthetic Matrix for Three-Dimensional In Vitro Retinal Differentiation from Mouse Pluripotent Cells. Tissue Eng Part C Methods. 2019 07; 25(7):433-445.
- In Situ Cross-linking Hydrogel as a Vehicle for Retinal Progenitor Cell Transplantation. Cell Transplant. 2019 05; 28(5):596-606.
- Photoreceptor preservation induced by intravitreal controlled delivery of GDNF and GDNF/melatonin in rhodopsin knockout mice. Mol Vis. 2018; 24:733-745.
- Author Correction: Retinal progenitor cells release extracellular vesicles containing developmental transcription factors, microRNA and membrane proteins. Sci Rep. 2018 Oct 22; 8(1):15801.
- Novel engineered, membrane-localized variants of vascular endothelial growth factor (VEGF) protect retinal ganglion cells: a proof-of-concept study. Cell Death Dis. 2018 10 03; 9(10):1018.
- Multifarious Biologic Loaded Liposomes that Stimulate the Mammalian Target of Rapamycin Signaling Pathway Show Retina Neuroprotection after Retina Damage. ACS Nano. 2018 08 28; 12(8):7497-7508.
- Regenerative medicine in the retina: from stem cells to cell replacement therapy. Ther Adv Ophthalmol. 2018 Jan-Dec; 10:2515841418774433.
- Retinal progenitor cells release extracellular vesicles containing developmental transcription factors, microRNA and membrane proteins. Sci Rep. 2018 02 12; 8(1):2823.
- The iPSc-Derived Retinal Tissue as a Tool to Study Growth Factor Production in the Eye. Adv Exp Med Biol. 2018; 1074:619-624.
- A Novel Neuroprotective Small Molecule for Glial Cell Derived Neurotrophic Factor Induction and Photoreceptor Rescue. J Ocul Pharmacol Ther. 2017 06; 33(5):412-422.
- Interphotoreceptor matrix based biomaterial: Impact on human retinal progenitor cell attachment and differentiation. J Biomed Mater Res B Appl Biomater. 2018 02; 106(2):891-899.
- Decellularized retinal matrix: Natural platforms for human retinal progenitor cell culture. Acta Biomater. 2016 Feb; 31:61-70.
- A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity. Stem Cell Reports. 2015 Nov 10; 5(5):763-775.
- The Effect of Transient Local Anti-inflammatory Treatment on the Survival of Pig Retinal Progenitor Cell Allotransplants. Transl Vis Sci Technol. 2015 Sep; 4(5):6.
- Enhanced differentiation and delivery of mouse retinal progenitor cells using a micropatterned biodegradable thin-film polycaprolactone scaffold. Tissue Eng Part A. 2015 Apr; 21(7-8):1247-60.
- Interphotoreceptor matrix-poly(?-caprolactone) composite scaffolds for human photoreceptor differentiation. J Tissue Eng. 2014; 5:2041731414554139.
- Functional and morphological analysis of the subretinal injection of human retinal progenitor cells under Cyclosporin A treatment. Mol Vis. 2014; 20:1271-80.
- Hybrid vitronectin-mimicking polycaprolactone scaffolds for human retinal progenitor cell differentiation and transplantation. J Biomater Appl. 2015 Jan; 29(6):894-902.
- Approaches to cell delivery: substrates and scaffolds for cell therapy. Dev Ophthalmol. 2014; 53:143-54.
- Low-oxygen culture conditions extend the multipotent properties of human retinal progenitor cells. Tissue Eng Part A. 2014 May; 20(9-10):1465-75.
- Human retinal progenitor cell transplantation preserves vision. J Biol Chem. 2014 Mar 07; 289(10):6362-6371.
- Synthetic peptide-acrylate surface for self-renewal of human retinal progenitor cells. Tissue Eng Part C Methods. 2013 Apr; 19(4):265-70.
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