Mohamed Ismail Ashrafali, Ph.D.

Harvard Medical School

Instructor in Ophthalmology

Massachusetts Eye and Ear

Investigator

Research Summary

Dr. Ashrafali is an investigator in the field of virology. He received his PhD in 2013 from Christian Medical College in Vellore, India, where his research focused on hepatitis B virus genomics and antiviral resistance mechanisms. Following the completion of his academic program, Dr. Ashrafali joined the Chodosh laboratory at Mass. Eye and Ear where he researches the biology and evolution of human adenoviruses that are associated with epidemic keratoconjunctivitis, a severe and contagious eye infection. There is currently no antiviral treatment for this disease.

Dr. Ashrafali’s research interest includes i) evolutionary analysis of human adenoviruses, ii) genome-wide binding profiles of transcription factors to adenoviral DNA and its gene regulation, iii) virus-host protein interactions using affinity purification and mass spectrometry methods, and iv) viral DNA sensors and immune evasion strategies.

Download his CV for more information.

Education

2004: B.Sc., Microbiology, Bharathiar University, Coimbatore, TN, India

2006: M.Sc., Applied Microbiology, Vellore Institute of Technology (VIT), Vellore, TN, India

2013: Ph.D., Clinical Virology, Christian Medical College (CMC) Vellore, TN, India

Postgraduate Training

2018: Research Fellowship, Ophthalmology, Viral Pathogenesis Laboratory, Massachusetts Eye and Ear

Academic Appointments

2018: Instructor in Ophthalmology, Harvard Medical School

Professional Memberships

2014-present: Member, American Society for Virology

2014-present: Member, International Adenovirus Meeting

2014-present: Member, Program in Quantitative Genomics, Harvard School of Public Health

Honors

2016: Travel Award, American Society for Virology

2017: Travel Award, Harvard Program in Quantitative Genomics



Publications

Selected Publications

Ismail AM, Sivakumar J, Anantharam R, Dayalan S, Samuel P, Fletcher GJ, Gnanamony M, Abraham P. Performance characteristics and comparison of Abbott and artus real-time systems for hepatitis B virus DNA quantification. J Clin Microbiol. 2011 Sep;49(9):3215-21.

Ismail AM, Sharma OP, Kumar MS, Eapen CE, Kannangai R, Abraham P. Virological response and antiviral resistance mutations in chronic hepatitis B subjects experiencing entecavir therapy: an Indian subcontinent perspective. Antiviral Res. 2013 May;98(2):209-16.

Ismail AM, Lee JS, Dyer DW, Seto D, Rajaiya J, Chodosh J. Selection Pressure in the Human Adenovirus Fiber Knob Drives Cell Specificity in Epidemic Keratoconjunctivitis. J Virol. 2016 Oct 14;90(21):9598-9607. 

Ismail AM#, Cui T#, Dommaraju K, Singh G, Dehghan S, Seto J, Shrivastava S, Fedorova NB, Gupta N, Stockwell TB, Madupu R, Heim A, Kajon AE, Romanowski EG, Kowalski RP, Malathi J, Therese KL, Madhavan HN, Zhang Q, Ferreyra LJ, Jones MS, Rajaiya J, Dyer DW, Chodosh J, Seto D. Genomic analysis of a large set of currently-and historically-important human adenovirus pathogens. Emerg Microbes Infect. 2018 Feb 7;7(1):10. #Co-first author

Lee JY, Lee JS, Materne EC, Rajala R, Ismail AM, Seto D, Dyer DW, Rajaiya J, Chodosh J. Bacterial RecA Protein Promotes Adenoviral Recombination during In Vitro Infection. mSphere. 2018 Jun 20;3(3). pii: e00105-18.