Rachel Huckfeldt, M.D., Ph.D.


Inherited Retinal Disorders


Diabetic Retinopathy

Macular Degeneration

Board Certification

  • Ophthalmology

Main Campus
243 Charles Street
Boston, MA 02114
Phone: 617-573-3621
Retina Consultants
1 Montvale Avenue
Stoneham, MA 02180
Phone: 781-662-5520
Accepting New Patients



Dr. Rachel Huckfeldt is a full-time member of the Inherited Retinal Disorders Service at Mass. Eye and Ear. She is a retina specialist with expertise in inherited retinal degenerations as well as conditions including age-related macular degeneration and diabetic retinopathy.

Dr. Huckfeldt graduated from Washington University in St. Louis, summa cum laude, with a BA in Biology and Psychology. Subsequently, she earned her MD and PhD in Neuroscience at Washington University. Next, she completed her ophthalmology residency in Harvard Medical School’s Department of Ophthalmology. Before returning to Mass. Eye and Ear, she completed a postdoctoral Research Fellowship in Therapeutics for Inherited Retinal Diseases with Dr. Jean Bennett at the University of Pennsylvania as well as a Medical Retina Fellowship at the University of Iowa. She completed a clinical and research fellowship in inherited retinal degenerations under the guidance of Dr. Eric Pierce, supported by a Foundation Fighting Blindness Clinical/ Research Fellowship Award.

Dr. Huckfeldt’s research, which is funded by a Career Development Award from the Foundation Fighting Blindness, focuses on inherited retinal degenerations. Her current research focuses on understanding pathways leading to retinal degeneration and improving the clinical care of patients with retinitis pigmentosa-associated cystoid macular edema.  She also leads Mass Eye and Ear’s participation in a number of clinical trials assessing gene-specific therapies for IRDs.

Dr. Huckfeldt has received numerous honors and awards. In particular, she was selected to attend the Heed Resident’s Retreat, later received a Heed Fellowship, and also received an Association for Research in Vision and Ophthalmology/National Eye Institute travel grant.

Clinical Interests

Age-related macular degeneration, diabetic retinopathy, retinal vein occlusions, inherited retinal degenerations

Research Interests

Inherited retinal degenerations, retinal imaging

Selected Publications

For a full publications list, please see her CV.

Circadian entrainment to temperature, but not light, in the isolated suprachiasmatic nucleus. Herzog ED, Huckfeldt RM. J Neurophysiol. Aug 2003;90(2):763-770.

Transient neurites of retinal horizontal cells exhibit columnar tiling via homotypic interactions. Huckfeldt RM, Schubert T, Morgan JL, et al. Nat Neurosci. Jan 2009;12(1):35-43.

Assembly of the outer retina in the absence of GABA synthesis in horizontal cells. Schubert T, Huckfeldt RM, Parker E, Campbell JE, Wong RO. Neural Dev. 2010;5:15.

Neuroprotection for retinal detachment. Huckfeldt RM, Vavvas DG. Int Ophthalmol Clin. 2013 Fall;53(4):105-17.

Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter. Cronin T, Vandenberghe LH, Hantz P, Juttner J, Reimann A, Kacsó AE, Huckfeldt RM, Busskamp V, Kohler H, Lagali PS, Roska B, Bennett J. EMBO Mol Med. 2014;6(9):1175-1190.

Promising first steps in gene therapy for choroideremia. Huckfeldt RM, Bennett J. Hum Gene Ther. 2014 Feb;25(2):96-7.

View a list of publications on pubmed.gov >>

View a list of publications on Google Scholar>>

To learn more about Dr. Huckfeldt, read her "Meet a Specialist" profile.



  • Biology and Psychology, Washington University in St. Louis, BA
  • Washington University in St Louis, M.D.
  • Washington University in St. Louis, Ph.D.


  • Newton-Wellesley Hospital


  • Ophthalmology, Harvard Medical School


  • Medical Retina, University of Iowa
  • Therapeutics for Inherited Retinal Diseases, University of Pennsylvania