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Yin Ren, M.D., Ph.D.


Originally from Wuhan, China and Windsor, Ontario, Canada, Dr. Yin Ren is currently a fourth-year resident in otolaryngology—head and neck surgery at Mass. Eye and Ear/Harvard Medical School. He obtained his Bachelor’s in electrical engineering and biomedical engineering from the Massachusetts Institute of Technology (MIT). He then matriculated in the M.D.-Ph.D. program at Harvard Medical School, where he developed nanotechnology tools to study the cancer genome under the mentorship of Dr. Sangeeta Bhatia at the MIT. 

He is currently working in the Molecular Neuro-Otology and Biotechnology Laboratory with Dr. Konstantina Stankovic and his research focuses on tumor targeting and drug delivery in human vestibular schwannomas.

For more information on Dr. Ren, check out his Harvard Catalyst website and Google Scholar page.


Undergraduate School
Massachusetts Institute of Technology (Electrical Engineering, Biomedical Engineering)

Medical School
Harvard Medical School, Harvard-MIT Division of Health Sciences and Technology

Graduate School
Massachusetts Institute of Technology (Ph.D. Medical Engineering)

FOCUS Project
Tumor-penetrating delivery of nanoparticles to human vestibular schwannomas


Revision neural monitored surgery for recurrent thyroid cancer: Safety and thyroglobulin response. Salari B, Ren Y, Kamani D, Randolph GW. Laryngoscope. 2016 Apr. 126(4):1020-5.
PMID: 26608969.

Intra-tumor genetic heterogeneity and mortality in head and neck cancer: Analysis of data from the Cancer Genome Atlas. Mroz EA, Tward AD, Tward AM, Hammon RJ, Ren Y, Rocco JW. PLoS Med. 2015 Feb. 12(2):e1001786.
PMID: 25668320.

Identification and characterization of receptor-specific peptides for siRNA delivery. Ren Y, Hauert S, Lo JH, Bhatia SN. ACS Nano. 2012 Oct 23. 6(10):8620-31. doi: 10.1021/nn301975s. Epub 2012 Aug 27.
PMID: 22909216.

Cancer vulnerabilities unveiled by genomic loss. Nijhawan D, Zack TI, Ren Y, Strickland MR, Lamothe R, Schumacher SE, Tsherniak A, Besche HC, Rosenbluh J, Shehata S, Cowley GS, Weir BA, Goldberg AL, Mesirov JP, Root DE, Bhatia SN, Beroukhim R, Hahn WC. Cell. 2012 Aug 17. 150(4):842-54. doi: 10.1016/j.cell.2012.07.023.
PMID: 22901813.

Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4. Ren Y, Cheung HW, von Maltzhan G, Agrawal A, Cowley GS, Weir BA, Boehm JS, Tamayo P, Karst AM, Liu JF, Hirsch MS, Mesirov JP, Drapkin R, Root DE, Lo J, Fogal V, Ruoslahti E, Hahn WC, Bhatia SN. Sci Transl Med. 2012 Aug 15. 4(147):147ra112.
PMID: 22896676.

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Cheung HW, Cowley GS, Weir BA, Boehm JS, Rusin S, Scott JA, East A, Ali LD, Lizotte PH, Wong TC, Jiang G, Hsiao J, Mermel CH, Getz G, Barretina J, Gopal S, Tamayo P, Gould J, Tsherniak A, Stransky N, Luo B, Ren Y, Drapkin R, Bhatia SN, Mesirov JP, Garraway LA, Meyerson M, Lander ES, Root DE, Hahn WC. Proc Natl Acad Sci U S A. 2011 Jul 26. 108(30):12372-7. doi: 10.1073/pnas.1109363108. Epub 2011 Jul 11.
PMID: 21746896.

Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells. Goldberg MS, Xing D, Ren Y, Orsulic S, Bhatia SN, Sharp PA. Proc Natl Acad Sci U S A. 2011 Jan 11. 108(2):745-50. doi: 10.1073/pnas.1016538108. Epub 2010 Dec 27.
PMID: 21187397.

Silicon nanoparticles as hyperpolarized magnetic resonance imaging agents. Aptekar JW, Cassidy MC, Johnson AC, Barton RA, Lee M, Ogier AC, Vo C, Anahtar MN, Ren Y, Bhatia SN, Ramanathan C, Cory DG, Hill AL, Mair RW, Rosen MS, Walsworth RL, Marcus CM. ACS Nano. 2009 Dec 22. 3(12):4003-8. doi: 10.1021/nn900996p.
PMID: 19950973.

In vivo tumor cell targeting with "click" nanoparticles. von Maltzahn G, Ren Y, Park JH, Min DH, Kotamraju VR, Jayakumar J, Fogal V, Sailor MJ, Ruoslahti E, Bhatia SN. Bioconjug Chem. 2008 Aug. 19(8):1570-8. doi: 10.1021/bc800077y. Epub 2008 Jul 9.
PMID: 18611045.