Support Ophthalmology Research

617-573-3345

or Use Our Simple Online Form to Give Us Feedback

We welcome your comments and feedback. Please include contact information if you'd like a response.

Did you find this page helpful?





If you would like a response, please include your contact information.

Connor Lab

Age-related Macular Degeneration

ARD

Figure: Age-related Macular Degeneration. (a) A schematic cartoon of a normal human eye compared with an eye with AMD (lower) depicting deposits of drusen (c) (yellow spots) and choroidal neovascularization with subretinal hemorrhage in the macula (e). A schematic cross-section of a normal eye (b), showing retinal neuronal layers, RPE, Bruch’s membrane and choroid vessels. (d) In AMD, the intimate relation between photoreceptors, RPE and choroid is disrupted by drusen (lipid and cellular debris-containing deposits). The formation of drusen separates RPE from Bruch’s membrane and the underlying choroidal vessels in association with RPE atrophy and photoreceptor degeneration (hallmarks of dry AMD). (f) In wet AMD with choroidal neovascularization, abnormal leaky choroidal vessels proliferate and penetrate the altered Bruch’s membrane protruding into the subretinal space, causing hemorrhage and rapid loss of vision.

Photo of Kip Connor, Ph.D.

Kip Connor, Ph.D.


Contact

Mass. Eye and Ear

243 Charles Street

Boston, MA 02114

T: 617-573-6949

email