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Otopathology Laboratory

Temporal Bone


The long-term goal of the research performed in the Otopathology Laboratory is to provide insight into the causes, pathogenesis, treatment and prevention of otologic disease through the study of temporal bones obtained from subjects with well documented ear disease. Temporal bones are studied by a variety of techniques including traditional light microscopy, immunohistochemistry and computer-aided morphometry. Selected cases are also studied by genomic and proteomic techniques. The application of genomic and proteomic assays to temporal bone research offers great potential for realizing the promise of molecular otopathology. A computerized data base is used to store, analyze, and retrieve all clinical and pathologic data. Our temporal bone collection also serves as a resource for the training of residents and researchers, and particularly for the training of academic otologists through the mechanism of research fellowships.

Learn more about the Otopathology Laboratory at

The Otopathology Laboratory is the headquarters of the Otopathology Research Collaboration Network established by the National Institutes of Health.

Learn more about the Network at

Photo of Joseph B. Nadol, Jr., M.D.

Joseph B. Nadol, Jr., M.D.


243 Charles Street

Boston, MA 02114