Paradoxical vocal fold motion disorder (Disorder of Vocal Cord)

Paradoxical Vocal Fold Motion Disorder


Exercise-induced paradoxical vocal fold motion disorder: Clinical features and potential mechanisms

MEEI Protocol ID


National Clinical Trial (NCT) Number



Paradoxical vocal fold motion disorder (Disorder of Vocal Cord)


University of Pittsburgh

Principal Investigator

Christopher Hartnick, MD, MS

Study Design

The Voice and Speech Laboratory at Massachusetts Eye and Ear Infirmary (243 Charles Street, Boston MA 02114) is conducting a diagnostic study with adolescents who compete in sports or other athletic activities.

Study Objective

The goal of the study is to evaluate responses of the larynx (voice box) to exercise to better understand paradoxical vocal fold motion disorder, a condition that causes breathing difficulties.

Who is Eligible

Adolescent athletes (ages 12-18 years; males and females) who are currently involved in competitive sports or other physical activities for at least 40 minutes, 3 times a week. Participants must be able to vigorously ride a stationary bike and not have any known disorders or conditions that affect the heart, lungs, or nervous system.

Subject Enrollment

Open to enrollment

Study Procedures

Eligible participants will be asked to ride a stationary bike with increasing levels of resistance upwards of 10 minutes while movement of the voice box (larynx) is video recorded. To see laryngeal movement, a small, thin, long camera, called a laryngoscope, is inserted into the nose and throat. Participants will also have their blood pressure and heart rates measured and will be asked to complete personality and symptom severity questionnaires.

For More Information

For more information, contact Adrianna Shembel at or 617-702-2619.

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Page updated 4/20/2017.