Dr. Milica Margeta is a member of the Mass. Eye and Ear Glaucoma Service, where she specializes in medical and surgical management of moderate and advanced glaucoma.
Dr. Margeta earned her MD and PhD from Stanford University, and attended Duke University for her ophthalmology residency and glaucoma fellowship. During residency, she received the prestigious Robert Machemer Resident Research Award for her project "CSF protein levels in children with idiopathic intracranial hypertension (IIH)," as well as the Duke Ocular Innovation Award for creating a novel approach for adjusting glaucoma drainage device surgery in children with glaucoma.
As a K12 Scholar in the Harvard Vision Clinical Scientist Development Program, which is funded by the National Institutes of Health/National Eye Institute, Dr. Margeta is interested in developing novel neuroprotective strategies in glaucoma, a chronic degenerative disease that damages the eye's optic nerve and can lead to progressive loss of vision. In particular, she is studying the role of retinal neuroinflammation during glaucomatous optic nerve damage, with a special focus on microglia, the resident immune cells of the retina and the brain. Her research has shown that in mouse models of glaucoma, microglia take on a neurodegeneration-associated molecular phenotype, which can worsen glaucoma damage. By modulating microglial signaling in glaucoma, she hopes to ultimately develop novel neuroprotective treatments for this common blinding disease.
Moderate, advanced and complex glaucoma
Glaucoma, inflammation, neuroprotection, macrophages/microglia
For a full publications list, please see her CV.
CD163+ macrophages infiltrate axon bundles of postmortem optic nerves with glaucoma. Margeta MA, Lad EM, Proia AD. Graefes Arch Clin Exp Ophthalmol, 2018 Aug 2. [Epub ahead of print]
Staying away from the optic nerve: a formula for modifying glaucoma drainage device surgery in pediatric and other small eyes Margeta MA, Proia AD, Freedman SF. 2017. J AAPOS. 21:39-43.
Low cerebrospinal fluid protein in prepubertal children with idiopathic intracranial hypertension. Margeta MA, Buckley EG, El-Dairi M. J AAPOS. 2015;19:135-9.
Molecular mechanisms of synaptic specificity. Margeta MA, Shen K. Mol Cell Neurosci. 2010;43:261-7
Clathrin adaptor AP-1 complex excludes multiple postsynaptic receptors from axons in C. elegans. Margeta MA, Wang GJ, Shen K. Proc Natl Acad Sci USA. 2009;106:1632-7
Building a synapse: lessons on synaptic specificity and presynaptic assembly from the nematode C. elegans. Margeta, MA, Shen, K, Grill B. Curr Opin Neurobiol. 2008;18:69-76
Glia promote local synaptogenesis through UNC-6 (netrin) signaling in C. elegans. Colón-Ramos DA, Margeta MA, Shen K. Science. 2007; 318: 103-6.
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