David M. Wu, M.D., Ph.D.



Board Certification

  • Ophthalmology

800 Huntington Ave.
Boston, MA 02115
Phone: 617-936-6156
Main Campus
243 Charles Street
Boston, MA 02114
Phone: 617-573-3492



Dr. David Wu is a retina surgeon and researcher at Mass. Eye and Ear. His primary practice is located at Mass. Eye and Ear, Longwood at 800 Huntington Avenue in Boston. He also sees patients at the main Mass. Eye and Ear campus at 243 Charles Street. He treats patients with vitreoretinal diseases, including diabetic retinopathy, macular degeneration, retinal detachments, retinal vascular occlusions, macular holes, epiretinal membranes, and vitreomacular traction. Dr. Wu also is an active participator in the Diabetic Teleretinal Screening Program at Mass. Eye and Ear.

Dr. Wu was a member of the selective Inteflex BS/MD program at the University of Michigan (UM). He earned both an MD with distinction in research and a PhD in Neuroscience. After medical school, he completed his ophthalmology residency at the UM W.K. Kellogg Eye Center where he won the George Slocum and James M. LaBerge awards for research as well as the Walter R. Parker teaching award. After residency, he was named a Heed Fellow and completed a Medical Retinal and Research fellowship at UM. Next, he completed subspecialty training in vitreoretinal surgery at the Doheny Eye Institute, Keck School of Medicine at the University of South California where he won an Excellence in Teaching award. He joined the faculty at Mass. Eye and Ear in July 2012.

A clinician scientist, Dr. Wu conducts basic and clinical research. He is one of few vitreoretinal surgeons who is comfortable using cutting-edge molecular technologies, such as next-generation sequencing, to advance research from bench to bedside. His current research interests are on the molecular pathways of photoreceptor survival. He holds a grant from the National Eye Institute (NEI/NIH) to perform single cell transcriptome profiling of photoreceptors in retinal disease. The goal of this work is to identify new therapeutic approaches to rescue photoreceptors from death in retinal disease. A prolific scholar, Dr. Wu has published several research and clinical manuscripts as well as book chapters. His research work is often presented at Association for Research in Vision and Ophthalmology (ARVO) annual meetings.

For more information, download his CV [PDF].

Clinical Interests

Retinal detachments, macular degeneration, diabetic retinopathy, retinal vascular occlusions, macular holes, epiretinal membranes, vitreomacular traction

Research Interests

Molecular basis of photoreceptor survival and death in retinal disease


Chincore Y, Begaj T, Wu D, Drokhlyansky E, Cepko CL. Glycolytic reliance promotes anabolism in photoreceptorsElife.  6. pii: e25946. 2017.

Finn AP, Eliott D, Kim LA, Husain D, Wu DM, Young LH, Kim IK, Andreoli C, Skonda D, Vavvas DG, Miller JB. Characteristics and Outcomes of Simultaneous Bilateral Rhegmatogenous Retinal DetachmentsOSLI Retina. 47(9): 840-845. 2016.

Zhang T, Wu DM, Xu G, Puro DG. The electrotonic architecture of the retinal microvasculature: modulation by angiotensin II.  J Physiol. 589(9): 2383-2399. 2011.

Matsushita K, Fukumoto M, Kobayashi T, Kobayashi M, Ishikazi E, Minami M, Katsumura K, Liao SD, Wu DM, Zhang T, Puro DG. Diabetes-induced inhibition of voltage-dependent calcium channels in the retinal microvasculature: role of spermine. IOVS. 51(11): 5979-5990. 2010.

Wu DM, Minami M, Kawamura H, Puro DG. Electrotonic transmission within pericyte-containing retinal microvessels. Microcirculation. 13(5): 353-363. 2006.

View a complete list of publications on pubmed.gov>>

To learn more about Dr. Wu, read his "Meet a Specialist" profile here.



  • University of Michigan, Inteflex Program, BS
  • Neuroscience, University of Michigan, Ph.D.
  • University of Michigan Medical School, M.D.


  • Ophthalmology, University of Michigan, WK Kellogg Eye Center


  • Medical Retina and Research, University of Michigan, WK Kellogg Eye Center
  • University of Southern Vitreoretinal Surgery, California, Doheny Eye Institute, Keck School of Medicine