Louis R. Pasquale, M.D.

Director, Glaucoma Service and Director, Telemedicine



Board Certification

  • Ophthalmology

Main Campus
243 Charles Street
Boston, MA 02114
Phone: 617-573-3674
Fax: 617-573-4300



Dr. Louis Pasquale is the Director of both the Mass. Eye and Ear Glaucoma Service and the Ophthalmology Telemedicine program, where he specializes in glaucoma-a leading cause of blindness in the United States and throughout the world. He is especially interested in normal tension glaucoma, difficult surgical glaucoma, and secondary glaucoma in children.

A summa cum laude graduate of Manhattan College, Dr. Pasquale obtained his MD with distinction in research from State University of New York in Stony Brook. He completed his ophthalmology residency at Temple University Hospital in Philadelphia before completing a fellowship at Wilmer Eye Institute at Johns Hopkins University Hospital in Baltimore.

Dr. Pasquale aims to eradicate functional blindness from primary open angle glaucoma (POAG) and exfoliation syndrome through early detection and an improved understanding of disease pathogenesis. In addition to his clinical practice, he is investigating how genes interact with the environment to cause glaucoma. He was awarded a grant as part of the National Institutes of Health's Genes, Environment & Heath Initiative to rapidly scan the entire human genome in order to discover the genetic determinants of POAG. In addition to focusing on the etiology of POAG, disease detection is an important component of his research. Along with his other responsibilities, Dr. Pasquale is involved in an initiative that integrates telemedicine technologies to improve access to ophthalmic services. This developing technology allows patients to receive ophthalmic consultations virtually.

Dr. Pasquale also is a dedicated teacher and mentor. He trains residents and medical students and serves as the Director of Mass. Eye and Ear's fellowship program.

Throughout his career, Dr. Pasquale has received numerous honors, including the Harvard Ophthalmology Distinguished Ophthalmology Scholar Award, the Secretariat Award from the American Academy of Ophthalmology, the Silver Fellow Award from the Association for Research in Vision and Ophthalmology (ARVO), and many others.

Clinical Interests

Normal tension glaucoma, difficult surgical glaucoma, secondary glaucoma in the pediatric population

Research Interests

Gene-environment interactions in glaucoma


For a full publication list, please see his CV.

Estrogen pathway polymorphisms in relation to primary open angle glaucoma: an analysis accounting for gender from the United States. Pasquale LR, Loomis SJ, Weinreb RN, Kang JH, Yaspan BL, Bailey JC, Gaasterland D, Gaasterland T, Lee RK, Scott WK, Lichter PR, Budenz DL, Liu Y, Realini T, Friedman DS, McCarty CA, Moroi SE, Olson L, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Brilliant M, Sit AJ, Christen WG, Fingert J, Kraft P, Zhang K, Allingham RR, Pericak-Vance MA, Richards JE, Hauser MA, Haines JL, Wiggs JL. Mol Vis. 2013 Jul 12;19:1471-81.

A cross-sectional survey of the association between bilateral topical prostaglandin analogue use and ocular adnexal features. Shah M, Lee G, Lefebvre DR, Kronberg B, Loomis S, Brauner SC, Turalba A, Rhee DJ, Freitag SK, Pasquale LR. PLoS One. 2013.8(5):e61638.

Soluble guanylate cyclase: an emerging therapeutic target in primary open angle glaucoma. Buys ES, Ko Y-C, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerte M, Abernathy E, Tainsch RET, Oh D-J, Malhotra R, Arora P, DeWaard N, Yu B, Turcotte R, Nathan D, Scherrer-Crobie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR. PLoS One 2013;8:e60156.

Effects of dorzolamide-timolol and brimonidine-timolol on retinal vascular autoregulation and ocular perfusion pressure in primary open-angle glaucoma. Feke GT, Rhee DJ, Turalba AT, Pasquale LR. J Ocul Pharmcol Ther. 2013;29:639-45.

A nested case control study of plasma ICAM-1, E-selectin and TNF receptor 2 levels and incident primary open-angle glaucoma. Kang JH, Wiggs JL, Pasquale LR. Invest Ophthalmol Vis Sci. 2013;54:1797-804.

View a list of publications on pubmed.gov>>

To learn more about Dr. Pasquale, read his "Meet a Specialist" profile here.



  • Manhattan College, BS
  • State University of New York at Stony Brook, M.D.


  • Ophthalmology, Temple University Hospital


  • Glaucoma, Johns Hopkins University, Wilmer Eye Institute