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James Chodosh, M.D., MPH

Harvard Medical School

David Glendenning Cogan Professor of Ophthalmology in the field of Cornea and External Disease, Department of Ophthalmology

Massachusetts Eye and Ear

Associate Director, Cornea and Refractive Surgery Service
Director, Cornea Fellowship (AUPO FCC)
Director, Boston Keratoprosthesis Clinical Programs
Medical Director, Optometry and Contact Lens Service
Senior Scientist
Surgeon


Center/Research Area Affiliations

Research Summary

Dr. Chodosh illuminates the molecular pathogenesis of adenoviral ocular infection and restores vision to those with blinding, autoimmune, corneal diseases through expanding the clinical scope of the Boston Keratoprosthesis (B-KPro), a unique corneal substitute developed by Dr. Claes H. Dohlman. His group is the worldwide leader inadenoviral ocular pathogenesis. Dr. Chodosh studies the viruses that cause the most severe form of pink eye, known as epidemic keratoconjunctivitis (EKC). In particular, his group generated the first whole genome sequence for the adenoviruses that cause EKC, created the first mouse model of adenovirus keratitis, and pioneered the cornea as a model system in which to study the role of tissue fibroblasts in innate immune responses to infection.

Select Publications

For a full publication list, please see his CV.

Homologous recombination in E3 genes of human adenovirus species D. Singh G, Robinson CM, Dehghan S, Jones MS, Dyer DW, Seto D, Chodosh J. J Virol. 2013 Nov;87(22):12481-8.

Molecular evolution of human adenoviruses. Robinson CM, Singh G, Lee J-Y, Dehghan S, Rajaiya J, Liu EB, Yousuf MA, Betensky RA, Jones MS, Dyer DW, Seto D, Chodosh J. Sci Rep. 2013 May 9;3:1812.

Predicting the next pathogen: analysis of a novel human adenovirus. Robinson CM, Zhou X, Rajaiya J, Yousuf MA, Singh G, DeSerres JJ, Walsh MP, Wong S, Seto D, Dyer DW, Chodosh J, Jones MS. mBio. 2013;4(2):e00595-12.

Heat shock protein 27 mediated signaling in viral infection. Rajaiya J, Yousuf MA, Singh G, Stanish H, Chodosh J. Biochemistry. 2012;51:5695-702.

Analysis of human adenovirus type 19 associated with epidemic keratoconjunctivitis and its reclassification as adenovirus type 64. Zhou X, Robinson CM, Rajaiya J, Dehghan S, Seto D, Jones MS, Dyer DW, Chodosh J. Invest Ophthalmol Vis Sci. 2012;53:2804-11.

View a complete list of publications on pubmed.gov »

Education

  • 1975-1978: B.A., Film, Hampshire College
  • 1982-1984: Premed, New York University
  • 1984-1988: M.D., with Honors, Medicine, Baylor College of Medicine
  • 2003-2007: M.P.H., with Honors, Biostatistics, University of Oklahoma Health Sciences Center

Postgraduate Training

  • 1988-1989: Internship, Transitional, St. Joseph's Hospital
  • 1989-1992: Residency, Ophthalmology, Cullen Eye Institute, Baylor College of Medicine
  • 1992-1993: Clinical Fellowship, Cornea and External Diseases, Bascom Palmer Eye Institute, University of Miami School of Medicine
  • 1993-1995: Postdoctoral Research Associate, Molecular Biology and Virology; Infectious Diseases, St. Jude Children's Research Hospital

Academic Appointments

  • 1993: Instructor, Ophthalmology, University of Tennessee College of Medicine
  • 1994: Assistant Professor, Ophthalmology, University of Tennessee College of Medicine
  • 1995: Assistant Professor, Ophthalmology, University of Oklahoma Health Sciences Center
  • 2000: Associate Professor, with Tenure, Ophthalmology, University of Oklahoma Health Sciences Center
  • 2001: Adjunct Associate Professor, Cell Biology, University of Oklahoma Health Sciences Center
  • 2004: Adjunct Associate Professor, Microbiology and Immunology, University of Oklahoma Health Sciences Center
  • 2005: Professor, Ophthalmology, University of Oklahoma Health Sciences Center
  • 2005: Adjunct Professor, Cell Biology; Microbiology and Immunology, University of Oklahoma Health Sciences Center
  • 2006-2008: M.G. McCool Chair, Ophthalmology, University of Oklahoma Health Sciences Center
  • 2008-2010: Lecturer, Ophthalmology, Harvard Medical School
  • 2011: Professor, Ophthalmology, Harvard Medical School
  • 2011: David G. Cogan Professor of Ophthalmology in the Field of Cornea and External Disease, Ophthalmology, Harvard Medical School

Professional Memberships

  • 1990-present: Member, Association for Research in Vision and Ophthalmology
  • 2000-2007: Public Relations Committee, Association for Research in Vision and Ophthalmology
  • 2006-2012: Member, Advocacy Committee, Research Agency Subcommittee, Association for Research in Vision and Ophthalmology
  • 2007: Moderator, Translational Research in Microbial Pathogenesis, Association for Research in Vision and Ophthalmology
  • 2010-2012: Chair, Advocacy Committee, Research Agency Subcommittee, Association for Research in Vision and Ophthalmology
  • 1992-present: Member, Society of Heed Fellows
  • 1992-present: Member, Dan B. Jones Society
  • 1994-present: Member, American Academy of Ophthalmology
  • 1995-1996: Clinical Case Reviewer, ProVision Interactive Clinical Case Studies, American Academy of Ophthalmology
  • 2000-2005: Basic and Clinical Science Course Sub-Committee, External Disease and Cornea, American Academy of Ophthalmology
  • 2001: Reviewer, AAO Summary Benchmarks for Preferred Practice Patterns, American Academy of Ophthalmology
  • 2001: Reviewer, Focal Points: Clinical Modules for Ophthalmologists, American Academy of Ophthalmology
  • 2004: Leadership Development Program, American Academy of Ophthalmology
  • 2005: Pay for Performance Subspecialty Society and Specialized Interest Society Liaison, American Academy of Ophthalmology
  • 2006: Member, Subspecialty Specialized Interest Section Nominating Committee, American Academy of Ophthalmology
  • 2006-present: Member, Cornea/External Disease-Panel Subcommittee of the Practicing Ophthalmologists Curriculum, American Academy of Ophthalmology
  • 2007-present: Committee for Research Regulatory and External Scientific Relations, American Academy of Ophthalmology
  • 2008: Subspecialty Co-Chair, Tornado Belt Region, American Academy of Ophthalmology
  • 2008: Member, Council Credentials Committee, American Academy of Ophthalmology
  • 2008-present: Member, EyeNet Editorial Advisory Board, American Academy of Ophthalmology
  • 1995-present: Member, American Society for Virology
  • 1995-present: Member, American Society for Microbiology
  • 1996-present: Member, Tear Film & Ocular Surface Society
  • 2001-present: Medical and Scientific Advisory Board, Tear Film & Ocular Surface Society
  • 2006-2009: Chairperson, Medical and Scientific Advisory Board, Tear Film & Ocular Surface Society
  • 1999-present: Member, American Association of Immunologists
  • 1999-present: Member, International Ocular Surface Society
  • 1999: Founding Member, Board of Directors, International Ocular Surface Society
  • 2009-2012: Member, Governing Board, International Ocular Surface Society
  • 2000-present: Member, Ocular Microbiology and Immunology Group
  • 2000-2002: Moderator, Annual Meeting, Ocular Microbiology and Immunology Group
  • 2002-2003: Secretary, Ocular Microbiology and Immunology Group
  • 2003-2004: Vice-President, Ocular Microbiology and Immunology Group
  • 2003-2009: Councilor to American Academy of Ophthalmology, Ocular Microbiology and Immunology Group
  • 2004-2005: President, Ocular Microbiology and Immunology Group
  • 2006-2007: Co-Moderator, Annual Meeting, Ocular Microbiology and Immunology Group
  • 2002-present: Member, American Board of Ophthalmology, Associate Examiner
  • 2006-2007: Member, International Society of Eye Research
  • 2006: Scientific Program Organizer, XVII International Congress of Eye Research, Buenos Aires, Argentina, International Society of Eye Research
  • 2006-present: Member, American Ophthalmological Society
  • 2007: Inducted, American Ophthalmological Society
  • 2009-2012: Member, Thesis Committee, American Ophthalmological Society
  • 2010-2012: Chair, Thesis Committee, American Ophthalmological Society
  • 2006-2008: Member, Association of University Professors of Ophthalmology
  • 2008-present: Member, Cornea Society
  • 2011-present, Member, Education Committee, Cornea Society
  • 2008-present: Member, KPro Study Group
  • 2010-present: Member, Steering Committee, KPro Study Group
  • 2012-present: Member, International Adenovirus Meeting
  • 2012: Co-Moderator, 10th International Adenovirus Meeting

Honors (select)

  • 1992: Thomas D. and Ruth Byers Heed Fellowship
  • 2005: Achievement Award, American Academy of Ophthalmology
  • 2006: Secretariat Award, American Academy of Ophthalmology
  • 2009: Silver Fellow, Association for Research in Vision and Ophthalmology
  • 2010: Gold Fellow, Association for Research in Vision and Ophthalmology
  • 2012: Senior Achievement Award, American Academy of Ophthalmology
  • 2012: Honorable Mention, Compassionate Caregiver Award, Schwartz Center for Compassionate Healthcare

Teaching (select)

  • 2010: Course Director, Cornea Conference, Massachusetts Eye and Ear

 

Photo of James Chodosh, M.D., MPH

James Chodosh, M.D., MPH


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