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David G. Cogan Laboratory of Ophthalmic Pathology

The Eye Pathology Service is dedicated to the histopathologic diagnosis of ocular conditions. For optimal diagnosis and management of cases, the laboratory interacts with other clinical ophthalmology services. It facilitates accessioning, preparation of specimens, and obtaining special stains and immunohistochemistry. The close proximity of the eye pathology service to the Massachusetts General Hospital enriches collaboration and utilization of their expertise in evaluating challenging cases. The laboratory therefore has access to a wide spectrum of ancillary supports, such as flow-cytometry, histochemical and immunoperoxidase staining, and EM facilities.

The Director, Dr. Frederick Jakobiec, has clinical and research interests focused on ophthalmic oncology, notably the characterization of ocular and adnexal (conjunctiva, eyelids, and orbital soft tissue and bones) inflammations and tumors. Pre-malignant and malignant conjunctival melanocytic disorders (so-called primary acquired melanosis) have been intensively studied. Clinicopathologic series with immunologic investigations have been employed in the study of lympho-proliferations of the ocular adnexa. He has subjected idiopathic orbital inflammations (pseudotumors) and Wegener’s granulomatosis to more rigorous clinicopathologic diagnostic criteria.
Dr. Jakobiec has edited over 20 volumes devoted to eye tumors and eye pathology, and written over 300 journal articles and book chapters. He co-edited the first two editions of the Principles and Practice of Ophthalmology (6 volumes, W.B. Saunders, 1991 and 1998), and the third edition (2008) is now called Albert and Jakobiec’s Principles and Practice.

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