Publications

2017

Connectome-wide phenotypical and genotypical associations in focal dystonia. Fuertinger S, Simonyan K. Journal of Neuroscience. 3 July 2017;0384–17.

Screening study of TUBB4A in isolated dystonia. Vulinovic F, Schaake S, Domingo A, Kumar KR, Defazio G, Mir P, Simonyan K, Ozelius LJ, Brüggemann N, Chung SJ, Rakovic A, Lohmann K, Klein C. Parkinsonism and Related Disorders. 2017 Jun 10. [Epub ahead of print]. 
PMID: 28655586.

Central voice production and pathophysiology of spasmodic dysphonia. Mor N, Simonyan K, Blitzer A. Laryngoscope. 2017 May 23. [Epub ahead of print]. 
PMID: 28543038.

Phenotype- and genotype-specific structural alterations in spasmodic dysphonia. Bianchi S, Battistella G, Huddleston H, Scharf R, Fleysher L, Rumbach AF, Frucht SJ, Blizer A, Ozelius LJ, Simonyan K. Movement Disorders. 2017 Apr;32(4):560–568. 
PMID: 28186656.

An open-label study of sodium oxybate (Xyrem) in spasmodic dysphonia. Rumbach AF, Blitzer A, Frucht SJ, Simonyan K. Laryngoscope. 2017 Jun;127(6):1402–1407. 
PMID: 27808415.

Neural correlates of dystonic tremor: A multimodal study of voice tremor in spasmodic dysphonia. Kirke DN, Battistella G, Kumar V, Rubien-Thomas E, Choy M, Rumbach A, Simonyan K. Brain Imaging and Behavior. 2017 Feb;11(1):166–175.
PMID: 26843004. 

Isolated focal dystonia as a disorder of large-scale functional networks. Battistella G, Termsarasab P, Ramdhani RA, Fuertinger S, Simonyan K. Cerebral Cortex. 2017 Feb 1;27(2):1203–1215.
PMID: 26679193.  


2016

Functional genomic analyses of Mendelian and sporadic disease identify impaired elF2α signaling as a generalizable mechanism for dystonia. Rittiner JE, Caffall ZF, Sanderson SM, Pearson JL, Tsukayama KK, Liu AY, Xiao C, Tracy S, Hickey P, Johnson J, Scott B, Stacy M, Saunders-Pullman R, Bressman S, Simonyan K, Sharma N, Ozelius LJ, Cirulli ET, Calakos N. Neuron. 2016 Dec 21;92(6):1238–1251.
PMID: 27939583. 

Polygenic risk of spasmodic dysphonia is associated with vulnerable sensorimotor connectivity. Putzel GG, Battistella G, Rumbach AF, Ozelius LJ, Sabuncu MR, Simonyan K. Cerebral Cortex. 2016 Nov 24. [Epub ahead of print].  

New developments in understanding the complexity of human speech production. Simonyan K, Ackermann H, Chang EF, Greenlee JD. Journal of Neuroscience. 2016 Nov 9;36(45):11440–11448. 

Stability of network communities as a function of task complexity. Fuertinger S, Simonyan K. Journal of Cognitive Neuroscience. 2016 Aug 30;1–14. [Epub ahead of print].
PMID: 27575646. 

Cortical sensorimotor alterations classify clinical phenotype and putative genotype of spasmodic dysphonia. Battistella G, Fuertinger S, Fleysher L, Ozelius LJ, Simonyan K. European Journal of Neurology. 2016 Oct;23(10):1517–27.
PMID: 27346568.

High-frequency brain networks undergo modular breakdown during epileptic seizure. Fuertinger S, Simonyan K, Sperling MR, Sharan AD, Hamzei-Sichani F. Epilepsia. 2016 Jul;57(7):1097–108.
PMID: 27221325.

Structural organization of the laryngeal motor cortical network and its implication for evolution of speech production. Kumar V, Croxson PL, Simonyan K. Journal of Neuroscience. 2016 Apr 13;36(15):4170–81.
PMID: 27076417.

GNAL mutation in isolated laryngeal dystonia. Putzel GG, Fuchs T, Battistella G, Rubien-Thomas E, Frucht SJ, Blitzer A, Ozelius LJ, Simonyan K. Movement Disorders. 2016 May;31(5):750–5.
PMID: 27093447.


2015

Neural correlates of abnormal sensory discrimination in laryngeal dystonia. Termsarasab P, Ramdhani RA, Battistella G, Rubien-Thomas E, Choy M, Farwell IM, Velickovic M, Blitzer A, Frucht SJ, Reilly RB, Hutchinson M, Ozelius LJ, Simonyan K. NeuroImage Clinical. 2015 Oct 30;10:18–26.
PMID: 26693398.

The functional connectome of speech control. Fuertinger S, Horwitz B, Simonyan K. PLoS Biology. 2015 Jul 23;13(7).
PMID: 26204475.

Alcohol responsiveness in laryngeal dystonia: A survey study. Kirke DN, Frucht SJ, Simonyan K. Journal of Neurology. 2015 Jun;262(6):1548–56.
PMID: 25929664.

Speech networks at rest and in action: Interactions between functional brain networks controlling speech production. Simonyan K, Fürtinger S. Journal of Neurophysiology. 2015 Apr 1;113(7):2967–78.
PMID: 25673742. 

Negative dystonia of the palate: A novel entity and diagnostic considerations in hypernasal speech. Sinclaire C, Simonyan K, Brin MF, Blitzer A. Laryngoscope. 2015 Jun;125(6):1426–32.
PMID: 25646795.


2014

A neural population model incorporating dopaminergic neurotransmission during complex voluntary behaviors. Fürtinger S., Zinn JC, Simonyan K. PLoS Computational Biology. 2014 Nov 13;10(11).
PMID: 25393995.

The laryngeal motor cortex: Its organization and connectivity. Simonyan K. Current Opinion in Neurobiology. 2014 Jun 11;28C:15–21.
PMID: 24929930.  

What’s special about task in dystonia? A voxel-based morphometry and diffusion tensor imaging study. Ramdhani RA, Kumar V, Velickovic M, Frucht SJ, Tagliati M, Simonyan K. Movement Disorders. 2014 Aug;29(9):1141–50.
PMID: 24925463. 

PET Neuroimaging: Plenty of studies still need to be performed. Horwitz B, Simonyan K. NeuroImage. 2014 Jan 1;84:1101–3.
PMID: 23954490.


2013

Long-term effect of sodium oxybate (Xyrem) in spasmodic dysphonia with vocal tremor. Simonyan K, Frucht SJ. Tremor and Other Hyperkinetic Movements (N Y). 2013 Dec 9;3.
PMID: 24386608.

Striatal dopaminergic dysfunction at rest and during task performance in writer's cramp. Berman BD, Hallett M, Herscovitch P, Simonyan K. Brain. 2013 Dec;136(Pt 12)3645–58.
PMID: 24148273.

Abnormal striatal dopaminergic neurotransmission during rest and task production in spasmodic dysphonia. Simonyan K, Berman BD, Herscovitch P, Hallett M. Journal of Neuroscience. 2013 Sep 11;33(37):14705–14.
PMID: 24027271.

Primary dystonia: Conceptualizing the disorder through a structural brain imaging lens. Ramdhani RA, Simonyan K. Tremor and Other Hyperkinetic Movements (N Y). 2013 Apr 18;3.
PMID: 23610744. 

Speech-induced striatal dopamine release is left lateralized and coupled to functional striatal circuits in healthy humans: A combined PET, fMRI and DTI study. Simonyan K, Herscovitch P, Horwitz B. NeuroImagd. 2013;70:21–32.
PMID: 23277111.
*NeuroImage Editors' Choice Award 


2012

Whispering dysphonia (DYT4 dystonia) is caused by a mutation in the TUBB4 gene. Lohmann K, Wilcox RA, Winkler S, Ramirez A, Rakovic A, Park JS, Arns B, Lohnau T, Groen J, Kasten M, Brüggemann N, Hagenah J, Schmidt A, Kaiser FJ, Kumar KR, Zschiedrich K, Alvarez-Fischer D, Altenmüller E, Ferbert A, Lang AE, Münchau A, Kostic V, Simonyan K, Agzarian M, Ozelius LJ, Langeveld AP, Sue CM, Tijssen MA, Klein C. Annals of Neurology. 2012 Dec 13. [Epub ahead of print].
PMID: 23595291.

Combined laryngeal inflammation and trauma mediate long-lasting immunoreactivity response in the brainstem sensory nuclei in the rat. Simonyan K, Feng X, Henriquez VM, Ludlow CL. Frontiers in Integrative Neuroscience. 2012 Nov 15;Vol 6, Article 97, 1–10.
PMID: 23162441.  

Commentary on "Bilateral cerebellar stroke presenting with acute dysphonia and late palatal tremor". Simonyan K, Blitzer A. Movement Disorders. 2012 Mar;27(3):346–8.
PMID: 22411847. 

Dopamine regulation of human speech and song: A critical review. Simonyan K, Horwitz B, Jarvis ED. Brain and Language. 2012 Sep;122(3):142–50.
PMCID: PMC3362661.              
*Recommended by Faculty of 1000 as "being of special significance in its field"  

Abnormal structure-function relationship in spasmodic dysphonia. Simonyan K, Ludlow CL. Cerebral Cortex. 2012 Feb;22(2):417–25.
PMCID: PMC3256408. 


2011

Laryngeal motor cortex and control of speech in humans. Simonyan K, Horwitz B. Neuroscientist. 2011 Apr;17(2):197–208.
PMID: 21362688. 

Neuroanatomical changes due to hearing loss and chronic tinnitus: A combined VBM and DTI study. Husain FT, Medina RE, Davis CW, Szymko-Bennett Y, Simonyan K, Pajor NM, Horwitz B. Brain Research. 2011 Jan 19;1369:74–88. Epub 2010 Nov 1.
PMID: 21047501. 


2010

Abnormal activation of the primary somatosensory cortex in spasmodic dysphonia: An FMRI study. Simonyan K, Ludlow CL. Cerebral Cortex. 2010 Nov;20(11):2749–59. Epub 2010 Mar 1.
PMID: 20194686.

Brainstem pathology in spasmodic dysphonia. Simonyan K, Ludlow CL, Vortmeyer AO. Laryngoscope. 2010 Jan;120(1):121–4.
PMID: 19795469. 


2009

Functional but not structural networks of the human laryngeal motor cortex show left hemispheric lateralization during syllable but not breathing production. Simonyan K, Ostuni J, Ludlow CL, Horwitz B. Journal of Neuroscience. 2009 Nov 25;29(47):14912–23.
PMID: 19940187. 


2008

Sensory stimulation activates both motor and sensory components of the swallowing system. Lowell SY, Poletto CJ, Knorr-Chung BR, Reynolds RC, Simonyan K, Ludlow CL. Neuroimage. 2008 Aug 1;42(1):285–95. Epub 2008 Apr 26.
PMID: 18515150. 

Focal white matter changes in spasmodic dysphonia: A combined diffusion tensor imaging and neuropathological study. Simonyan K, Tovar-Moll F, Ostuni J, Hallett M, Kalasinsky VF, Lewin-Smith MR, Rushing EJ, Vortmeyer AO, Ludlow CL. Brain. 2008 Feb;131(Pt 2):447–59. Epub 2007 Dec 14.
PMID: 18083751.
*Rated "Recommended" by Faculty of 1000, Medicine 


2007

Functional neuroanatomy of human voluntary cough and sniff production. Simonyan K, Saad ZS, Loucks TM, Poletto CJ, Ludlow CL. Neuroimage. 2007 Aug 15;37(2):401–9. Epub 2007 May 24.
PMID: 17574873.
*Rated "Recommended" by Faculty of 1000, Biology 

Human brain activation during phonation and exhalation: Common volitional control for two upper airway functions. Loucks TM, Poletto CJ, Simonyan K, Reynolds CL, Ludlow CL. Neuroimage. 2007 May 15;36(1):131–43. Epub 2007 Mar 12.
PMID: 17428683.


2005

Afferent cortical connections of the motor cortical larynx area in the rhesus monkey. Simonyan K, Jürgens U. Neuroscience. 2005;130(1):133–49.
PMID: 15561431. 

Afferent subcortical connections into the motor cortical larynx area in the rhesus monkey. Simonyan K, Jürgens U. Neuroscience. 2005;130(1):119–31.
PMID: 15561430. 


2004

Human cortical motor representation of the larynx as assessed by transcranial magnetic stimulation (TMS). Rödel RM, Olthoff A, Tergau F, Simonyan K, Kraemer D, Markus H, Kruse E. Laryngoscope. 2004 May;114(5):918–22.
PMID: 15126757.


2003

Efferent subcortical projections of the laryngeal motorcortex in the rhesus monkey. Simonyan K, Jürgens U. Brain Research. 2003 Jun 6;974(1–2):43–59.
PMID: 12742623. 


2002

Cortico-cortical projections of the motorcortical larynx area in the rhesus monkey. Simonyan K, Jürgens U. Brain Research. 2002 Sep 13;949(1–2):23–31.
PMID: 12213296.