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Constance L. Cepko, Ph.D.

Harvard Medical School

Bullard Professor of Genetics and Neuroscience
Professor of Ophthalmology, Department of Ophthalmology

Center/Research Area Affiliations

Research Summary

The brain is a complex tissue, comprising myriad cell types and more than 109 cells and 1015 connections in humans. Through cell division, commitment, and differentiation, cells are generated and become the final cell types observed in mature tissue. We are studying these processes in the retina of rodents and chicks, which exhibit patterns of development and final structures very similar to those of humans (Retinal Cell Fate Determination). We are also interested in the circuitry of retinal neurons and have developed viral vectors that transmit across synaptically connected cells, revealing both local and long distance connections (Development of Transsynaptic Tracers). To aid in this endeavor, and to more broadly allow the manipulation of biological activities within specific cell types, we have also developed a novel method that utilizes green fluorescent protein (GFP) as a scaffold. This method allows us to manipulate gene expression, or other activities, specifically in GFP-positive cells (GFP as a Scaffold for Biological Activities). Finally, we are also committed to preserving vision in people who inherit disease genes leading to blindness. To this end, we have been studying why retinal photoreceptors die and then designing gene therapy approaches to combat these mechanisms (Photoreceptors in Development and in Disease). And more ongoing projects here.

 

Education

1960: Ut enim ad minim veniam, quis nostrud exercitation
1964: Ut enim ad minim veniam, quis nostrud exercitation
1968: Ut enim ad minim veniam, quis nostrud exercitation

Postgraduate Training

1969: Internship: Ut enim ad minim veniam, quis nostrud exercitation
1971: Residency: Ut enim ad minim veniam, quis nostrud exercitation
1972: Fellowship: Ut enim ad minim veniam, quis nostrud exercitation
1973: Research Fellowship: Ut enim ad minim veniam, quis nostrud exercitation

Academic Appointments

1973 - 1978: Ut enim ad minim veniam, quis nostrud exercitation
1978 - 1983: Ut enim ad minim veniam, quis nostrud exercitation
1983 - present: Ut enim ad minim veniam, quis nostrud exercitation

Professional Memberships

1973 - present: Ut enim ad minim veniam, quis nostrud exercitation
1973 - present: Ut enim ad minim veniam, quis nostrud exercitation

Honors

1993: Ut enim ad minim veniam, quis nostrud exercitation
1998: Ut enim ad minim veniam, quis nostrud exercitation
2003: Ut enim ad minim veniam, quis nostrud exercitation

Advisory Boards

1993 - present: Ut enim ad minim veniam, quis nostrud exercitation
1998 - present: Ut enim ad minim veniam, quis nostrud exercitation
2004 - present: Ut enim ad minim veniam, quis nostrud exercitation
2010 - present: Ut enim ad minim veniam, quis nostrud exercitation

Teaching

1993 - present: Ut enim ad minim veniam, quis nostrud exercitation
1994 - present: Ut enim ad minim veniam, quis nostrud exercitation

Photo of Constance L. Cepko, Ph.D.

Constance L. Cepko, Ph.D.



Contact

Genetics NRB Room 360

77 Avenue Louis Pasteur

Boston, MA 02115

T: 617-432-7618

email