Joseph B. Nadol, Jr., M.D.

Harvard Medical School

Professor of Otolaryngology

Massachusetts Eye and Ear

Director, Otopathology Laboratory
Director, NIDCD National Temporal Bone, Hearing and Balance Pathology Resource Registry
Senior Scientist


Research Summary

Research Area Affiliations

Research Summary

Dr. Nadol’s current research focus is the histopathology of the human temporal bone, including those from patients who in life had undergone cochlear implantation. Anatomic correlates of word recognition and evaluation of damage done to the cochlea and spiral ganglion during implantation and the biologic response, including new bone formation and cellular infiltrates, are studied. To date, 65 specimens with a detailed clinical history of deafness and implantation results have been collected. The principal methods used include semi-serial two-dimensional and three-dimensional reconstruction of the inner ear by computer-assisted methods.

Select Publications

The Pathologic Basis of Facial Nerve Stimulation in Otosclerosis and Multi-Channel Cochlear Implantation. Seyyedi M, Herrmann BS, Eddington DK, Nadol JB Jr. Otol Neurotol. 2013 Aug 7. [Epub ahead of print] PMID: 23928519

Effect of monopolar and bipolar electric stimulation on survival and size of human spiral ganglion cells as studied by postmortem histopathology. Seyyedi M, Eddington DK, Nadol JB Jr. Hear Res. 2013 Aug;302:9-16. doi: 10.1016/j.heares.2013.04.007. Epub 2013 May 6. PMID: 23660399

Temporal bone histopathology in a case of sensorineural hearing loss caused by superficial siderosis of the central nervous system and treated by cochlear implantation. Nadol JB Jr, Adams JC, O'Malley JT. Otol Neurotol. 2011 Jul;32(5):748-55. PMID: 21758021

Analysis of intracochlear new bone and fibrous tissue formation in human subjects with cochlear implants. Li PM, Somdas MA, Eddington DK, Nadol JB Jr. Ann Otol Rhinol Laryngol. 2007 Oct;116(10):731-8. PMID: 17987778

Histologic evaluation of the tissue seal and biologic response around cochlear implant electrodes in the human. Nadol JB Jr, Eddington DK. Otol Neurotol. 2004 May;25(3):257-62. PMID: 15129102

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B.A. Harvard College, 1966
M.D. Johns Hopkins School of Medicine, 1970

Postgraduate Training

Internship and First Year Residency in General Surgery, Beth Israel Hospital, 1972
Residency in Otolaryngology, Massachusetts Eye and Ear Infirmary, 1975

Professional Memberships (select)

1990 President, Association for Research in Otolaryngology
2008 President, American Otological Society

Advisory Boards (select)

1994-1998 Member, Advisory Council, NIDCD, NIH

Teaching (select)

1975-present, Harvard Medical School: medical students, residents and fellows

1992-present, MIT, Division of Health Sciences and Technology: graduate students

Awards and Honors (select)

1990    Claude Pepper Award for Excellence in Research, National Institutes of Health
2005    Distinguished Alumnus Award, Johns Hopkins University School of Medicine
2008    Shambaugh Prize in Otology, Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum, Berlin, Germany, August 24
2010    Recognition as “Compassionate Caregiver” by The Schwartz Center, November 16
2012    Award of Merit, American Otological Society, April 21
2012    Paparella (IHF) Award for Distinguished Contributions in Clinical Otology, American Academy of Otolaryngology-Head and Neck Surgery Foundation, September 11