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Alan D. Workman, MD, MTR

Dr. Alan Workman portrait

Dr. Alan Workman grew up in Westfield, New Jersey, and graduated summa cum laude from Cornell University with a degree in psychology. Following his undergraduate work, he matriculated at the University of Pennsylvania Perelman School of Medicine as a 21st Century Scholar. While there, he also obtained his Master’s in translational research (MTR). He’s a member of the Alpha Omega Alpha honor society and is a recipient of the Kimmelman Prize and Mary Ellis Bell Prize for research in otolaryngology.  

While at the University of Pennsylvania, Dr. Workman worked with Dr. Noam Cohen and the Division of Rhinology on several basic science and clinical research projects, and he received grant funding from the National Institute of Health to study airway innate immune defense and physiology. His research experiences include the study of cellular signaling and ciliary dynamics in the airway, development of diagnostics and therapeutics for chronic rhinosinusitis, and analysis of treatment and surveillance paradigms in sinonasal malignancy. 

For more information on Dr. Workman, check out his Google Scholar page.


Education

Undergraduate School
Cornell University (Psychology)

Medical School
University of Pennsylvania Perelman School of Medicine

Graduate School
University of Pennsylvania


Publications

Accuracy of self-reported diagnosis of chronic rhinosinusitis. Workman AD, Parasher AK, Blasetti MT, Palmer JN, Adappa ND, Glicksman JT. Journal of Allergy and Clinical Immunology – In Practice. 2018. 

Species-level bacterial community profiling of the healthy sinonasal microbiome using Pacific Biosciences sequencing of full-length 16S rRNA genes. Earl JP, Adappa ND, Krol J, Bhat AS, Balashov S, Ehrlich RL, Palmer JN, Workman AD, Blasetti M, Hammond J, Cohen NA, Ehrlich GD, Mell JC. Microbiome. 2018;6(1):190. 

Sinonasal undifferentiated carcinoma: A 15-year single institution experience. Workman AD, Brody RM, Parasher AK, Glicksman JT, Brooks SG, Alonso-Basanta M, Newman JG, Rassekh CH, Chalian AA, Chiu AG, Weinstein GS, Adappa ND, O’Malley BW, Palmer JN. Journal of Neurological Surgery, Part B: Skull Base. 2018. In press. 

Taste receptors in respiratory innate immunity. Workman AD, Kohanski MA, Cohen NA. Flavour Science: – Proceedings of the XV Weurman Flavour Research Symposium, 18-22 September, 2017, Graz University of Technology, Austria. Editors: Barbara Siegmund & Erich Leitner. Pgs 255–262. 2018. 

Role of taste receptors as sentinels of innate immunity in the upper airway. Patel NN, Workman AD, Cohen NA. Journal of Pathogens. 2018. 

Sentinels at the wall: Epithelial-derived cytokines serve as triggers of upper airway type-2 inflammation. Patel NN, Kohanski MA, Maina IW, Workman AD, Herbert DR, Cohen NA. International Forum of Allergy and Rhinology. 2018. 

Rates of symptomatology are lower in recurrent sinonasal malignancy than in other recurrent cancers of the head and neck: A multi-institutional study. Workman AD, Velasquez N, Khan NI, Wang EW, Patel ZM, Adappa ND. International Forum of Allergy and Rhinology, 2018. In press. 

Biomarkers in chronic rhinosinusitis with nasal polyps. Workman AD, Kohanski MA, Cohen NA. Immunology and Allergy Clinics, 2018;38(4):679–692. 

Ciliostimulatory properties of Broncho-Vaxom soluble components. Triantafillou V, Workman AD, Patel NN, Maina IW, Tong CL, Kuan EC, Kennedy DW, Palmer JN, Adappa ND, Cohen NA. American Journal of Rhinology and Allergy. 2018. In press. 

The role of bitter and sweet taste receptors in upper airway innate immunity: Recent advances and future directions. Maina IW, Workman AD, Cohen NA. World Journal of Otorhinolaryngology – Head and Neck Surgery. 4(3):200–208. 

Adenoid cystic carcinoma of the sinonasal tract: A review of the National Cancer Database. Trope M, Triantafillou V, Kohanski MA, Kuan EC, Tong CL, Patel NN, Maina IW, Carey RM, Workman AD, Palmer JN, Adappa ND, Newman JG, Brant JA. International Forum of Allergy and Rhinology. In press.

Solitary chemosensory cells are a primary epithelial source of interleukin-25 in chronic rhinosinusitis with nasal polyps. Kohanski MA, Workman AD, Hung LY, Shtraks JP, Chen B, Blasetti M, Doghramji L, Kennedy DW, Adappa ND, Palmer JN, Herbert D, Cohen NA. Journal of Allergy and Clinical Immunology. 2018;142(2):460–469.  

Solitary chemosensory cells producing IL-25 and group-2 innate lymphoid cells are enriched in chronic rhinosinusitis with nasal polyps. Patel NN, Kohanski MA, Maina IW, Triantafillou V, Workman AD, Tong CL, Kuan EC, Adappa ND, Palmer JN, Herbert DR, Cohen NA. International Forum of Allergy and Rhinology. 2018.  

Costs in pituitary surgery: Racial, socioeconomic, and hospital factors. Parasher AK, Workman AD, Kidwai S, Goljo E, Del Signore A, Iloreta AM, Genden EM, Shrivastava R, Navathe A, Govindaraj S. Journal of Neurological Surgery, Part B: Skull Base. 2018;79(6):522–527.

A population-based analysis of nodal metastases in esthesioneuroblastomas of the sinonasal tract. Kuan EC, Nasser HB, Carey RM, Workman AD, Alonso JE, Wang MB, St. John A, Palmer JN, Adappa ND, Tajudeen BA. The Laryngoscope. 2018.

The role of quinine-responsive T2Rs in airway immune defense and chronic rhinosinusitis. Workman AD, Maina IW, Brooks SG, Kohanski MA, Cowart CJ, Mansfield C, Kennedy DW, Palmer JN, Adappa ND, Reed DR, Lee RJ, Cohen NA. Frontiers in Immunology. 2018;9(624).  

The role of taste receptors in airway innate immune defense. Workman AD, Patel NN, Carey RM, Kuan EC, Cohen NA. Sinusitis. 2018;3(2),6. 

Odontogenic sinusitis: Developments in diagnosis, microbiology, and treatment. Workman AD, Granquist EJ, Adappa ND. Current Opinion in Otolaryngology–Head and Neck Surgery. 2017;26(1):27–33.  

Taste receptor polymorphisms and immune response: A review of receptor genotypic-phenotypic variations and their relevance to chronic rhinosinusitis. Triantafillou V, Workman AD, Kohanski MA, Cohen NA. Frontiers in Microbiology. 2018;8(64).  

Leiomyosarcoma of the head and neck: A 15-year single institution experience and review of the National Cancer Data Base. Workman AD, Farquhar DR, Brody RM, Parasher AK, Carey RM, Purkey MT, Nagda DA, Brooks JS, Hartner L, Brant JA, Newman JG. Head and Neck Journal. 2017;40(4):756–762.

Basolateral Protease-Activated Receptor 2 activates human sinonasal apical membrane chloride permeability and increases ciliary beating. McMahon DB, Workman AD, Carey RM, Freud JR, Hariri BM, Chen B, Dogrhamji LJ, Adappa ND, Palmer JN, Kennedy DW, Lee RJ. Federation of American Societies for Experimental Biology (FASEB) Journal. 2017;32(1):155–167.  

Bitter and sweet taste tests are reflective of disease status in chronic rhinosinusitis. Workman AD, Brooks SG, Kohanski MA, Blasseti MT, Cowart BJ, Mansfield C, Kennedy DW, Palmer JN, Adappa ND, Reed DR, Cohen NA. Journal of Allergy and Clinical Immunology–In Practice. 2017;6(3):1078–1080. 

Patient, disease, and treatment factors associated with overall survival in esthesioneuroblastoma. Carey RM, Godovchik J, Workman AD, Kuan EC, Parasher AK, Chen J, Palmer JN, Adappa ND, Newman JG, Brant JA. International Forum of Allergy & Rhinology. 2017;7(12):1186–1194. 

Posttreatment surveillance for sinonasal malignancy. Workman AD, Palmer JN, Adappa ND. Current Opinion in Otolaryngology–Head and Neck Surgery. 2017;25:1. 

Bitter taste receptors in innate immunity: T2R38 and chronic rhinosinusitis. Workman AD, Cohen NA. Journal of Rhinolaryngo-Otologies. 2017;5,12–18. 

Denatonium-induced bacterial killing may play a role in chronic rhinosinusitis outcomes. Carey RM, Workman AD, Hatten KM, Siebert AP, Brooks SG, Chen B, Adappa ND, Palmer JN, Kennedy DW, Lee RJ, Cohen NA. International Forum of Allergy & Rhinology. 2017;7(7):699–704. 

Relative susceptibility of airway organisms to antimicrobial effects of nitric oxide. Workman AD, Carey RM, Kohanski MA, Kennedy DW, Palmer JN, Adappa ND, Cohen NA. International Forum of Allergy & Rhinology. 2017;7(8):770–776.  

Effects of ophthalmologic solutions on sinonasal ciliated epithelium. Workman AD, Carey RM, Kohanski MA, Adappa ND, Palmer JN, Cohen NA. International Forum of Allergy & Rhinology. 2017;7(8):801–808.  

Sinonasal T2R-mediated nitric oxide production in response to Bacillus cereus. Carey RM, Workman AD, Yan CH, Chen B, Adappa ND, Palmer JN, Kennedy DW, Lee RJ, Cohen NA. American Journal of Rhinology & Allergy. 2017;31(4):211–215. 

CALHM1-mediated ATP release and ciliary beat frequency modulation in nasal epithelial cells. Workman AD, Saunders CJ, Chen B, Carey R, Lee RJ, Marambaud P, Mitchell CH, Tordoff MG, Cohen NA. Nature Scientific Reports. 2017;7(1):6687.  

The fate of the bone graft in cerebrospinal fluid rhinorrhea endoscopic repair for idiopathic intracranial hypertension: A retrospective case series analysis. Workman AD, Carey RM, Parasher AK, Godovchik J, Glicksman JT, Kennedy DW, Palmer JN, Adappa ND. Rhinology. 2017;55(4):376–381. 

18FDG PET/CT in routine surveillance of asymptomatic patients following treatment of sinonasal neoplasms. Workman AD, Glicksman JT, Parasher AK, Carey RM, Brooks SG, Kennedy DW, Nabavizadeh DA, Learned KO, Palmer JN, Adappa ND. Otolaryngology–Head and Neck Surgery. 2017;157(6):1068–1074.  

Disparities in sinonasal squamous cell carcinoma short and long term outcomes: Analysis of the National Cancer Database. Carey RM, Parasher AK, Workman AD, Yan CH, Glicksman JT, Chen J, Palmer JN, Adappa ND, Newman JG, Brant JA. The Laryngoscope. 2017;128(3):560–567. 

Increasing medical student exposure to interventional radiology: Integration of IR into the gross anatomy course and a model for IR education. DePietro DM, Kiefer RM, Redmond JW, Workman AD, Trerotola SO, Nadolski GJ, Redmond JW, Hunt SJ. Journal of Vascular and Interventional Radiology. 2017;28(10):1455–1460. 

Sinonasal quality of life after endoscopic resection of malignant sinonasal and skull base tumors. Glicksman JT, Parasher AK, Brooks SG, Workman AD, Lambert J, Bergman J, Palmer JN, Adappa ND. The Laryngoscope. 2017;128(4):789–793. 

The timing of retears after arthroscopic rotator cuff repair. Chona DV, Lakomkin N, Lott A, Workman AD, Henry AC, Kuntz AF, Huffman R, Glaser DL. Journal of Shoulder and Elbow Surgery. 2017;26(11):2054–2059. 

Correlation of T2R38 taste phenotype and in vitro biofilm formation from nonpolypoid chronic rhinosinusitis patients. Adappa ND, Truesdale C, Workman AD, Doghramji L, Mansfield C, Kennedy D, Palmer JN, Cowart B, Cohen NA. International Forum of Allergy & Rhinology. 2016;6(8),783–791. 

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis, sections “Biofilms” and “Ciliary Derangements”. Workman AD, Cohen NA. International Forum for Allergy and Rhinology. 2016;6(S1):S22–S209. 

Fungal aflatoxins reduce respiratory mucosal ciliary function. Lee RJ, Workman AD, Carey R, Chen B, Rosen P, Doghramji L, Adappa N, Palmer J, Kennedy D, Cohen NA. Nature Scientific Reports. 2016;6:33221. 

T2R38 genotype is correlated with sinonasal quality of life in homozygous ΔF508 cystic fibrosis patients. Adappa ND, Workman AD, Hadjiliadis D, Dorgan D, Brooks S, Doghramji L, Palmer JN, Reed DR, Cohen NA. International Forum of Allergy & Rhinology. 2015;6(4):356–61. 

Staphylococcus aureus triggers nitric oxide production in human upper airway epithelium. Carey R, Workman AD, Chen B, Adappa ND, Palmer JN, Kennedy D, Lee RJ, Cohen NA. International Forum of Allergy & Rhinology. 2015;5(9):808–813.  

The role of bitter and sweet taste receptors in upper airway immunity. Workman AD, Palmer JN, Adappa ND, Cohen NA Current Allergy and Asthma Reports. 2015;15(12),72.  

The effect of drugs and other compounds on the ciliary beat frequency of human respiratory epithelium. Workman AD, Cohen NA. American Journal of Rhinology and Allergy. 2014;28(6):454–464. 

Human exceptionalism. Finlay BL, Workman AD. Trends in Cognitive Sciences. 2013;17(5):199–201.  

Modeling transformations of neurodevelopmental sequences across mammalian species. Workman AD, Charvet CJ, Clancy B, Darlington RB, Finlay BL. Journal of Neuroscience. 2013;33(17):7368–83.