Findings published on PNAS Early Edition
Contact: Mary Leach
BOSTON (Jan. 27, 2014) -- Deprivation of vision during critical periods of childhood development has long been thought to result in irreversible vision loss. Now, researchers from the Schepens Eye Research Institute/Massachusetts Eye and Ear, Harvard Medical School (HMS) and Massachusetts Institute of Technology (MIT) have challenged that theory by studying a unique population of pediatric patients who were blind during these critical periods before removal of bilateral cataracts. The researchers found improvement after sight onset in contrast sensitivity tests, which measure basic visual function and have well-understood neural underpinnings. Their results show that the human visual system can retain plasticity beyond critical periods, even after early and extended blindness. Their findings were recently published in the Proceedings of the National Academy of Sciences (PNAS) Early Edition.
Pictured are simulated views of an abstract painting to depict the development of pattern vision following early and extended blindness. Working with children who gained sight after several years of early onset blindness, Kalia et al. found that they had poor spatial resolution and impoverished contrast perception immediately after cataract surgery. This is simulated in the left panel. Follow-up assessments six months later revealed surprising enhancement of contrast sensitivity. The middle panel depicts the substantial improvements in perceptual quality this corresponds to. The right panel shows the original painting. These findings suggest that the visual system retains considerable plasticity beyond the early years believed to be critical for normal development. The painting (acrylics on canvas) was created by a child who gained sight after extended blindness. (Image is courtesy of Luis Lesmes, Michael Dorr, Peter Bex, Amy Kalia, &
“Our research group has been studying the development of vision in children who were blind from birth because of congenital cataracts. We have been measuring if and how their vision develops after surgery in late childhood and adolescence to remove cataracts, which enables sight for the first time. Our results show remarkable plasticity and vision continues to improve in many children long after the surgery,” said Senior Author Peter J. Bex, Ph.D., Senior Scientist, Schepens Eye Research Institute/Mass. Eye and Ear and Associate Professor, HMS Department of Ophthalmology.
The authors explain the research: Project Prakash is a joint scientific and humanitarian effort led by Pawan Sinha, Ph.D., full professor at MIT. The humanitarian part aims to address problems of treatable blindness in India by providing surgeries free of cost to children with cataracts. In the Western world, children born with cataracts typically are treated in the first year of life, but children with this condition in rural India often go untreated because their families lack the necessary financial resources. The project also aims to answer the questions: can children who suffer from extended congenital blindness develop vision after cataract surgery and if so, how does this process happen?
The "critical period" or the "critical window" is a traditional concept in the field of neuroscience that suggest that there is "plasticity,” or potential for development, early in life. But as we grow older ― and in the case of vision, pass the age of 7 or 8 ― there is less and less plasticity in the visual system.
The concept of the critical period intersects with clinical care in the practice patterns for children with amblyopia: it was once thought that if you didn't treat amblyopia before age 8, then the window of opportunity for saving sight was lost. For these patients, one potential justification for not removing them during their adolescence was that "they'll just be blind anyway.” However, this once accepted mantra has started to change in the last 10 years with new insights into plasticity and the potential impact of brain or sensory training following surgery.
The Schepens/Mass. Eye and Ear contribution to Project Prakash was an iPad-based assessment of the contrast sensitivity function developed in the Bex Laboratory. It is more precise and easier to apply than previous contrast sensitivity assessments.
“Given this background and past research, the most conservative hypothesis for our study would have been that children between 8 and 18 would show no changes in low-level vision, and no changes in their contrast sensitivity functions , when they were tested after their cataract surgery,” said Dr. Bex. “With our test (which usually requires specialized laboratory equipment) and some analytics we developed, we showed that some patients developed substantial vision after 15 years of blindness. This visual change could not be accounted for by simple optical factors, either.”
This research has important implications for potential treatments of congenital cataracts, in addition to the fundamental questions of development and plasticity in neuroscience, the researchers conclude.
This work was supported by National Institutes of Health Grants R01EY019281 and RO1EY20517. Amy Kalia and Luis Lesmes were co-lead authors. A full list of authors and acknowledgments is available in the paper.