Daniel R. Lefebvre, M.D., FACS


Ophthalmic Plastic Surgery

Ophthalmic Oncology

Board Certification

  • Ophthalmology

800 Huntington Ave.
Boston, MA 02115
Phone: 617-936-6156
Main Campus
243 Charles Street
Boston, MA 02114
Phone: 617-573-5550



A member of Mass. Eye and Ear's Ophthalmic Plastic Surgery Service, as well as the Center for Thyroid Eye Disease and Orbital Surgery, Dr. Daniel R. Lefebvre specializes in the evaluation and treatment of disorders of the eyelids, lacrimal system, and orbit. Striving to provide the best possible care-both clinically and surgically-for his patients, he has a special interest in tearing, including endoscopic tear duct surgery; trauma, including orbital fractures; cosmetic eyelid surgery; and eyelid and orbital oncology, including post-Mohs eyelid reconstruction.

After Dr. Lefebvre received his medical degree from SUNY Upstate Medical University in Syracuse, NY, he completed a rigorous internship in general surgery at Thomas Jefferson University Hospital in Philadelphia, PA, then ophthalmology residency at Nassau University Medical Center in Long Island, NY. With interests in neurosurgery, orthopedic surgery, plastic surgery, and ophthalmology, he pursued the field of Ophthalmic Plastic and Reconstructive Surgery, and completed a prestigious two-year fellowship sponsored by the American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS), of which there are only twenty such training positions per year nationally. This training took place at Massachusetts Eye and Ear/Harvard Medical School, Boston University School of Medicine, and Brown University School of Medicine. Through completion of a thesis and passing a written and oral examination, Dr. Lefebvre was inducted into ASOPRS-a select group of only 500 highly trained oculoplastic surgeons.

As a teacher and educator, Dr. Lefebvre regularly instructs medical students, residents and fellows in clinic, the emergency ward, and the operating room. He delivers lectures at national and international meetings as well as on volunteer surgical missions. He recently lectured in East Jerusalem, Israel and at Colby College in Waterville, Maine. His teaching also extends to the lay community, and he is involved with the Graves' Disease and Thyroid Foundation Support Group.

Involved with several research projects, Dr. Lefebvre is investigating a CT-based analysis of orbital anatomy. He also is studying the effect of camera / flash type and reflex position in facial photography, among many others.

Clinical Interests

Tearing and endoscopic tear duct surgery (DCR), cosmetic eyelid surgery, eye trauma including orbital fractures, Graves' Disease/thyroid eye disease and orbital decompression surgery, eyelid and orbital oncology including post-Mohs reconstruction

Research Interests

Imaging of orbital anatomy, eye trauma, anatomy and physiology of the eyelid


For a complete list, please see his CV.

Cellular neurothekeoma of the eyelid: a unique internal palpebral resentation. Lefebvre DR, Robinson-Bostom L, Migliori ME. Ophthal Plast Reconstr Surg. 2013 Nov 5.

Endoscopic orbital floor decompression with preservation of the inferomedial strut. Bleier BS, Lefebvre DR, Freitag SK. Int Forum Allergy Rhinol. 2013 Oct 2.

Diagnosis and treatment of penetrating orbital cranial foreign body injuries. Lefebvre DR, Chandra RV. Digit J Ophthalmol. 2012 Dec 31;18(4):9-11.

A cross-sectional survey of the association between bilateral topical prostaglandin analogue use and ocular adnexal features. Shah M, Lee G, Lefebvre DR, Kronberg B, Loomis S, Brauner SC, Turalba A, Rhee DJ, Freitag SK, Pasquale LR. PLoS One. 2013 May 1;8(5):e61638.

An enzyme-mediated assay to quantify inoculation volume delivered by suture needlestick injury: two gloves are better than one. Lefebvre DR, Strande LF, Hewitt CW. J Am Coll Surg. 2008 Jan;206(1):113-22.

View a list of publications on pubmed.gov>>

To learn more about Dr. Lefebvre, read his "Meet a Specialist" profile here.



  • Biology, Boston University, BS
  • SUNY Upstate Medical University, Syracuse, NY, M.D.


  • General Surgery, Thomas Jefferson University Hospital


  • Ophthalmology, Nassau University Medical Center


  • Ophthalmic Plastic and Reconstructive Surgery, Boston University Medical Center
  • Plastic and Reconstructive Surgery, ASOPRS, Mass. Eye and Ear