Dr. Janey Wiggs is a clinician scientist specializing in the genetics of glaucoma with particular interest in complex and advanced glaucoma, and inherited ocular disorders. She directs the CLIA-certified clinical diagnostic laboratory where patients are tested for mutations in genes that can cause inherited retinal disorders, early-onset glaucoma or primary optic neuropathy. She also is the Associate Director of the Howe Laboratory and Associate Chief for Clinical Research at Mass. Eye and Ear. Among her leadership roles in Harvard Ophthalmology, she serves as Vice Chair for Clinical Research, Co-Director of the Glaucoma Center of Excellence, and leader of the Genetic Diagnostics Section of the Ocular Genomics Institute.
Dr. Wiggs attended Harvard Medical School (HMS), and completed her residency in the Harvard Ophthalmology Residency Training Program. She then completed fellowships in Glaucoma and Medical Genetics at Massachusetts Eye and Ear and Tufts University School of Medicine, respectively. She is board-certified in both Ophthalmology and Medical Genetics.
Using a uniquely collaborative and multidisciplinary approach, Dr. Wiggs aims to identify genetic factors that underlie various forms of glaucoma, including adult onset primary open angle glaucoma, pseudoexfoliation glaucoma, juvenile open angle glaucoma, and others. Her research, which has been continuously funded by the National Eye Institute for over 20 years, has provided critical information regarding the biology of the disease. Ongoing studies may greatly improve current methods of diagnosis, and lead to more effective and specific therapies.
Dr. Wiggs lectures nationally and internationally and is the recipient of numerous awards including the Alcon Research Institute award, the Lew R. Wasserman Merit Award from Research to Prevent Blindness and is a member of the American Ophthalmological Society. She instructs residents, fellows, and medical students in the Glaucoma Service at Mass. Eye and Ear. Because glaucoma is a chronic disease, a major emphasis of her teaching is in the early detection and long-term management of glaucoma as a means of preventing ultimate blindness from the disease. She has also organized two, full-day symposium addressing specific issues of human inherited ocular disease.
Complex and advanced glaucoma, inherited ocular disorders
Identification of genetic factors that predispose to glaucoma, including adult onset primary open angle glaucoma (POAG), pseudoexfoliation glaucoma, and early-onset glaucoma (congenital glaucoma, pigment dispersion syndrome and pigmentary glaucoma, glaucoma associated with Rieger syndrome, and juvenile open angle glaucoma)
For a full publication list, please see her CV.
Hypothesis-independent pathway analysis implicates GABA and Acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma. Bailey JN, Yaspan BL, Pasquale LR, Hauser MA, Kang JH, Loomis SJ, Brilliant M, Budenz DL, Christen WG, Fingert J, Gaasterland D, Gaasterland T, Kraft P, Lee RK, Lichter PR, Liu Y, McCarty CA, Moroi SE, Richards JE, Realini T, Schuman JS, Scott WK, Singh K, Sit AJ, Vollrath D, Wollstein G, Zack DJ, Zhang K, Pericak-Vance MA, Allingham RR, Weinreb RN, Haines JL, Wiggs JL. Hum Genet. 2014 Jul 19.
Variations in COL15A1 and COL18A1 influence age of onset of primary open angle glaucoma. Wiggs JL, Howell GR, Linkroum K, Abdrabou W, Hodges E, Braine CE, Pasquale LR, Hannon GJ, Haines JL, John SW. Clin Genet. 2013 Aug;84(2):167-74.
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma. Hysi PG, Cheng CY, Springelkamp H, Macgregor S, Bailey JN, Wojciechowski R, Vitart V, Nag A, Hewitt AW, Hhn R, Venturini C, Mirshahi A, Ramdas WD, Thorleifsson G, Vithana E, Khor CC, Stefansson AB, Liao J, Haines JL, Amin N, Wang YX, Wild PS, Ozel AB, Li JZ, Fleck BW, Zeller T, Staffieri SE, Teo YY, Cuellar-Partida G, Luo X, Allingham RR, Richards JE, Senft A, Karssen LC, Zheng Y, Bellenguez C, Xu L, Iglesias AI, Wilson JF, Kang JH, van Leeuwen EM, Jonsson V, Thorsteinsdottir U, Despriet DD, Ennis S, Moroi SE, Martin NG, Jansonius NM, Yazar S, Tai ES, Amouyel P, Kirwan J, van Koolwijk LM, Hauser MA, Jonasson F, Leo P, Loomis SJ, Fogarty R, Rivadeneira F, Kearns L, Lackner KJ, de Jong PT, Simpson CL, Pennell CE, Oostra BA, Uitterlinden AG, Saw SM, Lotery AJ, Bailey-Wilson JE, Hofman A, Vingerling JR, Maubaret C, Pfeiffer N, Wolfs RC, Lemij HG, Young TL, Pasquale LR, Delcourt C, Spector TD, Klaver CC, Small KS, Burdon KP, Stefansson K, Wong TY; BMES GWAS Group; NEIGHBORHOOD Consortium; Wellcome Trust Case Control Consortium 2, Viswanathan A, Mackey DA, Craig JE, Wiggs JL, van Duijn CM, Hammond CJ, Aung T. Nat Genet. 2014 Aug 31. doi: 10.1038/ng.3087
CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States. Pasquale LR, Loomis SJ, Kang JH, Yaspan BL, Abdrabou W, Budenz DL, Chen TC, Delbono E, Friedman DS, Gaasterland D, Gaasterland T, Grosskreutz CL, Lee RK, Lichter PR, Liu Y, McCarty CA, Moroi SE, Olson LM, Realini T, Rhee DJ, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Allingham RR, Pericak-Vance MA, Weinreb RN, Zhang K, Hauser MA, Richards JE, Haines JL, Wiggs JL. Am J Ophthalmol. 2013 Feb;155(2):342-353.e5.
Estrogen pathway polymorphisms in relation to primary open angle glaucoma: an analysis accounting for gender from the United States. Pasquale LR, Loomis SJ, Weinreb RN, Kang JH, Yaspan BL, Bailey JC, Gaasterland D, Gaasterland T, Lee RK, Scott WK, Lichter PR, Budenz DL, Liu Y, Realini T, Friedman DS, McCarty CA, Moroi SE, Olson L, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Brilliant M, Sit AJ, Christen WG, Fingert J, Kraft P, Zhang K, Allingham RR, Pericak-Vance MA, Richards JE, Hauser MA, Haines JL, Wiggs JL. Mol Vis. 2013 Jul 12;19:1471-81.
Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. Wiggs JL, Yaspan BL, Hauser MA, Kang JH, Allingham RR, Olson LM, Abdrabou W, Fan BJ, Wang DY, Brodeur W, Budenz DL, Caprioli J, Crenshaw A, Crooks K, Delbono E, Doheny KF, Friedman DS, Gaasterland D, Gaasterland T, Laurie C, Lee RK, Lichter PR, Loomis S, Liu Y, Medeiros FA, McCarty C, Mirel D, Moroi SE, Musch DC, Realini A, Rozsa FW, Schuman JS, Scott K, Singh K, Stein JD, Trager EH, Vanveldhuisen P, Vollrath D, Wollstein G, Yoneyama S, Zhang K, Weinreb RN, Ernst J, Kellis M, Masuda T, Zack D, Richards JE, Pericak-Vance M, Pasquale LR, Haines JL. PLoS Genet. 2012;8(4):e1002654.
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