John H. Kempen, M.D., MPH, M.H.S., Ph.D.

Specialties

Immunology and Uveitis

Infectious Disease

Emergency Eye Service

Board Certification

  • Ophthalmology

Main Campus
243 Charles Street
Boston, MA 02114
Phone: 617-573-3202

Overview

Biography

Dr. John Kempen is well-known nationally and internationally as an expert in ocular inflammatory diseases—such as uveitis, scleritis, and others—as well as ocular complications of AIDS. He is also engaged in international research in India and Ethiopia regarding ophthalmic epidemiology and trachoma research.

Dr. Kempen is Co-Founder and President of Sight for Souls, a US 501(c)(3) charity developing self-sustaining, tertiary eye institutes in developing countries as a strategy to address global blindness through self-sustaining service delivery, public health outreach, training and research. Approximately 80% of global blindness and low vision requires individual-level clinical care, which is directly addressed by this strategy.

Dr. Kempen has doctoral training in epidemiology, and masters-level training in biostatistics and public health.  He has completed research fellowships in clinical trials and in preventive ophthalmology.  He is a fellow of the American Academy of Ophthalmology, and a member of the American Uveitis Society, the International Uveitis Study Group, the Society for Clinical Trials, and the Association for Research in Vision and Ophthalmology.  He was appointed by President Bush to serve as a member of the Office of AIDS Research Advisory Council (2004-2008), and has approximately 150 publications in the leading journals of his specialty. He serves as the Editor-in-Chief of Ophthalmic Epidemiology.

To learn more, download his CV [PDF].

Clinical Interests

Uveitis, iritis, pars planitis, panuveitis, sympathetic ophthalmia, choroiditis, retinitis, neuroretinitis, Vogt-Koyanagi-Harada disease, Fuchs’ heterochromic cyclitis, retinal vasculitis, serpiginous retinochoroiditis, birdshot chorioretinitis, immunosuppressive therapy for eye disease, scleritis, orbital inflammatory disease, ocular complications of AIDS, cytomegalovirus retinitis, acute retinal necrosis, infectious retinitis, toxoplasmic retinitis, trachoma, international ophthalmology, Ethiopia, India

Research Interests

Uveitis, iritis, pars planitis, panuveitis, sympathetic ophthalmia, choroiditis, retinitis, neuroretinitis, Vogt-Koyanagi-Harada disease, Fuchs’ heterochromic cyclitis, retinal vasculitis, serpiginous retinochoroiditis, birdshot chorioretinitis, immunosuppressive therapy for eye disease, scleritis, orbital inflammatory disease, ocular complications of AIDS, cytomegalovirus retinitis, acute retinal necrosis, infectious retinitis, toxoplasmic retinitis, trachoma, international ophthalmology, Ethiopia, India

Publications

Kempen JH*, Daniel E, Dunn JP, Foster CS, Gangaputra S, Hanish A, Helzlsouer KJ, Jabs DA, Kaçmaz RO, Levy-Clarke GA, Liesegang TL, Newcomb CW, Nussenblatt RB, Pujari SS, Rosenbaum JT, Suhler EB, Thorne JE. Risk of overall and cancer mortality among patients with ocular inflammation treated with immunosuppressive therapy: retrospective cohort study. BMJ. 3: 339, Jul 2009. *Corresponding Author

Writing Committee for the Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study Research Group, Kempen JH,* Altaweel MM, Holbrook JT, Sugar EA, Thorne JE, Jabs DA. Association Between Long-Lasting Intravitreous Fluocinolone Acetonide Implant vs Systemic Anti-inflammatory Therapy and Visual Acuity at 7 Years Among Patients With Intermediate, Posterior, or Panuveitis. JAMA. 317(19):1993-2005.  2017 May 16. Notes: *Corresponding Author.

Mehta S, Linton MM, Kempen JH. Outcomes of cataract surgery in patients with uveitis: a systematic review and meta-analysis. Am J Ophthalmol. 158(4): 676-92, 2014. Epub 2014 Jun 28.

Subburaman GB, Hariharan L, Ravilla TD, Ravilla RD, Kempen JH. Demand for Tertiary Eye Care Services in Developing Countries. Am J Ophthalmol. 160(4): 619-627, Oct 2015. Epub 2015 Jun 19.

Kempen JH*, Gangaputra S, Daniel E, Levy-Clarke GA, Nussenblatt RB, Rosenbaum JT, Suhler EB, Thorne JE, Foster CS, Jabs DA, Helzlsouer KH. Long-term risk of malignancy among patients treated with immunosuppressive agents for ocular inflammation: critical assessment of the evidence. Am J Ophthalmol. 146(6): 802-12, Dec 2008. *Corresponding Author.

Kempen JH, Tekle-Haimonot R, Hunduma L, Shifferaw MA, Pistilli M, Abashawl A, Lawrence SD, Alemayehu W.  Fluorometholone 0.1% as Ancillary Therapy for Trachomatous Trichiasis Surgery: Randomized Clinical TrialAm J Ophthalmol, in press.

Bourne RRA, Flaxman SR, Braithwaite T, Cicinelli MV, Das A, Jonas JB, Keeffe J, Kempen JH, Leasher J, Limburg H, Naidoo K, Pesudovs K, Resnikoff S, Silvester  A, Stevens GA, Tahhan N, Wong TY, Taylor HR; Vision Loss Expert Group. Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis. Lancet Glob Health. 2017 Sep;5(9):e888-e897.

View a complete list of publications on pubmed.gov>>

Education

Education

  • Biological Sciences, Stanford University, BS
  • University of California, San Diego, M.D.
  • International Health, Johns Hopkins University, MPH
  • Biostatistics, Johns Hopkins University, MHS
  • Epidemiology, Johns Hopkins University, Ph.D.

Residency

  • Ophthalmology, University of Washington

Fellowship

  • Uveitis and Clinical Immunology, Johns Hopkins University
  • Preventive Ophthalmology, Johns Hopkins University
  • Clinical Trials, Johns Hopkins University