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Corneal Infection and Inflammation Research

Infection and inflammation of the cornea accounts for a significant amount of visual loss in the U.S. and throughout the world. Researchers at Mass. Eye and Ear are investigating the risk factors and causative mechanisms for infection and inflammation as well as safe and more effective therapies. In addition, several studies are underway, using newest imaging techniques. These imaging techniques help researchers understand the effects of inflammation and treatment by taking pictures of the different layers of the cornea and by seeing inflammatory and immune cells. These studies will give physicians a better idea of what types of treatments are most effective and why. MEEI has been involved in clinical trials involving novel antibiotics for the cornea and conjunctiva and we have launched several clinical trials for evaluating new anti-inflammatory therapies for the cornea and conjunctiva. Many of these clinical studies stem from research conducted and conceived here at Massachusetts Eye and Ear Infirmary. 

Jim Chodosh, M.D., M.P.H.
Kathryn Colby, M.D., Ph.D.
Reza Dana, M.D., M.P.H., M.Sc.
Deborah Langston, M.D.
Pedram Hamrah, M.D.

Roberto Pineda, M.D.

Clinical Trials and Studies (Primary Investigator)

• Topical Anti-inflammatory Treatment of Dry Eye (Reza Dana MD, MPH, MSc) 

• Topical Anti-inflammatory Treatment of Corneal Neovascularization (Reza Dana MD, MPH, MSc)

• Epidemiology of Atypical Keratitis (Kathryn Colby MD, PhD)

• Management of Herpes Simplex (cold sore virus) and Herpes Zoster (shingles virus) in the Cornea (Deborah Langston MD, FACS and Pedram Hamrah, MD)

• Corneal Imaging of Infectious Keratitis (Pedram Hamrah, MD)


Lab Studies

• Investigation of the role of human tears in the protection against Acanthamoeba keratitis (Kathryn Colby MD, PhD)